Abstract The elevated flow temperatures and pressures exiting gas turbine combustors affect the efficiency and durability of the high-pressure turbine stage. Understanding the effects that result from the upstream dilution and effusion flow interaction in creating the combustor exit profiles is important to advancing gas turbines. Understanding how common combustor features, such as dilution jets and effusion cooling, interact based on computational predictions guided the design of a non-reacting profile simulator capable of producing a wide range of non-uniform temperature profiles representative of those entering high-pressure turbines. The mechanical design of a new simulator device, which will be experimentally tested in the future, is presented in this paper along with computational predictions of flow and thermal fields. The simulator was designed for modular installation into the Steady Thermal Aero Research Turbine (START), which is a continuous-duration, steady-state turbine facility that houses a single-stage test turbine. Features of the simulator included interchangeable liner panels with multiple rows of dilution jets and wall effusion cooling to study various hole diameters and patterns. The dilution jets generate elevated turbulence intensities and tailor the temperature profiles in the radial and circumferential directions. The air mass flow distribution and source flow temperatures are independently controlled. To aid in the simulator design, computational fluid dynamics (CFD) simulations using Reynolds-averaged Navier–Stokes modeling were conducted with a two-level Design of Experiments (DOE) approach to determine a number of engine-representative target profiles with temperature shapes that are mid-radius peaked, outer-diameter peaked, inner-diameter peaked, and uniform. A sensitivity analysis of the CFD DOE results determined which factors significantly affected the profile shape so that the target profiles could be produced. The analysis indicated that the main contributor to the temperature profile shape at near-wall vane radial span locations of 0–15% and 85–100% was the injection temperature of the effusion flow. The main contributor at radial span locations of 15–40% and 60–85% was the injection temperature of the third-row dilution jets, and at the mid-radius location of 40–60% vane radial span, the main contributor was the diameter of the first-row dilution holes.