Significant Difference In Fat Mass Research Articles

Comparison of Body Compositions among Endurance, Strength, and Team Sports Athletes

Regular monitoring and evaluation of body composition determine an athlete’s output, such as their probability of winning competitions. The purpose of this study was to analyze the differences in athletes’ body composition among several sports categories. The data collected were on 251 athletes aged 20 to 30 years during the pre-competition period. The subjects were divided into three groups: endurance, power, and team sports. SECA 515mBCA was used to analyze the athletes’ body composition, which included their body fat percentage (BFP), fat mass (FM), fat-free mass (FFM), skeletal muscle mass (SMM), total body water (TBW), and extracellular water (ECW). The results showed that all body composition parameters were lowest in the endurance category. Fat composition was lowest in the endurance category but did not differ significantly between categories in male athletes. Meanwhile, in female athletes, there was a significant difference in FM between sports categories (p=0.009). FFM, SMM, TBW, and ECW differed significantly between categories (p<0.05). In female athletes, these variables were higher in the team sports category, as opposed to the power category among male athletes. This study concluded that there were differences in lean body mass composition between sport categories, while fat mass did not differ between sport categories in male athletes. This can be attributed to the differences in training programs and needs of each sport category in maximizing performance. These findings can provide advice to sports professionals that each sport category has its own body composition specifications.

Libifem® (Trigonella foenum-graecum) in conjunction with exercise on muscle strength, power, endurance, and body composition in females aged between 25 and 45 years.

This study examined the effects of Libifem® on exercise performance and body composition in females 25-45 years old. Participants were randomized to three equal groups to consume: 600 mg Libifem®/day, 300 mg Libifem®/day or a placebo for 8 weeks. Participants completed a whole-body exercise program three times a week for 8 weeks. At baseline, week 4 and week 8, muscle strength and endurance, functional threshold power, body composition, and sex hormones were measured. At week 8, all three groups increased leg press 1RM compared to baseline. A significant difference between group treatment effect was seen for leg press at week 8 (p = 0.045), with the 600 mg Libifem® group significantly increasing their leg press 1RM compared to placebo (p = 0.014). The 600 mg Libifem® group significantly reduced their total fat mass (0.96 kg loss) from baseline compared to placebo group (0.09 kg gain). There was no significant difference in fat mass for the 300 mg Libifem® group (0.23 kg loss). The 600 mg Libifem® group had a significant increase in lean mass compared to both the 300 mg and placebo groups (p = 0.011 and 0.009, respectively). Overall, there were significant and dose-related changes in body composition and ergogenic parameters, comparable with previous findings in males. This trial was registered with the Australian and New Zealand Clinical Trials registry [ACTRN12618001538235].

Cross-sectional study of characteristics of body composition of 24,845 children and adolescents aged 3–17 years in Suzhou

BackgroundWe aimed to analyze the characteristics of the body composition of children and adolescents aged 3–17 in Suzhou, China.MethodsA cross-sectional study between January 2020 and June 2022 using bioelectrical impedance was conducted to determine the fat mass (FM), fat-free mass (FFM), skeletal muscle mass, and protein and mineral contents of 24,845 children aged 3–17 who attended the Department of Child and Adolescent Healthcare, Children’s Hospital of Soochow University, China. Measurement data was presented in tables as mean ± SD, and groups were compared using the independent samples t-test.ResultsFM and fat-free mass increased with age in both boys and girls. The fat-free mass of girls aged 14–15 decreased after reaching a peak, and that of boys in the same age group was higher than that of the girls (p < 0.05). There were no significant differences in FM between boys and girls younger than 9- and 10-years old. The percentage body fat (PBF) and FM index of girls increased rapidly between 11 and 15 years of age (p < 0.05), and those of boys aged 11–14 were significantly lower (p < 0.05), suggesting that the increase in body mass index (BMI) was mainly contributed by muscle mass (MM) in boys.ConclusionsThe body composition of children and adolescents varies according to their age and sex. A misdiagnosis of obesity made on the basis of BMI alone can be avoided if BMI is used in combination with FM index, percentage body fat, and other indexes.

