Significant Decrease In Cholesterol Research Articles

Effect of a Physical Exercise Intervention on Physical Function Parameters and Blood Analytical Changes in Lung Cancer Survivors: A Feasibility Study.

Background: Lung cancer carries a high burden of systemic symptoms, including in survivors, leading to a reduced quality of life (QoL). We assessed whether a 12-week multicomponent supervised exercise programme, including muscular strength and aerobic training, was beneficial in patients who had undergone surgery for early non-small cell lung cancer (NSCLC) in terms of physical performance, QoL, and metabolic and nutritional analytical parameters. Methods: Physical performance was measured by gait speed, handgrip strength, 30 s sit-to-stand (30s-STS) test repetitions, distance covered in the 6 min walk test (6MWT), and the Short Physical Performance Battery (SPPB) score. QoL was assessed with the EORTC-QLQ-C30 questionnaire. Blood glucose, cholesterol, triglycerides, total proteins, albumin, pre-albumin, creatinine, c-reactive protein, insulin-growth factor 1 (IGF-1), and the haemoglobin and hematocrit percentages were measured before and after the intervention in order to observe any beneficial effects related to metabolic markers. Results: After the intervention, the mean scores for the 6MWT (p < 0.001), STS (p < 0.001), 6MWT (p < 0.01), and SPPB (p < 0.01) had significantly improved. However, handgrip strength and nutritional analytical were unchanged. The EORTC-QLQ-C30 functions and symptoms significantly improved after the intervention (p < 0.05 and p < 0.01, respectively). A significant decrease in cholesterol, triglycerides, and IGF-1 and a significant increase in pre-albumin in blood was also observed post-intervention (p < 0.05). Conclusions: This supervised, community-based 12-week multicomponent was feasible (adherence rate 70.35%) and provided benefits not only to physical performance but also to the quality of life of patients with NSCLC.

Use of placental-derived mesenchymal stem cells to restore ovarian function and metabolic profile in a rat model of the polycystic ovarian syndrome

IntroductionPolycystic ovary syndrome (PCOS) is an endocrine and metabolic disturbance that affects many women worldwide and is characterized by chronic anovulation, hyperandrogenism, and ovarian dysfunction. Placenta-derived mesenchymal stem cells (PDMSCs) are derived from the placenta and have advantages over other sources of MSCs in terms of availability, safety, and immunomodulation.Materials and methodsIn this experimental study, twenty female Wistar rats were assigned to four groups (n = 5) including control, sham, PCOS, and PCOS+PDMSCs groups. Then, PCOS was induced in the rats through administering letrozole for 21 days. PDMSCs (1 × 106 cells) were injected through the tail vein. Fourteen days after the cell infusion, evaluation was performed on the number of healthy follicles, corpus luteum, and cystic follicles as well as the levels of testosterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH), fasting blood glucose, fasting insulin, and insulin resistance. Moreover, the serum levels of cholesterol, triglyceride (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) were measured. Liver function was also determined by the evaluation of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels.ResultsThe number of corpus luteum and primordial, primary, secondary, and antral follicles was significantly elevated in the PCOS+PDMSCs group compared to the PCOS group. However, the number of cystic follicles significantly decreased in the PCOS+PDMSCs group. The LH and testosterone levels also decreased significantly, while FSH levels increased significantly in the PCOS+PDMSCs group. The levels of fasting blood glucose, fasting insulin, and insulin resistance notably decreased in the PCOS+PDMSCs group. Moreover, the lipid profile improved in the PCOS+PDMSCs group along with a significant decrease of cholesterol, LDL, and TG and an increase in HDL. The PCOS+PDMSCs group exhibited marked decreases in the AST and ALT levels as well.ConclusionThe results of this study suggest that PDMSCs are a potential treatment option for PCOS because they can effectively restore folliculogenesis and correct hormonal imbalances, lipid profiles and liver dysfunction in a rat model of PCOS. However, further research is needed to establish the safety and effectiveness of PDMSCs for treating PCOS.

