Immune dysregulation and cellular dysfunction mediate di-n-pentyl phthalate-induced hepatotoxicity: Insights from single-cell RNA sequencing.

Single-cell RNA sequencing unveils CD8+ T cell heterogeneity in the diffuse large B-cell lymphoma microenvironment: A systematic review.

scDCL: A multi-view single-cell RNA sequencing clustering method based on dual contrastive learning.

CEP-IP: An explainable framework for cell subpopulation identification in single-cell transcriptomics.

Dyslipidemia is common in people with HIV (PWH) and linked to cardiometabolic disease risk. Subcutaneous adipose tissue (SAT) regulates lipid storage and release, but how SAT cellular composition might influence circulating lipids in PWH on contemporary antiretroviral therapy (ART) is not well defined. Cross-sectional, observational cohort of PWH on long-term contemporary ART with virologic suppression. We performed untargeted fasting plasma lipidomic profiling on 127 individuals with a range of metabolic fitness (nondiabetes, prediabetes, diabetes). Adjusted logistic and linear regression models identified lipid species associated with diabetes status and HOMA2-IR, respectively. Linear regression assessed the relationship between abdominal SAT cell composition from single-cell RNA sequencing with circulating lipid classes ( n = 59). The median age was 48 years, body mass index 31.5 kg/m 2 , and 48% self-identified as non-White, with 23% women. Diabetes as a dichotomous outcome had few differences in lipid species. In contrast, HOMA2-IR was associated with higher levels of several species of tri- and diacylglycerols and inversely associated with phosphatidylcholine, phosphatidylethanolamine species, and many of their derivatives among those without diabetes. Adipose tissue microvasculature remodeling, characterized by a reduction in capillary endothelium and decreased expression of key lipid trafficking receptors ( LPL , GPIHBP1 ), was associated with the insulin-resistant lipidomic signature. Adipose tissue microvasculature remodeling in PWH on contemporary ART was associated with changes in several plasma lipid species, which are also linked to insulin resistance. Interventions targeting adipose tissue endothelial dysfunction may improve metabolic health in PWH on long-term ART.

Cepharanthine triggers immunogenic cell death in solid tumors by suppressing protein kinase C zeta-mediated poly(ADP-ribose) polymerase 1 expression and synergizes with immunotherapy.

Cucurbitacin B targets PPAT to suppress de novo purine biosynthesis in esophageal squamous cell carcinoma.

Dihydrotanshinone I inhibits PHGDH to suppress serine synthesis and remodel TME in NSCLC.

Single-cell RNA sequencing reveals the neuronal transcriptional differentiation program associated with ferroptosis-related heterogeneity in human hepatoblastoma.

CXCL16 promotes macrophage-driven inflammation and vascular smooth muscle cell phenotypic switching during carotid plaque destabilization.

A multi-scale biocompatibility atlas of porous silicon nanoparticles: From whole embryo to single-cell resolution.

Hypoxia-driven TCF21/CCL11 axis in GCMSCs orchestrates macrophage polarization and lymphatic remodeling to promote gastric cancer lymph node metastasis.

Common subtypes of CAFs and their research progress in immune evasion of colorectal cancer.

Inferring gene regulatory networks via adversarially regularized directed graph autoencoder.

Ligand-based directed differentiation to produce granulosa-like cells expressing steroidogenic enzyme genes.

Identify CCL20 as the key immune microenvironment regulator in APC-mutation colon cancer by sc-RNA data analysis.

Mesenchymal stem cells orchestrate a hypoxic niche that supports the generation of antigen-specific CD8+ tissue-resident memory T cells in bone marrow after vaccination.

Recombinant humanized type III collagen attenuates recurrent spontaneous abortion by regulating stromal cell decidualization and reinforcing protective immune microenvironment at the maternal-fetal interface.

NPTX2 accelerates cell cycle progression, activates EMT, and regulates glycolytic metabolic pathways to promote clear cell renal cell carcinoma progression.

Targeting CXCR6 suppresses granuloma formation and pulmonary fibrosis through inhibiting Th17 responses in sarcoidosis.