Mass Size Research Articles

CT imaging analysis differentiating papillary renal neoplasm with reverse polarity from papillary renal cell carcinoma: combined with a radiomics model.

To assess the computed tomography (CT) findings of papillary renal neoplasm with reverse polarity (PRNRP) and develop a radiomics-based model to distinguish PRNRPs from papillary renal cell carcinomas (PRCCs). We analyzed 31 PRNRPs and 68 PRCCs using preoperative kidney CT. We evaluated CT features that could discriminate PRNRPs from PRCCs. A radiomics signature was constructed using features selected through a least absolute shrinkage and selection operator algorithm. A radiomics-based model incorporating a radiomics signature and subjective CT parameters using multivariate logistic regression was developed. The diagnostic performance of the CT parameters, radiomics model, and their combination was evaluated using the area under the curve (AUC). Most of PRNRPs had a round shape (93.5%), well-defined margin (100%), and persistent enhancement (77.4%). Compared with PRCC, PRNRPs exhibited distinct CT features including small size (16.7 vs. 37.7mm, P < 0.001), heterogeneity (64.5 vs. 32.4%, P = 0.004), enhancing dot sign (16.1 vs. 1.5%, P = 0.001), and high attenuation in pre-contrast CT (44.2 vs. 35.5 HU, P = 0.003). Multivariate analysis revealed smaller mass size (odds ratio [OR]: 0.9; 95% confidence interval [CI] 0.9-1.0, P = 0.013), heterogeneity (OR: 8.8; 95% CI 1.9-41.4, P = 0.006), and higher attenuation in pre-contrast CT (OR: 1.1; 95% CI 1.0-1.2, P = 0.011) as significant independent factors for identifying PRNRPs. The diagnostic performance of the combination model was excellent (AUC: 0.923). Smaller tumor size, heterogeneity, and higher attenuation in pre-contrast CT were more closely associated with PRNRPs than with PRCCs. Though the retrospective design, small sample size, and single-center data of this study may affect the generalizability of the findings, combining subjective CT features with a radiomics model is beneficial for distinguishing PRNRPs from PRCCs.

Identification of Genomic Predictors of Muscle Fiber Size

The greater muscle fiber cross-sectional area (CSA) is associated with greater skeletal muscle mass and strength, whereas muscle fiber atrophy is considered a major feature of sarcopenia. Muscle fiber size is a polygenic trait influenced by both environmental and genetic factors. However, the genetic variants underlying inter-individual differences in muscle fiber size remain largely unknown. The aim of our study was to determine whether 1535 genetic variants previously identified in a genome-wide association study of appendicular lean mass are associated with the CSA of fast-twitch muscle fibers (which better predict muscle strength) in the m. vastus lateralis of 148 physically active individuals (19 power-trained and 28 endurance-trained females, age 28.0 ± 1.1; 28 power-trained and 73 endurance-trained males, age 31.1 ± 0.8). Fifty-seven single-nucleotide polymorphisms (SNPs) were identified as having an association with muscle fiber size (p &lt; 0.05). Of these 57 SNPs, 31 variants were also associated with handgrip strength in the UK Biobank cohort (n = 359,729). Furthermore, using East Asian and East European athletic (n = 731) and non-athletic (n = 515) cohorts, we identified 16 SNPs associated with athlete statuses (sprinter, wrestler, strength, and speed–strength athlete) and weightlifting performance. All SNPs had the same direction of association, i.e., the lean mass-increasing allele was positively associated with the CSA of muscle fibers, handgrip strength, weightlifting performance, and power athlete status. In conclusion, we identified 57 genetic variants associated with both appendicular lean mass and fast-twitch muscle fiber size of m. vastus lateralis that may, in part, contribute to a greater predisposition to power sports.