Biomonitoring of Serum Markers as a Measurement of Occupational Exposure in Personnel at Landfill Site

Improper handling and management of municipal solid wastes can produce adverse health effects on waste pickers through biological, chemical, physical, mechanical or psychological means. They are vulnerable to various occupational health hazards such as respiratory disorders, gastrointestinal diseases, skin diseases, eye infections and musculoskeletal disorders. Hence, we aimed to conduct biomonitoring and health risk assessment on women rag pickers. This study included 250 women waste pickers: 160 exposed working on the Pirana dumping site and 90 control subjects from around the residential areas of Ahmedabad city of Gujarat (India). C-reactive protein, Alkaline phosphatase, Alanine transaminase and Aspartate transaminase were significantly high in serum samples of exposed subjects suggesting gallbladder inflammation, acute hepatitis A and B or oxidative stress. After comparing the lipid profile of exposed and control subjects, we found a significant decrease in cholesterol, high-density lipoprotein cholesterol and triglyceride frequency which is a sign of malnutrition or hyperthyroidism. Random blood sugar, globulin and total serum protein were reduced significantly. In contrast, a significant increase was found in albumin, phosphorus, creatinine, urea and uric acid levels of exposed individuals, which indicates potential disorders of the liver and kidney. Direct exposure to solid waste, agrochemicals, heavy metals, toxic industrial and hospital waste, and toxic air having high concentrations of polyaromatic hydrocarbons and bioaerosols, unhealthy eating and sanitary habits, and negligence towards health were major contributing factors to ill effects on their liver and kidney. We suggest effective education, and communication programs for preventive and protective measures to address problems of rag pickers. The present study emphasizes the need for regular monitoring of contamination among the rag-picking population and areas around the Pirana landfill site for better information on exposure to rag pickers.

N-Chlorotaurine Solutions as Agents for Infusion Detoxification Therapy: Preclinical Studies.

N-chlorotaurine (NCT) is a broad-spectrum antimicrobial agent with outstanding tolerability, effective for topical and inhalation use. This paper presents the results of studies of single and repeated intravenous infusions of NCT to laboratory animals. The studies were conducted on female Wistar Han rats. The effect of NCT infusions on the general condition, behavioral reactions, main biochemical and hematological parameters, hemocoagulation system, cardiovascular system, and on the condition of the internal organs was studied. It was found that NCT infusions do not reveal deviations in the studied parameters that could indicate a toxic effect. The estimated LD50 is more than 80 mg/kg. In a subchronic experiment, a statistically significant decrease in cholesterol (by up to 11%), glucose (by up to 15%) and excess bases (up to four times) in the blood, and an increase in heart rate (by up to 31%) and frequency of defecations (by up to 35%), as well as pronounced antiplatelet effect, were found. In animals with simulated endotoxicosis, a decrease in the cytolysis and oxidative stress markers was observed. Such effects are caused by both chlorine-active compounds and taurine.The results obtained indicate broad prospects for the use of NCT solutions as an infusion detoxifying agent.

Lipid Quality Changes in French Fries, Chicken Croquettes, and Chicken Nuggets Fried with High-Linoleic and High-Oleic Sunflower Oils in Domestic Deep Fryers.

The quality of fried products greatly depends on the changes occurring during frying. The purpose of this work was to study the lipid quality changes taking place in selected frozen foods after domestic deep-frying. Conventional, high-linoleic sunflower oil (HLSO) and high-oleic sunflower oil (HOSO) were used, and the frozen foods selected were French fries, croquettes, and nuggets. The foods were fried in domestic fryers under discontinuous conditions. Analyses included fatty acid composition, sterols, tocopherols, squalene, and lipid alteration levels. In all fried foods, the content of lipids increased after frying, which is consistent with previous findings. However, the lipid exchange between the food and the oil greatly depended on the food characteristics. Specifically, the levels of frying oil in the food lipids were about 90, 40, and 58% for French fries, croquettes, and nuggets, respectively. The main results obtained showed that lipid alteration levels considerably decreased and amounts of sterols and tocopherols significantly increased in French fries' lipids after frying. In both chicken products, croquettes and nuggets, the best quality improvement observed was a significant decrease in cholesterol in food lipids due to the lipid exchange. Overall, frying with HLSO and HOSO improved the quality and nutritional properties of all products tested.