French-fried potato consumption and energy balance: a randomized controlled trial

Epidemiologic observations suggest increased potato consumption correlates with weight gain, adiposity, and diabetes risk, whereas nut consumption is associated with weight control and metabolic health. Randomized controlled trial (RCT) data indicate humans respond to changes in energy intake in single dietary components and compensate for extra energy consumed. We completed an RCT testing whether increased daily potato consumption influences energy balance [specifically, fat mass (FM)] compared with calorie-matched almond consumption. A 30-d RCT of 180 adults prescribed calorie-matched (300kcal/d, n=60 participants/group) than consumed 1 of the following: 1) almonds (almond group), 2) French fries (potato group), or 3) French fries with herb/spices mix (potato+herb/spices group). Baseline and 30-d FM were measured by DXA (primary outcome), with secondary outcomes including body weight and carbohydrate metabolism markers [glycated hemoglobin (HbA1c), fasting blood glucose and insulin, HOMA-IR)]. A subset of 5 participants/group participated in a postprandial meal-based tolerance test. A total of 180 participants were randomly assigned [gender: 67.8% female; mean±SD age: 30.4±8.7 y; BMI (in kg/m2): 26.1±4.2; and weight: 75.6±15.4kg], with 12 dropouts and 3terminations. No significantly different FM changes were observed between almond and potato consumption [combined±herb/spices; mean±SE almond: 230.87±114.01g; potato: 123.73±86.09g; P=0.443], fasting glucose (P=0.985), insulin (P=0.082), HOMA-IR (P=0.080), or HbA1c (P=0.269). Body weight change was not significantly different in the potato groups combined compared with the almond group (P=0.116), but was significantly different among the 3 groups (P=0.014; almond: 0.49±0.20kg; potato: -0.24±0.20kg; potato+herb/spices: 0.47±0.21kg). In meal tests, significantly lower post-prandial glucose and insulin responses to almonds compared with potatoes were observed (P=0.046, P=0.006, respectively), with potato+herb/spices having intermediate effects. There were no significant differences in FM or in glucoregulatory biomarkers after 30 d of potato consumption compared with almonds. Results do not support a causal relation between increased French fried potato consumption and the negative health outcomes studied. This trial was registered at clinicaltrials.gov as NCT03518515.

Bicycle Touring 480 km in Seven Days: Effects on Body Composition and Physical Fitness-A Case Study.

Bicycle touring as a modality of physical activity that involves whole-body cardiorespiratory and metabolic functions could be a potential strategy to improve body composition and cardiorespiratory fitness. Therefore, the aim of the current study was to investigate the effects of 7-days bicycle touring activity on body composition and physical fitness. A total of 13 individuals (three women) participated in this quasi-experimental study. The participants were evaluated at baseline and were tracked for up to 12 days after the intervention. The intervention consisted of a 480 km bicycle touring route performed over 8 days. Body weight and body composition (i.e., fat mass and lean mass) were assessed using a bioelectrical impedance analyser. Physical fitness was measured using the International Fitness Scale questionnaire. We conducted a repeated-measures analysis of variance to determine changes in body weight and body composition and paired sample t-tests to analyse changes in physical fitness. Significant differences in fat mass were observed between the baseline and both post-intervention (p = 0.003) and re-test values (p = 0.031). Significant differences were also noted in lean mass between the baseline and post-intervention values (p = 0.003), whereas no significant changes were observed when compared the baseline and re-test values (p = 0.178). Significant differences were obtained in cardiorespiratory fitness when comparing the baseline with the post-intervention values (p = 0.016), whereas no significant differences were noted in general fitness, muscular strength, speed/agility, and flexibility (all p > 0.05). In conclusion, a 7-day bicycle touring intervention can significantly reduce fat mass and increase lean mass and cardiorespiratory fitness in healthy individuals.

Effect of Modified Casein to Whey Protein Ratio on Dispersion Stability, Protein Quality and Body Composition in Rats.

The present study was designed to investigate the effects of protein formula with different casein (C) to whey protein (W) ratios on dispersion stability, protein quality and body composition in rats. Modification of the casein to whey protein (CW) ratio affected the extent of protein aggregation, and heated CW-2:8 showed a significantly increased larger particle (>100 μm) size distribution. The largest protein aggregates were formed by whey protein self-aggregation. There were no significant differences in protein aggregation when the CW ratios changed from 10:0 to 5:5. Based on the protein quality assessment (CW-10:0, CW-8:2, CW-5:5, and CW-2:8) for four weeks, CW-10:0 showed a significantly higher feed intake (p<0.05), but the high proportion of whey protein in the diet (CW-5:5 and CW-2:8) increased the feed efficiency ratio, protein efficiency ratio, and net protein ratio compared to other groups. Similarly, CW-2:8 showed greater true digestibility compared to other groups. No significant differences in fat mass and lean mass analyzed by dual-energy x-ray absorptiometry were observed. A significant difference was found in the bone mineral density between the CW-10:0 and CW-2:8 groups (p<0.05), but no difference was observed among the other groups. Based on the results, CW-5:5 improved protein quality without causing protein instability problems in the dispersion.

