Simple Process Research Articles

Targeted Topological Routine Regulation of RuNiOx Precursors for Excellent Alkaline Overall Water Splitting

Designing efficient and stable electrocatalysts for the hydrogen and oxygen evolution reactions (HER and OER) is crucial for green hydrogen production via the water‐splitting system. The bifunctional electrocatalyst offers a promising strategy due to the simplified preparation process and reduced expenses. However, the single‐component bifunctional catalysts often struggle to match the redox potential of water and to achieve proper adsorption/desorption of Gibbs free energy for both H and O intermediates simultaneously. Herein, through precisely controlling the topological transformation path of the RuNiOx precursor, we successfully prepared high‐performance RuNi/Ni and Ru/NiO heterostructure electrocatalysts for the HER and OER, respectively. The energy level matching between the fabricated electrocatalyst and water oxidation/reduction potential confirms the feasibility of HER and OER. The synergistic effect between the active sites ensures rapid, intermediate adsorption/desorption kinetics. As a result, the assembled alkaline overall water splitting setup achieves a current density of 1 A cm‐2 at 2 V and maintains stable operation at 100 mA cm‐2 for 100 hours.

SMEs in a Digital Era: The Role of Management

This article aims to explore the role of management in translating the external factors’ and internal barriers’ impacts on the level of adoption of digital technologies as a lever for change in business operations and processes in small- and medium-sized enterprises (SMEs). SMEs face a distinct set of challenges when adopting digital technologies, often lacking resources and knowledge. On the other hand, they have certain characteristics, such as simpler organisational structures and processes, that make them more flexible than larger firms in leveraging technologies into new business models. Data for this study are obtained from 989 SMEs in Bulgaria in the manufacturing and services sectors. A PLS–SEM analysis confirms eight hypotheses raised on the relationships between environmental factors and government support and internal factors (management support, organisational flexibility, and risk-tolerant culture) that impact digital business intensity. Environmental factors’ impact is stronger than government support, while internal barriers are found to have no statistically significant relationship. The research findings highlight the important role of management support in guiding digital transformation through supporting organisational flexibility and promoting a risk-tolerant culture.

A systematic approach of correct laboratory commissioning: special procedural features for medical laboratories using the example of specialised forms of care

Abstract Since the complexities of commissioning medical laboratory tests have grown continuously as a result of the increase in specialised forms of care, this article aims to create a practice-oriented structure of the legal and procedural requirements and to illustrate these using case studies – specifically using the example of so-called ambulatory medical specialist care (ASV) in accordance with Par. 116b SGB V and selected selective contracts in accordance with Par. 140a SGB V. Even if the system of correct laboratory billing described in our previous articles has remained largely valid, we believe that structuring specialised forms of care in the outpatient sector would be particularly helpful. In addition to our previous articles on the system of correct laboratory billing, it is shown that laboratory commissioning must also be systematically correct and that all parties involved in the process (doctor’s surgeries, clinics, medical laboratories and insured persons) will benefit from this. In doing so, we are developing a system for correct laboratory ordering that leads to an improvement in process quality and process simplification when functionalised via so-called “order/entry”- or automated registration systems.

A unified LOD model for river network and DEM based on an improved 3D_DP algorithm

The level of detail (LOD) modelling of vector and terrain data is individual, resulting in geometric and topological inconsistencies in simplification processes. The three dimension Douglas Peucker (3D_DP)algorithm can realize gradual discrete point selection through threshold, which is mainly used in DEM synthesis, and its simplified process is very suitable for the dynamic establishment of massive data sets. A new LOD modeling method based on 3D_DP algorithm is proposed to simplify the consistency of river network vector elements and DEM in this paper. The specific steps are as follows: Firstly, the “Bending Adjustment Index (BAI)” is introduced to improve the 3D_DP algorithm, called the improved 3D_DP algorithm; Secondly, the DEM data is extracted into a 3D discrete point dataset, and the river line vector data is also converted into a discrete point dataset, assigned with elevation attributes, and merges with the DEM’s 3D discrete points. The merged point datasets are equenced based on the importance of each point, which are computed by the improved 3D_DP algorithm. The order of deleting points is determined by the sequence and the corresponding model spatial errors are calculated with the deletion of points. Then, the DEM’s 3D discrete points are constructed a Delaunay network with the river line as a mandatory constraint condition. The required triangulation is called in real time with the change of sight distance depending on the simple correspondence between screen projection error and model space error, and the unified LOD model for river line vector and DEM is established. The results show that the river’s overall shape and the terrain’s main features can be reserved under the same simplified factor based on the improved 3D_DP algorithm. The unified LOD model for the river network and DEM is feasible under the importance sequence of merged point datasets by the improved 3D_DP algorithm. Under the proper operation of data blocking, the rendering frame rate can meet practical application requirements.

