Single Body Part Research Articles

Modular Reconfigurable Approach Toward Noninvasive Wearable Body Net for Monitoring Sweat and Physiological Signals.

In the realm of wearable technology, strategically placing sensors at various body locations enhances the detection of diverse physiological indicators crucial for remote medical care. However, current devices often focus on a single body part for specific physical parameters, which hinders the seamless integration of sensors across multiple body parts and necessitates redesign for new detection capabilities. Here, we propose a modular, reconfigurable circuit assembly method that can be adaptable for multiple body locations to construct the body net. By simply reassembling different child modules with the base module using flexible printed circuit board connectors, we can efficiently detect various parameters including sweat ion indicators, electrocardiogram signals, electromyography signals, motion data, heart rate, blood oxygen saturation, and skin temperature. These data can be transmitted to a mobile phone app via a Bluetooth Low Energy protocol for further evaluation. Comparative evaluations against established commercial devices substantiate the viability of our sensor technology. In addition, results from wearable body network detections using reconfigurable sensors across multiple body parts of volunteers also indicate promising application prospects, demonstrating the extensive potential for regular health monitoring and clinical applications.

WATSU (Water-Shiatsu) increases body awareness and improves pain and mood: A randomised controlled study

Background and purposeWATSU (Water-Shiatsu) is a body-oriented therapy in warm-water pool with passive movements, massage and breathing techniques. The present study investigated the short-term effect of a single session of WATSU on body awareness. Materials and methodsIn a randomized-controlled study 60 volunteers (18–65 years) were assigned to a 20-min intervention of WATSU or to a 20-min lecture on WATSU. Immediately before and after the intervention they had to answer questionnaires. Primary endpoint of the investigation was the change of the total score of the non-verbal Awareness Body Chart (ABC). Secondary endpoints were the changes of the scores of the 14 single body parts of the ABC, of the Visual Analogue Pain Scale, of a German self-perception questionnaire (KEKS) and changes in mood scored with a German questionnaire on mood (Bf-SR). To compare groups, Mann-Whitney U tests were used. ResultsThe WATSU group had a significantly higher increase in the ABC total score in comparison to the lecture group (WATSU: 0.3 (IQR 0 – 0.8), lecture: 0.1 (IQR -0.2 – 0.2), p = 0.014). In the KEKS no group differences were seen. In WATSU a significantly stronger improvement of pain (Visual Analogue Pain Scale: WATSU: −15 (IQR -29 to −8), lecture: −4 (IQR -9 – 2), p < 0.001) and of mood (Bf-SR: WATSU: −6 (IQR -14 to −2), lecture: −1 (IQR -5 – 1), p = 0.003) could be observed. ConclusionThis study showed that WATSU immediately increases body awareness and improves pain and mood.

Analysis of anatomic location of burns inpatients in China from 2009 to 2018

BackgroundBurns cause serious physical and psychological harm to patients, placing a heavy burden on the global healthcare system. Our previous study detailed the epidemiological characteristics of burn injuries in Chinese inpatients from 2009 to 2018. Interestingly, the anatomic locations of burn injuries vary by gender, age, provinces, and outcomes among different causes. Therefore, this current study aims to analyze the characteristics of burn injuries in inpatients with various burn sites by collecting data in China from 2009 to 2018. This analysis will inform future healthcare system decisions and provide effective strategies.MethodsBurns inpatients from 196 hospitals across 31 provinces in China were included in the study, covering the period from 2009 to 2018. The data collected encompassed information on gender, age, etiology, regions, clinical outcomes, and anatomical locations of the injuries. Data analysis was conducted using Microsoft Excel 2007.ResultsFrom 2009 to 2018, a total of 333,995 burns inpatients were recorded. The most vulnerable parts to burns were multiple burn sites (230,090, 68.89%). Women were more susceptible to lower limb burns (15,608, 14%), while men were more prone to eye injuries (8,387, 3.37%) and hand burns (6,119, 2.75%). The age group of 0–10 years was the most vulnerable to burns across all body areas, including internal organs. In China, individuals aged 20–50 years were at a higher risk of head and neck burns compared to other age groups. The Han population showed increased vulnerability to eye injuries (2.12 times higher than minorities), respiratory tract issues (2.09 times higher than minorities), and trunk burns (1.83 times higher than minorities), while being less susceptible to internal organ injuries (0.23 times fewer than minorities) and lower limb burns (0.78 times fewer than minorities). The southwest region had the highest proportion of burns inpatients with burns affecting single body parts, whereas the eastern area had the highest rates of respiratory tract burns (0.85%) and multiple burn sites (80.64%). Scalding was identified as the most common cause of burns, while flame burns (769, 55.81%) and chemical burns (438, 47.35%) were the main causes of respiratory tract and internal organ injuries, respectively.ConclusionsThis study provides an initial description of characteristics of burns inpatients with various anatomic locations of burns in China over the past decade. Our findings will contribute to the most up-to-date clinical evidence database for healthcare planning and prevention initiatives in both China and other countries.

