Background: Sialolithiasis is the most common salivary gland disease. Salivary gland disease usually occurs in middle age, with an incidence of 12 in 1000 in the adult population. The peak incidence is between the ages of 30 and 50. Sialolithiasis generally occurs in the submandibular gland. Sialoliths can be single or multiple. Diagnosis of sialolithiasis can be based on clinical examination or simple supporting examination in the form of sialography. Case Report: There were 3 patients with the main complaint of pain in the lower jaw area with similar symptoms, such as swelling and discomfort every time they chewed food. In all three patients, conventional plain radiographs were examined, namely Skull AP photos, followed by conventional radiological examinations using water-soluble contrast media known as sialography. Conclusion: Correct diagnosis and determine the appropriate treatment for the patient. Plain AP skull radiographs can be used as an early indication of the presence or absence of sialolith images, although they may not be visible if they are relatively small. Furthermore, sialography examination can become the gold standard in determining the location and size of sialoliths. In these three cases, an opacity or filling defect, accompanied by a dilatation of the proximal duct and even narrowing of the distal lumen of the duct, indicates either partial or total obstruction. An ultrasound examination was performed to confirm the diagnosis. In all three cases, it was found that there was indeed a hyperechoic surrounded by clear anechoic (saliva), thus suggesting a sialolithiasis.