Illness Situation Research Articles

Cross-cultural adaptation and primary approbation of the Russian version of Posttraumatic Growth and Depreciation Inventory — Expanded version

Numerous studies suggest that caring for someone with a chronic disease is often associated with the various negative consequences for the patient’s informal caregivers. At the same time, positive changes caused by the stress influence of patient’s disease can be also noted. For example, the so-called posttraumatic growth. Currently, there is a lack of assessment tools in domestic psychology, that allow to investigate the relation between constructive (developmental) and destructive aspects of the relative’s mental response in a situation of chronic illness of a loved one.The aim of this work was to carry out cross-cultural adaptation and primary approbation of the Posttraumatic Growth and Depreciation Inventory — Expanded version (PTGDI-X). Primary approbation was performed on a focus group of relatives of patients with cerebral pathology (n = 61, mean age 51,2 [SD = 15,3] years). Convergent and discriminant validity of the PTGDI-X assessed using World Assumption Scale (WAS), Symptom Checklist-90-Revised (SCL-90-R), Level of Relatives’ Emotional Burnout Questionnaire (LREB). In addition, a specially adapted for the research Burden questionnaire was used.The analysis revealed good psychometric characteristics of the PTGDI-X Russian version in terms of: internal subscales consistency (Cronbach’s α coefficients varied from 0,73 to 0,86), internal and external construct validity

End-of-life decision-making

The article begins with areflection on the intertwined nature of life and death; this reflection should also serve to sensitize us to the proactive and reactive expressions of aperson's life at the end of life. It will be shown that attachment to life can also manifest itself in the case of depression, fear and exhaustion: One must not lose sight of their potential existence. The existing commitment to life allows us to better understand why the remaining time of life may be perceived as something precious; this may be in contrast to statements made in the living will. Adistinction is made between subjectively, objectively and socially defined criteria for agood life in the borderline situation of aserious illness leading to death; their comparison is central to the end-of-life decision-making process. In addition to physical and neurocognitive illnesses, suicidality is at the centre of the article.

CUIDADOS PALIATIVOS NA UNIDADE DE TERAPIA INTENSIVA: VISANDO A EQUIPE MULTIDISCIPLINAR

Palliative care is essential in the intensive care unit (ICU) to promote patient well-being in situations of serious and terminal illness. The multidisciplinary team plays a fundamental role in the implementation of palliative care in the ICU, as each professional has specific skills that contribute to comprehensive patient care. General objective: Explore palliative care in the intensive care unit and its importance for the multidisciplinary team. This study was a literature review in the Scielo and Google Scholar databases with a time frame from 2020 to 2024, using the following keywords: palliative care, nurse, dental surgeon; intensive care unit and multidisciplinary team. This study was a literature review in the Scielo and Google Scholar databases with a time frame from 2020 to 2024, using the following keywords: palliative care, nurse, dental surgeon; intensive care unit and multidisciplinary team. The inclusion criteria used in this literature review were: complete scientific articles published between 2020 and 2024 and available in databases (Google Scholar and Scielo). Duplicate articles published outside the chosen period and which did not address the topic were excluded. Results and discussions: The nurse and the dental surgeon play important roles as members of the multidisciplinary team in the ICU. The nurse is responsible for coordinating care and ensuring the patient's well-being, while the dental surgeon contributes to the prevention and treatment of oral problems that can affect the patient's quality of life. It is concluded that palliative care in the ICU is effective in improving patients' quality of life, but they still face challenges such as lack of knowledge and difficulties in communication.

Self-Medication: A Response to Illness among Undergraduate Students of Federal University of Lafia, Nasarawa State, Nigeria

This study examined self-medication as a response to illness situations and its implications for healthy living among undergraduate students of the Federal University of Lafia (FULafia), Nasarawa State, Nigeria. The study adopted the Theory of Reasoned Action. A cross sectional research design was used in the study and was carried out at the Federal University of Lafia among undergraduate students of the University. A purposive sampling technique was implemented for the selection of respondents. A sample size of 400 was obtained using Rao (1985) determination formula. Data was collected through questionnaires and in-depth interviews. The analysis was accomplished using descriptive and inferential statistics. The findings of the study indicated a high rate of self-medication among undergraduates of the Federal University of Lafia. Both traditional and orthodox medicines were self-medicated among the undergraduates of FULafia. Self-medication was influenced by availability, accessibility, and affordability of drugs by the undergraduates. It was concluded that, self-medication helps as a response to illness, but it has both negative and positive implications on the healthy living of the students of the Federal University of Lafia, therefore, the school management should situate health facilities on the campus so as to enhance students’ free and easy access to healthcare whenever the need arises.

