Single Point Imaging Methods Research Articles

Magnetic resonance microscopy of samples with translational symmetry with FOVs smaller than sample size

In MRI, usually the Field of View (FOV) has to cover the entire object. If this condition is not fulfilled, an infolding image artifact is observed, which suppresses visualization. In this study it is shown that for samples with translational symmetry, i.e., those consisting of identical objects in periodic unit cells, the FOV can be reduced to match the unit cell which enables imaging of an average object, of which the signal is originated from all unit cells of the sample, with no punishment by a loss in signal-to-noise ratio (SNR). This theoretical prediction was confirmed by experiments on a test sample with a 7 × 7 mm2 unit cell arranged in a 3 × 3 matrix which was scanned by the spin-echo and by single point imaging methods. Effects of experimental imperfections in size and orientation mismatch between FOV and unit cell were studied as well. Finally, this method was demonstrated on a 3D periodic sample of tablets, which yielded well-resolved images of moisture distribution in an average tablet, while single tablet imaging provided no results. The method can be applied for SNR increase in imaging of any objects with inherently low signals provided they can be arranged in a periodic structure.

A study of MR signal reception from a model for a battery cell

Number of NMR/MRI studies on batteries is rapidly increasing in the past decade. As the test batteries designed for the studies contain metal parts such as electrodes and lead wires as well as other conductive parts (electrolyte), which all present obstacles for good MR signal reception, understanding of the role of battery design and of battery interactions with magnetic field is of a key importance for a successful performance of the experiments. For the study, five different samples mimicking a real battery cell were made. All the samples had two parallel copper electrodes separated by a gel layer, however, they differed in electrode thickness, gel conductivity and separation between the electrodes. The samples were inserted in an MRI magnet in different orientations with respect to magnetic fields B0 and B1 and scanned with the spin-echo and single point imaging methods in 2D and 3D (spin-echo only). The performed experiments confirmed that the main reason for poor MR signal reception from a test battery are RF-induced eddy currents. These were found stronger with the sample with the smaller distance between the electrodes. The effect of RF-induced eddy currents was efficiently suppressed when the sample was oriented with the electrodes parallel to the B1 field. However, in the orientation there were still susceptibility effects that caused a signal voiding in a narrow region near the electrodes. The susceptibility effects were found lower with the sample with thin electrodes and the non-conductive gel. The results of the study can help optimizing test battery and capacitor designs for NMR/MRI experiments.

Repetition time and flip angle variation in SPRITE imaging for acquisition time and SAR reduction

Single point imaging methods such as SPRITE are often the technique of choice for imaging fast-relaxing nuclei in solids. Single point imaging sequences based on SPRITE in their conventional form are ill-suited for in vivo applications since the acquisition time is long and the SAR is high. A new sequence design is presented employing variable repetition times and variable flip angles in order to improve the characteristics of SPRITE for in vivo applications. The achievable acquisition time savings as well as SAR reductions and/or SNR increases afforded by this approach were investigated using a resolution phantom as well as PSF simulations. Imaging results in phantoms indicate that acquisition times may be reduced by up to 70% and the SAR may be reduced by 40% without an appreciable loss of image quality.

MRI with the dipolar interaction refocusing techniques: analysis of the effectiveness for the solid-state polymers

The effectiveness of solid-echo and magic-echo phase-encoding solid-state magnetic resonance imaging methods was tested to determine possible improvement of sensitivity and spatial resolution for investigation of various types of solid polymers. The dipolar interaction refocusing pulse sequences have been used to elongate the possible phase-encoding period and to improve the signal sensitivity. The comparison of both dipolar refocusing techniques with conventional single point imaging method was made. The optimization of the phase-encoding time and magnetization recovery periods were performed basing on (1)H spectra and longitudinal relaxation measurements, respectively. The influence of imaging artifacts (intrinsic for each technique) on image quality was investigated. The effectiveness of the artifacts suppression methods was tested.