Molecular Classification of Endometrial Cancers Using an Integrative DNA Sequencing Panel.

Adoption of molecular classification in endometrial cancer (EC) into clinical practice remains challenging due to complexity in coordination of multiple assays. We aimed to develop a simple molecular technique to classify ECs into four subgroups using our custom-designed targeted sequencing panel. Patients with newly diagnosed ECs were prospectively recruited from three cancer centres in Ontario, Canada. Using our panel, 181 ECs were sequenced. Variants were analysed for pathogenicity and clinicopathologic information was collected through medical records retrospectively. Of 181, 86 (48%) were mismatch repair deficient (MMRd), of which 62 (72%) harboured MLH1 promoter methylation and 24 (28%) had pathogenic variants in MMR genes. Of single classifiers, three (1.8%) had pathogenic POLE (POLEmut), 15 (9%) had TP53 mutations (p53abn) and 61 (37%) had no specific molecular profile subtype (NSMP). Sixteen (9%) had more than one molecular classifying feature, with eight (4%) MMRd-p53abn, six (3%) POLEmut-MMRd, one (0.5%) POLEmut-MMRd-p53abn and one (0.5%) POLEmut-p53abn. When MMRd group was further subclassified according to mechanism of MMR loss, MLH1 promoter methylated group had worse outcomes than those with somatic MMR pathogenic variants. Our panel can classify ECs into four subgroups through a simplified process and can be implemented reflexively in clinical practice.

Evaluation of the thermomechanical properties of novel epoxy composites reinforced with Geonoma baculifera fibers

Natural lignocellulosic fibers (NLFs) have shown a great potential as reinforcements in composites in recent decades. Among other reasons, environmental concerns and the depletion of oil reserves justify research on natural composites as they offer an environmentally friendly alternative and align with the principles of sustainable development. Among the plethora of NLFs available in nature, the ubim fiber (Geonoma baculifera) has not yet been investigated as a reinforcement for composites in potential engineering applications. Therefore, this study evaluates, for the first time, the mechanical properties of epoxy composites with 10, 20, and 30 vol% of ubim fibers. These properties were assessed through Izod impact, tensile and flexural tests as well as dynamic mechanical analysis (DMA). The data were statistically analyzed using the ANOVA method. Scanning electron microscopy (SEM) analysis indicated a transition from a purely brittle fracture mechanism to a ductile-brittle combination as the fiber volume in the composite increased. Tensile tests of the composites demonstrated an increasing trend in strength and elastic modulus with fiber volume. The results of the flexural tests also displayed a similar trend in strength and elasticity modulus for the composites. The results of DMA tests showed that composite materials with a 30 vol% of ubim fibers exhibited a high glass transition temperature and a low tan δ value, suggesting higher stiffness of this composite compared to others. Overall, the results indicated that the incorporation of 30 vol% ubim fibers into the composites significantly improved their mechanical properties compared to other tested fiber fractions. Additionally, their functional characteristics, such as simplicity in the manufacturing process, low cost, and excellent strength-to-weight ratio, make these composites particularly suitable for applications in sectors such as the automotive industry, construction panels, and packaging. These factors contribute to the development of an efficient, sustainable, recyclable and environmentally friendly composite.