What Self-Management Skills Do Turkish Caregivers Have in Caring for People with Dementia? Results of a Qualitative Survey.

Family caregivers can be overwhelmed by the care they provide within the family without external support. The development of self-management skills and the associated ability to actively and responsibly manage one's own health or illness situation therefore plays a vital role in the home care of people living with dementia. As part of an individualized intervention for family caregivers of people of Turkish origin with dementia, existing self-management skills were examined through qualitative interviews to gain insight into health literacy and empowerment in caregiving and in interviewees' own practices to maintain their health. Ten caregivers of Turkish origin who were responsible for family members living with dementia were interviewed using problem-centered interviews. We found that the target group has very heterogeneous self-management competencies, which are based, on the one hand, on existing supportive resources and, on the other hand, on diverse care-specific, psychosocial and life-world challenges in intrafamily care that have not been overcome. Self-management skills in family caregivers are influenced by a complex interplay of both available resources that support these skills and challenging caregiving situations. This dynamic combination of resources and challenges results in varying levels of self-management ability among family caregivers. Strengthening resources can help caregivers to meet the challenges resulting from caregiving and to expand their self-management competencies. There is great need for action in promoting self-management skills among Turkish caregivers of people living with dementia in home care. Interventions to promote self-management skills must take into account the individual resources of those affected as well as their social and cultural diversity.

Assessment of the epizootic situation of dourine in horses in the North Caucasus and Southern Federal Districts of the Russian Federation from 2020 to 2022

Relevance. Accidental disease is an actual disease of horses in many countries, including Russia, where cases of the disease have been registered in 16 administrative territories. In the Russian Federation, the proportion of accidental illness is about 47% in the general infectious and parasitic pathology of horses. The mortality rate is high, up to 30–50%, sometimes higher. The treatment of sick animals is prohibited.The purpose of the study is to study the epizootic situation of accidental illness in the North Caucasus and Southern Federal Districts, where a high density of horse population is registered.Methods. The epizootic situation of accidental equine disease from 2020 to 2022 was studied based on the materials of annual reports submitted by the state veterinary laboratories of the Russian Federation.The complement binding reaction (CFT) is the main method of lifetime diagnosis of accidental illness.Results. Serological studies for accidental equine disease from 2020 to 2022 were performed in all subjects of the North Caucasus and Southern Federal Districts. It has been established that the epizootic situation of accidental illness in the territory of the Southern Federal District is prosperous, and in a number of regions of the North Caucasus Federal District it is tense. Thus, specific antibodies to the causative agent of accidental disease were detected in the North Caucasus Federal District in 36 cases, including in the Republic of Dagestan — 27, in the Chechen Republic — 4, in the Kabardino-Balkarian Republic — 3, in the Karachay-Cherkess Republic — 2. Thus, the epizootic situation in the South of Russia is different.

The Regulatory Network of hnRNPs Underlying Regulating PKM Alternative Splicing in Tumor Progression.

One of the hallmarks of cancer is metabolic reprogramming in tumor cells, and aerobic glycolysis is the primary mechanism by which glucose is quickly transformed into lactate. As one of the primary rate-limiting enzymes, pyruvate kinase (PK) M is engaged in the last phase of aerobic glycolysis. Alternative splicing is a crucial mechanism for protein diversity, and it promotes PKM precursor mRNA splicing to produce PKM2 dominance, resulting in low PKM1 expression. Specific splicing isoforms are produced in various tissues or illness situations, and the post-translational modifications are linked to numerous disorders, including cancers. hnRNPs are one of the main components of the splicing factor families. However, there have been no comprehensive studies on hnRNPs regulating PKM alternative splicing. Therefore, this review focuses on the regulatory network of hnRNPs on PKM pre-mRNA alternative splicing in tumors and clinical drug research. We elucidate the role of alternative splicing in tumor progression, prognosis, and the potential mechanism of abnormal RNA splicing. We also summarize the drug targets retarding tumorous splicing events, which may be critical to improving the specificity and effectiveness of current therapeutic interventions.