Effect of dietary dehydrated sour lemon peel (Citrus limon) powder on metabolic enzymes, serum biochemistry and stress status of rainbow trout (Oncorhynchus mykiss) juvenile

Lemon peel is by-products contain bioactive compounds that has beneficial effects on fish health. A 45-day feeding trial was conducted to evaluate the potential of dietary dehydrated lemon peel (Citrus limon) powder (DLPP) on metabolic enzyme, serum components and stress status of rainbow trout juvenile (initial weight of 26.8±1.9 g). Fish were randomly stocked to four treatments feeding diets containing 0 (control), 0.5, 1.5, and 2.5% of DLPP diets in triplicates. At the end of feeding experiment, metabolic enzyme (Alkaline phosphatase; ALP, Aalanine transaminase; ALT, Aspartate aminotransferase; AST), serum biochemistry (cholesterol, triglyceride, protein and albumin) and stress (glucose and cortisol) were assessed. There was no significant difference in fish growth performance between treatments (p&gt;0.05). Fish fed with 1.5% of DLPP showed a significant decrease in cholesterol and triglyceride (p&lt;0.05). Moreover, serum protein and albumin were improved in fish fed with 1.5% and 0.5% DLPPP, respectively (p&lt;0.05). The highest of AST, ALP and ALT were observed in control group (p&lt;0.05). There were no significant differences in cortisol and glucose of fish between the treatments (p&gt;0.05). Finally, it seems that the inclusion of 0.5 and 1.5% DLPP in diet can improve metabolic enzymes, biochemical parameters and reduced stress of rainbow trout juvenile.

Efficacy, safety, and tolerability of dolutegravir-based ART regimen in Durban, South Africa: a cohort study

BackgroundDolutegravir is an integrase strand transfer inhibitor that has been recommended for use in first-line antiretroviral regimens by the World Health Organisation and is currently being rolled out globally. There has been safety concerns with dolutegravir which has caused concern about its use in the general population. Dolutegravir first-line regimens have been used in South Africa since early 2020. Therefore, the aim of the present study was to assess the efficacy, safety, and tolerability of first-line dolutegravir-based antiretrovirals amongst adults living with HIV in Durban, South Africa.MethodsThis was a mixed-methods study, which comprised a cross-sectional survey and longitudinal retrospective follow-up of medical records. The study was conducted between October 2020 and January 2022. Data were described using descriptive and summary statistics. Bivariate logistic regression was applied to socio-demographic and clinical variables and crude odds ratios with a 95% confidence interval was calculated. Pearson chi-square tests, paired sample T-tests, and cross-tabulations were performed on selected variables.ResultsA total of 461 participants were enrolled in the study. There was a significant change in immunological outcomes (p < 0.001) after dolutegravir initiation. Furthermore, an assessment of laboratory parameters showed that there was a significant decrease in cholesterol (p < 0.001) and increase in creatinine (p < 0.001) levels. Increased weight was shown by 60.7% of the participants but was not associated with age, gender, CD4 counts, and previous antiretroviral usage. The study found that 43.6% of the participants experienced at least one side-effect. A total of 21.6% and 23.2% of the participants experienced neuropsychiatric and central nervous system side-effects, respectively. In the bivariate analyses, only gender was shown to be associated with side-effects, and only 1.7% of the participants discontinued the study due to side-effects.ConclusionOur results suggest that dolutegravir is effective, safe, and well tolerated in the study population.

Reduced toxic effects of nano‑copper sulfate in comparison of bulk CuSO4 on biochemical parameters in the Rohu (Labeo rohita)

Considering the wide application of nanoparticles in various fields of life and growing concern regarding their toxic effects, the present study was designed with the aim to evaluate the potential risks of using copper sulfate nanoparticles (CuSO4-NPs) in comparison to bulk form. Nanoparticles of CuSO4, having mean size of 73 nm were prepared by ball milling method, and fingerlings of Labeo rohita were exposed to two levels, 20 and 100 μg L−1 of CuSO4 in both bulk and nano forms for 28 days and their comparative effects on the metallothioneins (MTs), heat shock proteins 70 (HSP 70), lipid profile, cholesterol (CHOL) and triglyceraldehyde (TG) levels, activities of some metabolic enzymes Alanine transaminase (ALT), Aspartate transaminase (AST) Akaline phosphatase (ALP), and genes expressions of HSP-70, TNF-α and IL1-ß were investigated. CuSO4 showed the concentration and particle type dependent effects. The over expression of HSPs and MTs, significant decreases in CHOL, TG, low density lipid (LDL) levels and ALP activity, while significant increases in high density lipid (HDL)level as well as ALT and AST activities and HSP-70, TNF-α and IL1-β expressions were observed in response to higher concentration of both bulk and nano form of copper sulfate. At lower concentration (20 μg L−1), however, only bulk form showed toxicity. Thus, low concentrations of CuSO4-NPs pose negligible threat to freshwater fish.