Bulge+disc decomposition of HFF and CANDELS galaxies: UVJ diagrams and stellar mass–size relations of galaxy components at 0.2 ≤ z ≤ 1.5

Abstract Using deep imaging from the CANDELS and HFF surveys, we present bulge+disc decompositions with GalfitM for ∼17,000 galaxies over 0.2 ≤ z ≤ 1.5. We use various model parameters to select reliable samples of discs and bulges, and derive their stellar masses using an empirically calibrated relation between mass-to-light ratio and colour. Across our entire redshift range, we show that discs follow stellar mass–size relations that are consistent with those of star-forming galaxies, suggesting that discs primarily evolve via star formation. In contrast, the stellar mass-size relations of bulges are mass-independent. Our novel dataset further enables us to separate components into star-forming and quiescent based on their specific star formation rates. We find that both star-forming discs and star-forming bulges lie on stellar mass-size relations that are similar to those of star-forming galaxies, while quiescent discs are typically smaller than star-forming discs and lie on steeper relations, implying distinct evolutionary mechanisms. Similar to quiescent galaxies, quiescent bulges show a flattening in the stellar mass-size relation at ∼1010M⊙, below which they show little mass dependence. However, their best-fitting relations have lower normalisations, indicating that at a given mass, bulges are smaller than quiescent galaxies. Finally, we obtain rest-frame colours for individual components, showing that bulges typically have redder colours than discs, as expected. We visually derive UVJ criteria to separate star-forming and quiescent components and show that this separation agrees well with component colour. HFF bulge+disc decomposition catalogues used for these analyses are publicly released with this paper.

Prevalence of Squamous Cell Carcinoma of The Tongue In Dr. Hasan Sadikin General Hospital During 2017 – 2022

Introduction: Squamous cell carcinoma is the most common malignant neoplasm in the oral cavity, accounting for 90% of all malignancies in the oral cavity. Exposure of the oral epithelium to carcinogenic substances can cause squamous cell carcinoma. This study was show the prevalence of squamous cell carcinoma of the tongue in West Java which is used as education for the prevention of squamous cell carcinoma of the tongue. Purpose: This research is a descriptive study and carried out using purposive sampling method. The sample in this study were patients with a diagnosis of squamous cell carcinoma of the tongue at Dr. Hasan Sadikin Hospital Bandung during January 2017 - January 2022 who had been confirmed by histopathological examination results. Data analysis will be carried out on secondary data from collected medical records and the results of the pathologist's interpretation, then the results of the data analysis will be arranged and presented in tabular and percentage form. Methods: The data obtained were 218 cases. Based on age, the most patients were in the age group above 48 years (58%). Based on gender criteria, it shows more women (57%). Based on domicile criteria, the highest domicile was in Bandung (38%). Based on family history criteria, there were 215 patients with no family history or 99%. Based on the predisposing factor criteria, it shows more patients with a history of chronic irritation (48%). Based on the mass size criteria, it shows more patients with mass size T4 (60%). Based on KGB criteria, it shows more patient showed N1 lymph nodes involvement (63%). Based on tumor metastasis criteria, it shows more patients with Mx tumor metastasis (50%). Based on the therapy status criteria, it shows more patients with combined therapy (32%). Results: Type the result of your research, including statistical analysis. Conclusion: Patients suffering from squamous cell carcinoma in the tongue are mostly patients over 48 years old with female gender who live in Bandung City, West Java, and have no family history but have predilection factors such as irritation and infection. The size of the tumor mass in patients with squamous cell carcinoma mostly has a mass size &gt; 3 cm, with lymph node involvement mostly on the ipsilateral with a size &lt; 3 cm and metastasis to other organs is difficult to assess due to lack of supporting modalities. The therapy received was mostly combined therapy (surgery and chemotherapy or radiotherapy) Keywords: Squamous cell carcinoma of the tongue, prevalence, patient characteristics

Favourable clinical outcomes and low revision rate after M-ACI in adolescents with immature cartilage compared to adult controls: Results at 10 years.