Alzheimer's disease intelligent detection combining XGBOOST and NARX

Due to the current situation of mental health illness, which causing a huge impact on the society. In this paper, an attempt has been made to analyses and predict the data from ANDI using single and composite algorithms. This paper used chi-square test, Spearmans correlation coefficient and maximum mutual information number, cost-sensitive learning, SMOTE, ADASYN, SMOTE+ENN, SMOTE+TOMEK to investigations. Specifically, this paper adopted the random forest to fill the data, and besides, given the fact that the data shows the characteristics of imbalance, this paper identifies the method of SMOTE TOMEK integrated sampling, XGBOOST and Bayesian optimization scheme to give the best performance and the best classification was obtained by XGBOOST combined with SMOTE-TOMEK. Furthermore, this paper used the NARX network to track the changes generated by time-based indicators, providing another insight to refine the study of intelligent diagnosis of Alzheimer.

Interrelation of sociodemographic and clinical factors with burnout and engagement among mothers, who joined online peer support networks for persons raising children with disabilities

BACKGROUND: Parents raising children with disabilities are often exposed to stress and emotional burnout associated not only with the parenting process itself, but also with the need to create special conditions for the development and maintenance of the physical and mental well-being of their children. It is important to reveal factors that determine the parents’ adaptation success in a child’s illness situation. Parents of disabled children often join communities via Internet in order to exchange experiences and competencies in the field of care and interaction with children. This is rapidly developing trend of modern society and requires close attention of psychologists and other specialists working with parents of children with disabilities. This knowledge will allow us to develop appropriate mechanisms for cooperation, treatment and prevention in relevant peer support networks.
 AIM: The aim of the study was to reveal the relationships of sociodemographic and clinical factors with the severity of burnout and engagement in child care in parents who joined online peer support networks for persons raising children with disabilities.
 MATERIALS AND METHODS: The study involved 125 parents (121 mothers and 4 fathers) caring for children with disabilities. Mean [±SD] age, 36,3 ± 6,7 years. The “Level of relatives’ emotional burnout / parent-child version” was used as an assessment tools. Also, semi-structured interview for assessing socio-demographic and clinical characteristics was applied.
 RESULTS: The results of the study showed that age of the mother and child, the education and the work activities of the mother, the child’s kindergarten attendance, the age of onset and duration of the child’s illness, the nature of the relationship with him and the degree of parent’s activity in the treatment and rehabilitation process are the factors associated with engagement and burnout in parents of children with disabilities who joined online peer support networks. In particular, the lesser the age of the mother and the disabled child, the more exhaustion, tendency to devaluate successes and achievements in the process of children’s treatment (inefficacy) and tendency to destructively defuse of stress tension in mothers. The process of exhaustion is most likely at the initial periods of adaptation of the mother to the disease of the child, then the adaptation to the existing situation occurs. Burnout acts as a pathological process that contradicts the general trend and develops in cases when, due to environmental or personal factors, difficulties in adapting the parent to the child’s disease arise.
 CONCLUSIONS: Understanding of parents’ burnout processes is important for moderators of Internet communities, since it allows to route work with information content.

