Significant Similarities In Terms Research Articles

Gökpınar Baraj Gölü (Batı Anadolu, Türkiye)’ndeki Egzotik Güneş Levreği Popülasyonunun (Lepomis gibbosus) Biyo-Ekolojik Özellikleri Üzerine Bir Araştırma

This study was conducted to determine some bioecological characteristics of Lepomis gibbosus (L. 1758), commonly known as pumpkinseed sunfish, which spreads in Gökpınar Dam Lake (GDL) in Denizli Province. The fish samples were captured with an experimental seine net and multimesh gillnet from May 2019 to April 2020. During the samplings, certain physicochemical parameters of GDL were measured, habitat utilization, relations to environmental variables, feeding habits and interspecific interactions with other fishes of L. gibbosus individuals were observed. It is observed that GDL provides a suitable habitat for L. gibbosus in terms of water quality and other ecological requirements. A total of 1005 L. gibbosus individuals, consisting of 302 females, 605 males, and 98 juveniles, were sampled throughout the study, and biometric studies were conducted. In the population males were found to be dominant. The averages were determined as follows; total length as 5.82±2.09 cm (2.46-11.34), weight as 4.94±4.67g (0.20- 34.65), and condition factor as 1.71±0.24. The ages were determined between 0+ to II+and Age-length relationship (VBGE) was estimated as L_(t=) 19,85(1-e^(-0,2744(t+0,272) ) ) Spawning occurs between April and June in individuals at the age of I+. It has been observed that the species exhibits good growth rates in this habitat, displays opportunistic omnivorous feeding behavior, preys on another invasive alien species, Gambusia holbrooki, present in the lake, and competes with the same species for habitat sharing. It has been determined that L. gibbosus has formed a self-sustaining population in GDL, but it utilizes a limited lake area as its habitat. In conclusion, GDL is considered as a hydrologically unstable and highly variable habitat. L. gibbosus population of GDL exhibits significant similarities in terms of bioecological characteristics with populations that spread outside its natural spreading area. As L.gibbosus is an exotic fish and might be have invasive traits, it is necessary to monitor of the population regularly, and control measures should be taken to prevent its spread to other inland water bodies.

Occurrence and Health Risk Assessment of Heavy Metals in Lychee (Litchi chinensis Sonn., Sapindaceae) Fruit Samples

This study aimed to assess the occurrence of eight heavy metals in lychee (Litchi chinensis Sonn.) fruit samples collected from orchards of the Dehradun and Haridwar districts in Uttarakhand, India. Lychee fruit samples were collected from ten (10) sampling locations from May to June 2023 and analyzed using inductively coupled plasma optical emission spectroscopy (ICP-OES). Results showed that lychee fruit samples showed varying levels of selected heavy metals, i.e., Cd (0.009–0.095 mg/kg), Cr (0.079–0.960 mg/kg), Cu (0.095–0.258 mg/kg), Fe (0.254–0.531 mg/kg), Pb (0.000–0.011 mg/kg), Mn (0.862–1.903 mg/kg), Ni (0.166–0.310 mg/kg), and Zn (0.076–0.149 mg/kg). It was observed that lychee fruit sampling sites near urban and industrial areas had higher concentrations of heavy metals as compared to those in rural and agricultural areas. In addition, principal component analysis (PCA) and clustered heatmap dendrogram results showed that several sites had significant similarities in terms of heavy metal availability. Overall, the levels of all heavy metals were below the safe limits as suggested by health risk studies. The selected indices such as daily intake of metals (DIM), health risk index (HRI), and target hazard quotient (THQ) did not exceed the standard limit which indicated consumption of lychee fruit was safe at all sampling sites. The results of this study emphasize the need to regularly monitor lychee heavy metal levels and implement sustainable agricultural and environmental practices to reduce contamination sources.

