To clarify the hydrodynamic interference characteristics of flows around multiple cylinders under the wall effect, the two-dimensional (2D) flows around the near-wall single, two tandem and parallel cylinders are simulated under different gap ratios (0.15 ≤ G/D ≤ 3.0) and spacing ratios (1.5 ≤ T/D ≤ 4.0) at a Reynolds number of Re = 6300. We also examine the wake patterns, the force coefficients, and the vortex-shedding frequency with emphases on the wall effect and effects of the two-cylinder interference. A critical wall gap of G/D = 0.6 is identified in the single-cylinder case where the wall can exert significant influences. The two near-wall tandem cylinders exhibit three wake states: stretching mode, attachment mode, and impinging mode. The force coefficients on the upstream cylinder are significantly affected by the wall for G/D ≤ 0.6. The downstream cylinder is mainly influenced by the upstream cylinder. For G/D > 0.6, the force coefficients on the two cylinders exhibit a similar variation trend. In the parallel arrangement, the two cylinders exhibit four wake states in different G/D and T/D ranges: double stretching mode, hetero-vortex scale mode, unilateral vortex mode, and free vortex mode. Moreover, the two parallel cylinders in the hetero-vortex scale or free vortex mode have two states: synchronous in-phase state and synchronous out-of-phase state. The mean drag coefficients on the two cylinders decrease, while the mean lift coefficients exhibit opposite variation trends, as the T/D grows.