Skeletal Foundation Research Articles

Maxillomandibular Advancement for Obstructive Sleep Apnea Syndrome: Long-Term Results of Respiratory Function and Reverse Face-Lift.

Scientific literature considers maxillomandibular advancement (MMA) as the most effective surgical treatment for the management of adult obstructive sleep apnea syndrome (OSAS). Maxillomandibular advancement enlarges the pharyngeal space by expanding the skeletal framework. Moreover, it projects the soft tissue of the cheeks, the mouth, and the nose in the aging face, which is characterized by multiple signs affecting the middle third and the lower third. The potential of orthognathic surgery (double jaw surgical advancement) of expanding the skeletal foundation to increase the facial drape support and to rejuvenate the face by a "reverse face-lift" is now recognized. The aim of this study was to review the surgical outcomes after MMA in terms of respiratory function and assessment of facial esthetics. We retrospectively reviewed the charts of all patients affected by OSAS who underwent maxillomandibular advancement between January 2010 and December 2015 in 2 tertiary hospitals (IRCCS Policlinico San Martino of Genoa and IRCCS Policlinico Ca' Granda of Milan). During the postoperative follow-up examination, all patients underwent polysomnographic examination and esthetic assessment to evaluate the respiratory function and facial rejuvenation after double jaw surgical advancement. The final study sample included 25 patients (5 females, 20 males). The overall success rate of the surgical treatment (apnea/hypopnea index, AHI <20) was 79%; the overall rate of surgical cure (AHI <5) was 47%. Twenty-three patients (92%) showed a degree of rejuvenation after MMA. Maxillomandibular advancement is currently the most effective surgical treatment for the management of OSAS in adult patients who are not responders to medical treatment. "Reverse face-lift" is the consequence of the double jaw surgical advancement.

Advanced Facial Rejuvenation After Bimaxillary Surgery in Three Different Facial Types.

Facial aging is the consequence of many mechanisms involving the bones and the "soft tissue" (skin, fat, ligaments, muscles, and periosteum) of the face such as downward migration of the soft tissue, adipose and muscular tissue atrophy, and skeletal resorption. The potential of orthognathic surgery (double jaw surgical advancement) of expanding the skeletal foundation to increase the facial drape support is now recognized and widely popularized by several authors. The aim of this study was to analyze the rejuvenation change of the face after bimaxillary advancement for orthognathic surgery, focusing on the previously mentioned stigmata of the middle and the lower third of the aging face. A retrospective monocentric chart review was conducted for all patients affected by aging signs of the face who underwent orthognathic surgery between January 2015 and December 2019 at the Face Surgery Center (Parma, Italy). During the postoperative follow-up examination, all patients underwent anthropometric photographs and esthetic assessment to evaluate facial rejuvenation after double jaw surgical advancement. After application of the exclusion criteria, the final study sample included 85 patients (53 females, 32 males). Eighty-three patients (97%) showed a degree of rejuvenation after maxillo-mandibular advancement (MMA); the score of the postoperative face was less than the score of the preoperative face. Two patients reported no significant postoperative change; none reported a more aging face, with a successful "reverse face-lift" occurred in 97% of our cases. "Reverse face-lift" by bimaxillary advancement is a surgical procedure which is indicated for a selected group of middle-aged patients with a diagnosis of bimaxillary skeletal retrusion or posterior divergence very motivated to an extreme rejuvenation; this procedure provides support for the facial mask resulting in whole facial rejuvenation.

Multiplane Facelift Following Facial Bone Contouring for Enhanced Mobilization and Rejuvenation.

The aging process is inevitable in life, and the social demand for rejuvenation increases by year. The face acquires both soft tissue and skeletal changes through aging, and correcting only one side has limits in natural rejuvenation. Thus, the authors combined multiplane facelift with whole-facial bone contouring for maximal results. From March 2017 to February 2019, a total of 22 patients received multiplane facelift following facial bone contouring in our institute. The authors retrospectively reviewed information on demographics, surgical procedure, complications, and satisfaction. Under general anesthesia, the patient received reduction malarplasty, genioplasty, and mandible anglectomy via intraoral incisions, and multiplane facelift through retrotragal and postauricular incisions. All patients were females with the mean age of 42.86 ± 9.55. The mean operation time was 296.39 ± 31.87 minutes and the mean follow-up period was 12.59 ± 6.77 months. Few complications included hematoma and unfavorable scars. More than 95% of the patients were very satisfactory with the result. In this study, the authors present our novel procedure of combining whole-facial bone contouring and multiplane facelift. This technique can reestablish the facial skeletal foundation and effectively lift soft tissues in various vectors with longevity and safety.

