Significant Positive Linear Relationship Research Articles

Cerebellar Diameter as A Predictor of Gestational Age of Fetus: Comparison With Other Biometry Parameters

Objective: The aim of this study was to determine if the fetal cerebellum can be used as a predictor of gestational age (GA), in comparison with other biometric parameters, such as fetal head circumference (HC), biparietal diameter (BPD), abdominal circumference (AC), and femur length (FL). Materials and Methods: A grayscale sonographic examination was completed on a cohort of 200 pregnant participants, during their second and third trimester. A descriptive analysis was used to determine the fetal GA, utilizing the transcerebellar diameter (TCD), while comparing it with other biometry metrics. The mean and standard deviation were provided for quantitative variables, while frequencies were determined for categorical variables. A multivariate regression was used to construct models for determining the fetal GA by using the fetal TCD. Results: Paired sample statistics of this fetal data showed that the mean GA (i.e., fetal GA based on BPD, FL, HC, and AC) and TCD-GA have approximately the same mean values of 27.59. Moreover, the strength of correlation was 0.941 and a significance of P < .001, respectively. Based on the paired sampling, the analysis indicated that there was a very strong significant positive linear relationship between mean fetal GA and TCD-GA and strong reliability. Conclusion: This cohort study demonstrated a very strong significant positive linear relationship between mean fetal GA and TCD-GA, with strong reliability. This may suggest that it is possible to determine fetal GA by measuring TCD.

Changing climate intensifies downstream eutrophication by enhancing nitrogen availability from tropical forests

The contribution of diffuse nutrient exports from forests to downstream water bodies is significant owing to their extensive spatial distribution across watersheds. However, the intricacies of coupling mechanism between diffuse nutrient exports and meteorological factors driving downstream eutrophication remain poorly understood. Multiple methods involving field sampling, laboratory analysis, and model simulation were utilized to investigate the impact of diffuse nutrient exports from tropical forests on chlorophyll a concentration dynamic in the downstream reservoir. A strong positive correlation was observed between air temperature and chlorophyll a concentration, indicating the direct influence of climatic factors on microalgal biomass. The significant positive linear relationship was also observed between diffuse nitrate exports and chlorophyll a concentration, with a regression coefficient of 0.36 (P < 0.001), underscoring the role of nitrogen inputs in stimulating microalgal growth. The interplay between diffuse nitrate exports and meteorological factors was shown to regulate chlorophyll a concentration fluctuation. Additionally, the structural equation model revealed that increasing temperature and decreasing precipitation could elevate chlorophyll a concentration by enhancing nitrogen availability. Monte Carlo simulation results further revealed that temperature and precipitation were the most influential factors affecting chlorophyll a concentration during dry and rainy seasons, with sensitivity values of 0.94 and − 0.76, respectively. Notably, the eutrophication status was projected to deteriorate from light to moderate under diminishing precipitation conditions. These findings underscore the urgency of addressing eutrophication risks in reservoirs surrounded by tropical forests and the implementation of effective nitrate mitigation strategies is imperative, which offers theoretical guidance for the management of eutrophic water restoration within tropical rainforest regions under changing climate conditions.

Utilizing geodetectors to identify conditioning factors for gully erosion risk in the black soil region of northeast China