The Effect of Pyridoxine Hydrochloride Supplementation on Leptin, Adiponectin, Glycemic Indices, and Anthropometric Indices in Obese and Overweight Women.

Obesity has reached epidemic proportions globally. Among several methods for treating obesity, the use of dietary supplements is common recently. One supplement that can help in this regard might be vitamin B6 in high doses. The objective of this study was to evaluate the effect of pyridoxine hydrochloride supplementation on anthropometric indices, body composition, visceral adiposity index (VAI), and metabolic status in obese and overweight women. In this randomized controlled clinical trial, 44 obese and overweight women aged 18–50 years were selected and divided randomly into 2 groups: an intervention group (receiving 80 mg pyridoxine hydrochloride supplement for 8 weeks) and a control group (receiving placebo for 8 weeks). In the pyridoxine hydrochloride group, weight (p = 0.03), body mass index (p = 0.023), fat mass (p = 0.003), waist circumference (p = 0.005), VAI (p = 0.001), fasting insulin, insulin resistance (homeostasis model assessment of insulin resistance; HOMA-IR), total cholesterol, low-density lipoprotein, triglycerides (TG) and leptin (p < 0.001) decreased whereas adiponectin (p < 0.001) increased in comparison to the baseline values. There was a significant difference in fat mass, VAI, fasting insulin, HOMA-IR, and TG between pyridoxine hydrochloride and control groups following intervention in adjusted models (p < 0.05). The findings suggest that vitamin B6 supplementation may be effective in reducing BMI and improving body composition and biochemical factors associated with obesity.Trial RegistrationIranian Registry of Clinical Trials Identifier: IRCT20181002041206N1

Sex differences in response to short-term high fat diet in mice

BackgroundConsumption of high-fat diet (HF) leads to hyperphagia and increased body weight in male rodents. Female rodents are relatively resistant to hyperphagia and weight gain in response to HF, in part via effects of estrogen that suppresses food intake and increases energy expenditure. However, sex differences in energy expenditure and activity levels with HF challenge have not been systemically described. We hypothesized that, in response to short-term HF feeding, female mice will have a higher energy expenditure and be more resistant to HF-induced hyperphagia than male mice. MethodsSix-week-old male and female C57BL/6 J mice were fed either low fat (LF, 10% fat) or moderate HF (45% fat) for 5 weeks, and energy expenditure, activity and meal pattern measured using comprehensive laboratory animal monitoring system (CLAMS). ResultsAfter 5 weeks, HF-fed male mice had a significant increase in body weight and fat mass, compared with LF-fed male mice. HF-fed female had a significant increase in body weight compared with LF-fed female mice, but there was no significant difference in fat mass. HF-fed male mice had lower energy expenditure compared to HF-fed female mice, likely due in part to reduced physical activity in the light phase. HF-fed male mice also had increased energy intake in the dark phase compared to LF-fed male mice and a reduced response to exogenous cholecystokinin-induced inhibition of food intake. In contrast, there was no difference in energy intake between LF-fed and HF-fed female mice. ConclusionsThe data show that female mice are generally protected from short-term HF-induced alterations in energy balance, possibly by maintaining higher energy expenditure and an absence of hyperphagia. However, HF-feeding in male mice induced weight and fat mass gain and hyperphagia. These findings suggest that there is a sex difference in the response to short-term HF-feeding in terms of both energy expenditure and control of food intake.

