Significant Differences In Relation Research Articles

Peculiarities of the chemical enrichment of metal-poor stars in the Milky Way Galaxy

The oldest stars in the Milky Way are metal-poor with Fe/H $<$ -- 1.0, displaying peculiar elemental abundances compared to solar values. The relative variations in the chemical compositions among stars is also increasing with decreasing stellar metallicity, allowing for the pure signature of unique nucleosynthesis processes to be revealed. The study of the $r$-process is, for instance, one of the main goals of stellar archaeology and metal-poor stars exhibit an unexpected complexity in the stellar production of the $r$-process elements in the early Galaxy. In this work, we report the atmospheric parameters, main dynamic properties, and the abundances of four metal-poor stars: HE 1523-–0901, HD 6268, HD 121135, and HD 195636 (--1.5 $>$ Fe/H The abundances were derived from spectra obtained with the HRS echelle spectrograph at the Southern African Large Telescope, using both local and non-local thermodynamic equilibrium (LTE and NLTE) approaches, with the average error between 0.10 and 0.20 dex. Based on their kinematical properties, we show that HE 1523--0901 and HD 195636 are halo stars with typical high velocities. In particular, HD 121135 displays a peculiar kinematical behaviour, making it unclear whether it is a halo or an accreted star. Furthermore, HD 6268 is possibly a rare prototype of very metal-poor thick disk stars. The abundances derived for our stars are compared with theoretical stellar models and with other stars with similar metallicity values from the literature. HD 121135 is Al-poor and Sc-poor, compared to stars observed in the same metallicity range (--1.62 $>$ Fe/H $>$--1.12). The most metal-poor stars in our sample, HE 1523 -- 0901, HD 6268, and HD 195636, exhibit anomalies that are better explained by supernova models from fast-rotating stellar progenitors for elements up to the Fe group. Compared to other stars in the same metallicity range, their common biggest anomaly is represented by the low Sc abundances. If we consider the elements beyond Zn, HE 1523--0901 can be classified as an r-II star, HD 6268 as an r-I candidate, and HD 195636 and HD 121135 exhibiting a borderline $r$-process enrichment between limited-r and r-I star. Significant relative differences are observed between the $r$-process signatures in these stars.

Comparative clinicopathological study of the main anatomic locations of oral squamous cell carcinoma.

To analyze the clinicopathological and evolutionary profile of the main locations of oral squamous cell carcinoma (OSCC). This is a retrospective study on 133 patients treated for OSCC. The group was composed of 48 women and 85 men, with a mean age 63.9 ± 12.73 years. Most cases involved the lingual border of tongue (63), followed by the gingiva (36) and the floor of mouth (34). A comparative analysis was performed using multinomial regression. There were significant differences regarding age, sex, tobacco and alcohol consumption, liver pathology, oral potentially malignant disorders, and bone and perineural invasion. In multivariate regression, tobacco consumption, and bone invasion remained significant. There were no significant differences in relation to prognosis. The location of OSCC is an important factor in the clinicopathological assessment of this neoplasm. The main locations of OSCC show differential etiopathogenic and clinicopathological aspects. Tobacco consumption has a great relevance in the floor of mouth; nonetheless, it is less important in the tongue border and the gum, which suggests other pathogenic factors. It is necessary to consider the anatomical location of OSCC in preventive protocols, with the aim of reducing its high mortality.