The purpose of this study was to evaluate long-term survival, patient-reported outcomes (PROs)and radiographic results of matrix-associated autologous chondrocyte implantation (M-ACI) in adolescents with immature cartilage and compare them to adult controls. A retrospective matched-pair analysis was performed comparing the PRO after M-ACI for focal cartilage defect of the knee in cartilaginous immature adolescents to mature adults. Groups were matched for sex, body mass index, defect site and size, symptom duration and the number of previous knee surgeries. Knee Injury and Osteoarthritis Outcome Score (KOOS) and the Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART 2.0) scores were assessed at least 60 months postoperatively. Patient acceptable symptomatic state (PASS) and clinical response rate in KOOS and KOOS subscores were calculated. A total of 54 patients were matched. At a mean of 96 months (65-144 months), no surgical complications, graft hypertrophy or reoperations were noted in the cohorts studied. Adolescents showed superior PROs at the final follow-up (76.9 ± 14.1 vs. 66.4 ± 15.0, p = 0.03) and were significantly more likely to achieve PASS (74.1% vs. 55.6%; p = 0.02) compared to the adult cohort. The KOOS subscale analysis showed long-term benefits for adolescents in terms of symptom improvement, pain reduction, activities of daily living, sports and quality of life (p < 0.05). None of the patients in the adolescent group showed graft hypertrophy on magnet resonance imaging or signs of osteoarthritis on radiographs at long-term follow-ups. M-ACI is an effective treatment for chondral defects of the knee in patients with immature cartilage with low revision rates and high patient satisfaction over the long term. Adolescents showed comparable clinical and radiographic results in the short and medium term, with slightly more favourable, clinically relevant functional results in adolescents in the long term. M-ACI can be safely used in adolescents, and consideration should be given to expanding the indication to include these patients. Level III.

Characterisation of urban aerosol size distribution by radiocarbon and PIXE analyses in a middle-European urban environment for source identification: a pilot study.

This study, conducted in Debrecen, Hungary, aimed to analyse atmospheric particulate matter (APM or PM) through radiocarbon and PIXE analyses during the winter smog (23-25 January) and spring (15-18 May) seasons. The information presented in this pilot study aims to provide insight into the importance of utilising detailed characteristics of the mass size distributions of fossil carbon (ff) and contemporary carbon (fC) content. Additionally, it seeks to compare these characteristics with the size distributions of various elements to enable even more accurate PM source identification. In winter, APM concentrations were 86.27μg/m3 (total), 17.07μg/m3 (fC) and 10.4μg/m3 (ff). In spring, these values changed to 29.5μg/m3, 2.64μg/m3 and 7.01μg/m3, respectively. Notably, differences in mass size distribution patterns were observed between the two seasons, suggesting varied sources for contemporary carbon. Biomass burning emerged as a crucial source during the smog period, supported by similar MMAD (Mass Median Aerodynamic Diameter) values and a strong correlation (r = 0.95, p < 0.01) between potassium and fC. In spring, a significant change in the concentration and distribution of fC occurred, with a broad, coarse mode and a less prominent accumulation mode. Ff was found to have similar distributions as PM, with nearly the same MMADs, during both periods. Finally, a comprehensive comparison of modal characteristics identified specific sources for the various components, including biomass burning, vehicle exhaust, coal and oil combustion, vehicle non-exhaust, road dust, tyre abrasion, mineral dust and biogenic emission. This study showcases how using radiocarbon and PIXE analysis in size distribution data can enhance our understanding of the sources of PM and their effects on different size fractions of PM.

The effect of mass functionality on laparoscopic adrenalectomy outcomes.

This study aimed to determine the effect of adrenal mass functionality and different hormone subtypes synthesized by the adrenal masses on laparoscopic adrenalectomy (LA) outcomes. The study included 298 patients, 154 of whom were diagnosed with nonfunctional masses. In the functional group, 33, 62, and 59 patients had Conn syndrome, Cushing's syndrome, and pheochromocytoma, respectively. The variables were analyzed between the functional and nonfunctional groups and then compared among functional masses through subgroup analysis. The incidence of diabetes mellitus, hypertension, and obesity, blood loss, and length of hospital stay (LOH) were significantly higher in the functional group than in the nonfunctional group. In the subgroup analysis, patients with pheochromocytoma had significantly lower body mass index but significantly higher mass size, blood loss, and LOH than the other two groups. A positive correlation was found between mass size and blood loss in patients with pheochromocytoma (p ≤ 0.001, r = 0.761). However, no significant difference in complications was found among the groups. In this study, patients with functional adrenal masses had higher comorbidity rates and American Society of Anesthesiologists scores. Moreover, blood loss and LOH were longer on patients with functional adrenal masses who underwent LA. Mass size, blood loss, and LOH in patients with pheochromocytoma were significantly longer than those in patients with other functional adrenal masses. Thus, mass functionality did not increase the complications.

