Significant Fall In Diastolic Pressure Research Articles

"Salt sensitivity' of normotensives: interactions between changes in red blood cell 22Na efflux rate constant, dietary sodium intake and changes in blood pressure.

1. In normotensive people who altered dietary sodium intake there was no overall difference in blood pressure or efflux rate constant when on a low or high sodium intake. 2. Many individuals studied had changes in blood pressure or efflux rate constant greater than the expected variation. 3. Subjects were classified into three groups depending on the change in efflux rate constant. Seven subjects who had a fall in the efflux rate constant greater than 0.02 h when they changed from a low to a high sodium intake had a significant rise in diastolic blood pressure (73, s.e.m. = 4; to 80, s.e.m. = 3 mmHg). 4. Eight subjects who had a rise in the efflux rate constant greater than 0.02 h when they changed from a low to a high sodium intake had a significant fall in diastolic pressure (82, s.e.m. = 4; to 76, s.e.m. = 4 mmHg). 5. Eight subjects who had no change in efflux rate constant when they changed from a low to a high sodium intake had no significant change in blood pressure. 6. The above associations were found when the red blood cells were incubated in plasma. No association was found when the cells were incubated in artificial medium. 7. The data supports the hypothesis that changes in membrane Na transport have a role in the control of blood pressure. 8. It is postulated that normotensive subjects who had a decreased efflux rate constant when exposed to a high sodium intake may develop essential hypertension.

ORAL CONTRACEPTIVES AND BLOOD PRESSURE

Relation between use of oral contraceptives and blood pressure was examined in 1,575 white working females aged 15 to 44 years. Of these, 31.5% were using oral contraceptives when their blood pressure was measured. Covariance analysis revealed slightly higher and statistically significant mean systolic and diastolic pressures in women using oral contraceptives, after correction for age, height, weight, and arm circumference. A sample of this population one year later, showed little tendency for blood pressure to be affected by oral contraceptives, except for a slight but significant fall in diastolic pressures among women who did not use these drugs. These data are in part reassuring since little or no effect was observed in a population studied over a short period of time. The physician should carefully observe blood pressure changes in patients receiving this medication.

Oral Contraceptives and Blood Pressure

Relation between use of oral contraceptives and blood pressure was examined in 1,575 white working females aged 15 to 44 years. Of these, 31.5% were using oral contraceptives when their blood pressure was measured. Covariance analysis revealed slightly higher and statistically significant mean systolic and diastolic pressures in women using oral contraceptives, after correction for age, height, weight, and arm circumference. A sample of this population one year later, showed little tendency for blood pressure to be affected by oral contraceptives, except for a slight but significant fall in diastolic pressures among women who did not use these drugs. These data are in part reassuring since little or no effect was observed in a population studied over a short period of time. The physician should carefully observe blood pressure changes in patients receiving this medication.

Oral contraceptives and blood pressure

Relation between use of oral contraceptives and blood pressure was examined in 1,575 white working females aged 15 to 44 years. Of these, 31.5% were using oral contraceptives when their blood pressure was measured. Covariance analysis revealed slightly higher and statistically significant mean systolic and diastolic pressures in women using oral contraceptives, after correction for age, height, weight, and arm circumference. A sample of this population one year later, showed little tendency for blood pressure to be affected by oral contraceptives, except for a slight but significant fall in diastolic pressures among women who did not use these drugs. These data are in part reassuring since little or no effect was observed in a population studied over a short period of time. The physician should carefully observe blood pressure changes in patients receiving this medication.