Review of Methodologies for Displacement Checks in Modern Seismic Design Codes

This review paper discusses the procedures for evaluating the design displacement given in various design codes from seismically prone countries around the world (the United States, New Zealand, Chile, Japan, Greece, Italy, Iran, India, Turkey, and Romania). The limit displacements and the corresponding limit states are also presented and analyzed in this study besides the importance class factors considered in the selected seismic design codes. A presentation of the behavior factors necessary for evaluating the design value of the seismic action is also shown in this study. One of the observations of this review paper is that there are significant similarities in terms of the approach to the displacement check in the analyzed codes. In addition, it was observed that the displacement check is generally associated with the serviceability limit state (e.g., damage limitation). However, differences in terms of the mean return period for the serviceability check action were observed among the analyzed seismic design codes. Several aspects which have to be further adapted in the future versions of seismic design codes are also discussed in this review paper. One of the main aspects which must be further discussed is the enforcement of displacement limits, which are dependent on the structural system and on the importance of the class/height regime for the ultimate/serviceability limit state. In addition, the dependence of the TD control period on the probabilistic seismic hazard ordinates should be further discussed. Moreover, the pulse effects, which can affect both the acceleration and the displacement design of response spectra, should be accounted for as well in future generations of seismic codes. Finally, it appears necessary to perform a harmonization of the behavior factors employed in seismic design codes.

Tunnel Crack Detection With Linear Seam Based on Mixed Attention and Multiscale Feature Fusion

Crack detection techniques have been rapidly developed in recent years due to the rise of deep learning. However, existing methods struggle to produce accurate crack segmentation results because cracks and linear seams on the tunnel lining surface have significant similarities in terms of intensity value and texture features. At the same time, due to the scarcity of data, the existing tunnel lining surface crack detection methods still use multi-step traditional image processing methods for detection, which is inefficient. In this paper, we collect and label a dataset of 200 tunnel lining surface crack images named Tunnel200. For the first time, a deep learning-based method is used to detect cracks in the tunnel lining surface. To deal with the characteristics of crack and linear seam, which mostly present long strip or curved shapes, we propose a Mixed Attention (MA) module by efficient embedding channel and positional information. Unlike common spatial attention that aggregates information throughout space, mixed attention aggregates feature directly along with two directions, height, and width, in the spatial dimension. In this way, the long-range dependence of the crack features can be effectively captured. The proposed MA is simple to incorporate into the network. Meanwhile, we embed it in the traditional U-shape network while employing an efficient multi-scale feature fusion technique to build the Tunnel Crack Detection Network (TCDNet). TCDNet outperforms other crack detection and semantic segmentation methods on the Tunnel200 dataset. Additionally, we evaluate our method on two publicly available crack datasets, Crack500 and DeepCrack, and our method gets superior performance.

Therapeutic Targeting of Cancer: Epigenetic Homeostasis.

A large number of studies have revealed that epigenetics plays an important role in cancer development. However, the currently-developed epigenetic drugs cannot achieve a stable curative effect. Thus, it may be necessary to redefine the role of epigenetics in cancer development. It has been shown that embryonic development and tumor development share significant similarities in terms of biological behavior and molecular expression patterns, and epigenetics may be the link between them. Cell differentiation is likely a manifestation of epigenetic homeostasis at the cellular level. In this article, we introduced the importance of epigenetic homeostasis in cancer development and analyzed the shortcomings of current epigenetic treatment regimens. Understanding the dynamic process of epigenetic homeostasis in organ development can help us characterize cancer according to its differentiation stages, explore new targets for cancer treatment, and improve the clinical prognosis of patients with cancer.