A Dietary Model of Partial Meat Replacement with Walnuts Demonstrates Changes in the Nutrient Profile and Quality of the United States Population's Diet.

The purpose of the study is to assess the impact of partial meat replacement with walnuts using a dose-escalation approach on nutrient intake and diet quality in the usual US diet. Food modeling was implemented using the nationally representative 2015-2018 National Health and Examination Survey (NHANES), with a focus on non-nut consumers, which included 2707 children and adolescents and 5190 adults. Walnuts replaced meat in a dose-escalating manner (0.5, 1, 1.5, and 2 oz walnuts per day replaced 1, 2, 3, and 4 oz meat, respectively). Diet quality was estimated using the population ratio method of the 2015 Healthy Eating Index. The usual intake of nutrients was estimated using the National Cancer Institute method. Significant differences were determined using non-overlapping 95% confidence intervals. The partial replacement of meat with walnuts demonstrated significant increases in the mean intake of fiber, magnesium, and omega-3 fatty acids and significant decreases in cholesterol and vitamin B12 in the modeled diets for children, adolescents, and adults. Additionally, the partial replacement of meat with walnuts improved overall diet quality. Walnut consumption at 1-2 oz as a replacement for some meat may improve nutrient intake and diet quality across age groups.

EFFECT OF GALLIC ACID ON LIPID PROFILE AND ANTIOXIDANT STATUS IN CADMIUM CHLORIDE TREATED RATS

This study was aimed to explore the role of gallic acid (GA) in ameliorating in reducing adverse effects of cadmium chloride (CdCl2) on antioxidant status and lipid profile in adult male rats. Twenty-eight (28) adult male rats were divided randomly into four equal groups; they were daily handled for 30 days, as follows: control group (C), received tap water only. (G1), received 100ppm of CdCl2 in drinking tap water, animals in proceeding groups were given in addition to CdCl2 in drinking water the following: intraperitoneal injection of GA 100 mg/kg. daily (G2 group) and the combination of GA and CdCl2 were given to rats in group (G3) in the same pattern. At the end of the experiment, fasting blood samples were collected and serum was isolated for measuring of antioxidant status and lipid profile. The results showed that administration CdCl2 (G1 group) caused a case of dyslipidemia illustrated by significant elevation in serum cholesterol concentration in lipoprotein low density lipoprotein-cholesterol (LDL-C) and very low-density lipoprotein-cholesterol (VLDL-C), total cholesterol (TC), triglyceride (TAG) and non-HDL-C accompanied with significant decrease in cholesterol of high density lipoprotein (HDL-C) concentrations. The results also revealed a significant elevation in lipid indices including, coronary risk index (CRI), and cardiovascular risk index (CVRI) in CdCl2 exposed rats. While significant elevation in malondialdehyde (MDA) and reduction in (GSH) concentrations observed in the same group comparing to gallic acid and control group, indicating a case of oxidative stress. The current results also recorded that intraperitoneal injection of GA against CdCl2 caused amelioration of all previously estimated parameters.

Evaluation of Antidiabetic Effect of Combined Leaf and Seed Extracts of Moringa oleifera (Moringaceae) on Alloxan-Induced Diabetes in Mice: A Biochemical and Histological Study.

Moringa oleifera (Moringaceae) is a medicinal plant rich in biologically active compounds. The aim of the present study was to screen M. oleifera methanolic leaf (L) extract, seed (S) extract, and a combined leaf/seed extract (2L : 1S ratio) for antidiabetic and antioxidant activities in mice following administration at a dose level of 500 mg/kg of body weight/day. Diabetes was induced by alloxan administration. Mice were treated with the extracts for 1 and 3 months and compared with the appropriate control. At the end of the study period, the mice were euthanized and pancreas, liver, kidney, and blood samples were collected for the analysis of biochemical parameters and histopathology. The oral administration of the combined L/S extract significantly reduced fasting blood glucose to normal levels compared with L or S extracts individually; moreover, a significant decrease in cholesterol, triglycerides, creatinine, liver enzymes, and oxidant markers was observed, with a concomitant increase in antioxidant biomarkers. Thus, the combined extract has stronger antihyperlipidemic and antioxidant properties than the individual extracts. The histopathological results also support the biochemical parameters, showing recovery of the pancreas, liver, and kidney tissue. The effects of the combined L/S extracts persisted throughout the study period tested. To the best of our knowledge, this is the first study to report on the antidiabetic, antioxidant, and antihyperlipidemic effects of a combined L/S extract of M. oleifera in an alloxan-induced diabetic model in mice. Our results suggest the potential for developing a natural potent antidiabetic drug from M. oleifera; however, clinical studies are required.

