Persons who are deaf-blind represent a heterogeneous, low-incidence population of children and adults who, at some point in life, regardless of the presence of additional disabilities, may benefit from formal orientation and mobility (OM however, at this point, there has been no comprehensive review of single-subject research with participants who are deaf-blind specifically in O&M interventions. The study presented here sought to answer the following research questions: (1) What types of single-subject research were conducted with participants who are deaf-blind from 1965 to 2007 in the area of increasing O&M skills? and (2) What types of interventions and practices were shown to be effective in building participants' competence in the areas of O&M? METHOD Studies were culled through the following databases: DB-LINK (the National Information Clearinghouse on Children and Youth Who Are Deaf-Blind), Google Scholar, PsycINFO, ERIC, and Academic Search Premier. Search terms included deaf-blind studies, orientation and mobility, dual-sensory impairment, single-subject designs, single-case research, intervention, and research in deaf-blindness. To be considered for evaluation, the studies had to be published in peer-reviewed journals, to include at least one or more deaf-blind persons as participants, to focus on some type of intervention or teaching practice that related to building the person's orientation or mobility skills, and to use single-subject design methodology and not some other type of research design. RESULTS Of the 860 articles I reviewed, I identified 13 studies, published from 1988 to 2007, that met the search requirements. It was striking that all the research within this initial search was conducted by the same lead scholar. …