In the black soil region of Northeast China, the issue of gully erosion persists as a significant threat, resulting in extensive damage to farmland, severe degradation of the black soil, and decreased productivity. It is therefore of utmost importance to accurately identify areas that are susceptible to gully erosion to effectively prevent and control its negative impact. This study tried to utilize geographical detectors (geodetectors) as a means to identify the factors that contribute to the distribution of gullies and assess the risk of gully erosion (GER) in five catchments within the region, with areas ranging from approximately 80 km2–200 km2. By employing the geodetectors method, fourteen geo-environmental factors were analyzed, including topographic attributes (such as aspect, catchment area, convergence index, elevation, plan curvature, profile curvature, slope length, slope, stream power index, and topographic wetness index), channel network distance, vegetation index (NDVI and EVI), as well as land use/land cover (LULC). The modeling of GER was conducted using the random forest algorithm (RFA). Out of the fourteen examined geo-environmental factors, only a subset, comprising less than or equal to 50%, demonstrated a significant (p < 0.05) influence on the spatial distribution of gullies. These selected factors were sufficient in assessing GER, with LULC (mean q-value = 0.270) and elevation (mean q-value = 0.113) identified as the two most important factors. Furthermore, the RFA exhibited satisfactory performance across all catchments, achieving AUC values ranging from 0.712 to 0.933 (mean = 0.863) in predicting GER. Overall, the catchment areas were classified into high, moderate, low, and very low-risk levels, representing 9.67%–15.95%, 19.28%–26.08%, 24.59%–30.55%, and 30.54%–39.08% of the total area, respectively. Importantly, a significant positive linear relationship (r2 = 0.722, p < 0.05) was observed between the proportion of cropland area and the occurrence of high-level GER. Although the primary risk levels were categorized as low and very low, the proportion of high-risk levels exceeded the existing gully coverage (0.34%–3.69%). These findings highlight the substantial potential for gully erosion and underscore the necessity for intensified efforts in the prevention and control of gully erosion within the black soil region of Northeast China.

Validation of quantitative magnetic resonance imaging techniques in head and neck healthy structures involved in the salivary and swallowing function: Accuracy and repeatability

Background and PurposeRadiation-induced damage to the organs at risk (OARs) in head-and-neck cancer (HNC) patient can result in long-term complications. Quantitative magnetic resonance imaging (qMRI) techniques such as diffusion-weighted imaging (DWI), DIXON for fat fraction (FF) estimation and T2 mapping could potentially provide a spatial assessment of such damage. The goal of this study is to validate these qMRI techniques in terms of accuracy in phantoms and repeatability in-vivo across a broad selection of healthy OARs in the HN region. Materials and MethodsScanning was performed at a 3 T diagnostic MRI scanner, including the calculation of apparent diffusion coefficient (ADC) from DWI, FF and T2 maps. Phantoms were scanned to estimate the qMRI techniques bias using Bland-Altman statistics. Twenty-six healthy subjects were scanned twice in a test–retest study to determine repeatability. Repeatability coefficients (RC) were calculated for the parotid, submandibular, sublingual and tubarial salivary glands, oral cavity, pharyngeal constrictor muscle and brainstem. Additionally, a linear mixed-effect model analysis was used to evaluate the effect of subject-specific characteristics on the qMRI values. ResultsBias was 0.009x10-3 mm2/s for ADC, -0.7 % for FF and -7.9 ms for T2. RCs ranged 0.11–0.25x10-3 mm2/s for ADC, 1.2–6.3 % for FF and 2.5–6.3 ms for T2. A significant positive linear relationship between age and the FF and T2 for some of the OARs was found. ConclusionThese qMRI techniques are feasible, accurate and repeatable, which is promising for treatment response monitoring and/or differentiating between healthy and unhealthy tissues due to radiation-induced damage in HNC patients.

Technology Acceptance Model (TAM) -Based Assessmentof User Acceptance for a Smart Crop Management System

A smart system that can monitor critical growth parameters and control irrigation and fertilizer applications for tomato production was developed to answer the need for a better and data-driven farm management. The technology was then introduced to tomato farmers in one of the project sites. Technology Acceptance Model (TAM) was used to assess the receptiveness of the farmers to the developed technology focusing on two (2) key predictors: perceived usefulness (PU) and perceived ease of use (PEU). A questionnaire based on TAM principles was formulated for a self-administered survey to assess participants’ perceptions and opinions about the developed technology. The reliability of the questionnaire was validated using Cronbach’s alpha with a value of 0.93 and 0.96 for PU and PEU, respectively. The PU and PEU scores were found to be 94.83% and 88.41%, respectively. The PU score classified the developed technology as very useful while the PEU score categorized it as very easy to use. A Pearson correlation test was also conducted to investigate if there is a linear relationship between PU and PEU. Results showed that there is a statistically significant positive linear relationship between the two predictors. Several issues were pointed out during the conduct of the technology demonstration that might affect the perception of the farmer group towards the developed technology. Nonetheless, it was concluded that the farmers are indeed receptive and interested with the technology, and their appreciation of the benefits it entails to their livelihood is evident.

