Sites In Israel Research Articles

The foraging behavior of gerbils reveals the ecological significance of crude oil pollution

Despite extensive ecotoxicological evidence on the adverse effects of oil pollution on rodents, little is known about how rodents make decisions in oil-polluted environments (i.e., outside of lab settings). We investigated the foraging behavior of Allenby gerbils, Gerbillus andersoni allenbyi (GA), that were presented with feeding trays in a semi-natural environment. The trays contained seeds mixed into one of three types of soils – clean soil, and two different soil samples collected from two well-documented terrestrial oil spill sites in Israel. The oil spill disasters occurred in 1975 and 2014 and the spill sites are located within a few hundred meters of each other, in the 'Avrona Nature Reserve in the Arava hyper-arid region in Israel.Gerbils of both sexes avoided foraging in 2014-polluted soil, but surprisingly, they foraged more in 1975-polluted soil. Our results indicate that for the GA, the 1975-polluted soil is an advantageous substrate to forage on, probably because its texture facilitates more efficient foraging, leading to greater energetic gain, and creating a trade-off between energetic gain and perceived foraging cost due to its pollution. We also proceeded to investigate some physiological consequences of chronic exposure to the 2014-polluted soil in the laboratory. Chronic oil exposure did not lead to mortality or weight loss, but female gerbils exhibited heightened cortisol. We conclude that terrestrial oil pollution may have significant sublethal impacts on animal behavior, even when there is no obvious short-term physiological cost to the exposure.

Cultural heritage education and militarization: a case-study of the Castel National Heritage Site in Israel

Taking the Castel National Heritage site in Israel as an empirical case study, this paper explores how experiential pedagogies at cultural heritage sites can facilitate militarization processes. The 1948 War is a pivotal moment in Israel’s history and collective memory. The war has been commemorated in the Israeli landscape for decades, notably at the Castel National Heritage Site. This article provides a critical analysis of the educational strategies at the Castel site, using a multi-method ethnographic approach. Three main results are presented. First, the memorialization of the Castel battle has shifted, from a commemoration-oriented heritage site to an experiential-educational heritage site. Second, cultural heritage is used to evoke emotions among learners that, in turn, facilitate militaristic values. Third, the Castel site contributes to characterizing Israeli society as upholding prominent ethical standards in the context of a ‘just war’ against a continual existential threat.

Comparative analysis of cyanobacterial communities in gypsum outcrops: insights from sites in Israel and Poland.

Today, the biodiversity of endolithic microbial colonisations are only partly understood. In this study, we used a combination of molecular community metabarcoding using the 16S rRNA gene, light microscopy, CT-scan analysis, and Raman spectroscopy to describe gypsum endolithic communities in 2 sites-southern Poland and northern Israel. The obtained results have shown that despite different geographical areas, climatic conditions, and also physical features of colonized gypsum outcrops, both of these sites have remarkably similar microbial and pigment compositions. Cyanobacteria dominate both of the gypsum habitats, followed by Chloroflexi and Pseudomonadota. Among cyanobacteria, Thermosynechococcaceae were more abundant in Israel while Chroococcidiopsidaceae in Poland. Interestingly, no Gloeobacteraceae sequences have been found in Poland, only in Israel. Some of the obtained 16S rRNA gene sequences of cyanobacteria matched previously detected sequences from endolithic communities in various substrates and geographical regions, supporting the hypothesis of global metacommunity, but more data are still needed. Using Raman spectroscopy, cyanobacterial UV-screening pigments-scytonemin and gloeocapsin have been detected alongside carotenoids, chlorophyll a and melanin. These pigments can serve as potential biomarkers for basic taxonomic identification of cyanobacteria. Overall, this study provides more insight into the diversity of cyanobacterial endolithic colonisations in gypsum across different areas.