Increased bone mineral density for 1\xa0year of romosozumab, vs placebo, followed by 2\xa0years of denosumab in the Japanese subgroup of the pivotal FRAME trial and extension

SummaryRomosozumab, which binds sclerostin, rebuilds the skeletal foundation before transitioning to antiresorptive treatment. This subgroup analysis of an international, randomized, double-blind study in postmenopausal women with osteoporosis showed efficacy and safety outcomes for romosozumab followed by denosumab in Japanese women were generally consistent with those for the overall population.PurposeIn the international, randomized, double-blind, phase 3 FRActure study, in postmenopausal woMen with ostEoporosis (FRAME; NCT01575834), romosozumab followed by denosumab significantly improved bone mineral density (BMD) and reduced fracture risk. This report evaluates Japanese women in FRAME.MethodsPostmenopausal women with osteoporosis (T-score − 3.5 to − 2.5 at total hip or femoral neck) received romosozumab 210 mg or placebo subcutaneously monthly for 12 months, then each group received denosumab 60 mg subcutaneously every 6 months for 24 months. The key endpoint for Japanese women was BMD change. Other endpoints included new vertebral, clinical, and nonvertebral fracture; the subgroup analysis did not have adequate power to demonstrate statistically significant reductions.ResultsOf 7180 enrolled subjects, 492 (6.9%) were Japanese (247 romosozumab, 245 placebo). BMD increases from baseline were greater (P < 0.001) for romosozumab-to-denosumab than placebo-to-denosumab at the lumbar spine (36 months, 12.7%), total hip (4.2%), and femoral neck (4.1%). Fracture risk was lower through 36 months for romosozumab-to-denosumab vs placebo-to-denosumab for new vertebral (1.7% vs 4.5%; relative risk reduction (RRR) 63%, P = 0.070), clinical (3.2% vs 7.3%; RRR 53%, P = 0.072), nonvertebral (2.8% vs 6.1%; RRR 50%, P = 0.12), and all other fracture types evaluated. Rates of adverse events and positively adjudicated serious cardiovascular events were generally balanced between groups.ConclusionsEfficacy and safety for romosozumab-to-denosumab were similar between Japanese women and the overall population. The sequence of romosozumab to rebuild the skeletal foundation before transitioning to antiresorptive treatment with denosumab is a promising regimen for Japanese postmenopausal women with osteoporosis at high risk of fracture.

Fat Grafting into Younger Recipients Improves Volume Retention in an Animal Model.

Soft-tissue deficits associated with various craniofacial anomalies can be addressed by fat grafting, although outcomes remain unpredictable. Furthermore, consensus does not exist for timing of these procedures. Whereas some advocate approaching soft-tissue reconstruction after the underlying skeletal foundation has been corrected, other studies have suggested that earlier grafting may exploit a younger recipient niche that is more conducive to fat graft survival. As there is a dearth of research investigating effects of recipient age on fat graft volume retention, this study compared the effectiveness of fat grafting in younger versus older animals through a longitudinal, in vivo analysis. Human lipoaspirate from three healthy female donors was grafted subcutaneously over the calvaria of immunocompromised mice. Volume retention over 8 weeks was evaluated using micro-computed tomography at three experimental ages: 3 weeks, 6 months, and 1 year. Histologic examination was performed on explanted grafts to evaluate graft health and vascularity. Recipient-site vascularity was also evaluated by confocal microscopy. The greatest retention of fat graft volume was noted in the youngest group compared with both older groups (p < 0.05) at 6 and 8 weeks after grafting. Histologic and immunohistochemical analyses revealed that improved retention in younger groups was associated with greater fat graft integrity and more robust vascularization. The authors' study provides evidence that grafting fat into a younger recipient site correlates with improved volume retention over time, suggesting that beginning soft-tissue reconstruction with fat grafting in patients at an earlier age may be preferable to late correction.