Comparison between two methods of variable resistance training on body composition, muscular strength and functional capacity among untrained males

Several studies have shown a positive association between variable resistance training and improvement of muscular performance. However, the effect of variable resistance training to improve body composition in untrained individuals remains unclear. The objective of this research was to examine the comparison of 12 weeks combined weight and chain versus combined weight and elastic band variable resistance training on body composition among untrained male adults. Fifty healthy untrained males (age: 21.5 ± 1.95 years) were randomly selected and assigned into three groups: combined weight and chain (WC), combined weight and elastic band (WE), and free-weight (CG). All groups trained with 3 sets of 8 - 12 repetitions with 70% to 80% of 1RM for 2 days per week. Approximately 65% of the resistance was provided by free-weights and 35% of the resistance was provided by chains and elastic bands for the WC and WE groups. Body fat mass (FM) and body fat free mass (FFM) using bioelectrical impedance analyser were measured before, in the middle and after the intervention. Results reported although in the middle and after the intervention all groups showed a significant reduction in FM and significant gained in FFM (p &lt; 0.05), there were not significant differences in FM and FFM among all groups (p &gt; 0.05). However, FM decreased and FFM increased more insignificantly in WE and WC groups compared with CG group, and also FM decreased and FFM increased more insignificantly in WE group to compare with WC group during and after 12 weeks of variable resistance training (p &gt; 0.05). The results showed WE variable resistance training had a better effect insignificantly to improve body composition in the middle and after 12 weeks of variable resistance training among untrained male adults.

Condición física de adultos mayores de grupos para la tercera edad en Cali (Colombia)

IntroductionAging results in decreased physical ability, which directly impacts people's functionality. ObjectiveTo determine the physical condition of older adults that participate in working groups for the third age of the city of Cali. MethodsDescriptive cross-sectional study that considered the analysis of the records of assessment of the physical condition of older adults linked to 17 groups that promote physical activity in Santiago de Cali (Colombia). The data were processed using the statistical package SPSS® version 20. Frequencies were calculated, measures of central tendency and dispersion. To establish differences in the variables of physical condition by sex and age group, we used the non-parametric tests Mann Whitney U test and Kruskal-Wallis test with multiple comparisons per couple. ResultsThe results show significant differences in fat mass (P=.000), strength of upper limbs (P=.000) and aerobic capacity (P=.032) of the men and the women; and on lower body strength (P=.027), dynamic equilibrium (P=.011) and aerobic capacity (P=.011) to compare the group aged 60 to 64 years with the group aged 90 or more. ConclusionsThese findings confirm that physical activity programmes for older adults must be adapted according to age, sex, physical condition and risks to the health of this population.

Relative Contributions of Lean and Fat Mass to Bone Mineral Density: Insight From Prader-Willi Syndrome.

Context: Low bone mineral density (BMD) is the most important risk factor for fragility fracture. Body weight is a simple screening predictor of difference in BMD between individuals. However, it is not clear which component of body weight, lean (LM), or fat mass (FM), is associated with BMD. People with the genetic disorder of Prader-Willi syndrome (PWS) uniquely have a reduced LM despite increased FM.Objective: We sought to define the individual impact of LM and FM on BMD by investigating subjects with and without PWS.Design, Setting and Participants: This cross-sectional study was conducted at the Clinical Research Facility of the Garvan Institute of Medical Research, with PWS and control participants recruited from a specialized PWS clinic and from the general public by advertisement, respectively. The study involved 11 adults with PWS, who were age- and sex-matched with 12 obese individuals (Obese group) and 10 lean individuals (Lean group).Main Outcome Measures: Whole body BMD was measured by dual-energy X-ray absorptiometry. Total body FM and LM were derived from the whole body scan. Differences in BMD between groups were assessed by the analysis of covariance model, taking into account the effects of LM and FM.Results: The PWS group had significantly shorter height than the lean and obese groups. As expected, there was no significant difference in FM between the Obese and PWS group, and no significant difference in LM between the Lean and PWS group. However, obese individuals had greater LM than lean individuals. BMD in lean individuals was significantly lower than in PWS individuals (1.13 g/cm2 vs. 1.21 g/cm2, p < 0.05) and obese individuals (1.13 g/cm2 vs. 1.25 g/cm2, p < 0.05). After adjusting for both LM and FM, there was no significant difference in BMD between groups, and the only significant predictor of BMD was LM.Conclusions: These data from the human genetic model Prader-Willi syndrome suggest that LM is a stronger determinant of BMD than fat mass.