The System Design of Payroll Accounting Information System at Private Primary School in East Jakarta

This research aims to design a system design of payroll Accounting Information System (AIS) at a primary private school (Madrasah Ibtidaiyah Al-Baidlo/”MIAB”), East Jakarta to improve the efficiency of payroll business processes. Business Process Improvement was used as a design approach in this research, with an applied research type. Collect data by interview with Headmaster and Treasurer. The tool used to document business processes is the Bizagi Modeler. Automation is carried out to prevent human error and increase the processing speed of payroll business processes. The business processes that are designed will be tested by material and information technology experts. The result of this research is that the proposed (to-be) business process increases the simplification of payroll activities by improving the quality of fast and accurate decision making which has economic value. Using Business Process Modelling Notation allows this research to present proposed business processes related to needs and solutions to problems in the research objects observed. This research is proven to be able to increase the simplification of business processes, increase efficiency in decision making by school principals in a relatively short time from 337 minutes to 41 minutes or a time saving of around 296 minutes (equivalent to 4.93 hours).Cutting manual activities to automated processes increases the opportunity for fraud and human error.

Dynamic photomask directed lithography based on electrically stimulated nematic liquid crystal architectures

Lithography technology is a powerful tool for preparing complex microstructures through projecting patterns from static templates with permanent features onto samples. To simplify fabrication and alignment processes, dynamic photomask for multiple configurations preparation becomes increasingly noteworthy. Hereby, we report a dynamic photomask by assembling the electrically stimulated nematic liquid crystal (NLC) into multifarious architectures. This results in reconfigurable and switchable diffraction patterns due to the hybrid phase arising from the NLC molecular orientations. These diffraction patterns are adopted as metamask to produce multiple microstructures with height gradients in one-step exposure and hierarchical microstructures through multiple in-situ exposures using standard photolithography. The fabricated pattern has feature size about 3.2 times smaller than the electrode pattern and can be transferred onto silicon wafer. This strategy can be extended to design diverse microstructures with great flexibility and controllability, offers a promising avenue for fabricating metamaterials via complex structures with simplified lithography processes.

The Efficiency of Procurement Process, Organization Performance, and Product Training in Public Organization

The manufacturing sector is considered a key driver of economic progress across different sectors. Industrial products typically enjoy higher "terms of trade," making them more profitable and generating greater added value compared to products from other sectors. This is due to the sector’s diverse range of products and its ability to offer substantial marginal benefits to users. As a result, business players including manufacturers, distributors, traders, and investors are more inclined to participate in this sector because of its attractive profit margins. The government has implemented various initiatives to promote industrial development, which has in turn increased the demand for funding to support this growth, particularly in the industrial sector. In addition to relying on internal sources of finance, the government has been working to secure more external funding, such as foreign investment and foreign loans, to complement development efforts. Given the limited availability of funds, the government needs to adopt policies that open up more opportunities for both domestic and foreign private sector participation in national development. To support this, the government has enacted legislation such as Law No. 1 of 1967 on Foreign Investment (PMA) and Law No. 6 of 1968 on Domestic Investment (PMDN). These laws were later refined through Law No. 11 and Law No. 12 of 1970 and various deregulation policies, including the May 6, 1986 Package, Pakto 1993, and Government Regulation No. 20 of 1994. The government later reorganized its investment policies by passing Law No. 25 of 2007 concerning Capital Investment, which aimed to provide legal certainty, protection, and simplified licensing processes for both domestic and foreign investors. This law is designed to create a more favorable investment environment in Indonesia.

A Rapid Synthesis of Amorphous LiTaOCl4 Solid Electrolytes Through a Two‐Step Reaction Pathway for High‐Rate and Long‐Cycling Lithium Batteries

