Intracardiac echocardiography (ICE) has been widely used in the catheter ablation of atrial fibrillation (AF). However, the value of ICE in the training of transseptal puncture (TSP) is unclear. ICE-Training Study was a single-center, parallel-group, unmasked, randomized controlled trial registered in ChineseClinicalTrials.gov. Participants were randomly assigned (1:1) to different groups (1) the ICE simulator training group (ICE-ST), in which TSP was trained and performed under the guidance of both ICE and x-ray; and (2) the conventional simulator training group (Con-ST), in which TSP was trained and performed only under the guidance of x-ray. The trainees need to undergo the training stage and the evaluation stage. From October 2022 to December 2022, 18 consecutive fellows (age 32.4±4.4years, 12 males) without experience of TSP were included. The training period (16.9±6.6 vs. 29.6±8.7 times, p=0.003) and the fluoroscopy time (120.3±25.3 vs. 189.3±40.2s, p<0.001) of the ICE-ST group was significantly shorter than that of the Con-ST group. No significant difference was found in the comprehensive performance of TSP in the ICE-ST group (composite score 96.7±5.7) and the Con-ST group (composite score 95.9±6.3, p=0.62), but the selection of TSP sites in the ICE-ST group was commonly better than that in the Con-ST group. ICE could improve the efficiency of TSP training and optimize the site of TSP to facilitate catheter manipulation in the ablation. ChineseClinicalTrials.gov identifier: ChiCTR2200058377.
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