Significant Attenuation Research Articles

Windshear Detection in Rain Using a 30 km Radius Coherent Doppler Wind Lidar at Mega Airport in Plateau

Convective weather is often accompanied by precipitation and windshear, seriously endangering the safety of aircraft during takeoff and landing. However, under rainfall conditions, conventional wind lidars have a limited detection range due to significant signal attenuation. To solve this problem, a 200 mm temperature-controlled telescope coated with a hydrophobic film is applied in the coherent Doppler wind lidar system to improve the detection capability in rain. The maximum detection range of the lidar is extended to 30 km and demonstrated at Kunming Changshui International Airport at an altitude of 2102 m. Firstly, the detection accuracy and maximum detection range of the lidar are verified. Through the analysis of the horizontal wind field under two typical convective weather conditions, it is found that convective weather often accompanies low-level convergence and divergence structures, leading to headwind shear and crosswind shear on the airport runway. From the vertical profile, it is shown that the triggering of convective weather is accompanied by low-level southwest winds and high-altitude northeastern winds. According to the statistics of wind speed and direction on clear and rainy days over 9 months, rainy days are usually caused by the invasion of cold air from Northeast China, resulting in airport windshear. In summary, the enhanced lidar can effectively identify and analyze windshear during rainy days, which is very useful for aviation safety, especially for takeoff and landing in all weather conditions.

Inhalation Delivery of Interferon-λ-Loaded Pulmonary Surfactant Nanoparticles Induces Rapid Antiviral Immune Responses in the Lung.

The interferon-λ (IFN-λ)-regulated innate immune responses in the airway expand our understanding toward antiviral strategies against influenza A virus (IAV). The application of IFN-λ as mucosal antiviral therapeutic is still challenging, and advanced research will be necessary to achieve more efficient delivery of recombinant IFN-λs to the damaged respiratory mucosa. In this study, we examine the capability of IFN-λ to stimulate the innate immune response, promoting the swift elimination of IAV in the lungs. Additionally, we develop IFN-λ-loaded nanoparticles incorporated into pulmonary surfactant for inhalation therapy aimed at treating lung infections caused by IAV. We found that inhaled delivery of IFNλ-PSNPs significantly restricted IAV replication in the lungs from 3 days after infection (dpi), and IAV-caused lung histopathologic findings were completely improved in response to IFNλ-PSNPs. More significant and rapid attenuation of viral RNA was observed in the lung of mice with inhaled delivery of IFNλ-PSNPs compared to mice with recombinant IFN-λs. Inhalation treatment of IFNλ-PSNPs to IAV-infected mice can result in the increase of monocyte frequency in concert with restoration of T and B cells composition. Furthermore, the transcriptional profiles of monocytes shifted toward heightened IFN responses following IFNλ-PSNP treatment. These results imply that IFN-λ could serve as a robust inducer of innate immunity in the lungs against IAV infection, and inhalation of IFN-λs encapsulated in PSNPs effectively resolves lung infections caused by IAV through rapid viral clearance. PSNPs facilitated improved delivery of IFN-λs to the lungs, triggering potent antiviral immune responses upon IAV infection onset.

Propyl gallate induces human pulmonary fibroblast cell death through the regulation of Bax and caspase-3

Propyl gallate (PG) has been found to exert an inhibitory effect on the growth of different cell types, including lung cancer cells. However, little is known about the cytotoxicological effects of PG specifically on normal primary lung cells. The current study examined the cellular effects and cell death resulting from PG treatment in human pulmonary fibroblast (HPF) cells. DNA flow cytometry results demonstrated that PG (100–1,600 μM) had a significant impact on the cell cycle, leading to G1 phase arrest. Notably, 1,600 μM PG slightly increased the number of sub-G1 cells. Additionally, PG (400–1,600 μM) resulted in the initiation of cell death, a process that coincided with a loss of mitochondrial membrane potential (MMP; ΔΨm). This loss of MMP (ΔΨm) was evaluated using a FACS cytometer. In PG-treated HPF cells, inhibitors targeting pan-caspase, caspase-3, caspase-8, and caspase-9 showed no significant impact on the quantity of annexin V-positive and MMP (ΔΨm) loss cells. The administration of siRNA targeting Bax or caspase-3 demonstrated a significant attenuation of PG-induced cell death in HPF cells. However, the use of siRNAs targeting p53, Bcl-2, or caspase-8 did not exhibit any notable effect on cell death. Furthermore, none of the tested MAPK inhibitors, including MEK, c-Jun N-terminal kinase (JNK), and p38, showed any impact on PG-induced cell death or the loss of MMP (ΔΨm) in HPF cells. In conclusion, PG induces G1 phase arrest of the cell cycle and cell death in HPF cells through apoptosis and/or necrosis. The observed HPF cell death is mediated by the modulation of Bax and caspase-3. These findings offer insights into the cytotoxic and molecular effects of PG on normal HPF cells.

Effectiveness of Radiation Transport Variance Reduction Methods for Wide-Area Environmental Contamination Assay Applications

This study compares the accuracy, efficiency, and reliability of variance reduction (VR) methods for Monte Carlo radiation transport simulations involving wide-area ground plane (i.e., “surface”) and buried (i.e., “volumetric”) gamma source emissions from environmental soil. The simulation models are idealized external exposure scenarios intended as a basis for deriving site-specific dose-based or carcinogenic risk–based regulatory limits in the radiological site remediation process. These simulations are computationally resource intensive since particle tracks are transported from an extremely large source region to a relatively small detector region. For each simulation, several VR methods are compared with metrics of accuracy, efficiency, and reliability. The MCNP deterministic transport (DXTRAN) VR method was most effective for problems involving sources emitting low-energy gamma rays, and a coupled multicode method was more effective for problems involving sources emitting higher-energy gamma rays that undergo significant attenuation in the soil.

