Star identification plays a key role in spacecraft attitude measurement. Currently, most star identification algorithms tend to perform well only in a scene without noise and are highly sensitive to noise. To solve this problem, this paper proposes a star identification algorithm based on the maximum spanning tree (MST) index and multi-order continuous cycle angle (CCA) intended for the lost-in-space mode. In addition, a neighboring star selection method named dynamic eight-quadrant (DEQ) is developed. First, the DEQ method is used to select high-confidence neighboring stars for the main star. Then, the star image is regarded as a graph, and the Prim algorithm is employed to construct the MST pattern for each guide star, which is then combined with the K vector index to perform the main star candidate search. Finally, the Jackard similarity voting for the multi-order CCA of the main star is used to identify the main star, and the global neighboring star identification is conducted by the multi-order CCA of neighboring stars. The simulated and real star images test results show that compared with five mainstream algorithms, when the position noise is 1 pixel, the number of false stars is five, the magnitude noise is 0.5, and the identification accuracy of the proposed algorithm is higher than 98.5%. Therefore, the proposed algorithm has excellent anti-noise ability in comparison to other algorithms.