Youth Participation in Competitive Sports Associates with Midlife Lean Body Mass and Physical Activity

Benefits of life-long physical activity (PA) are widely recognized. Fewer studies have investigated how being young competing athlete reflects to later life body composition and PA. PURPOSE: To investigate the impact of participation in competitive sports in youth on the body composition and subjectively and objectively measured PA at middle- age. METHODS: The study participants are 47-to-55-year old Finnish women (n=985) attending to the Estrogenic Regulation of Muscle Apoptosis study (ERMA). Their participation in competitive sports at the age of 13-to-16 was assessed with retrospective self-report. Midlife lean body mass (LBM), skeletal muscle mass (SMM) and fat mass (FM) were measured with bioimpedance (Inbody 720) after overnight fast (n=866). Midlife PA included 7-scaled self-estimate that was reclassified to form sedentary, light, moderate and vigorous PA categories (n=985), a detailed assessment of leisure-time PA volume, duration and intensity (a modified Kuopio Ischemic Heart Disease Risk Factor Study Questionnaire, n=982) enabling calculation of mean daily metabolic equivalent (MET-h/day) index as a proxy of the previous 12 months PA and objectively measured total PA over seven-days by hip-worn accelerometer (Actigraph GT3X+ or wGT3X+, n=734). Statistical differences were tested using chi-squared test, independent samples t-test or Mann-Whitney U test. RESULTS: Participants were assigned into youth athlete (n=136) or non-athlete (n=849) groups based on their participation in competitive sports at the age of 13-to-16. Youth athlete group had 1.5 kg higher LBM (p=0.002) and 1.0 kg higher SMM (p=0.001) at middle-age, but no statistically significant difference in FM. Youth athletes reported more vigorous PA (32.4% vs. 20.3%, p=0.007) and higher leisure-time MET index (4.3 vs. 3.4 h/day, p<0.001) than non-athletes. No difference was observed in accelerometer-measured sedentary time, light PA, moderate-to-vigorous PA or total PA (counts) between groups. CONCLUSION: Participation in sport competitions as a teenager has long lasting health benefits that associates with healthier body composition and higher leisure-time PA later in life. However, the discrepancy between self-reports and objective measures needs further studies to delineate the benefits of different components of PA.

Physical, Physiological, and Dietary Comparisons Between Marine Corps Forces Special Operations Command Critical Skills Operators and Enablers.

Tactical demands of a Marine Corps Forces Special Operations Command (MARSOC) Critical Skills Operator (CSO) require high levels of physical performance. During combat deployments, teams of CSOs are supplemented with enablers who specialize in mission-specific tasks. MARSOC CSOs and enablers serve alongside each other in extreme combat environments, often enduring the same physical demands, but the selection process for each group is very different. The purpose of this observational study was to quantify the physical, physiological, and dietary differences of MARSOC CSOs and enablers, as this may have a direct impact on tactical performance and provide important information to shape future research. Fat free mass (FFM), fat mass (FM), fat mass index (FMI), fat free mass index (FFMI), anaerobic power (AP), anaerobic capacity (AC), aerobic capacity (VO2max), knee flexion (KF), knee extension (KE), trunk extension (TE), and trunk flexion (TF) isokinetic strength were collected. Dietary intake was collected using automated self-administered 24-hr dietary recalls (ASA24) for a subgroup of subjects. Testing on 164 male CSOs (age: 27.5 ± 3.8 yr, height: 178.7 ± 6.5 cm, mass: 85.7 ± 9.1 kg, and 7.6 ± 2.9 yr of military service) and 51 male enablers (age: 27.8 ± 5.4 yr, height: 178.4 ± 8.5 cm, mass: 83.8 ± 11.8 kg, and 7.9 ± 5.4 yr of military service) showed there were no significant differences for age, height, mass, or years of military service. (p > 0.05). CSOs demonstrated greater physiological performance in AP (W/kg) (p = 0.020), AC (W/kg) (p = 0.001), and VO2max (ml/kg/min) (p = 0.018). There were no significant differences in FM and FFM (p > 0.05), however CSOs demonstrated significantly higher FFMI (p = 0.011). CSOs also demonstrated greater KF (%BW) (p = 0.001), KE (%BW) (p = 0.001), TE (%BW) (p = 0.010), and TF (%BW) (p = 0.016). No differences in energy or macronutrient intake were observed in the subgroup. MARSOC CSOs demonstrated significantly greater FFMI, AP, AC, VO2max, KF, KE, TE, and TF compared with enablers. Dietary intake was consistent between groups, but fueling concerns were identified for all personnel in the subgroup. These findings suggest the need for future studies to examine what physiological and strength thresholds are necessary to operate effectively as a member of a MSOT and determine the relationship between specific performance deficits and risk of injury. In addition, the integration of nutrition strategies that augment and optimize the performance of both CSOs and enablers may be beneficial.