The effect of mass functionality on laparoscopic adrenalectomy outcomes.

This study aimed to determine the effect of adrenal mass functionality and different hormone subtypes synthesized by the adrenal masses on laparoscopic adrenalectomy (LA) outcomes. The study included 298 patients, 154 of whom were diagnosed with nonfunctional masses. In the functional group, 33, 62, and 59 patients had Conn syndrome, Cushing's syndrome, and pheochromocytoma, respectively. The variables were analyzed between the functional and nonfunctional groups and then compared among functional masses through subgroup analysis. The incidence of diabetes mellitus, hypertension, and obesity, blood loss, and length of hospital stay (LOH) were significantly higher in the functional group than in the nonfunctional group. In the subgroup analysis, patients with pheochromocytoma had significantly lower body mass index but significantly higher mass size, blood loss, and LOH than the other two groups. A positive correlation was found between mass size and blood loss in patients with pheochromocytoma (p ≤ 0.001, r = 0.761). However, no significant difference in complications was found among the groups. In this study, patients with functional adrenal masses had higher comorbidity rates and American Society of Anesthesiologists scores. Moreover, blood loss and LOH were longer on patients with functional adrenal masses who underwent LA. Mass size, blood loss, and LOH in patients with pheochromocytoma were significantly longer than those in patients with other functional adrenal masses. Thus, mass functionality did not increase the complications.

Particle size distributions of current-use pesticides in three European atmospheric environments

As an implication of their semivolatility, aerosols play a key role in the environmental transport and fate of current-use pesticides (CUPs). Size-segregated PM10 samples were collected at each one rural, urban residential and coastal site during a pesticide application season. Out of 72 targeted CUPs, the mass size distribution of 48 CUPs was determined. Individual pesticide mass median diameters were found in the submicrometer as well as in the supermicrometer range. The findings suggest that the PM10 mass size distribution and chemical composition influenced the CUPs mass size distributions.

Galaxies with grains: unraveling dust evolution and extinction curves with hydrodynamical simulations

Dust in galaxies is an important tracer of galaxy properties and their evolution over time. The physical origin of the grain size distribution, the dust chemical composition, and, hence, the associated ultraviolet-to-optical extinctions in diverse galaxies remains elusive. To address this issue, we introduce a model for dust evolution in the RAMSES code for simulations of galaxies with a resolved multiphase interstellar medium. Dust is modelled as a fluid transported with the gas component, and is decomposed into two sizes, 5 nm and 0.1 μm, and two chemical compositions for carbonaceous and silicate grains. This dust model includes the growth of dust by accretion of elements from the gas phase and by the release of dust in stellar ejecta, the destruction by thermal sputtering, supernovae, and astration, and the exchange of dust mass between the two main populations of grain sizes by coagulation and shattering. Using a suite of isolated disc simulations with different masses and metallicities, the simulations can explore the role of these processes in shaping the key properties of dust in galaxies. The simulated Milky Way analogue reproduces the dust-to-metal mass ratio, depletion factors, size distribution and extinction curves of the Milky Way. Galaxies with lower metallicities reproduce the observed decrease in the dust-to-metal mass ratio with metallicity at around a few 0.1 Z⊙. This break in the dust-to-metal ratio corresponds to a galactic gas metallicity threshold that marks the transition from an ejecta-dominated to an accretion-dominated grain growth, and that is different for silicate and carbonaceous grains, with ≃0.1 Z⊙ and ≃0.5 Z⊙ respectively. This leads to more Magellanic Cloud-like extinction curves, i.e. with steeper slopes in the ultraviolet and a weaker bump feature at 2175 Å, in galaxies with lower masses and lower metallicities. Steeper slopes in these galaxies are caused by the combination of the higher efficiency of gas accretion by silicate relative to carbonaceous grains and by the low rates of coagulation that preserves the amount of small silicate grains. Weak bumps are due to the overall inefficient accretion growth of carbonaceous dust at low metallicity, whose growth is mostly supported by the release of large grains in SN ejecta. We also show that the formation of CO molecules is a key component to limit the ability of carbonaceous dust to grow, in particular in low-metallicity gas-rich galaxies.