Ablation of Mea6/cTAGE5 in oligodendrocytes significantly impairs white matter structure and lipid content

Abstract Lipid-rich myelin is a special structure formed by oligodendrocytes wrapping neuronal axons. Abnormal myelin sheath is associated with many neurological diseases. Meningioma-expressed antigen 6 (Mea6)/cutaneous T cell lymphoma-associated antigen 5C (cTAGE5C) plays an important role in vesicle trafficking from the endoplasmic reticulum (ER) to Golgi, and conditional knockout (cKO) of Mea6 in the brain significantly affects neural development and brain function. However, whether the impaired brain function involves the development of oligodendrocytes and white matter beyond neurons remains unclear. In this study, by using different models of diffusion magnetic resonance imaging, we showed that cKO of Mea6 in oligodendrocytes leads to significant impairment of the gross and microstructure of the white matter, as well as a significant decrease of cholesterol and triglycerides in brains. Our lipidomic analysis of purified myelin sheath for the first time showed that Mea6 elimination in oligodendrocytes significantly altered the lipid composition in myelin lipidome, especially the proportion of very long chain fatty acids (VLCFAs). In particular, the levels of most VLCFA-containing phosphatidylcholines were substantially lower in the myelin sheath of the cKO mice. The reduction of VLCFAs is likely due to the downregulated expression of elongation of very long chain fatty acids (ELOVLs). Our study of an animal model with white matter malformation and the comprehensive lipid profiling would provide clues for future studies of the formation of myelin sheath, myelin lipids, and the pathogenesis of white matter diseases.

The Effect of Moringa Oleifera Leaf and Canola Seed Powder on Fattening, Laying Performance, Blood Plasma Constituents, and Microbiota in Japanese Quails

The aim of the study was to investigate the effect of feeding Japanese quail chicks with diets containing different levels of Moringa oleifera leaf and canola seed powder on growth performance, carcass yield, blood plasma constituents, and egg production. The trial lasted for a total of 7 weeks, with 5 weeks of fattening and two weeks of laying. The first group was the control group, while the second group was supplemented with Moringa oleifera leaves (4g/kg diet), the third group was supplemented with canola seed powder (4g/kg diet), the fourth group was supplemented with a mix of Moringa oleifera leaves and canola seed powder (8g/kg diet). The results showed that canola seed powder from 0-3 weeks of age increased body weight in comparison to the control group, but there were no significant differences (p<0.05) among groups in terms of the final body weight and feed conversion ratio. Average daily feed intake was significantly different (p<0.05). However, body weight, carcass weight, liver weight, gizzard weight, and abdominal fat weight increased significantly compared to the control group. Feeding Moringa oleifera leaves and canola seed powder significantly increased the total plasma protein, as compared to the control group. There were significant decreases in cholesterol, triglycerides and HDL levels among groups, with no significant differences in glucose, ALT and LDL among all treatments. The addition of Moringa oleifera leaf and canola seed powder showed significant effects on calcium and magnesium. Both Moringa oleifera leaf and Moringa-canola mixture significantly reduced the presence of some pathogenic bacteria in the digestive system, which was seen as an important contribution to the digestive and immune systems.

Influence of the Oral Administration of Fish Oil on Hematological and Biochemical Performance in Local Male Rabbits.

