During long-term deep geological disposal process, high-level liquid waste (HLW) glass may be exposed to “Thermodynamics-Hydrodynamics-Mechanics-Chemistry” (THMC)multi-field coupling effects. The leaching properties of sulfur-containing borosilicate HLW glass at different temperatures (40–150 °C) and different flow rates (0.01–0.10 mL/min) under THMC coupling effects were studied in this work. The alteration layer structure of waste glass surface was also characterized. The results show that honeycomb-shaped phyllosilicate alteration layer forms after leaching in simulated groundwater and white block-shaped BaSO4 crystals appear on the glass surface at 90 °C after 28 d. The amount of BaSO4 crystals increases obviously at 150 °C. The leaching rates of B, Si, Cs and U elements increase with increasing temperature and flow rate. Particularly, the leaching rates of B, Si, Cs, and U under THMC coupling effects (90 °C, 0.01 mL/min, 10 MPa, pH=8.05) after 28 d in the simulated groundwater are 1.10 × 10–1, 1.73 × 10–1, 2.91 × 10–1, 3.79 × 10–1 g·m-2·d-1, respectively.