A design integration study (KDII4) was conducted in the DEMO Pre-Concept Design Phase with the primary goal to develop a pre-concept feasibility design and concept of operation for the Vertical Blanket Segment Architecture. The primary goal was to develop two workable variants for removal of large in-vessel components. This, prompted by two earlier studies, highlighting the integration challenge finding a self-consistent DEMO design point (KDII) and secondly the complexity of operation required to ensure compatibly with the proposed port-based maintenance schemes. Initially, only a single null (SN) divertor configuration was considered, but due to additional identified issues and technical challenges centred on the extraction of the BB segments, a double null (DN) alternative variant has also been investigated. This was prompted by other KDII's studies, especially KDII1 (Design, performance and feasibility of wall protection limiters during plasma transients) and KDII3 (Advanced Magnetic Configurations). Alternative forms of vertical maintenance architecture have been investigated by breaking down the study into Ports, In-vessel Components, Operations and Safety. SN and DN configurations were studied with split and full blankets numbering seven variants in total. Each variant was studied in some detail, comparatively assessing each on its merits. However, no viable solution has been found for down-selection. Nevertheless, the question of vertical maintenance is now better understood. This paper will describe the findings of KDII4 in conjunction with the Remote Maintenance (RM) technology work package, which suggests that the current ‘reference’ design envelope available for RM is too constrained.