Clinical and genomic characterization of sporadic medullary thyroid carcinoma in Chinese patients.

6094 Background: Medullary thyroid carcinoma (MTC) is a C-cell-derived epithelial neuroendocrine neoplasm. MTC has a low prevalence and a relatively worse prognosis compared with differentiated thyroid carcinoma. About 75% of all MTCs are sporadic. The clinicogenomic landscape of sporadic medullary thyroid carcinoma (sMTC) in the Chinese population was rarely described. Methods: Formalin-fixed paraffin-embedded (FFPE) samples and/or tumor tissues from a total of 121 sMTC patients from 22 centers were retrospectively collected and tested using a targeted 28-gene next-generation sequencing (NGS) panel (May 2022 to November 2023). Clinicopathological data, including age, gender, histological diagnoses, site, tumor size, and status of the lymph nodes and distant metastasis were reviewed. Regression analyses were performed to examine the association between the clinicogenomic characterization and pathologic features. Results: A total of 105 out of 121 sMTC were NGS-positive. The mutant genes included RET(66.9%), RAS(20.7%), BRAF(1.6%), TSHR(0.8%). The top 5 frequent mutations were RET M918T (24.8%, 30/121), HRAS Q61R (8.3%, 10/121), RET C634R (7.4%, 9/121), RET V804M (4.1%, 5/121), HRAS Q61K (4.1%, 5/121). Of the 13 co-mutations, 12 were RET mutations or co-occurrence of RET with other genetic alterations. Besides, the higher the age, the lower the probability of lymph node metastasis (OR=0.95, p=0.005). Also, patients with common RET mutations (including M918T, C634, C630, C611, C618, C620, A883F, S891 and V804) tended to have lymph node metastases (OR=5.67, p=0.016). We observed a significant positive linear relationship (Beta=2.0) between other gene mutations (non-RET mutations and non-RAS mutations) and tumor size. However, when the tumor diameter was analyzed according to whether it was greater than 1cm, we found that clinical factors such as age, sex, and gene mutation were not related to tumor size. Moreover, we did not find any association between this cutoff value of tumor size and lymph node metastases. It indicated that sMTC clinical diagnosis and treatment may consider pathologic and genomic features, not just whether the tumor size is &gt;1cm. Conclusions: Our study first provided the molecular characteristic of Chinese patients with large-scale sMTC. Analysis revealed that common RET mutations may be potential predictors of lymph node metastases. These conclusions remain to be validated in prospective large-scale cohorts.

Correction of the Tuberous Breast with Fat Grafting and Implant: Techniques, Evaluation with BREAST-Q, and Preliminary Results.

The correction of tuberous breast deformity with fat grafting has gained popularity in recent years, but it remains unclear whether this new technique can produce patient satisfaction levels comparable to those achieved with implant-based correction. This study aimed to compare patients' satisfaction and quality of life using the BREAST-Q questionnaire after correction of tuberous breast deformity with fat grafting and implants. Twenty-four patients (36 breasts) were included in our study. Thirteen patients (15 breasts) had a correction with lipofilling (mean 2.67 interventions) and 11 patients (21 breasts) had an implant-based correction (mean 1 intervention). Both fat and implant treatments showed statistically significant improvements in breast satisfaction (p value=0.001, 0.002, respectively), psychosocial (p value=0.003, 0.003, respectively), and sexual satisfaction (p value=0.008, 0.002, respectively) between the pre-treatment and post-treatment stages. However, the only statistically significant differences between the treatments were observed in the physical condition pre-treatment (p value=0.008) and sexual condition post-treatment (p value=0.030). The outcome of both treatments was not statistically different. Furthermore, the outcome exhibited a statistically significant positive linear relationship with breast satisfaction for both treatments. This study suggests that lipofilling can achieve breast and outcome satisfaction comparable to that of implants, although this parity in results comes at the cost of more interventions. These preliminary results lend support to the notion that, as surgeons have access to two equally effective techniques, it is crucial to provide appropriate guidance to patients to ensure their satisfaction. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Amplicon-based metagenomics to study the effect of coir age and wood biochar on microbiome in relation to strawberry yield