Changes in body composition in early breast cancer patients treated with aromatase inhibitors

PurposeThe aim of the study was to analyze the modification of total and regional body composition in early breast cancer patients treated with aromatase inhibitors (AIs).MethodsThis is a prospective, single-center, observational, longitudinal study. Four-hundred and twenty-eight patients treated with adjuvant aromatase inhibitors were enrolled at the Medical Oncology and Breast Unit of Spedali Civili Hospital in Brescia from September 2014 to June 2022. Several body composition parameters including total and regional fat and lean body mass were investigated with dual-energy X-ray absorptiometry (DXA) scan at baseline and after 18 months of treatment with aromatase inhibitors.ResultsA significant increase in fat body mass (mean + 7.2%, 95% confidence interval [CI]: 5.5;8.9%) and a reduction in lean body mass (mean −3.1%, 95% CI −3.9; −2.4) were documented in this population. The changes in fat and lean body mass varied considerably according to different body districts ranging between + 3.2% to + 10.9% and from−1.3% to −3.9%, respectively.ConclusionAromatase inhibitor adjuvant therapy in early breast cancer is associated with changes in body composition, with a wide variability among different body districts, leading to a risk of sarcopenic obesity. Supervised physical exercise that focuses on single body parts that may display detrimental variations may be beneficial for AIs treated patients.

Investigating the perceptual attribution of a virtual robotic limb synchronizing with hand and foot simultaneously

Introduction:Incorporating an additional limb that synchronizes with multiple body parts enables the user to achieve high task accuracy and smooth movement. In this case, the visual appearance of the wearable robotic limb contributes to the sense of embodiment. Additionally, the user’s motor function changes as a result of this embodiment. However, it remains unclear how users perceive the attribution of the wearable robotic limb within the context of multiple body parts (perceptual attribution), and the impact of visual similarity in this context remains unknown.Methods:This study investigated the perceptual attribution of a virtual robotic limb by examining proprioceptive drift and the bias of visual similarity under the conditions of single body part (synchronizing with hand or foot motion only) and multiple body parts (synchronizing with average motion of hand and foot). Participants in the conducted experiment engaged in a point-to-point task using a virtual robotic limb that synchronizes with their hand and foot motions simultaneously. Furthermore, the visual appearance of the end-effector was altered to explore the influence of visual similarity.Results:The experiment revealed that only the participants’ proprioception of their foot aligned with the virtual robotic limb, while the frequency of error correction during the point-to-point task did not change across conditions. Conversely, subjective illusions of embodiment occurred for both the hand and foot. In this case, the visual appearance of the robotic limbs contributed to the correlations between hand and foot proprioceptive drift and subjective embodiment illusion, respectively.Discussion:These results suggest that proprioception is specifically attributed to the foot through motion synchronization, whereas subjective perceptions are attributed to both the hand and foot.

A Deep-Learning Driven Investigation of the Circuit Basis for Reflexive Hypersensitivity to Thermal Pain.

Objectively measuring animal behavior is vital to understanding the neural circuits underlying pain. Recent progress in machine vision has presented unprecedented scope in behavioral analysis. Here, we apply DeepLabCut (DLC) to dissect mouse behavior on the thermal-plate test - a commonly used paradigm to ascertain supraspinal contributions to noxious thermal sensation and pain hypersensitivity. We determine the signature characteristics of the pattern of mouse movement and posture in 3D in response to a range of temperatures from innocuous to noxious on the thermal-plate test. Next, we test how acute chemical and chronic inflammatory injuries sensitize mouse behaviors. Repeated exposure to noxious temperatures on the thermal plate can induce learning. In this study, we design a novel assay and formulate an analytical pipeline to facilitate the dissection of plasticity mechanisms in pain circuits in the brain. Last, we record and test how activating Tacr1 expressing PBN neurons (PBNTacr1) - a population responsive to sustained noxious stimuli- affects mouse behavior on the thermal plate test. Taken together, we demonstrate that by tracking a single body part of a mouse, we can reveal the behavioral signatures of mice exposed to noxious surface temperatures, report the alterations of the same when injured, and determine if a molecularly and anatomically defined pain-responsive circuit plays a role in the reflexive hypersensitivity to thermal pain.

