Introduction: The elderly will experience a process of decline in body functions that will experience various medical and psychological problems that can interfere with mental health and cause depression. Depression in the elderly can interfere with their ability to complete daily tasks, which ultimately affects their independence and quality of life. This study aims to determine the effect of depression on the quality of life of the elderly at the Surakarta aisyiyah elderly center. Methods: This study was based on analytic observational research with a cross sectional approach. Samples in this study were taken directly by interview and measurement by researchers totaling 30 patients with total sampling technique. In collecting data, researchers used the GDS questionnaire to assess the level of depression and the WHOQOL-BREF questionnaire to assess quality of life. Results: There is a significant effect of nutritional status on the quality of life of the elderly. There is no significant effect of education level on the quality of life of the elderly.There is a significant effect of age on quality of life. There is a significant effect of depression level on the quality of life of the elderly. Conclusion: There is a significant effect of the level of depression on the quality of life of the elderly.
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