AbstractA simplified process to prepare solid electrolytes (SEs) that fulfill long cyclability, fast‐charging performance, and wide‐temperature feasibility in all‐solid‐state lithium batteries (ASSLBs) is important. Here, amorphous LiTaOCl4 (aLTOC) SE is synthesized within only four hours via a two‐step reaction by high‐energy ball milling method, which exhibits high ionic conductivity and excellent interfacial compatibility. A bilayer SE based on aLTOC and sulfide along with corresponding ASSLBs, are constructed. Furthermore, slight evolution of the unusual microstructure in the chloride/sulfur interfacial region is observed and analyzed. Density functional theory calculations show that S tends to displace O sites in TaO2Cl4 octahedra instead of Cl sites. As a result of the enhanced interfacial stability and reduced formation of ionically insulating phases, the assembled ASSLBs achieve superior rate performance and cyclability in a wide temperature range. Notably, the ASSLBs show capacity retention of 84.4% and 77.6% after 2000 and 1000 cycles at current density of 10C at 30 and 60 °C, respectively. Importantly, even under −20 °C, the cell works stably over 1600 cycles with capacity retention of 76.3% at 0.5C. The work pave the way for the massive production of high‐performance amorphous chloride electrolytes and the realization of fast‐charging ASSLBs with long cycle life.

Effect of ozone gas exposure on drain current of solution-processed IGZO-TFT

The drain current (ID) of indium gallium zinc oxide thin-film transistors (IGZO-TFTs), fabricated by spin coating, decreases even when they are exposed to ozone gas at a concentration equal to or lower than 5 ppm. The ID reduction rate increases when the film thickness and the firing temperature in the spin-coating process of IGZO layer decreases. In these samples, the peak intensity ratio of the O 1s X-ray photoelectron spectroscopy (XPS) peak due to the OH group and the intensity of the infrared (IR) absorption band at 3000 cm−1–3500 cm−1 due to the OH stretching vibration increase. This indicates that OH groups within the IGZO film contribute to the ozone reaction mechanism. These findings are significant for developing high-sensitivity ozone sensors using a simpler process.

Assessment of cell-binding capacity of shed rAAV particles after gene therapy vector administration: implications for environmental risk and hygiene recommendations

ABSTRACT Background Currently, adeno-associated viruses (AAVs) are the most commonly used in vivo gene therapy (GT) vector platform. Risks posed to the environment, including the public, have not been well studied in the past. There is uncertainty concerning the necessary level of biocontainment and appropriate hygiene behavior for the handling of secreta/excreta of GT patients during the shedding phase. Research design and methods Here, feces and urine samples from non-human primates, treated with an AAV9-based vector at 2 × 1013 vector genomes per kilogram body weight (vg/kg), were analyzed for vector presence and subsequently analyzed for their capacity to bind to cells. Results Both sample types contained particles which bound to cells at concentrations in the range of ~104 (and higher) vg/mL of culture medium. Novel control rAAV vector displayed a ~2-3 orders of magnitude higher affinity to cells than shed particles. Conclusions The lower binding capacity of the shed vector particles speaks in favor of a more relaxed containment and hygiene approach in the context of GT. It is recommended that current hygiene and contact-avoidance-based containment measures after GT administration are reduced. The results also support the efforts to achieve a simplification of the regulatory review process of medicinal genetically modified organisms.

Robust tetra-armed poly (ethylene glycol)-based hydrogel as tissue bioadhesive for the efficient repair of meniscus tears.

Repair and preservation of the injured meniscus has become paramount in clinical practice. However, the complexities of various clinic stitching techniques for meniscus repair pose challenges for grassroots doctors. Hence, there is a compelling interest in innovative therapeutic strategies such as bioadhesives. An ideal bioadhesive must cure quickly in aqueous and blood environments, bind strongly, endure arthroscopic washing pressures, and degrade appropriately for tissue regeneration. Here, we present a tetra-poly (ethylene glycol) (PEG)-based hydrogel bioadhesive, boasting high biocompatibility, ultrafast gelation, facile injectable operation, and favorable mechanical strength. In view of the synergistic effects of chemical anchor and physical chain entanglement to tightly bind the meniscus, a seamless interface was formed between the surrounding meniscal tissues and hydrogels, enabling the longitudinal tear of the meniscus fused in situ to withstand large tensile force with the adhesive strength of 541.5±31.4kPa and arthroscopic washout resistance of 29.4kPa. Superior to existing commercial adhesives, ours allows sutureless application and arthroscopic assistance, without requiring specialized clinical skills. This research is expected to significantly impact our understanding of meniscal healing and ultimately promote a simpler process for achieving functional and structural recovery in torn menisci.