Совладание личности с психологическими последствиями тяжелой болезни при локальной и сосудистой патологии головного мозга

Background. The study of the psychological resources of a person experiencing a life-threatening disease is important due to the increased number of social requests related to improving the quality of a patient's full-fledged adaptation to life. The effectiveness of coping with the psychological consequences of a serious illness is determined by the system of internal conditions of the individual as well as by the age characteristics, due to which a subjective assessment of the psychotraumatic situation, the nature of a person's appeal to potential opportunities are specified. Objective. The study focuses on human resources when coping with the psychological consequences of post-traumatic stress, depending on age and the characteristics of the life-threatening brain disease (local or vascular pathology of the brain). Study Participants. 125 people showing no signs of cognitive deficits and who have given their informed consent were involved in the study. Of those, 64 people had a diagnosis of benign meningioma (30–70 years), and 61 people were diagnosed with cerebrovascular disease (31–69 years). Methods. To assess the level of psychotraumatization in respondents, the “Impact of Event Scale” technique was used, emotional and personal characteristics were studied using the Freiburg Personality Inventory and the “World assumptions scale” technique. Results. It has been established that, regardless of the type of disease, caused by local or vascular pathology of the brain, and the age of a person, a common resource for coping with psychotraumatic experiences is, on the one hand, accepting the situation of the disease and on the other, distancing oneself from experiences that mark it as hopeless, causing despair. For people with symptoms of cerebrovascular disease coping with stress, it is more important to regulate relationships with the outside world and maintain their functionality. While for people with meningioma, a positive self-attitude and the focus on unlocking inner potential, which becomes especially relevant in older age, are more important. Conclusions. The resourcefulness of a person in a situation of severe illness is determined by the rational nature of emotional self-regulation, including through selective appeal to social support. Specific resources associated with the peculiarities of the stressful situation of brain disease become more significant with age and manifest themselves in the specifics of the personality orientation (outward or inward).

Facilitating the creation of compassionate cities in Flanders. The case of Bruges and Herzele.

This paper presents the case studies of Compassionate Bruges and Herzele, as experienced in the role of a project leader/facilitator. Two cities want to grow more solidarity and more carefulness for their citizens as an answer to social bitterness, coldness and isolation. Two PhD students search for an answer to the question ‘how can we develop and foster a civic approach that is complementary to institutional health care, improving the quality of life in situations of severe illness, dying and grieving?’. And to the question ‘how can we invite people to think and act differently to realise this social change?’.
 The uniqueness of this testimonial lies in the top-down approach that was chosen to implement the compassionate city as well as the compassionate community aspect of this project. This is unlike a lot of international examples of compassionate community projects that are rather driven by an individual ‘sponsor’ or grassroots initiatives. In the top-down approach, we bring together partners like schools, employers, life stance groups,… In the bottom-up approach we work with civil society organisations and key figures in local networks. We aim at developing a compassionate community in Bruges Sint-Kruis as well as in Herzele-Centre.
 We will give an overview of how the project was conceived and how both cities evolved in their own way, driven by local differences in policy making, social network dynamics and the people involved. We will present the tensions that emerged and what we did to try and manage these tensions, as well as to manage the complexity of the global context in which these projects deployed. 
 Since some of our interventions proved to be more successful than others, we will conclude with some learnings and reflections and a brief presentation of the ‘Navigation Triangle’ framework. This framework is the synthesis of the levers we experienced to be crucial to understand and use in the process of leading cultural change in a complex environment. This framework might inspire project leaders and facilitators in their navigation processes through the complexity of their own projects, trying to involve people from a top-down as well as a bottom-up point of view.

Review of electrospun microtube array membrane (MTAM)-a novel new class of hollow fiber for encapsulated cell therapy (ECT) in clinical applications.

Encapsulated cell therapy (ECT) shows significant potential for treating neurodegenerative disorders including Alzheimer's and Parkinson's, which currently lack curative medicines and must be managed symptomatically. This novel technique encapsulates functional cells with a semi-permeable membrane, providing protection while enabling critical nutrients and therapeutic substances to pass through. Traditional ECT procedures, on the other hand, pose difficulties in terms of cell survival and retrieval. We introduce the Microtube Array Membrane (MTAM), a revolutionary technology that solves these constraints, in this comprehensive overview. Microtube Array Membrane has distinct microstructures that improve encapsulated cells' long-term viability by combining the advantages of macro and micron scales. Importantly, the MTAM platform improves biosafety by allowing the entire encapsulated unit to be retrieved in the event of an adverse reaction. Our findings show that MTAM-based ECT has a great potential in a variety of illness situations. For cancer treatment, hybridoma cells secreting anti-CEACAM 6 antibodies inhibit triple-negative breast cancer cell lines for an extended period of time. In animal brain models of Alzheimer's disease, hybridoma cells secreting anti-pTau antibodies successfully reduce pTau buildup, accompanied by improvements in memory performance. In mouse models, MTAM-encapsulated primary cardiac mesenchymal stem cells dramatically improve overall survival and heart function. These findings illustrate the efficacy and adaptability of MTAM-based ECT in addressing major issues such as immunological isolation, cell viability, and patient safety. We provide new possibilities for the treatment of neurodegenerative illnesses and other conditions by combining the potential of ECT with MTAM. Continued research and development in this subject has a lot of promise for developing cell therapy and giving hope to people suffering from chronic diseases.

