Fluctuations arising in nonlinear dissipative systems (diode, transistors, chemical reaction, etc.) subject to an external drive (voltage, chemical potential, etc.) are well known to elude any simple characterisation such as the fluctuation-dissipation theorem (also called Johnson-Nyquist law, or Einstein's law in specific contexts). Using results from stochastic thermodynamics, we show that the variance of these fluctuations exceeds the variance predicted by a suitably extended version of Johnson-Nyquist's formula, by an amount that is controlled by the skewness (third moment) of the fluctuations. As a consequence, symmetric fluctuations necessarily obey the extended Johnson-Nyquist formula. This shows the physical inconsistency of Gaussian approximation for the noise arising in some nonlinear models, such as MOS transistors or chemical reactions. More generally, this suggests the need for a stochastic nonlinear systems theory that is compatible with the teachings of thermodynamics.