You have accessJournal of UrologyProstate Cancer: Detection & Screening III1 Apr 2014MP63-05 SERUM TESTOSTERONE IMPROVES THE ACCURACY OF PROSTATE HEALTH INDEX FOR THE DETECTION OF PROSTATE CANCER Frank Friedersdorff, Kurt Miller, Klaus Jung, and Carsten Stephan Frank FriedersdorffFrank Friedersdorff More articles by this author , Kurt MillerKurt Miller More articles by this author , Klaus JungKlaus Jung More articles by this author , and Carsten StephanCarsten Stephan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.1942AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The detection of prostate cancer (PCa) hampers on low specificity when using prostate-specific antigen (PSA) alone. This study investigated the effects of total testosterone (tT) and its free (fT) and bioavailable (bioT) subforms in serum to improve the diagnostic validity of serum (-2)pro-PSA-based prostate health index (PHI). METHODS Total and free PSA (tPSA, fPSA), (-2)pro-PSA, testosterone, and sex-hormone-binding protein were measured by automated immunoassays from the serum of 193 men scheduled for prostate biopsy (99 with PCa and 94 with no evidence of malignancy). FT and bioT were calculated using an online calculator. Statistical analyses were performed by non-parametric tests (Wilcoxon signed rank, Mann-Whitney, Kruskal-Wallis), binary logistic regression, and receiver operating characteristics (ROC) analyses. RESULTS Compared to the non-malignant controls, PCa patients had significantly higher levels of tPSA and PHI, but lower levels of %fPSA, tT, fT, and bioT. PCa could be differentiated from controls by PHI, tT, fT, bioT, and %fPSA. PHI showed the largest area under the ROC curve (AUC = 0.73) that was additionally increased by the inclusion of bioT or tT in a binary logistic regression model. The AUC of PHI in patients with tT concentrations of <8 nmol/L indicating biochemical hypogonadism was significantly larger than that in patients with higher tT values (0.86 vs 0.70). CONCLUSIONS The PHI based discrimination between PCa patients and non-malignant controls could be improved by the simultaneous determination of testosterone, while patients with testosterone concentration of <8 nmol/L have the greatest advantage. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e710 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Frank Friedersdorff More articles by this author Kurt Miller More articles by this author Klaus Jung More articles by this author Carsten Stephan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...