Office workers represent one of the most sedentary groups. Alarmingly, more than a third of their sitting time during workdays occurs in prolonged bouts. Sit-stand desk (SSD) interventions have been found to be effective in reducing sitting time, but heterogeneity exists amongst studies, which may be due to compensations outside the workplace. This study aimed to assess the impact of a 6-month SSD intervention on office workers' sitting and standing times during the work shift and outside work (leisure time). A two-arm (1:1) clustered randomized controlled trial was conducted with 38 participants randomly assigned to either the intervention or control group. The intervention included a psychoeducational session, motivational prompts, and environmental modification (SSD implemented in the workplace). The waiting-list control group maintained the usual work conditions and only received the initial session. We employed repeated measures ANCOVA to compare changes between groups while adjusting for relevant covariates, with significance set at 5%. In the intervention group, there was a significant reduction in sitting time at work by 32.97 min, along with a notable increase in standing time by 27.88 min (p<0.05). Although not significant (p>0.05), there was an increase in sitting time in the leisure context of about 23.07 min. This study underscores the effectiveness of SSD as a key strategy to mitigate sitting time among office workers. However, future interventions should consider integrating comprehensive behavioral strategies beyond the workplace to sustain potential increases in sitting time during the leisure time and avoid compensatory behaviors. What is already known on this topic: Sedentary behavior, particularly in the workplace, is associated with increased risks of non-communicable diseases and premature mortality. Previous studies have shown that sit-stand desk (SSD) interventions can significantly reduce sitting time at work. However, uncertainties remain about whether these effects persist outside of the workplace and if compensatory behaviors occur during leisure time. This study demonstrated that a 6-month SSD intervention resulted in a significant reduction of 32.97 minutes in sitting time during work hours and a corresponding increase in standing time. However, a non-significant increase of 23.07 minutes in sitting time during leisure was observed, suggesting potential compensatory behaviors outside of work. Additionally, the response to the intervention varied among participants, highlighting the influence of individual factors. How this study might affect research, practice, or policy: The findings emphasize the importance of extending behavioral interventions beyond the workplace to maintain sustainable reductions in sedentary behavior. To maximize health benefits, future interventions should consider personalized strategies that address sedentary behavior in the workplace and during leisure time. Moreover, the variability in individual responses suggests that more tailored interventions may be necessary to ensure widespread effectiveness.
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