Releasing a dataset of 3D models of artificial reefs from the northern red-sea for 3D printing and virtual reality applications

Artificial reefs are anthropogenic structures that are submerged in purpose to mimic some of the attributes of natural reefs. Here we describe our workflow for 3D mapping of artificial reefs, particularly shipwrecks, and release a dataset containing two 3D models of some of the most epic dive sites in Israel. Our goal is to share our 3D models and protocol with the general public and to enable the scientific and recreational community to document artificial reefs in 3D and use the models in 3D visualization and printing applications. We envision that the models will be used by divers and 3D printing enthusiasts, dive operators, Non-Governmental Organizations, and government agencies dealing with underwater monitoring and marine spatial planning.

A Case Study of the Integration of Ground-Based and Drone-Based Ground-Penetrating Radar (GPR) for an Archaeological Survey in Hulata (Israel): Advancements, Challenges, and Applications

This study delves into the fusion of ground-based and drone-based ground-penetrating radar (GPR) technologies in archaeological exploration. Set against the backdrop of the Hulata solar panel construction site in Israel, the research confronts daunting obstacles such as clayey soil, accurate detection of small objects, and the imperative of timely reporting crucial for construction management. The drone-based GPR, a testament to technological innovation, showcases remarkable adaptability to challenging terrains, dispelling doubts about electromagnetic wave decay in clayey soil. Methodologically, the study employs detailed orthophoto mapping and grid-type surveys. The correlation of the results significantly bolsters the reliability of archaeological discoveries, uncovering scattered artifacts buried approximately 1–1.5 m below the surface. Meticulous excavations validate the geophysical surveys, affirming the presence of structures constructed from boulders. The application at the Hulata site validates the adaptability of drone-based GPR in challenging terrains. It provides a swift, cost-effective, and minimally invasive alternative to traditional excavation techniques, thereby transforming the field of archaeology.

P244 The first step to IBD prevention exploring rate of pre-clinical inflammation in subset of asymptomatic subjects at risk of IBD: screening stage of the PIONIR trial

Abstract Background With the increasing prevalence of inflammatory bowel diseases (IBD) globally, it is necessary to start focusing efforts on prevention of the diseases. The Genetic, Environmental, Microbial (GEM) study identified biological signatures predictive of developing IBD in first degree relatives (FDR) of patients with Crohn’s disease (CD). The ongoing PIONIR (Preventing IBD ONset in Individuals at Risk) study is a randomized controlled trial aimed to explore whether the Tasty & Healthy diet can change the CD-risk associated biomarkers of healthy FDRs who are particularly high risk of developing CD, originally followed in the GEM cohort. We report here the rate of IBD and pre-IBD inflammation in a subset cohort. Methods Subjects, 6-35 years of age from the GEM cohort who were identified by a combination of predictors at recruitment to GEM to have an increased risk for persistently elevated fecal calprotectin (FC) (i.e. Microbiome Risk Score (MRS), increased gut permeability and/or multiplex family of CD) were approached to perform a new FC test. Subjects who had FC>70µg/g, confirmed by a second sample, were offered a panenteric video capsule endoscopy (VCE), but some elected to proceed to ileocolonoscopy instead. Results For the PIONIR recruitment, a total of 450 subjects were approached from 7 sites in Israel and Canada, of whom 183 consented and provided a stool sample for FC (Figure). FC was elevated in 57 (31%) subjects, confirmed by re-testing in 36 (20%); 25/36 underwent VCE/ileocolonoscopy (Figure). In total, 8 (4.4% of the screened cohort) had normal-appearing mucosa, in 10 (5.5%) there were non-specific mucosal changes (e.g. several erosions or erythema), 6 (3.3%) had ulcers compatible with CD and 1 (0.6%) was inconclusive. The median FC of those eventually diagnosed with CD (816 [IQR 361-1123) was higher than the remaining 30 without IBD with elevated FC (175 [111-281], p=0.003). FC>275µg/g was highly predictive of CD in the entire cohort (AUROC 0.97 (95%CI 0.93-0.99); sensitivity 83%, specificity 94%). Conclusion Preclinical mucosal inflammation in VCE/ileocolonoscopy was found in 18 of 183 (9.8%) screened subjects (i.e. elevated FC with either normal or nonspecific mucosal findings), 134 (73%) had normal FC and 11 (6%) with elevated FC had missing VCE/ileocolonoscopy data. Six had CD (3.3%, or 17% of the 36 with elevated FC). Detecting subjects at risk at their preclinical stages, possibly with FC>275µg/g, is the first necessary step in developing preventive strategies for IBD.

