Density wave oscillation (DWO) in parallel channels is an important problem that has been widely studied. The marginal stability boundary (MSB) is often found to be “L" shaped on the Npch-Nsub plane, but some very different shapes were also reported. In this paper, the instability marsh region which could occur in the traditional instable region but having both instability and stability sections was presented and discussed, which is found to be an explanation of the distortion of MSB. The analysis of the instability marsh region showed that the evolution of instability marsh should be due to the stability change when operation condition changes, which can be estimated with the analysis of the two-phase and single phase pressure drop variation, as well as Ma's stability criterion for different heat flux profiles. Variation of instability marsh with different heat flux profile, inlet and outlet resistance coefficient, mass flow and pressure were obtained and analyzed, and the effects of these parameters on instability marsh variation were found to be well interpreted with stability change. The calculation and analysis of instability marsh showed a clear evolution figure of the distortion of MSB under different conditions, and related research could be helpful in better understanding the flow instability in parallel channels.