Lichtenstein versus laparoscopic transabdominal preperitoneal (TAPP) hernia repair: Retrospective study, our experience

Abstract: Surgical correction of inguinal hernias is the most commonly used surgical procedure in the world. Currently only three surgical techniques have been validated, that is the Shouldice technique, the Lichtenstein technique, and laparoscopic techniques such as transabdominal preperitoneal (TAPP) hernioplasty and totally extraperitoneal endoscopic hernioplasty (TEP).The aim of the study: The aim of this study is to show the results in terms of postoperative recovery, complications, length of hospitalization after inguinal hernia surgery in patients who underwent the Lichtenstein and the laparoscopic (TAPP) methods.Material and methods: This is a monocentric, retrospective cohort study, conducted in the period from 2019 to 2023. The research period covered 70 patients who underwent surgery at the Clinic for General and Abdominal Surgery with Glandular Surgery, of the University Clinical Center, Sarajevo. The patients were divided into two groups: Group 1: 20 patients who underwent the TAPP method and Group 2: 50 patients who underwent the Lichtenstein method. All patients underwent surgery performed by two doctors.Results: One woman (1.4%) and 69 men (98.6%) participated in the research. Of the total number, 50 patients (72.5%) were treated with the Lichtenstein technique, and 19 (27.5%) were treated with the TAPP technique (p=0.539). The statistical results did not show a significant difference in the average age between patients who underwent the Lichtenstein and the TAPP technique (T=0.759; p=0.450).Discussion: There was no significant difference in relation to age and type of surgery (T=0.759; p=0.450). There was no statistical difference in the choice of surgical approach in relation to the laterality of the hernia (P<0.001), nor any statistically significant difference between the TAPP and Lichtenstein surgical procedures in relation to BMI T=0.613; p=0.542. Our analyses showed that patients treated with the TAPP technique had a statisticallysignificantly higher probability of shorter postoperative hospitalization compared to those treated with the Lichtenstein technique (B=0.245; p=0.019). Two patients in the study had complications within 30 days (Clavien-Dindo Grade I and Grade IIIB).Conclusion: Using an individual approach for each patient, surgical treatment of hernia using laparoscopic TAPP can be the first choice in patients without comorbidities, without previous pelvic surgery, bilaterality or recurrence of previous surgery (anterior approach). Patients treated with the laparoscopic technique (TAPP) have a shorter hospitalization time, which ultimately affects the economic aspect.

Echocardiographic Assessment of Left Ventricular Function in Three Oncologic Therapeutic Modalities in Women with Breast Cancer: The ONCO-ECHO Multicenter Study.

Background: Oncological treatment of breast cancer may be associated with adverse effects on myocardial function. Objectives: The objective of this study was to compare the influence of three oncological treatment methods of intervention on the echocardiographic (ECHO) parameters of left ventricular function. Materials and Methods: One hundred and fifty-five women with breast cancer were divided into three groups depending on the type of therapy used: group I (AC)-anthracyclines; group II (AC + TZ)-anthracyclines + trastuzumab; and group III (RTls+)-anthracyclines with or without trastuzumab + left-sided radiotherapy. Prospective ECHO examinations were performed at baseline and every 3 months, up to 12 months from the start of the therapy. Patients with a history of chemotherapy or who were diagnosed with heart disease were not included in the study. Results: Out of 155 patients, 3 died due to cancer as the primary cause, and 12 withdrew their consent for further observation. Baseline systolic and diastolic ECHO parameters did not differ between the analyzed groups. Cardiotoxicity, according to the LVEF criteria, occurred during follow-up in 20 patients (14.3%), irrespective of the treatment method used. Diastolic echocardiographic parameters did not change significantly after 12 months in each group, except for the left atrial volume index (LAVi), which was significantly higher in the AC + TZ compared to the values in the RTls+ group. Conclusions: All three oncologic therapeutic modalities in women with breast cancer showed no significant differences in relation to the incidence of echocardiographic cardiotoxicity criterion; however, transient systolic decrease in LVEF was most frequently observed in the AC + TZ therapeutic regimen. Left-sided radiotherapy was not associated with excess left ventricular systolic and diastolic dysfunction during a 12-month follow-up period. The predictors of negative changes in diastolic parameters included age and combined anthracycline and trastuzumab therapy.