Aboriginal laws and colonial foundation

ABSTRACTFirst Nations Peoples of this continent we now call Australia experienced the violence of colonialism for longer than the coloniser and now the Australian state is prepared to admit. A more than 150-year frontier war has been passed off as peaceful settlement. This was a lie. Terra nullius was another lie, if terra nullius was the truth why was there a frontier war. This war enabled the invasion and colonisation of Aboriginal lands. While ‘justice’ remains overdue, this paper examines how it is the Australian state has mythologised the rejection of terra nullius. And at the same time normalising the Australian colonial project. This paper considers how it is we might move beyond the colonial matrix of impossibility and ‘skeletal foundation.’

Applications of Fat Grafting in Facial Aesthetic Skeletal Surgery

Aesthetic skeletal surgery of the face is a powerful tool to alter the facial skeleton; the facial form is enhanced through the use of alloplastic implants and osteotomies of the facial bones. However, the ultimate aesthetic appearance is dictated by how the soft tissue envelope drapes over the altered skeletal foundation. Intraoperative and postoperative fat grafting enhances the final aesthetic result in patients who undergo skeletal aesthetic procedures. The authors describe cases in which selective fat grafting has been successful in optimizing facial soft tissue symmetry in patients undergoing skeletal aesthetic surgery of the face. A retrospective chart review of all patients who underwent aesthetic skeletal surgery of the face between November 1, 2003, and October 31, 2011, in the Department of Surgery at Georgetown University Hospital was performed, and any patient who required fat grafting either at the time of aesthetic facial skeletal surgery or in the postoperative period was identified (n = 21). Common indications for fat grafting and the surgical plans are reviewed and presented in this article. Twenty-one patients were identified who required 37 fat grafting procedures either at the time of aesthetic skeletal surgery of the face or in the postoperative period. The procedures most frequently requiring fat grafting were genioplasty, facial shape modifications, and facial symmetry improvement. Fat grafting most commonly corrected irregularities or asymmetries and improved the soft tissue contour overlying repositioned bone or alloplastic implants. Most patients were female (72%) with a mean age of 42 years (range, 4-58 years). There were 4 complications in total: 3 surgical site infections (managed conservatively in 1 patient and with incision and drainage in the remaining 2) and 1 hematoma requiring drainage and closure on the day of surgery. Knowledge of which procedures are likely to require fat grafting and the techniques for doing so can improve the plastic surgeon's ability to provide optimal aesthetic results following facial skeletal alterations.

Neuroimaging: Intrinsic Lesions of the Central Skull Base Region

The sphenoid bone is the osseous foundation of the central skull base. The body of the sphenoid is cuboid in shape and its posterior margin is joined to the basilar occipital bone (basiocciput) via a synchondrosis to form the complete clivus. Traditionally, radiologic discussions of intrinsic disease of the central skull base emphasize marrow space-occupying lesions including metastatic disease, myeloma, and chordoma. Based on our practical experience and the anatomical boundaries of the central skull-based region put forth, we include lesions of the sphenoid sinus and petrous apex in our discussion. We describe lesions that might originate within, be confined to, or principally involve the skeletal foundation of the central skull base, including the pneumatized regions contained within. Intrinsic lesions affecting the central skull base are emphasized and the most important computed tomography and magnetic resonance imaging findings that allow for effective diagnosis, planning, and treatment are highlighted.

Aging Changes of the Periorbita, Cheeks, and Midface

The periorbita, cheeks, and midface are an area of complex facial form and function. There is a particular pleasing visual harmony of these regions in the youthful face. With time, the robust glow and fullness of youth fades and diminishes. The skin is the first component to show the passage of time as it dulls, wrinkles, and blemishes. This is followed by a slow loosening and sagging of soft tissues as they descend from their once-fixed points of the skeletal foundation. The smooth transitions between regions are separated and hollows and ridges appear. These processes continue throughout life and eventually are accompanied by the visible consequences of bone resorption. The faces age, and as the countenance of the human spring turns through summer into autumn, function follows form, and symptoms accompany signs. A thorough understanding of both youthful and elder anatomy as well as the stigmata of aging is prerequisite to perform rejuvenating procedures. This article discusses these changes and how the older anatomy becomes the new norm.