Analysis of fabrics obtained during the archeological excavation sites in Israel

AbstractThe aim of this work is to determine the type of material in the given unknown fabric which was excavated from the various archeological sites in Israel using advanced material technology. The four fabrics that were obtained appeared as fragmentary and very degraded textiles. Therefore, we established the treatment method for these fabrics that would be most suitable to deal with the analysis and identification of the material they are made. Fourier transform infrared spectrometry (FTIR), nuclear magnetic resonance (NMR), energy dispersive x‐ray analysis (EDX), scanning electron microscope (SEM) and differential scanning calorimeter (DSC) analysis were used to confirm the material in the fabric samples. Upon detailed analysis it was concluded that all the fabrics are composed either of the synthetic materials such as nylon 6, polyester, and polyacrylonitrile (PAN). The developed method and analysis present herein has the advantages of being rapid and effective for identification of the fabrics and can be applied to varieties of archeological fabrics.

Sedimentology and stratigraphy of the Jordan River Dureijat archeological site reveal subtle late Pleistocene water-level changes at Lake Hula, Jordan Valley, Israel

AbstractSedimentary records of environmental conditions retrieved from archeological sites provide valuable insight into the milieux of ancient humans and context to understand societal and cultural changes. At Jordan River Dureijat, an open-air site in Israel’s Hula Valley documenting the entire Epipaleolithic period as well as the Early Neolithic, sediments exposed on the walls of the excavation pit reveal a sequence of lacustrine deposits accumulated continuously between c. 21.1 and 11.3 cal ka BP near the southeast margin of Paleolake Hula. Through sediment-grain-size, geochemical, and paleontological analyses, we describe the nature of the Paleolake Hula from the Last Glacial Maximum (LGM) to the start of the Holocene. Until c. 17.2 cal ka BP, Paleolake Hula existed as a relatively large and well-buffered waterbody. A rapid and substantial drawdown of the lake occurred at 17.2 cal ka BP, followed by more frequent changes in the position of the shoreline in a smaller and shallower lake, resulting in the deposition of alternating near-shore and deeper lacustrine facies. Since the LGM, seven beds of structureless, silty sediments preserve archeological artifacts belonging to three Epipaleolithic cultures as well as the Early Neolithic pre-pottery Neolithic A culture. These sediments were deposited during phases of low lake level during which times humans waded into the shallow part of the lake, leaving behind stone and bone tools such as bladelets, lunates and burins, fishing hooks, line weights and net sinkers. Using radiocarbon-dated charcoal and a Bayesian statistical model, we produced a chronostratigraphic model for the archeological site, which enables the comparison of proxy paleoclimate records produced from this site’s sediments with regional archives as well as with global trends and changes in the Northern Hemisphere climate. Periods of low lake stands are correlated with the end of the LGM, Heinrich Event 1, and the beginning of the Younger Dryas Stadial. High water stands occurred contemporaneously with the peak of the LGM and during the Bølling–Allerød interstadial. This new water-level record from Lake Hula confirms that lake-level changes here broadly paralleled those of the Dead Sea and Sea of Galilee during the late Pleistocene, highlighting the importance of northern water sources to the overall water balance of the lakes along the Dead Sea Transform.