Why do you not show us the outside of the school? Opportunities and limitation to conduct outdoor activities in physical education

ABSTRACT This study sought to determine the preferences, barriers, and resources that active Andalusian Physical Education teachers (Primary and Secondary) have about conducting outdoor education (OE) as well as the main limitations teachers currently encounter in performing outdoor education. Also, to analyse whether the environment, school context, and size of the school facilitate or hinder the inclusion of OE. A total of 413 teachers (age: 42.31 ± 8.62 years) joined in this research. The questionnaire ‘Diagnóstico de las actividades físicas en el medio natural en el ámbito escolar’ (DAFNE) was used. Our results showed significant differences in relation to primary and Secondary educational stages. Regarding public and private school, the size of the school, as well as the number of inhabitant where the school is situated, significant differences were found. School context, environment, size of the school and educational stage could have an influence to include OE in physical education sessions.

Avaliação do estado nutricional em idosos com diabetes mellitustus

Objective: To analyze the nutritional status of elderly individuals with diabetes mellitus. Methods: Cross-sectional population-based study. Part of the Longitudinal Study of Health of the Elderly of Alcobaça – ELSIA, including 465 elderly people. Data analysis was performed using a structured questionnaire containing sociodemographic, health and behavioral information. Nutritional status was assessed using the Mini Nutritional Assessment – MNA. Results: There was a prevalence of risk of malnutrition/malnutrition of 47,1% (15,7% in men and 30,1% in women) in the group with diabetes. The MNA analysis revealed that the individuals in the group with diabetes, when compared to the group without diabetes, presented greater weight loss in the last three months (p=0,017), took more than three different medications per day (p=≤0,0001), believed they were malnourished (p=0,003) and considered their own health as not very good (p=0,027). When comparing genders, the male diabetes group showed differences in relation to the use of multiple medications (p=≤0,0001), mobility (p=≤0,0001), and neuropsychological problems (p=0,029). While females showed a statistically significant difference in relation to use of multiple medications (p=≤0,0001). Conclusion: The findings showed a significant prevalence of risk of malnutrition/malnutrition in elderly with diabetes mellitus, especially in females. However, the presence of the disease in males has been shown to have a significant impact on nutritional status when analyzing MNA parameters.

Emotional Regulation Mechanisms of University Students in Group Work Situations.

A total of 107 students from a Chilean university and a Spanish university, all of them enrolled in the degree in Physical Activity and Sport Sciences, participated in the study. The instrument used was the Adaptative Instrument for Regulation of Emotions questionnaire. The analysis of the data shows that there are some significant differences (p ≤ 0.05), between the groups of students who worked virtually and those who worked in hybrid situations, in the aspects related to personal motivations (learn from my classmates, not to disappoint my working group, and enjoying the experience of working in a group). The students who worked online resolved conflicts mainly through individual regulation mechanisms with significant differences in relation to the students who worked in hybrid mode. No significant differences were found in the socioemotional challenges or in the balance of the metacognitive experience. The group that worked in hybrid learning valued group purposes over personal purposes and used the social regulation mechanism over individual regulation in conflict resolution. On the other hand, the group that worked virtually valued group and personal purposes equally and used the mechanism of individual regulation and social regulation to solve difficulties. Differences between students who worked in virtual and hybrid environments may be due to greater social interaction and group dynamics in hybrid environments, as well as differences in culture and access to resources and technology.

Neurosurgery in Saudi Arabia: Navigating Through Future Pathways and Students' Perspectives

Neurosurgery is a surgical discipline that demands comprehensive knowledge in other specialties. It is regarded as one of the most competitive specialties. However, there is a new trend toward considering life-style friendly specialties. Therefore, this study aims to assess the neurosurgery perception and identify potential factors influencing such attitudes. An observational, survey-based study was conducted on medical students at the College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, Saudi Arabia. An online-based questionnaire was administered to the participants. It consisted of two main parts: the first part collected demographic data, while the second part included 20 Likert scale-based questions. Pearson's Chi-square test was utilized, with statistical significance set at p<0.05. A total of 305 medical students from various academic years participated in the questionnaire survey, with nearly an equal gender distribution. Remarkably, a significant majority (76.72%) expressed uncertainty or disagreement regarding the adequacy of neurosurgery education during their medical studies. While a substantial portion of participants (69.5%) found neurosurgery intriguing, almost half (47.87%) indicated that they would not pursue it as their future specialty. The consideration of neurosurgery as a career path showed statistically significant differences in relation to both gender and academic year (p=0.009 and p<0.001, respectively). This study emphasizes how gender and academic year affect choosing neurosurgery as a career but notes limitations like self-reporting bias and a single-institution scope, which may affect generalizability. Future research might consider national summer training programs to engage more students in neurosurgery.