A COMPARISON OF MALAY AND TAMIL TRADITIONS SHADOW-PLAY

The main objective of this study is to identify the similarities and differences between Malay and Tamil tradition of shadow-play. The design of this study is qualitative in nature using descriptive analysis methods based on Comparative literature theory. The researcher had collected and studied the similarities and differences in the Malay and Tamil tradition shadow-play. The findings of the study show that Malay and Tamil tradition of shadow-play have significant similarities in terms of story and form of puppets as the shadow-play in Malaysia have Hindu influences from Java or Pattani. However, many Malay shadow-plays have also been adapted and adopted to the culture and tastes of the local community, especially with the comic relief, that is often found throughout the Malay tradition of the shadow-play, as a local element. This comparative study will further strengthen the links between the Malay and Tamil communities that have co-existed for generations. The research claims to be the first such attempt to do a comparative study in finding the similarities and differences between Malay and Tamil tradition of shadow-play.

A comparative analysis of pilgrim identities in Matthew 21:12-13 and that of Bernard Mzeki’s pilgrimage

The paper is a comparison of pilgrim identities between the Passover Feast and Bernard Mzeki pilgrimages. Bernard Mzeki is one of the most celebrated martyrs in the Anglican Church in Zimbabwe and worldwide. 18 June is reserved as the day of celebrating his martyrdom. Anglican pilgrims from all over the world travel to Bernard Mzeki shrine in Marondera, Zimbabwe in honour of his sacrificial life towards the propagation of the gospel. The form critical approach helps in the reconstruction of the identities of Passover pilgrims and the Comparative analysis help in comparing the two. The paper established some significant similarities in terms of the pilgrim identities of the two, while certain peculiarities had been considered as well. Though religious pilgrimages are purpose of worship and encounter the Holy One, not all pilgrims attend the festival for these primary focuses. Some have different purpose hence the quest for these different pilgrim identities.

Technological adaptations of early humans at the Lower Pleistocene Nihewan Basin, North China: the case of the bipolar technique

The Nihewan Basin in North China has proved to be a key area for the study of human evolution outside of Africa due to its continuous record of hominin occupation since the Early Pleistocene. Lower Paleolithic lithic assemblages at Nihewan are attributed to the East Asian Mode 1 techno-complex, which is often defined by the widespread use of freehand knapping techniques. However, our ongoing investigation of several early Pleistocene archaeological sites at Nihewan has revealed a higher prevalence of bipolar stone artifacts than previously considered, which may have been underestimated in the past due to the disparity of analytical techniques applied to Early Stone Age assemblages and the poor quality of the Nihewan Basin raw materials. This has constrained the identification of bipolar attributes and their differentiation from freehand knapping products. This study aims to investigate technological and economical differences between the two techniques based on experimental results of chert from the Nihewan Basin, creating a referential framework for the study of bipolar artifacts that we apply, to the Early Pleistocene assemblages of Xiaochangliang and Cenjiawan. Our results not only highlight morphological and technological differences between bipolar and freehand products but also demonstrate that both techniques share significant similarities in terms of dimensions and productivity. Overall, our results help to contextualize the technological flexibility of East Asian Mode 1 assemblages in the Nihewan Basin, where early hominins employed alternative flaking techniques, often in the same assemblage, to overcome constrains imposed by the poor quality of most of the raw materials available.

Does autonomy exist? Comparing the autonomy of teachers and senior leaders in England and Turkey

ABSTRACT Countries regarded as holding high levels of educational autonomy face a different set of constraints to that of countries with low levels of autonomy, these constraints being linked to the marketisation of schools. As schools become decentralised and given greater autonomy, school leaders are steered by a responsibilising framework that includes bureaucratic regulation, the discourses and practices of competitive enterprise, and external public accountability measures. This paper contrasts data gathered from school teachers and senior leaders from one high autonomy, high accountability context, England, with one low autonomy, low accountability context, Turkey. Through a process of semi-structured interviews with teachers and senior leaders, we investigated approaches to managing change. Responses revealed differences between countries with very different systems of accountability and the degree of autonomy available to staff. We also found that there were significant similarities in terms of the attitudes and pressures experienced by teachers and senior leaders that raise questions for our understandings and application of notions of teacher autonomy and accountability.