In some developing countries in Africa, Asia, and Latin America, rapid population growth is a complicated problem, and thus, it is necessary to raise the efficiency of foodstuff production to preserve human life. Therefore, this study was designed to investigate the effect of fish oil supplementation on male rabbits' productivity, as well as their biochemical and physiological characteristics. This experiment was conducted in the Animal House of the College of Veterinary Medicine, University of Baghdad (Baghdad, Iraq) for eight weeks. Twenty-four local male rabbits were randomly divided into three groups (each containing eight rabbits) as follows: the control group that was fed with a basal diet only, the first treated group in which each animal received fish oil orally at a dose of 0.75 ml every day, and another treated group in which each animal received fish oil orally at a dose of 1.5 ml every day. Both treated groups received the treatment for 60 days. Blood samples were collected from cardiac veins by cardiac puncture at the beginning of the experiment (Zero time). On day 60 of the experiment, samples were collected again to analyze potential changes in blood characteristics, including white blood cells count, hemoglobin, and red blood cells count. These blood samples recorded a significant decrease in cholesterol in the two treatment groups, compared to the control. In conclusion, the current findings recommend daily oral administration of fish oil at a dose of 0.75 mg/ml or 1.5 mg/ml to rabbits for 60 days before conception to improve performance trials, as well as biochemical and hematological results. These alterations, however, have a small impact on these features, compared to higher doses administered to rabbits.

Cardio-protective effect of Cocculus hirsutus in experimental hypertension in rats

BackgroundAyurdvedic derived medicines are most promising and effective in the treatment of several cardiovascular diseases. Cocculus hirsutus (CH) has been reported for broad spectrum of activities like anticancer, antidiabetic, antioxidant, cardiotonic and hypotensive etc. ObjectivesThe present study aimed to find the cardio-protective effect of CH in experimental hypertension in rats. Materials and methodsFor acute renal hypertension, CH animals were pre-treated with CH-1 (250 mg/kg) and CH-2 (500 mg/kg) p. o. for 14 days. On the 15th day, hypertension was induced by renal occlusion and the mean arterial blood pressure (MABP) was recorded. For CAL pretreatment of CH-1 and CH-2 was given for 7 days on the 8th day animals were operated on for ligation. The MABP and the time of onset of ventricular tachycardia (VT), premature ventricular systole (PVS) were recorded. For induction of hypercholesterolemia, animals were fed with a high cholesterol diet (CD) with CH-1 and CH-2 for 21 days. The antioxidant potential of CH was done using the assay of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and glutathione peroxidase (GPx). ResultsCH treatment significantly decreases the MABP, the onset of VT and PVS. The histology show intact cardiac muscle with minimum necrosis and inflammation. CH treatment shows significant decrease in cholesterol, triglycerides, and glucose while HDL levels are significantly increased. The aortic section of CH-treated animals shows the intact layers of the artery, normal thickness and restoration of antioxidant enzymatic activity. ConclusionThe study shows significant cardio protective effect of CH in experimental animals.

EFFECT DIFFERENT LEVELS OF TURMERIC ROOT POWDER TO DIET ON SOME TRAITS OF BROILER EXPOSED TO HEAT STRESS

This study was carried out in the poultry field in Jadiriyah, affiliated with the Department of Animal Production / College of Agricultural Engineering Sciences - University of Baghdad. This experiment used 480 one-day-old, unsexed broiler chicks of the broiler breed (Ross-308) with an average weight of 39.8 g to investigate the effect of adding different levels of turmeric root (CURCUMA LONGA) (CURCUMA LONGA) powder to the diet on some characteristics and physiology of commercial broilers exposed to heat stress. Chicks were distributed randomly and equally between 4 treatments (120 chicks/treatment), and each treatment included 3 replicates, at a rate of (40 chicks/repeat). Chicks were fed on the starter, growth and final diet for up to 6 weeks, and at the end of the experiment, at 42 days old, 12 birds were selected from each treatment at a rate of 4/duplicate treatment. The birds were placed in their kennel within an isolated space in the breeding hall and exposed to a temperature of (36-39-42°C) for 3 hours. The results of the experiment showed a significant increase (P &gt; 0.05) in total protein, albumin, globulin and high-density lipoprotein. The results also showed a significant decrease in cholesterol, LDL, VLDL, GOT enzyme level, sodium and potassium concentration, heterophil cells and the ratio (H/L), and turmeric treatments did not show a significant effect on basal, acidic and monocyte blood cells, and the results indicated a significant increase in the values of PCV and HDL cells. White blood, lymphocytes, chlorine concentration, GSH-PX and CAT enzyme levels in the blood. It can be concluded from this study that the addition of turmeric root powder at a rate of 6.5% has a positive effect on improving some physiological characteristics of broilers exposed to heat stress.