Photobiomodulation for Blood Pressure and Heart Rate Reduction in Mastectomized Women on Hormone Blockers: A Randomized Controlled Trial.

Objective: To assess the impact of intravascular laser irradiation of blood (ILIB) on the primitive carotid artery (PCA) hemodynamic variables, specifically blood pressure (BP) and heart rate (HR), in mastectomized patients undergoing hormone blocker treatments. Materials and methods: This study is a controlled, experimental, and randomized clinical trial. Patients were allocated into two groups: the experimental group (G1)-patients who received ILIB therapy using a 660 nm laser targeted at the PCA, and the control group (G2)-patients who did not receive ILIB therapy. Clinical research was conducted weekly, with measurements of systolic blood pressure (SBP), diastolic blood pressure (DBP), and HR. The Mann-Whitney U test for independent samples was used, with a significance level of α = 0.05. Results: Systemic photobiomodulation on the PCA did not demonstrate a statistically significant difference in relation to SBP and DBP. However, for HR, the p-value was <0.05, indicating a significant difference between G1 and G2. The initial mean p > decreased from 142.3 to 116.4 mmHg in G1, and from 130.4 to 119.8 mmHg in G2. The DBP varied from 78.8 to 72.8 mmHg in G1, and from 79.1 to 74.2 mmHg in G2. A statistically significant difference was observed in HR, decreasing from 81.3 to 62.06 bpm in G1, and changing minimally from 74.1 to 75.1 bpm in G2. A considerable reduction was present in the timing of application. Conclusions: ILIB therapy applied to the PCA induces a reduction in BP and, more notably, HR in mastectomized women using the tamoxifen or aromatase inhibitors.

Maternal Mortality from 2014 To 2017: Trend and Risk Factors at the Kintambo Maternity Ward, Democratic Republic of Congo

Introduction: Maternal mortality is a tragedy and constitutes a triple scourge. It is dramatic for the family (which falls apart after the death of the woman), unacceptable for the medical profession (since there are obstetric means to save mothers), and unacceptable for society (dying while giving birth). However, it seems to increase every year in the city of Kinshasa, due to several factors including the lack of easy access to quality care and childbirth services. The main objective for this study was to investigate the trend in maternal mortality at the Kintambo maternity ward from 2014-2017 including the relative contribution of risk factors linked to the lack of easy access to care and services quality delivery. Methods: This is an observational case-control study among pregnant women who followed ANC or not at the Kintambo maternity ward, but who all gave birth from January 2014 until December 2017. The use of the survey method, based on the analysis of registers, with a data collection sheet (check list) which was used for the collection of data, proved essential to bring this to fruition research. The sample size was exhaustive for cases (63 cases) and 63 controls. Results: Trend in female mortality between 2014-2017 at the Kitambo maternity ward in the city of Kinshasa has been decreasing, i.e. 22 cases in 2014, 17 cases in 2015, 14 cases in 2016 and 10 cases in 2017. It was observed that the variables show a very significant difference in relation to the factors which are the age of the pregnant woman, attendance at the CPN, delivery in the same center, the number of doctors in the delivery room and the distance between the residence and the center with an added value (P) less than 0.008; In comparison to pregnant women who die or not during childbirth and the factors in relation to their Chi-square, the age of gestation has a higher. Conclusion: Reducing this mortality requires strengthening the capacities of midwives /midwives in the care of pregnant women from conception to delivery and in the postpartum period , providing maternity wards with all the assets for good operationalization in the farthest corners of the city center , raising awareness among pregnant women of the importance of attending the CPN, ensuring good monitoring of the pregnant woman during her pregnancy and during childbirth, and for women to be always accompanied by their husbands during the CPN in order to help them internalize certain notions.