Terrace agriculture in a mountainous arid environment – A study of soil quality and regolith provenance: Jabal Akhdar (Oman)

In the Sultanate of Oman remnants of deteriorating terrace agricultural systems offer important insights into long-term human adaptation in the arid tropics. Irrigation and terrace agriculture in the mountainous Jabal Akhdar region reveal historic agricultural practices in a rugged, high elevation context. The present study examines soil quality and regolith provenance in abandoned agricultural soil terraces. Three soil profiles in each of the Villages of Hadash and Wijma were excavated and analyzed. Physical, chemical and mineralogical analyses were conducted for all soil horizons. In addition, six other soils, 3 possible soil parent rocks (regolith) and soil’s bedrock were collected. Soil ages were constrained by 14C assays and stable isotope, (13C and 18O) on the bulk carbonates in the calcrete (caliche). The results demonstrate that both sites display poor soil quality with very low average total organic carbon (TOC) (6.2–5.0 g kg−1) and mean weight diameter (MWD; 0.27–0.48 mm), with low water stable aggregate content (<42%). All the geochemical, mineralogical and the thin section analyses show that the soils exhibit unique characteristics that differ from those of other sediments (possible parent regolith) and soils in the vicinity. The finding of ostracod shells in the soil terraces in both areas and 14C dating of calcrete (10.193 ± 30–13.887 ± 40 a BP) indicate that regolith was human-transported to terraces to create soil. The 14C ages of the bulk carbonates match well with a dry period of high calcite precipitation contemporaneous to the Younger Dryas. The Hadash and Wijma soil terraces are located ~45 km away from each other, but still display significant similarities in terms of regolith provenance and soil development and were likely filled with regolith from the same source. These results offer new perspective on agricultural terrace development and oasis agriculture in a rugged, high-elevation, arid environment.

Identification of breast cancer risk modules via an integrated strategy.

Breast cancer is one of the most common malignant cancers among females worldwide. This complex disease is not caused by a single gene, but resulted from multi-gene interactions, which could be represented by biological networks. Network modules are composed of genes with significant similarities in terms of expression, function and disease association. Therefore, the identification of disease risk modules could contribute to understanding the molecular mechanisms underlying breast cancer. In this paper, an integrated disease risk module identification strategy was proposed according to a multi-objective programming model for two similarity criteria as well as significance of permutation tests in Markov random field module score, function consistency score and Pearson correlation coefficient difference score. Three breast cancer risk modules were identified from a breast cancer-related interaction network. Genes in these risk modules were confirmed to play critical roles in breast cancer by literature review. These risk modules were enriched in breast cancer-related pathways or functions and could distinguish between breast tumor and normal samples with high accuracy for not only the microarray dataset used for breast cancer risk module identification, but also another two independent datasets. Our integrated strategy could be extended to other complex diseases to identify their risk modules and reveal their pathogenesis.

Different Behaviors of a Substrate in P450 Decarboxylase and Hydroxylase Reveal Reactivity-Enabling Actors

Biological routes to the production of fuels from renewable feedstocks hold significant promise in our efforts towards a sustainable future. The fatty acid decarboxylase enzyme (OleTJE) is a cytochrome P450 enzyme that converts long and medium chain fatty acids to terminal alkenes and shares significant similarities in terms of structure, substrate scope and mechanism with the hydroxylase cytochrome P450 (P450BSβ). Recent reports have demonstrated that catalytic pathways in these enzymes bifurcate when the heme is in its iron-hydroxo (compound II) state. In spite of significant similarities, the fundamental underpinnings of their different characteristic wild-type reactivities remain ambiguous. Here, we develop point charges, modified parameters and report molecular simulations of this crucial intermediate step. Water occupancies and substrate mobility at the active site are observed to be vital differentiating aspects between the two enzymes in the compound II state and corroborate recent experimental hypotheses. Apart from increased substrate mobility in the hydroxylase, which could have implications for enabling the rebound mechanism for hydroxylation, OleTJE is characterized by much stronger binding of the substrate carboxylate group to the active site arginine, implicating it as an important enabling actor for decarboxylation.

