Aim: Report a clinical case of endodontic retreatment using a hybrid instrumentation technique, L&C paste associated with glycerin as intracanal medication and bioceramic cement. Methods: A 42-year-old male, melanoderma patient, attended the Nilton Lins University Dentistry clinic complaining of tooth fracture and sensitivity in the upper frontal region and pain on chewing. The image exams, showed a bone radiolucense on the root tip, suggestive of a periapical lesion. Clinicaly, pain on vertical percussion was observed. The findings indicated an unsatisfactory primary endodontic treatment. Given the characteristics presented, endodontic reintervention in two sessions was chosen. Results: After the endodontic obturation, the patient was followed through a year. During the months of follow-up, it was observed decrease of the radiolucense on the root tip, as well as the appearance of radiopaque areas, suggestive of bone formation, indicating the effectiveness of the proposed treatment. Conclusion: Therefore, the endodontic reintervention using hybrid instrumentation technique, L&C paste associated with glycerin as intracanal medication and bioceramic cement, showed a satisfactory result in the controlling of the infection. After 1 year, signs of bone remodeling can be seen, meeting the heal expectations predicted in the case planning, leaving the tooth suitable for prosthetic rehabilitation and return to its function.