Africanized honey bee colonies in Costa Rica: first evidence of its management, brood nest structure and factors associated with varroa mite infestation.

Management, brood nest structure and factors associated with varroa mite infestation were studied in 60 apiaries of Africanized honey bees in the northwest region of the Central Valley of Costa Rica. Apiaries were monitored two times. The first monitoring was taken forward during the rainy season between May and November 2019. The second monitoring during the dry season between February and March 2020. Information about the beekeepers, apiaries and management was collected through a survey. Amount of open and capped brood, honey and pollen were measured in the field. The infestation rate of varroa (IRV) was quantified using standard laboratory methods. A determination of multi-residue pesticides in bee bread was made through GC-MS/MS and LC-MS/MS techniques. According to the results, most of the beekeepers produce honey (96.7%), participate in training activities (82.2%), and change the bee queens annually (70%). The first monitoring was characterized by a lower amount of capped brood and honey reserves compared to the second one. IRV was significantly higher in the first monitoring (6.0 ± 0.4) in comparison with the second one (3.0 ± 0.3) (U Mann-Whitney p < 0.001). The maximum value for the first monitoring exceeds 40%, while this value was close to 25% in the second monitoring. Mite infestation exposed significant differences in relation to the variables associated to the beekeeper's management, i.e., change of bee queen (p = 0.002) or when beekeepers monitor varroa mites (p = 0.004). Additionally, the IRV had inverse correlations (p < 0.01) with the number of comb sides with capped brood (Spearman's rho coefficient = -0.190), and honey reserves (Spearman's rho coefficient = -0.168). Furthermore, 23 of 60 bee bread samples presented one to five pesticide residues, being the most frequent antifungal agrochemicals.

Evaluación del umbral de ciclo de la RT-PCR en tiempo real para SARS-CoV-2

Objective: To evaluate the cycle threshold (Ct) of the E and N2 markers for detection of SARS-CoV-2 in real-time RT-PCR and relate them to the age and service of origin of the patients.Materials and methods: A real-time RT-PCR assay was performed, obtaining the cycle threshold of 95 patients from different services. Results: The outpatient service was the highest (67.4 %); having average ages between 1 to 89 years. Regarding the “N2” and “E” genes, it was determined that there is no significant difference in relation to the age group, however, when performing inferential analysis, for the type of protein variable, it was concluded that there was a significant difference. Conclusions: SARS COV 2 is an etiology, present in different age groups, being more susceptible over 50 years of age, in addition to the threshold value of the genes, it is not usually related; this value may vary depending on the methodology used.

Predator-prey interactions in a coastal setting: Linking crab feeding rates to small scale distribution of clams

A coastal predator-prey system, juvenile green crabs (Carcinus maenas) preying upon juvenile hard clams (Mercenaria mercenaria), was used to explore the link between crab predation rates and clam density and small-scale distribution patterns. The channel working area of a racetrack flume was adapted to form a sedimentary arena in a flowing seawater system (5 cm s−1) to assess crab predation rates in relation to clam density and distribution patterns (clams clustered in one patch vs two nearby vs two farther apart). The trials detected significant differences in relation to clam initial density and distribution with strong (∼50%) declines in clam mortality levels among spatial arrangements (one patch > two nearby > two farther apart). Feeding of clams was associated with the time taken by crabs to handle the first clam (first patch), and the frequency of three distinct types of crab behavior (eating, resting, and searching). Altogether these results suggest that small-scale changes in number and distribution of juvenile clams matter and may have unexpectedly strong effects on the outcome of predator-prey interactions.