Trust in healthcare professionals of people with chronic cardiovascular disease.

Trust is an essential phenomenon of relationship between patients and healthcare professionals and can be described as an accepted vulnerability to the power of another person over something that one cares about in virtue of goodwill toward the trustor. This characterization of interpersonal trust appears to be adequate for patients suffering from chronic illness. Trust is especially important in the context of chronic cardiovascular diseases as one of the main global health problems. The purpose of the qualitative study was to gain a deeper understanding of how people with chronic cardiovascular disease experience and make sense of trust in healthcare professionals. Eleven semi-structured interviews with participants analysed using interpretative phenomenological analysis to explore in detail their lived experience of trust as a relational phenomenon. Participants with chronic cardiovascular disease were purposively recruited from inpatients on the cardiology ward of the university hospital located in central Slovakia. The study was approved by the faculty ethics committee. Participants gave their written informed consent. Sense of co-existence; Belief in competence; Will to help; Ontological security with eight subthemes were identified. The findings describe the participants' experience with trust in healthcare professionals as a phenomenon of close co-existence, which is rooted in the participants' vulnerability and dependence on the goodwill and competence of health professionals to help with the consequence of (re)establishing a sense of ontological security in the situation of chronic illness. Findings will contribute to an in-depth understanding of trust as an existential dimension of human co-existence and an ethical requirement of healthcare practice, inspire patient empowerment interventions, support adherence to treatment, and person-centred care.

Отношения с матерью и сверстниками у детей предподросткового возраста с сахарным диабетом

<p style="text-align: justify;">The paper examines the relationship of children with insulin-dependent diabetes (type 1 diabetes) with their mother and peers. The study involved 30 children aged 10–12 years (M=11.26; SD=0.69), and their mothers. 14 mother–child pairs formed the experimental group of children with type 1 diabetes; 16 mother–child pairs were included in the control group. The methods used were "Parent-child interaction"; the "Family relationship test"; the "My usual day with a child" essay; the "My usual day with mom" conversation with the child; the "Features of interaction with the parent" questionnaire for teachers; the "Features of communication of the child" questionnaire for teachers and educators; a modified version of the "Unfinished sentences" methodology. The results of the study suggest that control, exactingness, guardianship on the part of the mother can act as a way of coping with the situation of the child's illness. Mothers of children with diabetes are more focused on their own feelings and experiences; the main target of their concern is the health and education of the child. It is noted that children with diabetes, when interacting with peers, more often than healthy peers, demonstrate conformity, a friendly or neutral attitude, preferring to avoid situations of conflict or to solve them with the help of an adult. The links between the low competence of a child with type 1 diabetes in the ability to negotiate with peers, take leadership positions, and a "cooperating" relationship with the mother were revealed. Maternal control and hyper-indulgence in relation to healthy children is associated with a low level of interaction of the child with peers, his ability to solve communicative tasks.</p>

Precautionary planning at the end of life from the perspective of intensive care medicine

In recent years, the number of intensive care treatments has increased significantly. About every fourth patient who dies in hospital receives intensive care. Structured prevention planning is important in order to implement the patient's wishes in situations of serious illness in which patients cannot express their wishes themselves. However, the implementation in practice can be problematic since intensive care situations are complex and rarely correspond to the concrete pre-arranged situations. Communication of the prognosis and the prognostic uncertainty is therefore crucial in order to determine the presumed will of the patient, especially in the context of the process of weighing up the benefits and burdens of intensive care therapies. Hospital treatment can be the reason for targeted preventive planning and avoid unnecessary intensive care treatment during the same stay. Documentation templates can help to record the results of preventive care planning clearly and comprehensibly in the medical file.

