In superconducting qubit systems, microwave crosstalk among the qubit control lines is a prominent source of errors for gate operations, particularly when implemented simultaneously in a multiqubit system. In this work, we present an experimental study of crosstalk mitigation for the case of single-qubit gate operation, which involves the universal U3 gate decomposition into two Xπ/2 gates and three virtual Z gates. We demonstrate that by optimizing the virtual Z gate parameters, the crosstalk can be effectively mitigated, with the single-qubit gate fidelity recovered to the level comparable to that in the absence of crosstalk.