Patient satisfaction with primary health care services and primary health care providers.

To evaluate patients' satisfaction levels with primary healthcare services and providers in Jordan and assess differences in patients' satisfaction in relation to sociodemographic factors and accessibility to primary healthcare. A descriptive cross-sectional design was used in this study. A convenient sampling technique was utilized. A 34-item survey instrument was adopted and distributed to patients in nine primary healthcare centers in Amman in the period between October and December 2022. A total of 225 patients completed the survey. The mean total score for patient satisfaction with primary healthcare services was 25.22 (SD=4.13). There were significant differences in satisfaction with services in terms of educational level, visitation reason, mode of transportation, availability of parking, and suitably designed for patients with disabilities. Furthermore, the mean total score for patient satisfaction with primary healthcare providers was 22.85 (SD=5.86). There were significant differences in relation to visitation reason, mode of transportation, and parking space availability. It is important to improve patient satisfaction in primary healthcare facilities, and the Ministry of Health should implement policies for improving the quality of services provided by primary healthcare.

INTEGRATION OF THE ALTAI KRAI AND THE SIBERIAN REGIONS ON COMMODITY MARKETS IN DIFFERENT PERIODS BETWEEN 2001 AND 2022: EXPERIENCE OF COMPARATIVE ANALYSIS. PART 1. 2001-2007

This article is а publication devoted to presenting the results of a study of trade and the Altai Krai's economic relations of with the regions of Russia in 1990-2022. The authors are the first to attempt to reveal the dynamics&#x0D; of changes in the commodity markets of the region for more than twenty years, to assess the role and place of the Siberian regions as consumers of Altai products and suppliers of their products to the Altai market. At the same time, the assessment of the role of the Siberian regions was carried out in two ways: both their total role in the import (export) of products in comparison with other Russian federal districts, and each of the Siberian regions, taking into account their specialization.&#x0D; A special place in the study was occupied by the analysis of the situation in the food market of the region due to its significance for the region.&#x0D; Based on the results of the analysis, it was concluded that integration in the commodity markets of the Altai Krai and the Siberian regions as a whole is deeper compared to the other Russian regions. During the period under study, integration further deepened.&#x0D; The Siberian regions play a significant role both in the consumption of Altai goods, primarily food, and, in particular, in saturating the commodity markets of the region.&#x0D; The scale and nature of trade and economic relations between the Altai Krai and the Siberian regions are revealed in detail. Characteristic features were variability and inconstancy of the key characteristics of interregional trade and economic relations, coupled with their noticeable inertia, significant differences in trade relations with each of the Siberian regions.

Formation of intraneuronal iron deposits following local release from nanostructured silica injected into rat brain parenchyma

Nanostructured materials with controllable properties have been used to cage and release various types of compounds. In the present study, iron-loaded nanostructured sol-gel SiO2–Fe materials were prepared and injected into the rat brain to develop a method for gradual iron delivery into the neurons with the aims to avoid acute iron toxicity and develop an animal model of gradual, metal-induced neurodegeneration. Nanoparticles were prepared by the traditional method of hydrolysis and condensation reactions of tetraethyl orthosilicate at room temperature and subsequent heat treatment at 200 °C. FeSO4 was added in situ during the silica preparation. The resulting materials were characterized by UV-VIS and infrared spectroscopies, X-ray diffraction, and N2 adsorption-desorption. An in vitro ferrous sulfate release test was carried out in artificial cerebrospinal fluid as the release medium showing successful ferrous sulfate loading on nanostructured silica and sustained iron release during the test time of 10 h. Male Wistar rats administered with SiO2–Fe nanoparticles in the substantia nigra pars compacta (SNpc) showed significant intraneuronal increase of iron, in contrast to the animals administered with FeSO4 that showed severe neuronal loss, 72 h post-treatment. Both treatments induced lipid fluorescent product formation in the ventral midbrain, in contrast to iron-free SiO2 and PBS-only injection controls. Circling behavior was evaluated six days after the intranigral microinjection, considered as a behavioral end-point of brain damage. The apomorphine-induced ipsilateral turns in the treated animals presented significant differences in relation to the control groups, with FeSO4 administration leading to a dramatic phenotype, compared to a milder impact in SiO2–Fe administrated animals. Thus, the use of SiO2–Fe nanoparticles represents a slow iron release system useful to model the gradual iron-accumulation process observed in the SNpc of patients with idiopathic Parkinson's disease.