Changes in the Facial Skeleton With Aging: Implications and Clinical Applications in Facial Rejuvenation

In principle, to achieve the most natural and harmonious rejuvenation of the face, all changes that result from the aging process should be corrected. Traditionally, soft tissue lifting and redraping have constituted the cornerstone of most facial rejuvenation procedures. Changes in the facial skeleton that occur with aging and their impact on facial appearance have not been well appreciated. Accordingly, failure to address changes in the skeletal foundation of the face may limit the potential benefit of any rejuvenation procedure. Correction of the skeletal framework is increasingly viewed as the new frontier in facial rejuvenation. It currently is clear that certain areas of the facial skeleton undergo resorption with aging. Areas with a strong predisposition to resorption include the midface skeleton, particularly the maxilla including the pyriform region of the nose, the superomedial and inferolateral aspects of the orbital rim, and the prejowl area of the mandible. These areas resorb in a specific and predictable manner with aging. The resultant deficiencies of the skeletal foundation contribute to the stigmata of the aging face. In patients with a congenitally weak skeletal structure, the skeleton may be the primary cause for the manifestations of premature aging. These areas should be specifically examined in patients undergoing facial rejuvenation and addressed to obtain superior aesthetic results.Level of Evidence IVThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.Electronic supplementary materialThe online version of this article (doi:10.1007/s00266-012-9904-3) contains supplementary material, which is available to authorized users.

Changes in the Facial Skeleton With Aging: Implications and Clinical Applications in Facial Rejuvenation.

In principle, to achieve the most natural and harmonious rejuvenation of the face, all changes that result from the aging process should be corrected. Traditionally, soft tissue lifting and redraping have constituted the cornerstone of most facial rejuvenation procedures. Changes in the facial skeleton that occur with aging and their impact on facial appearance have not been well appreciated. Accordingly, failure to address changes in the skeletal foundation of the face may limit the potential benefit of any rejuvenation procedure. Correction of the skeletal framework is increasingly viewed as the new frontier in facial rejuvenation. It currently is clear that certain areas of the facial skeleton undergo resorption with aging. Areas with a strong predisposition to resorption include the midface skeleton, particularly the maxilla including the pyriform region of the nose, the superomedial and inferolateral aspects of the orbital rim, and the prejowl area of the mandible. These areas resorb in a specific and predictable manner with aging. The resultant deficiencies of the skeletal foundation contribute to the stigmata of the aging face. In patients with a congenitally weak skeletal structure, the skeleton may be the primary cause for the manifestations of premature aging. These areas should be specifically examined in patients undergoing facial rejuvenation and addressed to obtain superior aesthetic results.Level of Evidence IV This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Techniques on Dentoalveolar Distraction Ostegenesis: Accelerated Surgical Orthodontics