The quiescent population at 0.5 ≤ z ≤ 0.9: Environmental impact on the mass–size relation

Context. How the quiescent galaxies evolve with redshift and the factors that impact their evolution are still debated. It is still unclear what the dominant mechanisms of passive galaxy growth are and what role is played by the environment in shaping their evolutionary paths over cosmic time. Aims. The population of quiescent galaxies is altered over time by several processes that can affect their mean properties. Our aim is to study the mass–size relation (MSR) of the quiescent population and to understand how the environment shapes the MSR at intermediate redshift. Methods. We used the VIMOS Public Extragalactic Redshift Survey (VIPERS), a large spectroscopic survey of ∼90 000 galaxies in the redshift range 0.5 ≤ z ≤ 1.2. We selected a mass-complete sample of 4786 passive galaxies based on the NUVrK diagram and refined it using the Dn4000 spectral index to study the MSR of the passive population over 0.5 ≤ z ≤ 0.9. The impact of the environment on the MSR and on the growth of the quiescent population is studied through the density contrast. Results. The slope and the intercept of the MSR, α = 0.62 ± 0.04 and log(A) = 0.52 ± 0.01, agree well with values from the literature at the same redshift. The intercept decreases with redshift, Re(z) = 8.20 × (1 + z)−1.70, while the slope remains roughly constant, and the same trend is observed in the low-density (LD) and high-density (HD) environments. Thanks to the largest spectroscopic sample at 0.5 ≤ z ≤ 0.9, these results are not prone to redshift uncertainties from photometric measurements. We find that the average size of the quiescent population in the LD and HD environments are identical within 3σ and this result is robust against a change in the definition of the LD and HD environments or a change in the selection of quiescent galaxies. In the LD and HD environments, ∼30 and ∼40% of the population have experienced a minor merger process between 0.5 ≤ z ≤ 0.9. However, minor mergers account only for 30–40% of the size evolution in this redshift range, the remaining evolution likely being due to the progenitor bias.

Методика дослідження зародження кристалів у розплавах краплинним методом

The purpose of this work is to develop scientifically based ways of influencing the process of nucleation of crystallization centers in metal melts to control the formation of the cast structure and the properties of their blanks at the first stage of metal product production (at the casting stage). The possibility of controlling the nucleation of crystals in their melts was studied on transparent model environment (paraffin and salol) using the drop method, and the dependence of the crystallization kinetics of droplets with a dispersion of 100÷200 μm on their overheating temperature, the duration of exposure in an overheated state, and the degree of supercooling was established. Physical modeling on transparent environment made it possible to display images on a laptop screen with the help of a digital camera mounted on a microscope and to observe the nucleation and growth of crystals in real time, to determine the duration of solidification of all observed drops, depending on the experimental conditions. The criteria for evaluating the crystallization process of the investigated environment were the curves of the crystallization kinetics of drops from their melts. The nature of the change in the crystallization kinetics curves of the experimental environment, in our opinion, confirms the assumption about the decisive role of impurities in the crystallization processes of any alloys. The logical confirmation of the hypothesis about the decisive role of impurities in the processes of crystallization from the same positions of heterogeneous nucleation is the dependence of the number of solidified drops of experimental environment of the same diameter on the degree and duration of their overheating. It is likely that with greater overheating of the melt (or longer exposure to this overheating), partial deactivation (dissolution) of the impurities present occurs and the number of solidifying drops changes for the same supercooling. The analysis of the obtained results indicates a heterogeneous mechanism of crystal nucleation even in drops of microscopic size (~100 μm). The developed method of studying the processes of nucleation and growth of crystals in model alloys depending on their mass (size) can be applied in real conditions of mass crystallization. Keywords: model environment, droplet method, crystal nucleation, crystallization kinetics.