Bottom-up effects of nematode prey on soil predatory mites (Acari: Mesostigmata)

Pest suppression is one of the desirable functions of a healthy soil. Predatory Mesostigmata soil mites, with their high degree of omnivory, are one of the most remarkable groups performing this beneficial role. Food web bottom-up effects are important for the fitness of these predators, which ultimately affects their potential as biocontrol agents. In below-ground systems, free-living nematodes (FLN) are an important diet for mites, providing essential nutrients such as omega 3 long-chain polyunsaturated fatty acids (ω3-LC PUFAs). Here we assess the food quality of nematodes for the maintenance of predator fitness, i.e. development, reproduction and lipid content. We selected two mite species, different in size and morphology, collected from vegetable crops in Israel. Additionally, five species of FLN were isolated from the same fields. Additionally, one plant-parasitic species, common across arable sites in Israel, and maintained on tomato as host, was tested. Depending on species and trophic group, nematodes varied in fatty acid profile, and both mite species generally reflected the fatty acid pattern of their diet. All nematode species were able to produce ω3-LC PUFA de novo, except the bacterial feeder Acrobeloides bodenheimeri, which had the highest proportion of ω6-PUFA. Interestingly, the latter lacking ω3-LC PUFA, was the best diet for both mites. Macrocheles aff. scutatus, a medium-sized mite with a holodorsal shield, fed and developed on all nematodes except the entomophilious Oscheius tipulae. It was able to complete its development feeding on the plant parasitic Meloidogyne incognita, yet the reproduction was almost zero. The smaller and slender Protogamasellopsis zaheri, with a split dorsal shield, developed and reproduced with all nematodes, with M. incognita as an intermediate diet. Our results demonstrate that nematode species vary in their nutritional quality as prey. However, food quality is predator species dependent, likely affecting biocontrol efficacy. Besides ω3-LC PUFA, ω6-PUFA can play an important role in the reproductive and developmental parameters of mesostigmatid mites; yet, other factors such as nematode size and behaviour have to be considered.

Nature interactions and their associations with connection to nature and well‐being varies between different types of green spaces

Abstract Increasing urbanization leads to greater loss of interaction with nature over time in a process described as the extinction of experience. Urban green spaces are some of the most prominent sites where individuals can access and interact with nature in urban areas. There is currently a gap in research around how different types of urban green spaces influence nature interactions, their relationships with human well‐being, and what influences these relationships. Greater knowledge of these connections can aid in the design of green spaces that can increase human well‐being and mitigate the extinction of experience. We conducted a visitor survey in an urban nature site in Israel, which consists of both a garden and protected nature area dominated by natural Mediterranean vegetation. We aimed to understand how visitors interacted with nature at the site and how the interactions differed between the protected nature area and the garden. Both frequency of interactions and number of total interactions were measured. We also investigated the extent to which these interactions associated with nature relatedness (using the NRS scale), well‐being (using overall happiness and psychological well‐being) and the variables that influence nature interactions and well‐being outcomes. Visitors who visited the protected nature area were more likely to interact with nature than those who only visited the garden. Nature interactions were significantly associated with an individual's nature relatedness and their perception of whether the site functioned more similarly to an urban park or a protected nature area. Living nearby was associated with greater attachment to and identity with the site, but also lower frequency of nature interactions. Nature interactions were associated with measures of well‐being, including overall happiness, attachment, identity and reflection, but varied depending on well‐being measures. Interactions with nature, and their benefits, are not equal based on both actual opportunity for interaction and perceptions of green spaces. Incorporating user preferences of urban green spaces for more wild nature that individuals also perceive as wilder may allow for greater interaction. Developing urban nature sites that allow for greater interaction can promote human well‐being associated with interactions and combat extinction of experience. Read the free Plain Language Summary for this article on the Journal blog.

Comparing spatial management tools to protect highly migratory shark species in the Eastern Mediterranean Sea hot spots

Bycatch of non-target species is a pressing problem for ocean management. It is one of the most concerning issues related to human-wildlife interactions and it affects numerous species including sharks, seabirds, sea turtles, and many critically endangered marine mammals. This paper compares different policy tools for ocean closure management around a unique shark aggregation site in Israel's nearshore coastal waters. We provide a set of recommendations based on an optimal management approach that allows humans to enjoy marine recreational activities such as fishing, while maintaining safe conditions for these apex predators which are vital to the local marine ecosystem. To learn more about recreational fishers' derived benefits, we use a benefit transfer method. Our main conclusion is that dynamic time-area closures offer sustainable and effective management strategies. Since these closures are based on near real-time data, they might successfully preserve specific species in limited areas (i.e., small areas).