Traditional surgical orthodontic therapy utilizes cell mediated orthodontic tooth movement to align teeth within the alveolar processes prior to orthognathic procedures. Orthognathic procedures are used to align the skeletal structures of the face and orient the alveolar arches so that the teeth are positioned in proper molar and cuspid relationships. Treatment planning relies heavily on clinical assessment of facial defects and cephalometric analysis to determine these discrepancies. Once these discrepancies have been identified, appropriate skeletal movements are completed by the surgeon with procedures such as the sagital split osteotomy and Le Fort osteotomy. While these procedures have experienced very favorable outcomes, there are many cases in which the facial deficit is not truly a skeletal problem, but is an alveolar bone discrepancy. The alveolar bone discrepancy may be either an intra-alveolar arch defect that does not allow enough room for the dentition, or it may be an alveolar-skeletal defect that does not align the alveolus properly with its associated skeletal structures. Dentoalveolar discrepancies are difficult to treat with cellular mediated orthodontic tooth movement alone. Arch deformities usually require the orthodontist to prolong orthodontic treatment time to obtain proper tooth alignment. Many times this requires the extraction of multiple teeth or the positioning of the teeth outside the confines of their underlying bone. Traditional surgical procedures that have been used to correct arch width discrepancies are: surgically assisted rapid palatal expansion and the mandibular midline distraction. While these surgical procedures have provided favorable results, they do not assist in the anterior-posterior discrepancies or vertical discrepancies. Many of the anterior-posterior dentoalveolar discrepancies are treated with orthognathic surgical procedures even though the underlying skeletal foundation is in a relatively normal position. One example of this, is mandibular advancement in patients with mandibular alveolar deficiency. Often this can necessitate a reduction genioplasty to prevent over projection of the mandible. In 1959, Heinrich Kole suggested that the greatest resistance to tooth movement is created by the cortical bone of the alveolus. He described the use of interdental corticotomies to facilitate accelerated orthodontic tooth repositioning in three dimensions. This procedure was described by many other authors but became less favorable due to advancements in orthognathic surgery. With the recent decline in the number of orthognathic surgical cases being treatment planned or accepted for a variety of reasons, there is tremendous need to assist the orthodontist with alternative options that can augment orthodontic outcomes. In this chapter, we would like to present a new concept which addresses dentoalveolar bony discrepancies with inter-dental osteotomies, distraction osteogenesis, and active orthodontics. This procedure is designed to change the dentoalveolar complex so that the teeth, dentoalveolar bone, and the jaws are appropriately addressed to maximize ideal functional and esthetic relationships.

Treatment of Complete Bilateral Cleft Lip-Nasal Deformity

The modern technique of presurgical orthopedics and nasoalveolar molding produces a better skeletal foundation and nasal shape for the repair of the bilateral cleft lip-nasal deformity. The general principles are as follows: (1) preserve the presurgical columellar length; (2) keep the width of the central lip segment narrow without compromising the blood supply; (3) advance the columella prolabium complex superiorly to allow reconstruction of the orbicularis oris muscle behind the prolabium; (4) release the alar cartilage attachment from the pyriform rim and provide additional coverage of this soft tissue deficiency with the use of inferior turbinate flaps; (5) release and reposition the lower lateral cartilage; (6) adequately dissect above the maxillary periosteum; (7) reconstruct the nasal floor by local mucosal flaps; (8) reconstruct the prolabial buccal sulcus with tissue from the prolabium; (9) reconstruct the orbicularis muscle sphincter and attach it to the anterior nasal spine; (10) reconstruct a new Cupid's bow, central vermilion, and lip tubercle with tissue from the lateral lips; (11) balance the height of both lateral lips without any incision around the ala; and (12) maintain the presurgical nasolabial angle. The residual nasal deformity remains a problem that needs further improvement. The long-term result in Chang Gung Craniofacial Center suggests overcorrection of columella height before, during, and after lip repair.

Effect of physical activity on bone mass.

Maintenance of bone mass depends on several factors, including proper level of physical activity, hormones, and nutrition. Prescribing effective weight-training and weight-bearing exercise programs for improving bone mass is highly desirable. Specificity of each exercise program can contribute to an increment or reduction of bone mass. Cessation of physical activity induces rapid metabolic bone changes, although the effects on bone mass take time to develop. Therefore, weight-bearing and periodic high-intensity loading exercises are recommended for maintenance of bone mass in the spine and lower extremities. Patients who endure a period of immobility such as prolonged bed rest should resume their daily activities in addition to supervised exertional exercises. While research continues in an effort to find ways to increase bone mass despite aging and negative genetic factors, more focus can be given to building a solid skeletal foundation through good nutritional and exercise habits developed early in life.

Age-related changes of the craniofacial skeleton: an anthropometric and histologic analysis.