Early Infant Feeding and Body Composition In Pre-School Children

Objective: The purpose of this study was to examine the association between early infant feeding and childhood adiposity. Method: This was a cross-sectional study of 29 pre-school age (4 to 6 years) children and their mothers. Mothers were interviewed using a structured questionnaire to assess early infant feeding practices, while the children’s body composition was measured using the BOD POD Pediatric Option Body Composition System. Results: The mean age of the children was 4.9 ± 0.8 years, 82.8% Caucasian and 17.2% Black/African American, while 65.5% were female. None of the mothers reported alcohol consumption or smoking during the pregnancy with the child. Of the 29 children in the study, 41.4% were exclusively breastfed for at least 3 months, 48.3% mix-fed and 10.3% exclusively formula-fed. Although we found significant differences in BMI-for-age z-score (p = 0.033) and BMI-percentile-for-age (p = 0.023), there was no significant differences in fat mass and percent fat mass between the groups. Formula-fed children tended to have slightly higher fat-free mass and percent fat-free mass than both mix-fed and exclusively breastfed children although these differences were not statistically significant. Conclusions: Our findings suggest that the direction of the association between early infant feeding and childhood obesity may be dependent on the indicators used to assess obesity.

Graft function and nutritional parameters in stable postrenal transplant patients.

Bioelectrical impedance analysis (BIA) is a method for the assessment of nutritional status. We studied the effect of graft function on nutritional status in postrenal 45 transplant patients with borderline to good allograft function using BIA. The patients had a mean serum creatinine of 1.42 ± 0.42 mg% and mean glomerular filtration rate (GFR) of 45.1 ± 14.1 mL/min. Based on BIA-derived GFR, the patients were divided into two groups; group 1: borderline graft function GFR <40 mL/min and a mean of 27.34 ± 9.1 mL/min and group 2: good graft function GFR ≥40 mL/min and a mean of 51.60 ± 9.16 mL/min. The patient data were compared with 30 healthy individuals. There was a significant difference between healthy controls and the posttransplant patients. There were significant differences between the study groups in body weight (P <0.01), serum creatinine (P <0.005), body mass index (BMI) (P <0.000), fat free mass (FFM) (P <0.003), fat mass (FM) (P <0.003), body cell mass (P <0.000), and dry weight (P <0.001). Group 1 had significantly lower body weight, BMI, FFM, FM, and dry weight, indicating poorer nutritional status compared with those in group 2. Based on phase angle, there were significant differences between group A (phase angle <4.0) and group B (phase angle >4.0) in extracellular water (P <0.015), intracellular water (P <0.002), plasma fluid (P <0.016), interstitial fluid (P <0.016), and body cell mass (P <0.024). Subjective global assessment (SGA) scores showed that transplant patients had normal nutritional status, but when compared with healthy individuals as assessed by BIA, there were significant differences in FM, FFM, and body cell mass. In conclusion, BIA was more sensitive to evaluate nutritional depletion than SGA in transplant patients with borderline.

Aged-Related Changes in Body Composition and Association between Body Composition with Bone Mass Density by Body Mass Index in Chinese Han Men over 50-year-old.