Galactose-induced Aging Model in Rat Testicular Tissue.

To examine whether the D-galactose induced aging model is an appropriate model for further aging research. Experimental study. Aziz Sancar Institute of Experimental Medicine, Istanbul University, Turkey, June 2015- June 2017. The study comprises 3 groups of rats. Group I is young control (YC) 5-month-old rats. Group II is 5-month- old rats, which were mimetically aged (MA) for 6 weeks via intraperitoneal D-galactose (60 mg/kg body weight/day, 0.5 mL) administration. Group III is naturally aged (NA) 24-month-old rats. Group I and III received intraperitoneal saline (0.9% 0.5 mL) for 6 weeks as vehicle. Group I and Group II received injections at 21 weeks age and Group III rats 6 weeks before 24 months age. Tissues were harvested when rats became 6.5-month-old (Group I and Group II) and 24-month-old (Group III). Quantitative biochemical analyses of proteins, lipids, DNA biomarkers and Cu, Zn-SOD were conducted. Statistical analysis of the data was conducted using ANOVA, followed by post-hoc Bonferroni test. Higher magnitude of oxidative damage and diminished antioxidant defence capacity were found in both mimetically aged and naturally aged testicular tissues. It is observed that D-galactose aging model group shares significant similarities in terms of impaired redox homeostasis with the naturally aged rats. D-galactose induced testicular aging model successfully mimics aging process. Therefore, D-galactose induced aging model may be used as an accelerated aging model to study the age related alterations and interventions.

Diagenetic evolution of a shallow marine Kimmeridgian carbonate ramp (Jabaloyas, NE Spain): implications for hydrocarbon reservoir quality

The upper Kimmeridgian outcrops in Jabaloyas (NE Spain) studied here have significant similarity in terms of carbonate ramp morphology and its facies architecture with Member D of the Upper Jurassic Arab Formation reservoirs in the Middle East. Geological models from analogue outcrops enhance or challenge the understanding of multi-scale sedimentological and diagenetic heterogeneities in the subsurface hydrocarbon reservoir models by providing morphometric parameters. For this purpose, conventional diagenetic studies (petrographic microscopy analysis and cathodoluminescence) have been performed to assess the impact of diagenetic modifications through burial. More than 50 thin sections have been used to define a full paragenetic sequence. Additional mineralogical mapping (Qemscan®) on a selection of thin sections serves as a calibration tool for semiquantitative analytic studies of every mineral phases and the proposed porosity evolution. This work unravels the whole paragenetic diagenetic processes and focused on those that occurred right after deposition to shallow burial (eogenesis). High-sequence stratigraphy allows linking these events to variations of the environmental domains that, in fact, respond most likely to sea-level fluctuations. In particular, it provides key parameters to frame the diagenetic overprint such as cementation processes plugging primary interparticle porosity and selective dissolution linked to master bounding surfaces: calcite meniscus cements in vadose zones and selective dissolution processes linked to firmgrounds. Ultimately, they offer valuable trends that would be potentially relevant to decipher and characterize reservoir parameters for the upscaling workflow of fabrics from microscopic to inter-well scale in carbonate hydrocarbon reservoirs.

Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates.