With the development of increasingly sophisticated methods for the alteration of bony facial form consequent to age, it is imperative that the surgeon have a fundamental knowledge of the age-related changes the skeleton may undergo. To understand these changes better, a detailed anthropometric and histomorphic analysis of the craniofacial skeleton as a function of age was undertaken. The study consisted of a detailed craniometric analysis of 160 skulls selected randomly from a Caucasian population of skeletal remains totaling 1500 specimens. Additionally, a histologic analysis of the supraorbital ridge in a separate preserved cadaver population was performed. Although the results showed individual variation as expected, definite changes in craniofacial morphology were observed. These included (1) appreciable reduction of facial height, most marked in the maxilla and mandible, and strongly correlated with loss of teeth, (2) modest increase in facial width, (3) modest increase in facial depth, except in those regions associated with tooth loss, and (4) general coarsening of bony prominences. Histomorphic analysis demonstrated increasing porosity with age, more marked in the female population. Although these changes represent population trends, in any given patient, any or all of them may be present to varying degrees. Surgeons should be aware of these possibilities and consider selective alterations of the skeletal foundation, either separately or in concert with the overlying soft-tissue envelope, in order to optimize the results of surgery for the aging face.

Facial skeletal expansion: treatment strategies and rationale.

Forty-three nonconsecutive patients presenting with dentofacial deformity underwent surgical procedures designed intentionally to create skeletal disproportion in the sagittal and/or vertical dimensions. This was accomplished through expansion (enlargement) of the facial skeleton beyond normative standards. At the time of follow-up, which ranged from 14 to 36 months (mean 18.4 months), soft-tissue cephalometric analyses documented facial disproportion to exist in 37 of the 43 patients treated. Thirty-two patients had excessive anterior divergence (facial protrusion) at pogonion, and 17 patients had excessive lower face height as measured from subnasale to menton. All patients were judged to have had a favorable aesthetic outcome. This philosophy of facial skeletal expansion is predicated on two concepts: The first of these is that facial proportions and dimensions beyond those which are considered normal may be extremely attractive in a given individual. Second, the soft-tissue response to skeletal expansion is more favorable and predictable than it is to skeletal contraction in providing for well-supported soft tissues. This treatment planning approach is based on the dynamic interrelationship between the skeletal foundation and the soft-tissue facial mask. It relies on physical examination as the major determinant of aesthetic surgical options.

Maxillary Advancement for Mandibular Prognathism: Indications and Rationale

The surgical correction of mandibular prognathism has traditionally involved posterior repositioning of the mandibular body. This treatment approach corrects the skeletal disproportion at the expense of reducing facial skeletal volume and can unpredictably result in inadequately supported soft tissues with loss of skeletal definition. In an effort to avoid these sequelae of mandibular reduction, 18 patients diagnosed as having mandibular prognathism were treated with maxillary advancement surgery at the Le Fort I level. Mean patient SNB angle was 85.2 degrees, as compared with a normal 79 +/- 3 degrees. Maxillae were documented to be in normal position relative to both cranial base and Frankfort horizontal. The mean maxillary advancement was 6.9 mm, with a range of 4.5 to 8.8 mm. All patients required genioplasty to reduce vertical chin height and/or to laterally shift the chin. At the time of follow-up (mean 16.2 months), all patients retained cephalometric data suggestive of enlarged mandibles and excessive anterior facial divergence. However, maxillomandibular harmony and facial convexity had been restored without sacrificing skeletal volume. Treatment results demonstrated these faces to be skeletally well proportioned despite lower face protrusion that was beyond "normal." Postoperative appearances were characterized by a well-supported soft-tissue envelope and a highlighted skeletal foundation, creating angular, well-defined lower faces. These findings support the credibility of maxillary advancement as the procedure of choice in selected individuals with mandibular prognathism. Indications and an aesthetic rationale for this surgical approach are presented.

Aesthetic Contouring of the Facial Support System

The skeletal foundation and its attachments provide a basis for changing the basic structure of the face. Detailed preoperative evaluation and a clear understanding between the patient and surgeon of the aesthetic goals are essential prior to proceeding with surgery. Besides a knowledge of the normal aesthetic and arthropologic measurements, the surgeon must have an understanding of the range of methods available prior to proceeding with surgery. For minor alterations, contour reduction or augmentation should be considered. In the temporal fossa, augmentation with synthetic material is preferred. In the supraorbital ridge and chin autogenous tissue is generally the material of choice. An understanding of when and how to use these materials is the essence of achieving satisfactory results.