The February 2023 earthquakes in Türkiye caused widespread devastation and fatalities, highlighting the critical contrast in the seismic performance of reinforced concrete (RC) buildings with moment-resistant frames and those with structural walls. This study employs analyses of nonlinear single-degree-of-freedom (SDOF) systems using selected accelerograms from the earthquakes to evaluate the behavior of these structural systems. Three SDOF systems representing flexible and stiffer frame buildings, alongside RC wall buildings, were examined. The results highlighted the susceptibility of frame buildings to severe damage and collapse compared with the excellent performance of RC wall buildings. Moreover, the study emphasizes a shift of design focus from life safety to functional recovery. It also identifies potential scenarios regarding consecutive earthquake effects. Overall, the findings advocate adequately designed RC wall buildings for enhanced seismic performance and immediate occupation following major earthquakes.