Molecular Identification of Photobacterium damselae in Wild Marine Fish from the Eastern Mediterranean Sea

Infectious diseases caused by marine bacterial pathogens inflict increasing economic losses to fisheries and aquaculture, while also posing a growing risk to public health and affected species conservation. In this study, four wild marine fish species were collected at five fishing sites in Israel, divided into two regions—north (Acre, Haifa, Shefayim) and center-south (Tel-Aviv and Ashdod), and screened for Photobacterium damselae. An initial screening was carried out using PCR analysis with specifically designed primers on DNA extracted from livers and kidneys. P. damselae-positive samples had their 16S rRNA amplicons sequenced. Later, an attempt to specify relevant sub-species was performed, using a three-layered gene screen: Car, ureC and toxR. Of 334 fish samples, 47 (14%) were found to be P. damselae-positive, of which 20 were identified as P. damselae subsp. piscicida (Phdp), two as P. damselae subsp. damselae (Phdd) and 25 could not be identified to subspecies. Our results strengthen the view that fish residing in a polluted environment are receptive of pathogenic microorganisms. To assess how the presence of pathogens may affect population management and conservation, this research should be followed by studies aimed at: (i) quantifying levels of pollutants that may affect pathogen emergence, and (ii) creating a standard pollution-level index as a basis for setting criteria, above which authorities should take measures of precaution.

Roman coins at the edge of the Negev: characterisation of copper alloy artefacts and soil from Rakafot 54 (Beer Sheva, Israel)

The research presented in this paper focused on the preliminary non- and semi-destructive analysis of copper alloys, corrosion, and soil components from a Roman archaeological site in Israel. Investigations using portable X-ray fluorescence, X-ray diffraction and scanning electron microscopy with energy dispersive spectroscopy as well as micromorphological analyses were carried out to gain a better understanding of the corrosion processes affecting the copper alloy artefacts, by characterising the alloy composition, soil environments, and corrosion products. Preliminary results indicate that the artefacts consist of copper-lead-tin alloys, covered by copper hydroxy-chlorides and lead sulphate phases with slight variations in their crystallisation. The multi-analytical approach revealed the presence of quartz, calcite, gypsum and feldspars in the sediments, while thin sections more specifically indicate loess soils with local micro-environments

Three Types of Early Chalcolithic Prestige Stone Vessels from the southern Levant

Abstract. Three types of stone vessels from surveyed and excavated sites in Israel are presented and discussed: bowls with very small lug handles attached to the rim, bowls decorated with an incised row of lozenges on their exterior and chalices with a solid pedestaled base. The first two types are usually made of limestone, while the chalices are made of basalt. Each of the types was found in at least two sites and are associated only with Early Chalcolithic (ca. 5800-4500 BCE) remains, thus proposed to be characteristics of the period in central and northern Israel. Moreover, their high quality, relative scarcity and significance suggest they were prestige vessels.

Olive pits as a high-resolution proxy archive of climate: Δ13C in modern and archaeological olive pits reflecting environmental conditions

Charred olive pits are frequently preserved in archaeological sites in Israel, from ca. 5000 BCE. As olive fruits grow during one season, the carbon comprising their pits reflects their year of growth, making charred olive pits found in situ ideal for radiocarbon dating of archaeological contexts. An additional aspect, up until now not explored, is utilizing the ratio between the stable carbon isotopes (δ13C) in these charred olive pits as a proxy for climate. Olive pits provide multiple advantages as a proxy, allowing for higher resolution of climate reconstruction, both spatially and temporally, reflecting the environment in which the olive trees were growing, and humans were living. Here we show firstly, an analysis of modern olive pits and assess the connection between pit cellulose δ13C and aridity index. Specifically, we identify the threshold Δ13C for olive trees under severe drought stress as below 15.5 ± 0.5‰. Next, as olive pits are usually found charred in archaeological contexts, we evaluated the effect of charring on the δ13C signal of the modern olive pits. Finally, we present Δ13C values of more than 500 charred olive pits from 51 archaeological sites in Israel, spanning ∼6000 years. Based on these values we have identified periods of arid conditions and wet conditions in the past.