Impact of Sleep and Psychological Well-Being on the Academic and Clinical Performance of Nursing Students in Saudi Arabia.

Nursing students frequently encounter the challenge of balancing their studies with the demanding requirements of hands-on practice and this can greatly affect their mental wellbeing. This study aimed to investigate the impact of sleep and psychological well-being on the academic and clinical performance of nursing students in Saudi Arabia. This study used a cross-sectional approach with 218 student nurses selected through convenience sampling from King Khalid University, Abha, Saudi Arabia. The sleep quality, psychological wellbeing, academic performance and clinical performance questionnaires were adopted to measure the variables. The Google Forms survey was used to gather the data, which were collected in August through October 2023. t-test and chi-square were used to analyze the data. The sleep quality was higher with good/very good performers (p < 0.001). There was a significant difference with academic performance on positive relations (p < 0.007) and purpose in life (p < 0.004). Additionally, there was a significant difference in autonomy (p < 0.01), environmental mastery (p < 0.026), positive relations (p < 0.001), and purpose in life (p < 0.001) with clinical performance. Among students with good academic performance, those who were older than 25 years of age (p < 0.043) and level 3 students (p < 0.001) were found to have a significant correlation. Furthermore, those who were 25 years of age (p < 0.012) and level 3 students (p < 0.001) were also found to have a significant correlation with clinical performance. The sleep quality, positive relations, purpose in life, autonomy, and environmental mastery are all important factors for academic and clinical success. Moreover, older students and level 3 students may be more likely to have the skills and knowledge necessary to succeed in these areas. Further research exploring factors influencing academic and clinical success must be conducted.

Physical and physical activity exercises in relation to achieving psychological and social compatibility among the trainees Women and men in the gymnasiums

&#x0D; Physical exercise and its relationship to achieving social harmony among women and men trainees in the gymnasiumsResearch objective:- Knowing his relationship with physical exercise and exercise in achieving social and psychological compatibilityWomen and men trainees in the gyms.As for the imposition of the research, it was:- There are statistically significant differences in relation to physical exercise in exercise in achieving psychosocial compatibility among women and men trainees in sports halls..Therefore, the survey descriptive method was used to suit the research problem. The research sample consisted of women and men trainees in the sports halls in Baghdad, and their total number was (30) trainees (15) female trainees and (15) male trainees.The most important means used in this research is a questionnaire for the psychological and social compatibility scale and the statistical methods.The most important findings of this study are:1- Physical sporting activity has a positive effect on achieving psychological and social compatibility for women and men trainees in the gymnasiums, and in statistical terms.And the researcher recommended some of them1- Creating the appropriate sporting environment in which our youth grow for proper psychological development.2- Educating and guiding youth about the importance of the relationship between sports practices and psychosocial compatibility.3- Emphasizing the importance of physical and athletic activity in the psychological and social compatibility of those who practice it in the gymnasiums&#x0D; &#x0D;

Predicting radiation pneumonitis in lung cancer: a EUD-based machine learning approach for volumetric modulated arc therapy patients.