In the UK, strawberry is mostly grown in coconut coir substrate under protection. Coir substrate is usually used only for one or two cropping seasons because the continuous reuse of coir without any treatment leads to yield decline. In this study, we investigated the changes in bacterial and fungal communities in strawberry roots and bulk coir in relation to (i) the coir substrate age (cropping seasons) and (ii) oak or beech biochar amendment at planting. Coir age did not affect fungal/bacterial alpha (within-sample) diversity but affected beta (between-sample) diversity. Amendment with either oak or beech biochar did not lead to significant changes in either alpha or beta diversity for both fungi and bacteria, but it did alter the relative abundance of 13 fungal ASVs. This study identified six bacterial and 20 fungal ASVs with a significant positive linear relationship with coir age and also eight bacterial and 22 fungal ASVs with a significant negative linear relationship with coir age. Notably, the observed strawberry yield decline in reused coir substrate could be associated with a generalist root pathogen, Ilyonectria destructans (ex. Cylindrocarpon destructans), of which the abundance increased annually by 225% and 426% in strawberry root and bulk coir, respectively. Future research is needed to confirm the role of I. destructans in reused coir on strawberry plant health and fruit productivity and then to identify management strategies for yield decline mitigation.

Effect of Employee Coaching Practices on Universities’ Performance in Tanzania

This study assessed the effect of employee coaching practices on the performance of universities in Tanzania. It was guided by one alternative hypothesis; there is a significant positive linear relationship between employee coaching practices and performance of universities in Tanzania. The Human Capital Theory (HCT) anchored the study. It was underpinned by positivism philosophy. The study was a census and the design was descriptive. 379 academic staff from Tanzanian Universities constituted the study’s respondents. This study used a quantitative approach that made use of survey questionnaires in data collection. Data were collected from academicians in Tanzanian Universities (Mainland and Islands, Zanzibar) and analysed by using descriptive and inferential techniques. The study found that employee coaching practices had a significant positive effect on performance of Universities in Tanzania at r=0.834, and p&lt;0.001, respectively. Universities should consider designing and implementing coaching programmes to help them perform better. To make this more effective, the need to show commitment to coaching practices should also be considered.

Exploring the Relationship Between Serum Creatinine and Salivary Creatinine Levels in Patients With Chronic Kidney Disease in South India: A Cross-Sectional Study.

Background In this study, researchers investigated non-invasive methods for analyzing creatinine levels by using saliva to address the need for frequent phlebotomy in chronic kidney disease (CKD) patients, which can damage their veins due to repeated blood withdrawals for creatinine level assessments. Methods This is a cross-sectional study in a tertiary healthcare setting conducted on 50 patients diagnosed with CKD. After collecting serum and salivary creatinine, we used Pearson correlation to assess the correlation between the two factors. Results The mean age of the patients was 50 years with a standard deviation of ± 15.32 years. 33 (66%) patients were males and 17 (34%) were females. Most patients were in the age group of 51 - 70 years, comprising 26 (52%) of the sample. The serum creatinine and salivary creatinine values ranged between 7.26-12.00 and 0.45-0.98, respectively. The median values were 9.72 and 0.75, respectively. There was a very weak positive linear relationship between serum and salivary creatinine levels; however, there was no significant association between them (p = 0.52). Nonetheless, a statistically significant, moderately negative linear correlation exists between serum urea and serum albumin (r = -0.36; p = 0.01). Additionally, there is a statistically significant weak negative linear correlation between serum chloride and serum urea (r = -0.3; p = 0.03). Comparing serum chloride and serum sodium reveals a statistically significant, moderately positive linear relationship (r = 0.4; p = 0.004). Serum phosphorus and serum creatinine display a statistically significant moderate positive linear relationship (r = 0.44; p = 0.001). Moreover, estimated glomerular filtration rate (eGFR) and serum creatinine exhibit a statistically significant strong negative linear correlation (r = -0.79; p < 0.001), while eGFR and serum phosphorus demonstrate a statistically significant weak negative linear correlation (r = -0.30; p = 0.03). Conclusion The study found no significant association between salivary and serum creatinine levels. Further multicentric studies on a larger population must be conducted to find the potential correlation between serum and salivary markers.

