To develop a single-shot SNR-efficient distortion-free multi-echo imaging technique for dynamic imaging applications. Echo planar time-resolved imaging (EPTI) was first introduced as a multi-shot technique for distortion-free multi-echo imaging. This work aims to develop single-shot EPTI (ss-EPTI) to achieve improved robustness to motion/physiological noise, increased temporal resolution, and higher SNR efficiency. A new spatiotemporal encoding that enables reduced phase-encoding blips and minimized echo spacing under the single-shot regime was developed, which improves sampling efficiency and enhances spatiotemporal correlation in the k-TE space for improved reconstruction. A continuous readout with minimized deadtime was employed to optimize SNR efficiency. Moreover, k-TE partial Fourier and simultaneous multi-slice acquisition were integrated for further acceleration. ss-EPTI provided distortion-free imaging with densely sampled multi-echo images at standard resolutions (e.g., ˜1.25 to 3 mm) in a single-shot. Improved SNR efficiency was observed in ss-EPTI due to improved motion/physiological-noise robustness and efficient continuous readout. Its ability to eliminate dynamic distortions-geometric changes across dynamics due to field changes induced by physiological variations or eddy currents-further improved the data's temporal stability. For multi-echo fMRI, ss-EPTI's multi-echo images recovered signal dropout in short- regions and provided TE-dependent functional information to distinguish non-BOLD noise for further tSNR improvement. For diffusion MRI, it achieved shortened TEs for improved SNR and provided images free from both B0-induced and diffusion-encoding-dependent eddy-current-induced distortions with multi-TE diffusion metrics. ss-EPTI provides SNR-efficient distortion-free multi-echo imaging with comparable temporal resolutions to ss-EPI, offering a new acquisition tool for dynamic imaging.
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