A Real-Time Key-Finding Algorithm Based on the Signature of Fifths

The signature of fifths is a special kind of music representation technique enabling acquisition of musical knowledge. The technique is based on geometrical relationships existing between twelve polar vectors inscribed in the circle of fifths, which represent individual pitch-classes detected in a given composition. In this paper we introduce a real-time key-detection algorithm which utilizes the concept of the signature of fifths. We explain how to create the signature of fifths and how to derive its descriptors required by the algorithm, i.e., the main directed axis of the signature of fifths, the major/minor mode axis, the characteristic vector of the signature of fifths, the characteristic angle of the signature of fifths, and the angle of the major/minor mode. We performed a series of experiments to test the algorithm’s effectiveness. The results were compared with those obtained using key-detection approaches based on key-profiles. All experiments were conducted using works composed by J.S. Bach, F. Chopin, and D. Shostakovich. The distinctive features of the presented algorithm, with respect to the considered key-detection approaches, are computational simplicity and stability of the decision-making process.

Single-use technologies in bio manufacturing: benefits and implementation challenges

Single-use technologies (SUT) have revolutionized the bio manufacturing industry by offering flexibility, cost efficiency, and improved contamination control. Initially adopted for simpler processes, SUT has expanded to complex bioprocessing operations, driven by the growing demand for biologics, vaccines, and personalized medicines. This review explores the benefits of SUT, including reduced capital and operational expenditures, faster setup and turnaround times, and enhanced product safety. The scalability of SUT allows for rapid adaptation to market demands, significantly accelerating the time-to-market for critical therapies. However, the implementation of SUT is not without challenges. Material compatibility, leachables, waste management, and supply chain reliability pose significant hurdles. Moreover, regulatory and validation challenges complicate the adoption of these technologies in large-scale production. Case studies, including the rapid deployment of COVID-19 vaccines and the production of monoclonal antibodies, illustrate SUT's practical applications and benefits. The review also examines future trends, highlighting advances in materials, automation, and digital integration, as well as the expanding applications of SUT in cell and gene therapy manufacturing. As the bio manufacturing landscape continues to evolve, SUT will play a crucial role in meeting the industry's growing needs, provided the challenges associated with its implementation are effectively managed.

Theoretical development and validation of asphalt concrete density measurement using non-contact interdigital coplanar capacitive sensor

Asphalt concrete (AC) density serves as a critical criterion for quality control and quality assurance in asphalt pavement construction. Current non-destructive testing (NDT) approaches have shown potential for AC density measurement, but they present disadvantages such as inefficiency and unstable accuracy. This paper developed a novel NDT approach for AC density measurement based on non-contact interdigital coplanar capacitive sensor (ICCS). The feasibility of this approach was evaluated through both numerical and experimental validations. Firstly, the theoretical model of non-contact ICCS for AC density measurement was established based on conformal mapping technique, partial capacitance technique, and dielectric mixing model. Secondly, numerical simulations were performed to validate the developed theoretical model under two scenarios. Thirdly, laboratory experiments were conducted to measure capacitance data and predict density for three common types of ACs. Finally, the error of non-contact ICCS was discussed and compared with that of other NDT instruments. The results indicated that the developed theoretical model could establish the relationship between AC density and capacitance value, which provided the basis for AC density measurement using non-contact ICCS. It was also observed that the capacitance data obtained by the proposed model closely matched those computed by numerical simulations. The maximum errors between theoretical and numerical data were 4.10% and 1.08% for two cases respectively, which proved the feasibility of the theoretical model. Furthermore, experimental results indicated that the capacitance value of AC specimens increased by about 1 pF as the rolling time increases due to a decrease in the volume of air in AC, which reaffirms the validity of AC density measurement using non-contact ICCS. Additionally, the non-contact ICCS demonstrated excellent accuracy with a maximum error of 6.69%, which is comparable to the current mainstream NDT approaches. And it has the advantages of lower cost, simpler data processing and higher efficiency. The findings of this paper offer a new and reliable method and tool for non-destructive and large-scale AC density measurement.