A study of size-selective renal elimination using a novel human model

The recently discovered selective glomerular hypofiltration syndromes have increased interest in the actual elimination of molecules in the human kidney. In the present study, a novel human model was introduced to directly measure the single-pass renal elimination of molecules of increasing size. Plasma concentrations of urea, creatinine, C-peptide, insulin, pro-BNP, β2-microglobulin, cystatin C, troponin-T, orosomucoid, albumin, and IgG were analysed in arterial and renal venous blood from 45 patients undergoing Transcatheter Aortic Valve Implantation (TAVI). The renal elimination ratio (RER) was calculated as the arteriovenous concentration difference divided by the arterial concentration. Estimated glomerular filtration rate (eGFR) was calculated by the CKD-EPI equations for both creatinine and cystatin C. Creatinine (0.11 kDa) showed the highest RER (21.0 ± 6.3%). With increasing molecular size, the RER gradually decreased, where the RER of cystatin C (13 kDa) was 14.4 ± 5.3% and troponin-T (36 kDa) was 11.3 ± 4.6%. The renal elimination threshold was found between 36 and 44 kDa as the RER of orosomucoid (44 kDa) was −0.2 ± 4.7%. The RER of creatinine and cystatin C showed a significant and moderate positive linear relationship with eGFR (r = 0.48 and 0.40). In conclusion, a novel human model was employed to demonstrate a decline in renal elimination with increasing molecular size. Moreover, RERs of creatinine and cystatin C were found to correlate with eGFR, suggesting the potential of this model to study selective glomerular hypofiltration syndromes.

Selectivity of crab pots with escape vents and the optimal vent height for reducing the catch of sublegal swimming crab in the East China Sea pot fishery

Catching and subsequent discarding of sublegal-sized swimming crab Portunus trituberculatus in the pot fishery may result in increased unaccounted fishing mortality and contribute to overexploitation of the crab stocks in the East China Sea. Developing technical measures and implementing related regulations to improve the size selection of pots to reduce the catch of sublegal crab has become urgent. In this study, we evaluated the size selectivity of pots with rectangular escape vents of different opening heights (25 mm, 28 mm, 30 mm and 33 mm) through comparative fishing experiments and by employing the SELECT model. The results show that the installation of escape vents significantly reduced the catch per pot (in numbers) of total and sublegal swimming crabs, and significantly increased the proportion of legal-sized crabs for most vented pots except the 25 mm vent height. A significant positive linear relationship was found between escape vent height and the 50% retention carapace width, selection range and fishing power. Increasing the height of the escape vent had substantial effect on the exploitation pattern for swimming crab and the pot with a 28 mm height escape vent seemed to be the optimal design, releasing 67.4% of sublegal-sized crab and maintaining 94.8% of legal-sized crabs. Results showing that a pot with an escape vent that significantly reduces sublegal crab catch, while maintaining catch efficiency for legal-sized crabs, is positive for the fishery and supports the implementation of escape vents in the East China crab pot fishery.

Productivity and Species Diversity of Plant Communities Are Higher inside than outside the West Ordos National Nature Reserve, Northern China.