Time to Move On: The Role of Greenness in Africa and Temperatures at a Mediterranean Stopover Site in Migration Decision of Long-Distance Migratory Passerines

Many migratory species have advanced their migration timing as a response to advanced breeding conditions. While data on arrival timing to breeding grounds in Europe is plentiful, information from the African departure sites are scarce. Here we investigated changes in arrival timing of four long-distance migratory passerines to a stopover site in Israel and potential links to Enhanced Vegetation Index (EVI) at the species-specific African pre-departure sites and local temperatures at the stopover site. We found that Lesser whitethroat (Curruca curruca) and Eastern Bonelli’s warbler (Phylloscopus orientalis) advanced arrival to the stopover site. The arrival timing of Thrush nightingale (Luscinia luscinia) and Olive-tree warbler (Hippolais olivetorum) did not change and was associated with mean EVI at the pre-departure site in Africa during the pre-migratory period. Additionally, temperatures at the stopover site affected the arrival timing of Lesser whitethroat only. This is probably because this species breed at higher northern latitudes and fine-tune their migration timing to match local conditions. Our results show that spring migration can be influenced by exogenous cues such as weather condition and food availability, and the level of response is species-specific. Moreover, some species show flexibility and fine-tuned migration speed in response to local conditions en route. While flexibility seems advantageous, dependence on multiple sites with varying conditions may ultimately limit advanced arrival to the breeding ground and result in mismatch with optimal conditions.

Reevaluation of the Classification Scheme of the Acheulian in the Levant - 50 Years Later: A Morpho-Technological Analysis of Handaxe Variability

The chrono-cultural scheme of the Acheulian Technocomplex in the Levant, developed in the 1970's on the basis of handaxe typological variability, still serves as the main framework for the description of this cultural entity and as a benchmark for the classification of new Acheulian assemblages. It consists of a tripartite division into Early, Middle, and Late Acheulian and it postulates a development in the shapes, sizes, and refinement of handaxes, suggesting that they become rounder, smaller, and more 'finely made' over time. The following study applies new analytical approaches, a 3D geometric morphometric shape analysis, a typo-technological attribute analysis, and diacritic diagrams to a large collection of handaxes from five sites in Israel in order to test the validity of the tripartite division, and to provide a detailed characterization of the nature of diachronic changes in handaxe properties. The results suggest that the general chrono-cultural division is valid, as assemblages pertaining to each of its three phases indeed differ significantly in terms of morphology and production technologies. In addition, they indicate a complex trend of change, in which the Middle Acheulian assemblage presents higher values of morpho-technological aspects associated with craftsmanship than some of the Late Acheulian assemblages. Lastly, the quantitative and objective nature of the approach and availability of the raw data establish a foundation for future expansion of this study by additional samples from different regions and chronologies.

Health-related quality of life outcomes in adults with nonmuscle-invasive bladder cancer receiving a mitomycin-containing reverse thermal gel as a primary treatment (Optima II: Phase 2b, single-arm, open-label trial).