Global distribution range of birds is negatively correlated with their level of diet specialization

AbstractAimUnderstanding the factors determining the size of a species distribution range is crucial to preventing the extinction of vulnerable species, particularly specialist species. Previous research has shown that climate and various traits of a species significantly affect its distribution range size. However, the impact of avian dietary specialization remains relatively unexplored and geographically restricted.LocationWorldwide.TaxonBirds.MethodsWe assessed the worldwide distribution range of 7416 bird species concerning the degree of diet specialization, including body mass size, daily activity and evolutionary distinctiveness (ED) as covariates. The phylogenetic generalized least squares (PGLS) model – including the avian phylogeny – was used to test the potential correlation between the distribution range size of bird species and the explored life history traits.ResultsWe found that, at a global scale, diet specialization negatively correlates with the distribution range size of bird species. Overall, diet specialist species displayed a distribution range of 60% smaller than generalist species.Main ConclusionsOur study demonstrates that an avian diet specialization is crucial in predicting its potential distribution range size. This information is essential for those species with narrow distribution ranges often threatened by global concerns.

Optimization of Batch Cooling Crystallization of Sodium Phosphite Through Genetic Algorithm

AbstractIn this paper, the seeded batch cooling crystallization of sodium phosphite (SP) is simulated and optimized through a coupled method of the genetic algorithm and nonlinear programming. At first, the modeling and simulation test methods of the crystallization process are applied for the crystallization of SP, which expands the relevant study of SP from the experiment to the simulation. A comprehensive model is established in MATLAB/Simulink, and based on this model, the results of the common cooling strategy (linear cooling) on the process are investigated. Meanwhile, the process sensitivity to the change of seeding conditions is analyzed. Then, the coupled optimization method based on the genetic algorithm and nonlinear programming is applied to optimize the crystallization process for the first time, and the obtained optimized cooling strategy is compared to the result of the traditional nonlinear programming method (NLPM). The traditional NLPM has more significant effects on large seeding mass and small mean size, while the coupled method has better adaptability. When the coefficient of variation is almost fixed, the cooling strategy obtained by the coupled method could produce more crystals with large mean size. In addition, the end of the process can be reached earlier. The results show that the coupled method is more suitable for the optimization of the batch cooling crystallization of SP.

Effects of Ovule Position on Seed Maturation, Seed Mass, and Seedling Size in Eastern Redbud (Cercis canadensis)

Effects of Ovule Position on Seed Maturation, Seed Mass, and Seedling Size in Eastern Redbud (<i>Cercis canadensis</i>)

Feeding dogs a high-fat diet induces metabolic changes similar to natural aging, including dyslipidemia, hyperinsulinemia, and peripheral insulin resistance.

The goal of this study was to characterize changes induced by a high-fat diet in body composition, insulin levels and sensitivity, blood lipids, and other key biomarkers also associated with the metabolic dysfunction that occurs with natural aging. 24 male Beagle dogs, 3 to 7 years of age, of mixed castration status. Dogs were randomly assigned to continue twice daily feeding of the commercial adult maintenance diet (n = 12, including 2 intact) that they were previously fed or to a high-fat diet (12, including 2 intact) for 17 weeks between December 1, 2021, and April 28, 2022. Assessments included body composition (weight, body condition score, and adipose mass determined by deuterium enrichment), clinical chemistries, plasma fatty acid quantification, oral glucose tolerance test, and histology of subcutaneous and visceral adipose biopsy samples. The high-fat diet led to increased body weight, body condition score, fat mass and adipocyte size, hyperinsulinemia and peripheral insulin resistance, and elevations in serum lipids, including cholesterol, triglycerides, and several species of free fatty acids. Leptin levels increased in dogs fed a high-fat diet but not in control dogs. There were no significant changes in routine clinical chemistry values in either group. Feeding a high-fat diet for 17 weeks led to potentially deleterious changes in metabolism similar to those seen in natural aging in dogs, including hyperinsulinemia, insulin resistance, and dyslipidemia. A high-fat diet model may provide insights into the similar metabolic dysfunction that occurs during natural aging.