Nature reserves play an important role in the protection of biological habitats and the maintenance of biodiversity, but the performance and mechanisms of desert steppe nature reserves in improving plant community productivity, biodiversity and soil nutrient content are still largely unknown. To investigate the conservation effects of desert steppe nature reserve management on plant productivity and biodiversity, we compared the plant biomass, diversity and soil nutrient content inside and outside the West Ordos National Nature Reserve through sample survey, biomass determination, diversity index calculation and soil nutrient content determination. We found the following: (1) The aboveground biomass and belowground biomass of plant communities in the nature reserve were significantly larger than those outside the reserve; and the aboveground biomass of plant communities in shrub-steppe was significantly larger than that of herb grassland in both the nature reserve and the outside of the reserve. (2) The Margalef richness index, Shannon-Wiener index and Simpson index were significantly greater in the reserve than outside the nature reserve. In the desert steppe, the establishment of the nature reserve increased the α-diversity of the plant community. (3) The soil organic carbon (SOC) and soil total nitrogen (STN) were greater in the nature reserve than outside the reserve, and for the 10-20 cm and 20-40 cm soil layers, the SOC and STN were significantly greater in the core protected zone of the reserve than outside the reserve. The reserve significantly increased the nutrient content of the deeper soil layers. (4) The aboveground biomass of the plant community had a significant positive linear relationship with the species richness index, the Shannon index, and the Simpson index. There was a positive correlation between the diversity of the plant community and the soil nutrients. In summary, the nature reserve improved local plant productivity, biodiversity and the soil nutrient content, and the soil nutrient content in deeper soil layers may be the driving factor for the increase in productivity and biodiversity, which deepens our understanding of the conservation effectiveness of the nature reserve and its mechanisms.

Assessment of Heavy Metal Accumulation in Freshwater Fishes in Irrigation Tanks, Anuradhapura

&#x0D; Sri Lanka is well known for its dense freshwater irrigation tanks, especially in dry zones, which play an important role in sustaining both the environment and human livelihoods by providing essential resources such as drinking water, irrigation for agriculture, and nutrition through fish proteins. However, heavy metal contamination poses a significant threat to the sustainability of these valuable freshwater irrigation tanks due to their persistence and non-biodegradability. These heavy metals tend to accumulate in living organisms and biomagnified and have harmful effects on high tropic level organisms like humans who rely on aquatic fish species via food chains. This study was carried out to assess the heavy metal accumulation in muscle and liver parts of freshwater fishes, Tilapia (Oreochromis sp.), and striped snakehead; Lula (Channa striata) in Kammalakkulama, Hammillewa, Kirindegama, and Madawalagama tanks in Anuradhapura district, Sri Lanka. The Inductively coupled plasma mass spectrometry (ICP-MS) was used to analyse the randomly collected fish samples for total Cadmium (Cd), Arsenic (As), Lead (Pb), and Mercury (Hg) in the tanks. The results indicated a significant difference (p&lt;0.05) in the detected concentrations of heavy metal levels in tested samples among the four tanks. The highest concentrations of Cd (2.098 mg/kg) and As (0.366 mg/kg) were recorded in the liver of Tilapia in the Kammalakkulama tank. The highest Pb (5.509 mg/kg) and Hg (2.015 mg/kg) concentration was recorded in the Tilapia muscle in the Hammillewa tank and the Lula muscle in the Madawalagama tank respectively exceeding the WHO/FAO standards. The accumulation levels of these heavy metals were higher in the fish liver compared to their muscle in most of the samples. Arsenic (As) showed a significant positive linear relationship (R2=0.531) between their dry body weight and accumulated concentration in the Tilapia muscle. The canonical discriminant analysis showed a significant differentiation among the four tanks concerning heavy metal levels in fish tissues.&#x0D; &#x0D; Keywords: Channa striata, Heavy metals, Irrigation tanks, ICP-MS, Oreochromis sp.

Model-Based Benefit/Risk Analysis for the Copanlisib Intermittent Dosing Regimen.