The third-person perspective full-body illusion induced by visual-tactile stimulation in virtual reality for stroke patients

This paper attempts to induce the third-person perspective full body illusion (3PP-FBI) with virtual reality (VR) in stroke patients. Nineteen individuals with stroke were recruited. The 3PP-FBI induction method, which was well-established in healthy individuals, using synchronous visual-tactile stimulation on one body part was used. Questionnaire scores and proprioceptive drift values were collected under different conditions for characterizing the induced 3PP-FBI. Results showed that synchronous visual-tactile stimulation of a single body part (back or upper limb) was sufficient to elicit 3PP-FBI in stroke patients, forming a sense of ownership (SOO) over the entire virtual body. Moreover, the intensity of 3PP-FBI was stronger when the back was stimulated, compared to stimulating the impaired upper limb. This study demonstrated the viability of visual-guided rehabilitation training while having a SOO to a virtual body from the third-person perspective, in anticipation of achieving better rehabilitation outcome for movements beyond the first-person perspective.

Transposons contribute to the functional diversification of the head, gut, and ovary transcriptomes across Drosophila natural strains.

Transcriptomes are dynamic, with cells, tissues, and body parts expressing particular sets of transcripts. Transposable elements (TEs) are a known source of transcriptome diversity; however, studies often focus on a particular type of chimeric transcript, analyze single body parts or cell types, or are based on incomplete TE annotations from a single reference genome. In this work, we have implemented a method based on de novo transcriptome assembly that minimizes the potential sources of errors while identifying a comprehensive set of gene-TE chimeras. We applied this method to the head, gut, and ovary dissected from five Drosophila melanogaster natural strains, with individual reference genomes available. We found that ∼19% of body part-specific transcripts are gene-TE chimeras. Overall, chimeric transcripts contribute a mean of 43% to the total gene expression, and they provide protein domains for DNA binding, catalytic activity, and DNA polymerase activity. Our comprehensive data set is a rich resource for follow-up analysis. Moreover, because TEs are present in virtually all species sequenced to date, their role in spatially restricted transcript expression is likely not exclusive to the species analyzed in this work.

Identification and relative depth estimation in natural images of single human body parts

Identification and relative depth estimation in natural images of single human body parts

Telerehabilitation System Based on OpenPose and 3D Reconstruction with Monocular Camera

Owing to aging populations, the number of elderly people with limb dysfunction affecting their daily lives will continue to increase. These populations have a great need for rehabilitation training to restore limb functions. However, the current numbers of rehabilitation hospitals and doctors are limited. Moreover, people often cannot go to a hospital owing to external conditions (e.g., the impacts of COVID-19). Thus, an urgent need exists for telerehabilitation system for allowing patients to have training at home. The purpose of this study is to develop an easy-to-use system for allowing target users to experience rehabilitation training at home and to remotely receive real-time guidance from doctors. The proposed system only needs a monocular camera to capture 3D motions. First, the 2D key joints of the human body are detected; then, a simple baseline network is used to reconstruct 3D key joints from the 2D key joints. The 2D detection only has an average angle error of 1.7% compared to that of a professional motion capture system. In addition, the 3D reconstruction has a mean per-joint position error of only 67.9 mm compared to the real coordinates. After acquiring the user’s 3D motions, the system synchronizes the 3D motions to a virtual human model in Unity, providing the user with a more intuitive and interactive experience. Generally, many telerehabilitation systems require professional motion capture cameras and wearable equipment, and the training target is a single body part. In contrast, the proposed system is low-cost and easier to use and only requires a monocular camera and computer to achieve real-time and intuitive telerehabilitation (even though the training target is the entire body). Furthermore, the system provides a similarity evaluation of the motions based on the dynamic time warping; this can provide more accurate and direct feedback to users. In addition, a series of evaluation experiments verify the system’s usability, convenience, feasibility, and accuracy, with the ultimate conclusion that the system can be used in practical rehabilitation applications.

Case report – Using homoeopathy to enable the holistic healing of a young athlete with epilepsy

Epilepsy is a chronic and non-communicable disease of the brain. It is characterised by recurrent seizures resulting in involuntary movements that can be generalised or localised in a single body part. Management through modern medicine takes care of the attacks, but may not help the patient. This case report demonstrates the handling of a young athlete with epilepsy stuck between his desire and his conscience. Identification of defence mechanisms, utilising them in patient management and the process of identifying the remedy are discussed. The case demonstrates the role of holistic management with homoeopathy in cases of seizure disorder.