Neoadjuvant chemotherapy as an indication to preserve nipple areolar complex in advanced breast cancer.

e12655 Background: Nipple areolar skin sparing mastectomy (NASSM) has similar oncologic and surgical safety compared to skin sparing mastectomy (SSM) and conventional mastectomy. It provides a superior cosmetic outcome, patient satisfaction and quality of life. With the increasing rate of pathological response rate with neoadjuvant chemotherapy (NAT), nipple preservation can be achieved. The aim of our study is to evaluate whether NASSM is an appropriate surgical procedure for patients in whom there is radiological evidence of extension or involvement of nipple areolar complex (NAC) prior to NAT. Methods: Patients with advanced breast cancer received neoadjuvant chemotherapy and NASSM or SSM between June 2006 and December 2021 at Asan Medical Center were retrospectively reviewed. We excluded patients with metastatic breast cancer on presentation, bilateral cancer and inflammatory breast cancer. Kaplan-Meier survival analysis and Cox proportional hazard models were applied to determine clinicopathological and radiological factors to determine NAC preservation. Our primary objective to assess tumor cells persistence in the NAC after radiological complete response or resolution of extension to NAC. Results: Total of 1,105 patients included. 71.7% of patients underwent NASSM and 17.2% SSM as a final operation. 144 patients (13%) had a change in the pre- NAT type of surgery decision. 83(7.5%) patients had nipple involvement on final pathology. Out of 312 patients who underwent SSM, only 76 patients had nipple involvement on final pathology When comparing patients who had nipple involvement to those who didn’t on final pathology, clinical T &amp; N stage, histologic &amp; nuclear grade, breast cancer subtype, presence of multifocality/multicentric disease on MRI pre or post NAT, distance of mass to NAC and mass size pre and post NAT, the presence of non mass extension to NAC post NAT, NAC thickening on any image pre and post NAT and presentation symptoms of nipple retraction and skin changes were statistically significant. A multivariate regression analysis was performed to compare all the above factors and showed that breast cancer subtype, tumor nipple distance on MRI pre NAT, nipple areolar thickening on MRI pre NAT, clinical response and nipple retraction on MMG post NAT were statistically significant and indicators of nipple involvement on final pathology. Only 8 patients developed NAC recurrence in the NASSM group. Conclusions: NASSM is a safe procedure in patients who had tumor extension to NAC prior to NAT and showed improvement post NAT as evident on MRI. Further prospective studies are needed to establish and criteria to preserve NAC in this subgroup of patients.