Judicious combinations of gravity, magnetic, electrostatic separators and microwave heat energy on recovery of ilmenite from Humma lean grade beach placer deposit

Microwave heating is an eco-friendly and novel technique for sintering and heating minerals and materials as it has several advantages in terms of phase transformation, energy efficiency, enhancing speed, process simplicity, improved properties. Such heating provides the composite materials to absorb electromagnetic energy volumetrically and transform into heat and produces larger densities as compared to conventional heating. This study focuses on two main objectives: the recovery of ilmenite through a strategic combination of mineral processing equipment, including a spiral concentrator, followed by magnetic and electrostatic separation, and the enhancement of ilmenite concentrate using microwave heat energy on a cleaner magnetic product, followed by electrostatic separation. Continuous magnetic separation results indicate that among the dry high-intensity belt magnetic separator, box mag wet high-intensity magnetic separator and dry rare earth drum magnetic separators, the rare earth magnetic separator yielded the highest quality product. The application of microwave heat energy before the rare earth drum magnetic separator at 1.4 T, followed by high-tension separation, produced the best grade of ilmenite. The magnetic product obtained after microwave treatment contained 98.6% ilmenite, which was further upgraded to a 99.6% ilmenite concentrate through high-tension separation. Therefore, it is recommended that an effective combination of gravity separation, microwave heat energy, rare earth drum dry magnetic separation and high-tension separation be employed to achieve the highest grade of ilmenite concentrate.

Study on the application amount optimization of water-based friction modifier based on field experiments

The utilization of friction modifiers (FMs) can reduce the adhesion coefficient of the top-of-rail to a moderate level, yielding a series of benefits. In this study, the influence of the FM application amount on the adhesion coefficient, noise, and braking distance was explored under field conditions. Results showed that when the FM application amount exceeded threshold values, the braking distance of the locomotive was greatly extended and the friction control performance of FM reached saturation. The FM application amount and application frequency were put forward through a simplified calculation process, which gave values of 0.33 mL/axle and 10axles/application, respectively. These application parameters achieve the desired intermediate friction level along with appropriate reductions in the noise and the lateral force.

Chemical Synthesis of Conjugation-Ready Trisaccharides Corresponding to Biological Repeating Units of Pseudomonas aeruginosa Serotype 10 and 19 O-Antigens.

Here we report the chemical synthesis of conjugation-ready trisaccharides, representing biological repeating units of Pseudomonas aeruginosa serotype 10 and 19 O-antigens. The α-d-QuiN3 glycosidic bond was stereoselectively synthesized through TMSI─Ph3P═O mediated 1,2-cis glycosylation. Selective oxidation of the C6-OH group at the disaccharide stage allowed for benzylidene-promoted construction of the α-l-GalN3 glycosidic bond and simplification of the postglycosylation process at the trisaccharide stage. The low reaction temperature and neighboring electron-donating effect facilitated the efficient synthesis of the trisaccharide.

Efficient synthesis of 2,5‐furandicarboxylic acid from corncob biomass using Ru/C and sulfonated carbon catalysts in a one‐pot system

AbstractThis study proposes a novel one‐pot method to produce 2,5‐furandicarboxylic acid (FDCA), which effectively simplifies the preparation process of FDCA by directly utilizing the biomass raw material corncob and its derived carbon‐based catalysts. In this work, we first prepared two different carbon‐based catalysts from corncobs: a ruthenium‐supported catalyst (Ru/C) and a sulfonated carbon catalyst. After detailed characterization and performance testing, these two catalysts were used to catalyze the pretreated corncob mixture to produce FDCA. Under optimized conditions, even using 0.12 g of Ru/C catalyst at a microwave power of 200 W, the yield of FDCA can reach 27 mol%. In comparison, the FDCA yield of the sulfonated carbon catalyst under the same conditions was 19 mol%. This work not only demonstrates the possibility of efficient production of FDCA by utilizing biomass resources and a simplified chemical conversion process, but also highlights the importance of selecting appropriate catalysts and controlling reaction conditions in improving yields. Through this method, we can promote the development of biomass conversion technology in a more efficient and environmentally friendly direction, providing technical support for the commercial production of bio‐based chemicals.