Visual recognition of single body parts in natural images

Visual recognition of single body parts in natural images

Lower Extremity Malformations.

Lower Extremity Malformations.

가축에 대한 3차원 형상 획득을 위한 측정시스템 개발

Smart farms are being actively developed to manage the growth of livestock. The quality of livestock is generally evaluated based on their body form and weight. Livestock of various sizes and appearances exist. Even within the same species, the appearance varies depending on the growth and pregnancy status. Live animals keep moving, and thus it is difficult to measure every single body part of them accurately. In this study, we propose a measurement system that can acquire the 3D shape of a moving livestock. A TOF (time of flight) camera is used to quickly measure the moving state, and multiple cameras are used to acquire the overall shape. A calibration work is required when using multiple cameras, and it is configured to be automatically calibrated using sphere targets. The accuracy and precision of the measurement system has been verified, and it is applied to pigs to obtain three-dimensional point cloud data.

Studying Regeneration in Ascidians: An Historical Overview.

Ascidians are sessile tunicates, that is, marine animals belonging to the phylum Chordata and considered the sister group of vertebrates. They are widespread in all the seas, constituting abundant communities in various ecosystems. Among chordates, only tunicates are able to reproduce asexually, forming colonies. The high regenerative potentialities enabling tunicates to regenerate damaged body parts, or the whole body, represent a peculiarity of this taxon. Here we review the methodological approaches used in more than a century of biological studies to induce regeneration in both solitary and colonial species. For solitary species, we refer to the regeneration of single organs or body parts (e.g., siphon, brain, gonad, tunic, viscera). For colonial species, we review a plethora of experiments regarding the surgical manipulation of colonies, the regeneration of isolated colonial entities, such as single buds in the tunic, or part of tunic and its circulatory system.

Recognizing Full-Body Exercise Execution Errors Using the Teslasuit.

Regular physical exercise is essential for overall health; however, it is also crucial to mitigate the probability of injuries due to incorrect exercise executions. Existing health or fitness applications often neglect accurate full-body motion recognition and focus on a single body part. Furthermore, they often detect only specific errors or provide feedback first after the execution. This lack raises the necessity for the automated detection of full-body execution errors in real-time to assist users in correcting motor skills. To address this challenge, we propose a method for movement assessment using a full-body haptic motion capture suit. We train probabilistic movement models using the data of 10 inertial sensors to detect exercise execution errors. Additionally, we provide haptic feedback, employing transcutaneous electrical nerve stimulation immediately, as soon as an error occurs, to correct the movements. The results based on a dataset collected from 15 subjects show that our approach can detect severe movement execution errors directly during the workout and provide haptic feedback at respective body locations. These results suggest that a haptic full-body motion capture suit, such as the Teslasuit, is promising for movement assessment and can give appropriate haptic feedback to the users so that they can improve their movements.

Pathophysiology of Coagulopathy Induced by Traumatic Brain Injury Is Identical to That of Disseminated Intravascular Coagulation With Hyperfibrinolysis.

Background: Traumatic brain injury (TBI)-associated coagulopathy is a widely recognized risk factor for secondary brain damage and contributes to poor clinical outcomes. Various theories, including disseminated intravascular coagulation (DIC), have been proposed regarding its pathomechanisms; no consensus has been reached thus far. This study aimed to elucidate the pathophysiology of TBI-induced coagulopathy by comparing coagulofibrinolytic changes in isolated TBI (iTBI) to those in non-TBI, to determine the associated factors, and identify the clinical significance of DIC diagnosis in patients with iTBI.Methods: This secondary multicenter, prospective study assessed patients with severe trauma. iTBI was defined as Abbreviated Injury Scale (AIS) scores ≥4 in the head and neck, and ≤2 in other body parts. Non-TBI was defined as AIS scores ≥4 in single body parts other than the head and neck, and the absence of AIS scores ≥3 in any other trauma-affected parts. Specific biomarkers for thrombin and plasmin generation, anticoagulation, and fibrinolysis inhibition were measured at the presentation to the emergency department (0 h) and 3 h after arrival.Results: We analyzed 34 iTBI and 40 non-TBI patients. Baseline characteristics, transfusion requirements and in-hospital mortality did not significantly differ between groups. The changes in coagulation/fibrinolysis-related biomarkers were similar. Lactate levels in the iTBI group positively correlated with DIC scores (rho = −0.441, p = 0.017), but not with blood pressure (rho = −0.098, p = 0.614). Multiple logistic regression analyses revealed that the injury severity score was an independent predictor of DIC development in patients with iTBI (odds ratio = 1.237, p = 0.018). Patients with iTBI were further subdivided into two groups: DIC (n = 15) and non-DIC (n = 19) groups. Marked thrombin and plasmin generation were observed in all patients with iTBI, especially those with DIC. Patients with iTBI and DIC had higher requirements for massive transfusion and emergency surgery, and higher in-hospital mortality than those without DIC. Furthermore, DIC development significantly correlated with poor hospital survival; DIC scores at 0 h were predictive of in-hospital mortality.Conclusions: Coagulofibrinolytic changes in iTBI and non-TBI patients were identical, and consistent with the pathophysiology of DIC. DIC diagnosis in the early phase of TBI is key in predicting the outcomes of severe TBI.