This study aims to develop an optimal machine learning model that uses lung equivalent uniform dose (lung EUD to predict radiation pneumonitis (RP) occurrence in lung cancer patients treated with volumetric modulated arc therapy (VMAT). We analyzed a cohort of 77 patients diagnosed with locally advanced squamous cell lung cancer (LASCLC) receiving concurrent chemoradiotherapy with VMAT. Patients were categorized based on the onset of grade II or higher radiation pneumonitis (RP 2+). Dose volume histogram data, extracted from the treatment planning system, were used to compute the lung EUD values for both groups using a specialized numerical analysis code. We identified the parameter α, representing the most significant relative difference in lung EUD between the two groups. The predictive potential of variables for RP2+, including physical dose metrics, lung EUD, normal tissue complication probability (NTCP) from the Lyman-Kutcher-Burman (LKB) model, and lung EUD-calibrated NTCP for affected and whole lung, underwent both univariate and multivariate analyses. Relevant variables were then employed as inputs for machine learning models: multiple logistic regression (MLR), support vector machine (SVM), decision tree (DT), and K-nearest neighbor (KNN). Each model's performance was gauged using the area under the curve (AUC), determining the best-performing model. The optimal α-value for lung EUD was 0.3, maximizing the relative lung EUD difference between the RP 2+ and non-RP 2+ groups. A strong correlation coefficient of 0.929 (P< 0.01) was observed between lung EUD (α = 0.3) and physical dose metrics. When examining predictive capabilities, lung EUD-based NTCP for the affected lung (AUC: 0.862) and whole lung (AUC: 0.815) surpassed LKB-based NTCP for the respective lungs. The decision tree (DT) model using lung EUD-based predictors emerged as the superior model, achieving an AUC of 0.98 in both training and validation datasets. The likelihood of developing RP 2+ has shown a significant correlation with the advancements in RT technology. From traditional 3-D conformal RT, lung cancer treatment methodologies have transitioned to sophisticated techniques like static IMRT. Accurately deriving such a dose-effect relationship through NTCP modeling of RP incidence is statistically challenging due to the increased number of degrees-of-freedom. To the best of our knowledge, many studies have not clarified the rationale behind setting the α-value to 0.99 or 1, despite the closely aligned calculated lung EUD and lung mean dose MLD. Perfect independence among variables is rarely achievable in real-world scenarios. Four prominent machine learning algorithms were used to devise our prediction models. The inclusion of lung EUD-based factors substantially enhanced their predictive performance for RP 2+. Our results advocate for the decision tree model with lung EUD-based predictors as the optimal prediction tool for VMAT-treated lung cancer patients. Which could replace conventional dosimetric parameters, potentially simplifying complex neural network structures in prediction models.

Evaluation of the use of chamomile in isolation and in association with laser photobiomodulation in the healing of rats oral mucosa.

Laser photobiomodulation (LPBM) has been shown to be one of the possible modulating agents of inflammation. Similarly, medicinal plants, such as chamomile (Matricaria recutita) are also used with the same purpose. To evaluate tissue repair in the dorsum of the tongue of rats under topical use of chamomile alone and in association with LPBM. Seventy-five male Wistar rats received a standardized wound on the dorsum of the tongue and were allocated into experimental groups: Control (G1), Chamomile Fluid extract (G2), Chamomile Infusion (G3), Laser (G4), Chamomile Infusion + Laser (G5). Euthanasia was done on days 3, 7, and 14 after surgery. Ulcers were evaluated and measured with a caliper. Sections stained with hematoxylin and eosin and Picrosirius Red allowed evaluation of edema, inflammatory infiltrate, cellularity, and re-epithelialization and characterization of total collagen. Histomorphometric analysis of the percentage of total collagen, the distance from the basal layer to the epithelial surface, and the thickness of the stratum corneum were performed. The G2 and G4 groups modulated the exudative and proliferative phases of inflammation, both clinically and histologically. The G3 and G5 groups did not show significant differences in relation to the G1 group in most of the evaluated parameters. Chamomile fluid extract and LPBM alone showed better clinical and histological responses for tissue repair than the association between these therapeutic modalities. There were differences in the parameters of clinical, histological, and histomorphometric patterns between the experimental groups of the present investigation. The LPBM proved to be superior in the performed analysis.