ObjectivesAging, body composition, and body mass index (BMI) are important factors in bone mineral density (BMD). Although several studies have investigated the various parameters and factors that differentially influence BMD, the results have been inconsistent. Thus, the primary goal of the present study was to further characterize the relationships of aging, body composition parameters, and BMI with BMD in Chinese Han males older than 50 years.MethodsThe present study was a retrospective analysis of the body composition, BMI, and BMD of 358 Chinese male outpatients between 50 and 89 years of age that were recruited from our hospital between 2009 and 2011. Qualified subjects were stratified according to age and BMI as follows: 50–59 (n = 35), 60–69 (n = 123), 70–79 (n = 93), and 80–89 (n = 107) years of age and low weight (BMI: < 20 kg/m2; n = 21), medium weight (20 ≤ BMI < 24 kg/m2; n = 118), overweight (24 ≤ BMI < 28 kg/m2; n = 178), and obese (BMI ≥ 28 kg/m2; n = 41). Dual-energy X-ray absorptiometry (DEXA) was used to assess bone mineral content (BMC), lean mass (LM), fat mass (FM), fat-free mass (FFM), lumbar spine (L1-L4) BMD, femoral neck BMD, and total hip BMD. Additionally, the FM index (FMI; FM/height2), LM index (LMI; LM/height2), FFM index (FFMI; [BMC+LM]/height2), percentage of BMC (%BMC; BMC/[BMC+FM+LM] × 100%), percentage of FM (%FM; FM/[BMC+FM+LM] × 100%), and percentage of LM (%LM; LM/(BMC+FM+LM) × 100%) were calculated. Osteopenia or osteoporosis was identified using the criteria and T-score of the World Health Organization.ResultsAlthough there were no significant differences in BMI among the age groups, there was a significant decline in height and weight according to age (p < 0.0001 and p = 0.0002, respectively). The LMI and FFMI also declined with age (both p < 0.0001) whereas the FMI exhibited a significant increase that peaked in the 80-89-years group (p = 0.0145). Although the absolute values of BMC and LM declined with age (p = 0.0031 and p < 0.0001, respectively), there was no significant difference in FM. In terms of body composition, there were no significant differences in %BMC but there was an increase in %FM (p < 0.0001) and a decrease in %LM (p < 0.0001) with age. The femoral neck and total hip BMD significantly declined with age (p < 0.0001 and p = 0.0027, respectively) but there were no differences in L1-L4. BMD increased at all sites (all p < 0.01) as BMI increased but there were declines in the detection rates of osteoporosis and osteopenia (both p < 0.001). A logistic regression revealed that when the medium weight group was given a BMI value of 1, a decline in BMI was an independent risk factor of osteoporosis or osteopenia, while an increase in BMI was a protective factor for BMD. At the same time, BMD in L1-L4 exhibited a significant positive association with FMI (p = 0.0003) and the femoral neck and total hip BMDs had significant positive associations with FFMI and LMI, respectively (both p < 0.0001).ConclusionsThese data indicate that LMI and FFMI exhibited significant negative associations with aging in Chinese Han males older than 50 years, whereas FMI had a positive association. BMD in the femoral neck and total hip declined with age but an increased BMI was protective for BMD. LMI and FFMI were protective for BMD in the femoral neck and total hip.

Anthropometrics of neonates born to mothers with diabetes in pregnancy in the Northern Territory

Type 2 diabetes (T2DM) is increasing in prevalence in Indigenous Australian children and adolescents. High rates of diabetes in pregnancy (DIP) in Indigenous Australians increases the risk of diabetes for the next generation. DIP is associated with neonatal adiposity, which correlates with long-term risk of obesity and diabetes. Indigenous Australians have high rates of low birth weight and increasingly, large for gestational age associated with DIP. The aims are: 1. To evaluate adiposity in babies born to Indigenous mothers and those of European background with DIP in the Northern Territory; 2. To evaluate the relationship between maternal factors and neonatal birth weight and body composition. Thus far 266 mothers and neonates from the PANDORA cohort (Pregnancy and Neonatal Outcomes in Remote Australia) have been assessed. Neonatal anthropometrics were performed on all neonates, including skin fold measures. Calculations of fat mass were made using a validated equation (fat mass=0.39055(birth weight)+0.0453(flank skinfold)-0.03237(length)+0.54657). Significant differences were found in maternal characteristics between Indigenous and European background participants, including diabetes type (T2DM 14.7% vs 1.1%, p<0.001), smoking in pregnancy (26.5% vs 9.1%, p<0.001) and location of residence (regional/remote 41.4%vs 9.8% p<0.001). Gestational age at birth was significantly different (38.2 vs 39 weeks p<0.001), however birth weight was not significantly different (3380 vs 3428g). Indigenous neonates had greater subscapular (4.69 vs 4.20mm, p=0.003) triceps (4.75 vs 4.22mm, p=0.004) and flank skin folds (4.08 vs 3.60mm, p=0.006). This difference remained significant for the flank skin fold only, after adjustment for diabetes type and maternal body mass index (BMI). There was no significant difference in calculated fat mass. On regression analysis, maternal BMI, smoking, nulliparity and T2DM were each independently associated with birth-weight z-score. Recruitment to PANDORA is ongoing. Preliminary data reveals higher skin fold measures, indicative of adiposity, in Indigenous neonates. There was no significant difference in fat mass. Smoking, BMI, nulliparity and T2DM were independently associated with birth-weight z-score, ethnicity was not independently associated.

Measurement of body composition in response to a short period of overfeeding.