Alzheimer's disease (AD) is a devastating neurodegenerative disorder and a major medical problem. Here, we have investigated the impact of amyloid-β (Aβ) oligomers, AD-related neurotoxins, in the brains of rats and adult nonhuman primates (cynomolgus macaques). Soluble Aβ oligomers are known to accumulate in the brains of AD patients and correlate with disease-associated cognitive dysfunction. When injected into the lateral ventricle of rats and macaques, Aβ oligomers diffused into the brain and accumulated in several regions associated with memory and cognitive functions. Cardinal features of AD pathology, including synapse loss, tau hyperphosphorylation, astrocyte and microglial activation, were observed in regions of the macaque brain where Aβ oligomers were abundantly detected. Most importantly, oligomer injections induced AD-type neurofibrillary tangle formation in the macaque brain. These outcomes were specifically associated with Aβ oligomers, as fibrillar amyloid deposits were not detected in oligomer-injected brains. Human and macaque brains share significant similarities in terms of overall architecture and functional networks. Thus, generation of a macaque model of AD that links Aβ oligomers to tau and synaptic pathology has the potential to greatly advance our understanding of mechanisms centrally implicated in AD pathogenesis. Furthermore, development of disease-modifying therapeutics for AD has been hampered by the difficulty in translating therapies that work in rodents to humans. This new approach may be a highly relevant nonhuman primate model for testing therapeutic interventions for AD.

Oxidation scrutiny in persuaded aging and chronological aging at systemic redox homeostasis level

BackgroundThe effect of the natural aging process on systemic redox homeostasis is previously documented. However, none of the studies specify the effect of experimental aging on systemic redox homeostasis. The purpose of this study is to clarify the ambiguity raised in preliminary reports as to mimetic aging dependency of the type and magnitude of oxidative damage on constituents of plasma. MethodsIn the current study, we investigated the interrelationship among various groups of the systemic oxidative damage markers such as protein oxidation products (protein carbonyl groups, protein hydroperoxides, advanced oxidation protein products, protein thiol groups), lipid peroxidation products (malondialdehyde, lipid hydroperoxides, conjugated dienes), glycoxidation adducts (advanced glycation end products), and antioxidant capacity (ferric reducing/antioxidant power, Cu,Zn-superoxide dismutase, total thiol, non-protein thiol). All these markers were measured in plasma of mimetically aged (MA) rats (5-month-old rats subjected to d-galactose-induced experimental aging), naturally aged (NA) rats (24-month-old), and their corresponding young controls (YC) (5months old). Results and conclusionsOur current results show that systemic oxidation markers of the MA group share significant similarities in terms of impaired redox homeostasis with the NA rats and may be considered as a reliable experimental aging model for intravascular aging. Additional methodological studies including d-galactose dosage and application time are warranted to clarify the potential involvement of all these systemic redox variations as mechanistic factors in the development of mimetic aging related intravascular deterioration. Reversing or preventing systemic oxidative damage in experimental and natural aging should therefore be considered the primary target for the development of effective therapeutic strategies to prevent or treat age-related vascular disorders.

HPV-related cervical disease and oropharyngeal cancer

Human papillomavirus (HPV), especially HPV 16, is associated with the development of both cervical and oral cancer. We show the case of a woman affected by HPV-related cervical disease and oropharyngeal squamous cell carcinoma (OPSCC). A 41-year-old woman arrived at our Colposcopy Center following an abnormal Pap smear result (ASC-H) and a diagnosis of moderate cervical dysplasia obtained by a cervical biopsy. She underwent a colposcopy that showed a cervical abnormal transformation zone grade 2. A laser conization was performed in November 2010. Histology reported a moderate/severe dysplasia. The cone resection margins were free. Follow-up colposcopy and cytology were negative. The HPV testing showed an infection by HPV 16. In October 2012, the patient presented to the Head-Neck ER after episodes of hemoptysis; a lesion was found in the left tonsillar lodge. A biopsy was performed with a result of squamous cell carcinoma with low-grade differentiation. The HPV testing detected a high-risk HPV and the immunohistochemical analysis was positive for p16. She was treated by chemotherapy and brachytherapy. She was followed at the head-neck center with monthly visits with oral visual inspection that showed complete absence of mucosal abnormalities. HPV-related OPSCC and cervical precancerous/cancerous lesions have significant similarities in terms of pathogenesis. They are both caused largely by HPV 16, as in the present case. In conclusion, because of this association found in literature and in our case, we think that women with HPV cervical lesions should have regular surveillance for oropharyngeal cancer, whereas women with OPSCC should be encouraged to have diligent cervical screening.