270 Background: The standard of care for low-grade non‐muscle‐invasive bladder cancer (LG NMIBC) is transurethral resection of the bladder tumor, which can worsen health‐related quality of life (HRQOL). The “OPTimized Instillation of Mitomycin for Bladder Cancer Treatment” (Optima II, clinicaltrials.gov: NCT03558503) is a Phase 2b, open label, single arm, multicenter trial evaluating a nonsurgical alternative as a primary treatment. Patients receive six weekly instillations of UGN-102, a mitomycin-containing reverse thermal gel with a sustained release time of up to 8 hours. We report on HRQOL changes between baseline and the primary endpoint of 3 months. Methods: A total of 63 patients enrolled in the Optima II trial at 20 sites in the U.S. and 2 sites in Israel between October 2018 and October 2020. Of the 63 patients enrolled, 44 were in the HRQOL cohort and completed a quarterly questionnaire. The QLQ-NMIBC24 has six subscales (urinary symptoms, malaise, future health worries, bloating and flatulence, sexual functioning, and male sexual problems) and five single items (intravesical treatment issues, sexual intimacy, worry about contaminating partner, sexual enjoyment, and female sexual problems) assessed with 24 items. Items were rescaled to 0-100 and reverse-coded so that higher scores indicate worse symptom burden. Longitudinal score changes were evaluated using the Sign test. We examined demographic and clinical characteristics associated with HRQOL change scores with regression modeling. A p-value of ≤0.01 was used. Results: The HRQOL cohort was 61% men, 57% age 65+, and 89% non-Hispanic White. Clinically, most LG NMIBC patients had multiple tumors (88%) with prior NMIBC episodes (77%), and two or more prior transurethral resection of bladder procedures (TURBT) (85%). Approximately half (55%) had their most recent TURBT surgery within 12 months of trial enrollment. No patients had missing HRQOL data at baseline or the primary end point of 3 months. The chemoablative reverse thermal gel used as a primary treatment did not cause decrements in patient-reported urinary symptoms, bloating/ flatulence, malaise, fever, general health, or future health worries. Sexual function mildly worsened between baseline and 3 months, and abated by 6 months. Demographic and clinical characteristics were not correlated with HRQOL change scores. By 3 months, 31/44 (70%) LG NMIBC patients achieved a complete response (negative endoscopic examination, cytology, and for-cause biopsy) and 0 experienced a recurrence. By 12 months, 8/44 (18%) patients had a recurrence. Conclusions: Adults with LG NMIBC in a Phase 2b trial who received a mitomycin-containing reverse thermal gel with sustained release maintained their HRQOL through 3 months. A Phase 3 trial is warranted. Clinical trial information: NCT03558503.

HAZOR EB III CITY ABANDONMENT AND IBA PEOPLE RETURN: RADIOCARBON CHRONOLOGY AND ITS IMPLICATIONS

ABSTRACTTel Hazor is one of only a few sites in Israel where remains of the Intermediate Bronze Age (IBA) in the second half of the 3rd millennium BC were found on top of Early Bronze III (EB III) city remains. A probe excavation was held at Hazor in 2017 to explore the chronological relation between the EB III and the IBA occupation. The radiocarbon (14C) absolute dates generated from this probe excavation show that following the EB III city demise, the site was abandoned for up to a few hundred years before it was resettled in the IBA. 14C dates obtained from the last level of the EB III city are well before 2500 BCE, fully aligned with the recent “High Chronology” for the EBA in the southern Levant. The excavation also produced dates associated with IBA “Black Wheel-Made Ware” vessels, which were found in large numbers at Hazor.

Envisioning future landscapes: A data-based visualization model for ecosystems under alternative management scenarios

Human-driven landscape changes strongly influence landscape functionality and aesthetics. While landscape planners have access to biophysical data for decision-making, they often do not have the necessary information about social variables, such as aesthetic tastes, feelings, or functions of a place. Visualizing future landscapes under alternative management scenarios could be a valuable tool for aiding land management decisions. Towards these ends, empirical, quantitative ecological data on vegetation composition, pattern, and processes in a Long-Term Ecological Research (LTER) site in Israel were integrated into a computerized, 3-D representation of current and future landscapes.Our objectives were (1) to visualize landscape-shaping processes, such as wildfire, grazing, and species colonization, that can assist managers, planners, and the public to envision the long-term visual significance of management alternatives and (2) to validate the similarity between the 3-D model and reality. The visual model we developed is based on 30 years of scientific knowledge and ecological data describing vegetation processes in Ramat Hanadiv, a case study of ecological conditions and processes relevant to the Mediterranean and other complex ecosystems worldwide.Before studying the role of the 3-D model in decision-making, validation was performed by comparing ‘current state’ model representation with real-world photos from the perspective of the observer. The model was found to be a valid representation of reality.Looking to the future, we suggest that the ability to create future landscapes using scientific data can assist to improve decision-making processes, balancing ecological and social needs.