Changes in Serum Blood Parameters in Farmed Rainbow Trout (Oncorhynchus mykiss) Fed with Diets Supplemented with Waste Derived from Supercritical Fluid Extraction of Sweet Basil (Ocimum basilicum)

The antimicrobial and immunostimulant proprieties of aromatic plant extracts have been widely described, but their effects on serum blood biochemistry in fish have not. For this study, we assessed the changes in serum blood biochemical parameters in rainbow trout fed with a fish diet supplemented with a basil supercritical extract (F1-BEO). Our hypothesis was that treatment and time would be associated with changes in 10 serum blood biochemical parameters. F1-BEO was added to a commercial feed (0.5, 1, 2, 3% w/w). The fish were fed for 30 days, and the blood samples were collected at 2 time points (15 and 30 days). A two-way ANOVA showed a significant effect of treatment, time, and interaction treatment × time on creatinine, urea, total protein, albumin, magnesium, and phosphorus (p &lt; 0.05), a significant effect of both time and interaction treatment × time on cholesterol (CHOL), glutamic oxaloacetic transaminase (GOT), and glutamic pyruvic transaminase (GPT) levels, and a significant effect of time on triglycerides (p &lt; 0.05). While changes in several of the parameters were observed, the levels remained within the normal range for rainbow trout. Notably, after 30 days there was a significant decrease in CHOL in fish treated with 0.5% and 1% w/w F1-BEO (p &lt; 0.05). The statistically non-significant increase in GOT and GPT in the fish fed with F1-BEO up to 3% w/w indicated a positive effect of basil on liver health. Our findings suggest a potential use for basil extracts (for example., F1-BEO) in fish feed to reduce antibiotic use and improve fish welfare.

Implementation of a self-determination based clinical program to reduce cardiovascular disease risk.

Health behaviors are the cornerstone of cardiovascular risk reduction but change is challenging and maintenance is uncommon. The use of Self-Determination Theory (SDT) can promote long-term change however the pathway is uncertain related to cardiovascular risk reduction. A multi-disciplinary clinical team trained in SDT counseled 294 individuals with high cardiovascular risk. Our participants had a significant decrease in cholesterol as well as a significant increase healthy diet and motivation measures. Autonomous motivation was a critical element in the pathways. We demonstrated that a SDT team-based clinical intervention can promote cardiovascular risk reduction through autonomous motivation.

Effect of Oregostem® and imbalance diet on body performance and reproductive efficiency in male quails

This study was aimed to determine the influence of Oregostem® and imbalance diet on body performance, hematology and spermatogenesis of male quails. A total of 160 birds have been distributed into four groups (40 birds) each with 2 replicates starting at 12 weeks of age, the four treatments includes:(G1) was fed on balanced diet only. (G2) was received a balanced diet with Oregostem® with drinking water. While G3 was fed on imbalance diet (ground yellow corn) and G4 received imbalance diet with Oregostem®. The parameters including body performance, reproduction, blood and biochemical Figure and histology of testes were measured at 4th and 8th weeks from beginning of treatment. The results showed that the supplementation of Oregostem® caused a significant increase in body and right testis weight, gonadosomatic index, sperm count as well as live sperm in G2 relative to other groups at 4th and 8th weeks post treatment. In G3, WBC and lymphocytes decrease significantly with increasing hetrophils percentage and stress index at 4th and 8th weeks post treatment. Also there was a significant decrease of cholesterol with an increase of total protein and creatine kinase in G3 at 8th week of treatment. While the groups treated with Oregostem® did not differ from control group. This study concluded that liquid form of Oregostem® had a positive effect on body weight, sperm count with improvement hematological and biochemical parameters of the male quails.

Study the effect of football sport on lipid profile in footballers in AL-Najaf governorate, Iraq.

The study was conducted on 60 footballers and 30 healthy non-athletes to determine the effect of football on cholesterol, triglycerides, high-density protein lipid, low-density protein lipids, very low-density protein lipids in athletes compared to the non-exercise group. In AL-Najaf province. The results showed a significant decrease in cholesterol , triglycerides , the level of low-density lipoprotein and very low-density lipoprotein( 153.93, 119,89.8,23.8)mg/dl compared with control group (162.9,132.23,102.13,26.493) mg/d but increased levels of high-density protein lipid (54) mg/d compared with control group ( 50) mg/d.