Forecasting oil prices: Smooth transition and neural network augmented GARCH family models

The study focuses on a new class of nonlinear volatility models based on neural networks and STAR type nonlinearity. Accordingly, LSTAR–LST–GARCH family and LSTAR–LST–GARCH–NN family of models will be evaluated to analyze petrol prices with economic applications. The nonlinear behavior and leptokurtic distribution are discussed in many studies. The study aims proposing augmentation of linear GARCH, fractionally integrated FI–GARCH and Asymmetric Power APGARCH models with LSTAR type nonlinearity modeling. Further, the proposed models will be augmented with neural networks to benefit from well known learning and forecasting capabilities. The multilayer perceptron (MLP) neural network model and LSTAR model have significant similarities in terms of their architecture. The proposed LSTAR–LST–GARCH family and ANN augmented LSTAR–LST–GARCH–MLP models are evaluated for modeling petrol prices. Empirical findings of the study are: (1) Fractionally integrated and asymmetric power improvements among the GARCH family models provide better forecasting capability for petrol prices; better captured long memory and high volatility characteristics of petrol prices. (2). LSTAR–LST–GARCH model family results in even better gains in out-of-sample forecasting. (3) Donaldson and Kamstra (1997) based MLP–GARCH family provided similar results with the LSTAR–LST–GARCH family models. One exception is for MLP–FIGARCH and MLP–FIAPGARCH models; FI and AP augmented models proposed in this study. (4) Volatility clustering, asymmetry and nonlinearity characteristics of petrol prices are best captured with the LSTAR–LST–GARCH–MLP model family. Forecasting capabilities of neural network techniques are promising. Among the evaluated models, the LSTAR–LST–APGARCH–MLP model provided the best performance overall. With a political perspective, in addition to the highly volatile structure, the long memory characteristics of petrol prices requires that the economic policy interventions should be kept at the modest levels to avoid persistent impacts of shocks.

Hydrophilicity Matching – A Potential Prerequisite for the Formation of Protein-Protein Complexes in the Cell

A binding event between two proteins typically consists of a diffusional search of binding partners for one another, followed by a specific recognition of the compatible binding sites resulting in the formation of the complex. However, it is unclear how binding partners find each other in the context of the crowded, constantly fluctuating, and interaction-rich cellular environment. Here we examine the non-specific component of protein-protein interactions, which refers to those physicochemical properties of the binding partners that are independent of the exact details of their binding sites, but which can affect their localization or diffusional search for one another. We show that, for a large set of high-resolution experimental 3D structures of binary, transient protein complexes taken from the DOCKGROUND database, the binding partners display a surprising, statistically significant similarity in terms of their total hydration free energies normalized by a size-dependent variable. We hypothesize that colocalization of binding partners, even within individual cellular compartments such as the cytoplasm, may be influenced by their relative hydrophilicity, potentially in response to local hydrophilic gradients.

Tracks of change in hospitals: a study of quasi-market transformation.

Examines the process of change in hospitals that has emerged following the introduction of the health quasi-market in 1991. Blends empirical evidence with Greenwood and Hinings' archetype and tracks of change concepts to analyse the process which is labelled quasi-market transformation (QMT). Argues that, before 1991, hospitals tended to operate within structures and systems underpinned by an interpretive scheme. Represents these similarities of configuration as the directly-managed (DM) hospital archetype. When change initiatives challenged this configuration, the outcomes were negotiated and resulted in "adjustmental" change. In contrast, shows the introduction of the quasi-market to have involved the first transformation of the DM archetype's interpretive scheme, systems and structures. Analyses four years of transition to reveal that QMT has been interpreted differently within hospitals. However, presents data to suggest that many hospitals now display significant similarities in terms of configuration. Represents these similarities within the emerging Trust hospital archetype.