Neurosurgical Interventions for Umpteen Psychological Afflictions: a Substantial Cross-Disciplinary Clinical Abridged Frame of Reference

Purpose: Clinical society faces tremendous difficulties while treating people with mental illnesses, and the best possible care can only be provided by using an integrative approach to assessment and therapy. Particularly, the field of "psychosurgery," or the neurosurgical management of mental diseases, has piqued interest as a possible means of changing behavior and awareness throughout human history. In cases of severe refractory mental disease, psychological surgery - including "deep brain stimulation" and "stereotactic ablation" - is a key therapy option. Recent developments in neuroimaging, as well as psychosurgery, have increased the focus on these therapy techniques. In this paper, the benefits and drawbacks associated with psychological surgery will be thoroughly examined. Objective: The main objective of the paper is to aid individuals in understanding the basics of psychosurgery and its applications. Additionally, it focuses on how to remove the stigma associated with psychosurgery by providing reliable scientific data. Basic information and an overview were supplied thoroughly and simply to fulfill the aforementioned claim. In order to address the "psychosurgery versus psychopharmacology" debate, this paper focuses on analyzing information from many sources and outlining the core principles of each of these treatment modalities. Design/Methodology/Approach: Psychological surgery, which includes "deep brain stimulation as well as "stereotactic ablation," is a crucial treatment strategy in situations of severe refractory mental illness. The fact that several large studies have shown a median rate of response of approximately fifty percent highlights the importance of choosing and selecting participants beforehand. This concept has received attention as a result of recent developments in neurological imaging. Markers of reaction in scientific journals on neuroimaging in psychological operations have also been carefully investigated in order to evaluate the current state of knowledge for imaging prior to surgery. Scientific information was acquired for this research from a variety of trustworthy and legitimate sources. Information has also been extracted from a variety of journal papers. Findings/Result: Even today, managing patients with mental diseases can be challenging, especially when it is felt that they lack the capacity to make intelligent decisions. Due to all of these factors, the practice of psycho-surgery should adopt an integrated method for assessment and therapy. The way psychological therapies are provided in the future will undoubtedly be impacted by concurrent breakthroughs in the fields of behavioral neuroscience, brain imaging, psychological medications, and neurosurgical procedures. According to studies, ablative neurosurgery and “deep brain stimulation” are successful experimental therapies for people with chronic, acute, and “treatment-resistant obsessive-compulsive disorder”, “major depressive disorder”, and “Tourette syndrome”. The careful identification of competent applicants has been guided by suggested criteria. After presenting the details and the expected outcome of the procedure, it is imperative to obtain the person's consent. Originality and Value: In order for readers from all academic disciplines to understand the basic concepts behind psychosurgery and how it can be used to treat a variety of psychological issues, all of the clinical material has been extracted from reliable, scientific publications and organized effectively in this paper without the use of many medical expressions. The scientific complexity of any theoretical or clinical information was avoided, and the material was organized so as to preserve consistency and systematization. Paper Type: Clinical/Healthcare management

Alleviating suffering of individuals with multimorbidity and complex needs: A descriptive qualitative study.

