Introduction: The majority of patients with liver cancer is non-operable due to high tumor burden and/or impaired liver function with low regenerative potential of the liver tissue. Selective internal radiation therapy (SIRT) applicated to one liver lobe can control the liver cancer there, buy time for hypertrophy and induce hypertrophy in the contra-lateral future liver remnant (FLR). Still hypertrophy could be insufficient for liver resection. Portal vein embolization (PVE) combined with liver vein embolization (LVE) boost liver hypertrophy and patients could become eligible for curative intended major liver resections. Aim of the multi-center European SIR Spheres Surgical Registry (ESSURE) is to evaluate if the concept of hemi-liver SIRT followed by liver resection is feasible for patients that were initially non-operable. Methods: First data analysis of patients enrolled to ESSURE Results: 14 patients were recruited (9 HCC in cirrhosis, 1HCC without cirrhosis, 2 iCCC with fibrosis,1 CRLM,1 NET). All received successful SIRT to the right liver lobe without major complications. SIRT dose was 1.4-2.4 Gbq. 5 patients received additional PVE & LVE to the right liver lobe. The increase of future liver remnant after SIRT was 22%, after additional PVE & LVE 34%. Finally in 5/14 (36%) patients major liver resection could be performed (3 HCC,2 iCCC). 1 patient died, the other 4 patients showed an uncomplicated post-operative course (no complications >3a Clavien-Dindo). Conclusion: Neoadjuvant hemi-Liver SIRT followed by portal vein and liver vein embolization seems feasible and could make selected, initially non-operable patients eligible for curative intended liver resection.