Copanlisib is an intravenously administered phosphatidylinositol 3-kinase (PI3K) inhibitor, which is approved as monotherapy for relapsed follicular lymphoma in adult patients who have received at least two systemic therapies. In an April 2022 US Food and Drug Administration (FDA) Oncology Drug Advisory Committee (ODAC), the benefit-risk profile of the class PI3K inhibitors were scrutinized for use in hematological malignancies. Specifically, their unique toxicities may contribute to the high incidences in reported serious and high-grade treatment emergent adverse events (TEAEs), thereby reducing their overall tolerability and potentially limiting their successful use. These tolerability concerns may be contributed by or compounded by inadequate dose optimization. The recommended dosing regimen of copanlisib 60 mg administered on days 1, 8, and 15 of a 28-day cycle was selected as the maximal tolerated dose (MTD) during phase I. Thus, this analysis sought to justify the copanlisib dose regimen selection. Copanlisib exposure-efficacy relationships were considered from its large phase III trial, CHRONOS-3, whereas copanlisib safety was investigated by pooling data across its two large clinical trials to comprehensively assess its exposure-safety relationships. Results demonstrated a statistically significant positive linear exposure-efficacy relationship at the MTD. Exposure-safety analyses revealed a borderline significant linear relationship for grade ≥3 TEAEs and no significant exposure-safety relationships for other investigated safety end points. The model-based benefit/risk framework considered the established exposure-response models and defined clinical utility function which confirmed the appropriateness of the copanlisib dosing regimen across the range of its achieved exposures.

Linear and nonlinear relationships between instructional leadership and teacher professional learning through teacher self-efficacy as a mediator: a partial least squares analysis

Although the investigation of instructional leadership and teacher professional learning is well-documented in the literature, one overlooked question concerns the linear and nonlinear relationships between these two variables. This study aims to examine the linear and nonlinear relationships of principal instructional leadership on teacher professional learning through teacher self-efficacy as a mediator. This study has collected 335 teacher samples encompassing both primary and secondary school levels in Penang, Malaysia. The analysis of data utilised partial least-squares structural equation modelling. The findings indicated a significant positive linear relationship between instructional leadership and teacher-professional learning. Likewise, there exists a significant mediating effect of teacher self-efficacy between instructional leadership on teacher professional learning. There exists a significant nonlinear relationship between principal instructional leadership on teacher self-efficacy and teacher professional learning respectively. The structural model exhibits a significantly high level of predictive power for in-sample and out-of-sample. This study offers theoretical and methodological advancements in comprehending the complex relationships between instructional leadership and teacher outcomes. It proposes that forthcoming studies could adopt a combination of linear and non-linear relationships to achieve robust empirical findings.

INFLUENCE OF MONITORING AND EVALUATION PLANNING ON PERFORMANCE OF AGRIBUSINESS PROJECTS IN KIAMBU COUNTY, KENYA

A lot of funds are spent on the public services by the government, amounting to between 15-45 percent of gross domestic product which has an immense effect on the agribusiness projects. One of the most pressing issues confronting policymakers and those with an interest in the sector is the declining performance of the agribusiness projects in regard to their growth. This study established the relationship between monitoring and evaluation planning and performance of agribusiness projects in Kiambu County, Kenya. The study was underpinned on the resource-based view theory. Descriptive and explanatory research design were adopted. Twenty-eight agribusiness projects in Kiambu County were targeted. Sample size was 82 respondents comprising of the agribusiness projects. Questionnaires were used to obtain primary data whereas data collection sheet was used to collect secondary data. Descriptive statistics, correlation and regression analysis was conducted. Results showed that respondents agreed to a great extent that monitoring and evaluation planning influenced performance of agribusiness projects in Kiambu County, Kenya. Correlation analysis demonstrated a significant positive linear relationship between performance of agribusiness projects and M &amp; E planning. Additionally, regression analysis showed that monitoring and evaluation planning influenced project performance positively and significantly. The study concludes that M &amp; E planning helps in setting project goals and objectives thus improving project performance and recommends that communication and reporting are essential components of project monitoring and evaluation as they help to facilitate information sharing, improve collaboration and supporting decision making.