Individuals living with multimorbidity and/or mental health issues, low education, socioeconomic status, and polypharmacy are often called complex patients. The complexity of their health and social care needs can make them prone to disease burden and suffering. Therefore, they frequently access health care services to seek guidance for managing their illness and suffering. The aim of this research was to describe the approaches used by nurses to alleviate the suffering of individuals with multimorbidity and complex needs in acute care settings. A qualitative descriptive approach. Semi-structured interviews were conducted with 19 nurses working in general, medical-surgical, specialized, and intensive care settings across five hospitals in Pakistan. Reflexive thematic analysis was used for analysis. Ethical approval was obtained from the Ethical Committee of Al-Nafees Medical College Islamabad, Pakistan. Four themes were generated: Deeper Exploration of Patients' Health-Illness Situation and Complexity, Prioritizing Patient Psychosocial and Emotional Needs, Instilling Hope and Encouragement in Patients, and Creating a Comforting Environment to Foster Sharing of felt needs. Nurses emphasized the need of deeper inquiry into patients illness situation and complexity to discern the impact of determinants on their well-being and develop care plans that are tailored to address psychosocial, emotional, and physical suffering of this patient population. Alleviation of patient suffering is integral to compassionate nursing care. Nurses use a multifaceted approach entailing sensitive understanding, recognizing sociocultural and structural determinants impact on patient situation, and individual and interdisciplinary altruistic actions to alleviate patient suffering.

Phytochemical Screening and Standardization of Cedrus Deodara Pinaceae

Several plants are important in human health care, both for self-medication and for public health. India is rich in naturally occurring plant medicines with promising pharmacological properties. A variety of medicinal plants are utilized as rejuvenators as well as to cure various illness situations. The common cedar, Cedrus deodara, is a significant plant in the Pinaceae family. C. deodara has demonstrated significant pharmacological potential, as well as value and use as folk medicine. This review reviewed the plant features, chemical makeup, phytochemicals its screening and standardization

Психологические особенности телесного опыта родильниц со здоровыми и с больными детьми: культурно-исторический подход в психосоматике

<p>From the standpoint of the cultural-historical approach in psychosomatics, physicality also changes in adulthood: in the situation of illness, aging, the birth of a child, etc., and factors that enrich bodily experience are highlighted. In the postpartum period, this factor may be the child's illness. The paper studies the bodily experience of maternity patients. It has been hypothesized that the bodily experience in the postpartum period changes compared to the usual one, and the bodily experience of maternity hospitals with sick children differs from that of maternity hospitals with healthy children. 136 women aged 19-30 took part in the work: women who do not have children, maternity hospitals with healthy children and maternity hospitals with sick children. The methods "Classification of sensations", "10 sensations", "Scale of sensations in the postpartum period", "Scale of vegetative perception", "Questionnaire for maternity hospitals", "Body attention questionnaire" were used. The features of the bodily experience of maternity hospitals with healthy children were revealed: the predominance of the number of physical descriptors over mental ones, etc., and with patients: increased concentration on the sensations from the child etc. The results reinforce the importance of the joint stay of the mother and the baby when placing him in the hospital.</p>

AGE RAGE Pathways: Cardiovascular Disease and Oxidative Stress.

It is well established that Advanced Glycation End Products (AGEs) and their receptor (RAGE) are primarily responsible for the development of cardiovascular disease. As a result, diabetic therapy is very interested in therapeutic strategies that can target the AGE-RAGE axis. The majority of the AGE-RAGE inhibitors showed encouraging outcomes in animal experiments, but more information is needed to completely understand their clinical effects. The main mechanism implicated in the aetiology of cardiovascular disease in people with diabetes is oxidative stress and inflammation mediated by AGE-RAGE interaction. Numerous PPAR-agonists have demonstrated favourable outcomes in the treatment of cardio-metabolic illness situations by inhibiting the AGE-RAGE axis. The body's ubiquitous phenomena of inflammation occur in reaction to environmental stressors such tissue damage, infection by pathogens, or exposure to toxic substances. Rubor (redness), calor (heat), tumour (swelling), colour (pain), and in severe cases, loss of function, are its cardinal symptoms. When exposed, the lungs develop silicotic granulomas with the synthesis of collagen and reticulin fibres. A natural flavonoid called chyrsin has been found to have PPAR-agonist activity as well as antioxidant and anti-inflammatory properties. The RPE insod2+/animals underwent mononuclear phagocyte-induced apoptosis, which was accompanied with decreased superoxide dismutase 2 (SOD2) and increased superoxide generation. Injections of the serine proteinase inhibitor SERPINA3K decreased proinflammatory factor expression in mice with oxygen-induced retinopathy, decreased ROS production, and increased levels of SOD and GSH.