BackgroundObesity and overweight are increasing in prevalence in developed countries as a result of changing dietary habits and a lack of physical activity. The purpose of the present study was to evaluate the changes in body composition during short-term overfeeding using the three-component model, which is composed of fat mass (FM), total body water (TBW), and fat-free dry solids (FFDS).MethodsTen healthy men completed 3 days of overfeeding during which they consumed 1,500 kcal/day more energy than consumed in their normal diets. Body composition was evaluated at three time points: the day before and after their normal diets and the day after the 3-day overfeeding diet.ResultsBefore and after their normal diets, there were no significant differences in body weight and composition, but after 3 days of overfeeding, body weight, TBW, and FFDS increased 0.7, 0.7, and 0.2 kg, respectively (P <0.0001). There was no significant difference in FM between the normal and overfeeding diets.ConclusionThis study suggests that TBW gain contributes to weight gain following a short-term overfeeding.

Body composition assessment in overweight women: validation of air displacement plethysmography

The purpose of this study was to evaluate the validity and reliability of air displacement plethysmography (ADP) compared to a dual energy x-ray absorptiometry (DXA) criterion for body composition measurement in overweight and obese women (BMI≥25·0kgm(2) ). Twenty-four overweight and obese women (Mean±SD; Age: 36·6±12·0years; Height: 166·4±5·8cm; Weight: 86·5±14·2kg; Body Fat: 38·5±3·7%; BMI: 31·3±5·5kgm(2) ) were tested after an 8-h fast. Fat mass (FM), fat-free mass (FFM) and percent body fat (%BF) were measured by ADP and compared to values determined by the DXA criterion. FFM from DXA was calculated as lean mass plus bone mineral content. A paired samples t-test was used to test for significant differences in the body composition variables between methods. A one-way ANOVA along with intraclass correlation coefficient (ICC), SEM,%SEM and MD was used to represent reliability. Validity data comparing ADP and DXA demonstrated no significant difference in FM (ADP-DXA FM=0·99kg; P=0·113), FFM (0·98kg; P=0·115) and %BF (1·56%; P=0·540). Reliability data for ADP between the first and second trials showed no significant difference in FM (P=0·168; ICC=0·994; SEM=0·668), FFM (P=0·058; ICC=0·973; SEM=0·892) or %BF (P=0·121; ICC=0·971; SEM=0·813). For overweight and obese women, ADP was found to be a valid measure of FM, FFM and %BF when compared with DXA. The reliability of ADP was supported for all body composition variables.

Failure to increase postprandial blood flow in subcutaneous adipose tissue is associated with tissue resistance to adrenergic stimulation

Adequate adipose tissue blood flow (ATBF) is essential for its metabolic and endocrine functions. From a metabolic point of view, sufficient increases in ATBF after meals permits full storage of excess energy into fat, thus protecting other tissues against the toxic effects of fatty acids and glucose spillover. It was previously shown that postprandial increases in ATBF are blunted in obese and insulin-resistant subjects, and that much of the postprandial ATBF response is the result of β-adrenergic activation. Examination of previously recorded data on postprandial ATBF responses revealed an underlying heterogeneity, with postprandial ATBF being largely unresponsive to food stimuli in a substantial proportion of normal weight healthy people (low responders). Our study tests the hypothesis that this unresponsive pattern is due to resistance to β-adrenergic stimulation in adipose tissue. Five responders and five low responders were selected from a previously studied cohort and matched for BMI (20.5±0.7 vs 22±1 kg/m(2), respectively), gender (male/female: 2/3) and age (30±3 vs 37±6 years). Subcutaneous adipose tissue microinfusions of stepwise increasing doses of isoproterenol were performed with concomitant monitoring of blood flow, using the (133)Xenon washout technique. Although BMI was similar between responders and low responders, there were significant differences in fat mass (9.9±1.6 vs 14.4±1.6 kg; P<0.05) and four-point skinfold thickness (33±4 vs 52±16 mm; P<0.05). Lack of ATBF response to oral glucose was confirmed in the low responder group. In responders, ATBF was higher at baseline (5.4±1 vs 3.4±1 mL/min/100 g of tissue) and responded more distinctly to increasing isoproterenol doses (10(-8) M: 7.6±1.4 vs 4.9±1; 10(-6) M: 12.5±1.7 vs 7.5±1.6; and 10(-4) M: 20 ±1.7 vs 9±0.9 mL/min/100 g of tissue). These data suggest that the lack of glucose-stimulated ATBF is associated with resistance to sympathetic activation in adipose tissue.