Case Series and Review of Uterine Lipoleiomyomata

Introduction Uterine lipoleiomyomas are benign neoplasms that are not often seen in clinical practice. First described in 1965, these entities were recognized by a composition of intermixed smooth muscle, mature adipocytes, and fibrous tissue [2,4]. The incidence of lipoleiomyoma has always been accepted as 0.03-0.2% by Willen et al. in 1978 [1,4]. However, recent studies propose a higher incidence at 2.9%, such as Akbulut et al. in 2014. Most commonly found in the uterus, these neoplasms can rarely be associated with the cervix, broad ligament, peritoneum, ovary, as well as other extrapelvic locations. These benign tumors present similarly to uterine leiomyomas in peri- and post-menopausal women with obesity, with symptoms of pelvic/abdominal pain, mild abnormal vaginal bleeding, constipation, increased urinary frequency, and possibly a palpable mass. Methods This case series, diagnosed in February and March of 2023, includes the presentation, clinical management, and ultimately pathologic diagnosis of two separate uterine lipoleiomyomas. Results A 51-year-old, G3P2, female presented with six months of severe post-menopausal bleeding, severe left-lower quadrant pelvic pain, and lightheadedness. A transvaginal ultrasound revealed a heterogeneous, thickened endometrium of 3.9 centimeters and a probable left ovarian dermoid cyst. CT showed distension of endometrial cavity due to polyps and/or submucosal masses, as well as a fat-containing mass in the uterine corpus. Hysteroscopy with dilation and curettage was performed with pathology of high-grade malignancy. Differential diagnosis at this time included high-grade stromal sarcoma, undifferentiated carcinoma, adenosarcoma, or malignant mixed Mullerian tumor. Patient underwent MRI due to concern for malignancy, which showed FDG-avid endometrial thickening with no other FDG-avid areas of concern. Histopathologic diagnosis found carcinosarcoma of the uterus, two positive lymph nodes, and an incidental finding of lipoleiomyoma. Further medical management will include chemotherapy and vaginal cuff brachytherapy for uterine carcinosarcoma. A 50-year-old, G5P5, female presented with increasing vaginal spotting and worsening urge incontinence. CT showed increased size of heterogeneous mass in right lateral uterine wall, consistent with previously identified fibroid/leiomyoma. An adjacent fat-containing lesion was identified within the uterine wall. Patient underwent MRI which revealed large uterine mass at fundus with associated fatty component. Due to abnormal rate of growth of fibroid and fat component, there was concern for uterine sarcoma and/or malignant transformation of leiomyoma. Histopathologic diagnosis found lipoleiomyoma with benign atrophic endometrium, paratubal cysts of bilateral fallopian tubes, and follicular cyst of the right ovary. Follow-up in one year was recommended. Conclusion Lipoleiomyomas are uncommon benign entities, occurring most commonly in post-menopausal women, similarly to uterine fibroids. While asymptomatic patients can be managed conservatively, these tumors can cause vaginal bleeding, pain, and urinary or fecal incontinence and can be definitively treated with hysterectomy. While imaging is necessary to initially characterize the lesion and determine malignancy concern, histopathologic diagnosis remains the gold standard for diagnosis. Lipoleiomyomas are associated with other gynecologic malignancies, metabolic disorders, and rarely tumor-to-tumor metastasis. For this reason, careful clinical evaluation and surgical management are required for complete evaluation of the patient.

Inflammatory Myofibroblastic Tumor of the Urinary Bladder of a Young Female: A Case Report on Diagnosis and Management Challenges

ABSTRACT Background: Inflammatory myofibroblastic tumor (IMT) is a rare tumor with intermediate biologic potential, in which lack of understanding often poses difficulties in preoperative diagnosis and management. Case Presentation: We report a case in which a 25-year-old female patient not known to have any medical illness presented with gross hematuria for one month. The patient was investigated with urine analysis, urine culture, urine cytology, and Ct-Urogram at a urology clinic. Her investigation showed a urinary bladder dome enhancing mass 3.6 * 3.8 * 3.3 cm with minimal surrounding perivesical stranding worrisome for early peritoneal carcinomatosis. She underwent cystoscopy and transurethral bladder tumor resection; resection was not complete due to the size of bladder mass. Six units of packed red blood cells were given. Histopathology showed IMT. Case was discussed in the tumor board and the patient underwent laparoscopic urachal resection and partial cystectomy. Discharged on day three post-op with Foley catheter and appointment for cystogram after 2 weeks. Histopathology confirms the diagnosis of IMT with four millimeters of free margin and two benign regional reactive lymph nodes. Patients were followed for two years with no sign of recurrence or any lower urinary tract symptoms. Conclusion: Our report reinforces the standard diagnostic and management approach, supporting consistent findings and successful surgical strategies, to enhance patient care and understanding of this rare neoplasm.

Study on Ultrasonic Characteristics and Prediction of Rock with Different Pore Sizes

The internal defects of rocks are the main cause of instability and failure in underground engineering. Therefore, using ultrasonic monitoring technology to study the defect characteristics of rocks containing voids is of great significance. The research results indicate that with the increase in the pore size, the longitudinal wave velocity and first wave amplitude of rocks containing voids decrease, the attenuation coefficient increases, and the difference in ultrasonic parameters between rocks containing voids and intact rocks increases, resulting in a significant decrease in the rock integrity. The propagation of ultrasonic waves in porous rocks can be divided into three stages, where obvious ultrasonic reflection, diffraction, and scattering occur. The attenuation of sound pressure is significant, and the ultrasonic sound pressure is negatively linearly correlated with the pore size. Based on the amplitude, velocity, and pressure of ultrasonic waves, an ANN-based method for predicting the pore size of rocks is proposed, which inverts and predicts the pore size of rock masses with high prediction accuracy.