El crédito en el sistema financiero peruano y su nivel de morosidad, durante el período 2013 – 2019

Within the Peruvian state, the financial system is made up of 59 entities, whose objective is to direct the surplus cash of surplus agents towards entities of smaller size or resources, in this way promoting the free flow of monetary resources; In this way, the objective of this investigation is to determine the relationship between the volume of loans granted by the Peruvian Financial System and the levels of delinquency observed in the period between 2013 and 2019, for which the hypothesis was raised that the The volume of credits granted by the Peruvian Financial System shows a direct relationship with the level of delinquency between the years 2013 - 2019. This research, in methodological terms, is developed in a longitudinal - non-experimental approach, through the deductive, descriptive method, causal, applicative and correlational, after the knowledge established through economic sciences (Economic and Monetary Theory); It is concluded that the volume of credits of the Peruvian Financial System has a significant positive linear relationship with delinquency. As loans increase annually by 10%, delinquency also grows by an average of 14% during the period studied.

Higher systemic immune-inflammation index is associated with sarcopenia in individuals aged 18–59 years: a population-based study

The association between the systemic immune-inflammation index (SII) and the risk of sarcopenia has not yet been revealed. The purpose of this study was to investigate the relationship between the SII and sarcopenia in individuals aged 18–59 years. All data for this study are from the National Health and Nutrition Examination Survey (NHANES) database, including 7258 participants (age range: 18–59 years). We divided SII values by quartiles (quartiles 1–4: 0.3–3.1, 3.2–4.4, 4.4–6.2, and 6.2–58.5). We constructed a multivariate logistic regression model to assess the association between the SII and the risk of sarcopenia, and an interaction test was run to test the stability of the model and identify high-risk individuals with sarcopenia. Compared to nonsarcopenia participants, sarcopenia patients had a significantly higher SII value (weighted average: 6.65 vs. 5.16) (P = 0.002). Multivariate logistic regression results showed a positive linear relationship between the SII and sarcopenia (OR [odds ratio] = 1.12, 95% CI [confidence interval] 1.03–1.21). Compared to the quartile 1 group, the quartile 4 group was associated with a higher risk of sarcopenia (OR = 3.94, 95% CI 1.42–10.94). Compared with the quartile 1 group, the OR value of the quartile 2 to quartile 4 groups showed an upwards trend (Ptrend < 0.001) as the level of SII increased. Subgroup analysis also indicate that the correlation between higher SII values and the risk of sarcopenia was stable. There was a significant positive linear relationship between SII and sarcopenia, indicating that higher SII values can increase the risk of sarcopenia in individuals aged 18–59 in the United States. The findings of this study will be beneficial in promoting the use of SII alone or in combination with other tools for the risk screening of sarcopenia in communities or large populations.

Health literacy-related knowledge, attitude, perceived barriers, and practice among primary care doctors in Malaysia.

This study aimed to assess the health literacy (HL) related knowledge, attitude, perceived barriers, and practice among primary care doctors (PCDs) in Malaysia, and to determine the factors associated with HL-related practice. A cross-sectional study was conducted using an online questionnaire. Sociodemographic and work-related details were collected. HL-related knowledge, attitude, perceived barriers, and practice were assessed. Descriptive and inferential analyses using linear regression were performed. 373 PCDs were included in the study with a mean (SD) age of 37.9 (8.1) years old. The mean (SD) HL-related knowledge, attitude, and practice scores were 6.89 (1.27), 36.33 (7.04), and 30.14 (4.7), respectively. 90.9% of the participants had good HL-related knowledge scores, and 89.5% had positive HL-related attitude. More than 80% of participants found that "time constraint to implement health literacy screening" and "lack of human resources to administer HL screening tools in their settings" were among the barriers for them to implement HL practices. PCDs of Chinese and other ethnicities had lower HL-related practice scores compared to those of Malay ethnicity (adjusted b = - 1.74; 95% CI - 2.93, - 0.54, and - 2.94; 95% CI - 5.27, - 0.60, respectively). PCDs who had heard of the term "health literacy" were associated with higher HL-related practice scores (adjusted b = 2.32; 95% CI 1.17, 3.47). Age (adjusted b = 0.10; 95% CI 0.04, 0.16) had significant linear positive relationship with HL-related practice. In conclusion, the HL-related knowledge, attitude, and practice among PCDs in Malaysia were at an acceptable level. Along with educating PCDs on HL, the perceived barriers identified need to be addressed to improve the HL-related practice and ultimately patient care.