Action-based organization of a cerebellar module specialized for predictive control of multiple body parts

The role of the cerebellum in predictive motor control and coordination has been thoroughly studied during movements of a single body part. In the real world, however, actions are often more complex. Here, we show that a small area in the rostral anterior interpositus nucleus (rAIN) of the mouse cerebellum is responsible for generating a predictive motor synergy that serves to protect the eye by precisely coordinating muscles of the eyelid, neck, and forelimb. Within the rAIN region, we discovered a new functional category of neurons with unique properties specialized for control of motor synergies. These neurons integrated inhibitory cutaneous inputs from multiple parts of the body, and their activity was correlated with the vigor of the defensive motor synergy on a trial-by-trial basis. We propose that some regions of the cerebellum are organized in poly-somatotopic"action maps" to reduce dimensionality and simplify motor control during ethologically relevant behaviors.

Probabilistic decision support system using machine learning techniques : A case study of Cardiovascular diseases

Diseases are an irregular event that affects single or multiple body parts of a human being. Different kinds of diseases are growing day by day in terms of lifestyle and heritage. Among all the ones, it turns out that heart disease is the most prevalent disease, and the consequence of this disease is dangerous relative to all other situations. In this paper, initially the author calculates immanent discreteness between two probability separations, based on information theory or relative entropy using Kullback-Leibler divergence (KL divergence). It can be used as shortcuts in the calculation of other widely used methods, such as mutual information for feature selection before modeling, and cross-entropy used as a loss function for many different classifier models. Seven computational intelligence techniques named logistic regression (LR), support vector machine (SVM), naïve bayes (NB), random forest (RF), and k-nearest neighbor (K-NN) have been applied and a comparative study had been drawn. The heart disease dataset is taken from the Department of Cardiology, Excelcare Hospitals, Guwahati, Assam and the analysis of performance in each technique has been evaluated.

Successful Use of Geochemical Tools to Trace the Geographic Origin of Long-Snouted Seahorse Hippocampus guttulatus Raised in Captivity.

Simple SummarySeahorses (Hippocampus spp.) are currently exposed to a multitude of anthropogenic pressures worldwide. The illegal, unreported, and unregulated (IUU) fisheries and trade of these flagship species undermine the efforts to manage and protect their wild populations. Here we aim to validate a forensic tool to identify the geographic origin of seahorses and contribute to the ongoing fight against the illegal capture and trade of these organisms. The elemental fingerprints of long-snouted seahorse (Hippocampus guttulatus) bony structures, including the subdermal bony plates that cover their body, revealed that they can be successfully employed to confirm their geographic origin. The results of this first study using seahorses raised in captivity indicate that this tool may also allow to discriminate between different populations of wild specimens and enhance the traceability of traded specimens.The global market of dried seahorses mainly supplies Traditional Chinese Medicine and still relies on blurry trade chains that often cover less sustainable practices targeting these pricey and endangered fish. As such, reliable tools that allow the enforcement of traceability, namely to confirm the geographic origin of traded seahorses, are urgently needed. The present study evaluated the use of elemental fingerprints (EF) in the bony structures of long-snouted seahorses Hippocampus guttulatus raised in captivity in two different locations (southern Portugal and Northern Spain) to discriminate their geographic origin. The EF of different body parts of H. guttulatus were also evaluated as potential proxies for the EF of the whole body, in order to allow the analysis of damaged specimens and avoid the use of whole specimens for analysis. The contrasting EF of H. guttulatus raised in the two locations allowed their reliable discrimination. Although no single body part exactly mimicked the EF of the whole body, seahorse trunks, as well as damaged specimens, could still be correctly allocated to their geographic origin. This promising forensic approach to discriminate the geographic origin of seahorses raised in captivity should now be validated for wild conspecifics originating from different locations, as well as for other species within genus Hippocampus.