Abstract Aim To assess retention and wear of two different bar materials (cobalt chromium and poly ether-ether ketone) used in implant-retained mandibular overdenture subjected to chewing simulation Robota during 1 year of functional simulation. Patients and methods This study is a comparative laboratory study which was carried out on 14 models of implant-retained mandibular overdenture, for each model two implants were inserted. The 14 models were divided equally into two equal groups: group A (overdenture constructed over two implant analogs with bar attachment and clip made from cobalt chromium material), and group B (overdenture constructed over two implant analogs with bar attachment and clip made from poly ether-ether ketone material). Drilling of the models was done using milling machine and each model received two implant analogs inserted 11 mm from midline at canine region. The overdentures were constructed in the usual manners and the teeth were set in lingualized occlusion. The mandibular overdentures were subjected to 150 000 chewing cycles using Robota chewing simulator and 1080 insertion-removal cycles. Retention of the samples was measured by the universal testing machine and wear observed under USB digital microscope both of which were done at the beginning of the study and after 3, 6, 9, and 12 months. Results The retention force for group A decreased significantly from baseline 43.43 ± 5.25 to 35.56 ± 8.30 after 3 months of cyclic loading, with similar reductions after 6, 9, and 12 months. Group B also showed reductions from baseline 26.75 ± 2.32 to 21.29 ± 6.74 after 3 months, and similar patterns over time. Group A had no statistically significant wear changes after cyclic loading, with a baseline mean of 0.2904 ± 0.0008, changing to 0.2913 ± 0.0008 after 3 months, while group B showed similar nonsignificant changes. There were no statistically significant differences in wear between both groups at any time point. Conclusion Retentive forces decrease with increasing cyclic loading. However, both materials displayed acceptable retentive values. Wear values were nonsignificant between two studied groups.