Nebulized platelet-derived extracellular vesicles attenuate chronic cigarette smoke-induced murine emphysema

Chronic obstructive pulmonary disease (COPD) is a prevalent lung disease usually resulting from cigarette smoking (CS). Cigarette smoking induces oxidative stress, which causes inflammation and alveolar epithelial cell apoptosis and represents a compelling therapeutic target for COPD. Purified human platelet-derived exosome product (PEP) is endowed with antioxidant enzymes and immunomodulatory molecules that mediate tissue repair. In this study, a murine model of CS-induced emphysema was used to determine whether nebulized PEP can influence the development of CS-induced emphysema through the mitigation of oxidative stress and inflammation in the lung. Nebulization of PEP effectively delivered the PEP vesicles into the alveolar region, with evidence of their uptake by type I and type II alveolar epithelial cells and macrophages. Lung function testing and morphometric assessment showed a significant attenuation of CS-induced emphysema in mice treated with nebulized PEP thrice weekly for 4 weeks. Whole lung immuno-oncology RNA sequencing analysis revealed that PEP suppressed several CS-induced cell injuries and inflammatory pathways. Validation of inflammatory cytokines and apoptotic protein expression on the lung tissue revealed that mice treated with PEP had significantly lower levels of S100A8/A9 expressing macrophages, higher levels of CD4+/FOXP3+ Treg cells, and reduced NF-κB activation, inflammatory cytokine production, and apoptotic proteins expression. Further validation using in vitro cell culture showed that pretreatment of alveolar epithelial cells with PEP significantly attenuated CS extract-induced apoptotic cell death. These data show that nebulization of exosomes like PEP can effectively deliver exosome cargo into the lung, mitigate CS-induced emphysema in mice, and suppress oxidative lung injury, inflammation, and apoptotic alveolar epithelial cell death.

Attenuation characteristics of concrete using smart aggregate transducers: Experiments and numerical simulations of P-wave propagation

Concrete is a highly heterogeneous construction material. Waves that propagate through concrete face significant reflection, scattering, and attenuation issues. Understanding the behavior of waves as they propagate through concrete and arrive at a sensor has generated much attention, especially for developing real-world field applications. In this study, a predictive model of attenuated P-wave propagation using Rayleigh damping is presented. The method used frequency excitations ranging from 20 to 200 kHz and smart aggregates (SAs) were embedded in a concrete specimen to excite and receive P-waves. Moreover, 10 distances were marked opposite the exciter at two propagation paths. In the simulations and experiments, signal processing methods were utilized to extract the first arrival packet for calculating amplitude attenuation. The P-wave damping coefficient was modeled using the multi-physical finite element method, and the results of the predictive model were compared with the experimental results. A discussion on the utilization of frequency-dependent attenuation coefficients was conducted to explore potential P-wave attenuation factors and their respective contributions to the overall attenuation. Numerical studies have demonstrated a strong correlation with the experiments when an appropriate level of material damping coefficient was considered. By enhancing the overall comprehension of the P-wave damping coefficient and attenuation characteristics within concrete, damage detection techniques based on P-waves can be improved.

Adaptive sliding mode control for vibration reduction on UAV carrying a payload

Unmanned aerial vehicles (UAVs) have been used to transport a variety of payloads, including medical materials, foods, and different electronic devices. This type of innovation generates important concerns regarding payload integrity, mainly when involving medical goods that can be affected by vibration. This paper presents the flight dynamics of suspended payload carried by an UAV, considering a flexible attachment between a quadrotor and its payload. Adaptive sliding mode control (ASMC) is proposed to enhance the trajectory tracking and consequently minimize the payload vibration. Adaptive coefficients are introduced to compensate the payload dynamics and uncertainties, which are computed for each proposed trajectory and cargo mass. The proposed adaptive control can efficiently compensate the extra dynamics and uncertainties caused by the attached payload, regardless of the chosen trajectory and weight of the cargo. A root mean square–based index is used to quantitatively evaluate the oscillations. The results show a significant attenuation of the undesired oscillations up to 27%, when the adaptive control is used. Therefore, the use of the proposed ASMC aims to guarantee an improved trajectory tracking and the attenuation of residual oscillations on the main state variables, allowing to be safely employed for transporting several types of medicines, including those sensitive to vibration and those that are dropped during a flight.

The protective effect of Enteromorpha prolifera polysaccharide on alcoholic liver injury in C57BL/6 mice

An alcohol-induced liver injury model was induced in C57BL/6 mice to assess the protective efficacy of Enteromorpha prolifera polysaccharides (EP) against liver damage. Histological alterations in the liver were examined following hematoxylin-eosin (H&E) staining. Biochemical assay kits and ELISA kits were employed to analyze serum and liver biochemical parameters, as well as the activity of antioxidant enzymes and alcohol metabolism-related enzymes. The presence of oxidative stress-related proteins in the liver was detected using western blotting. Liquid chromatography and mass spectrometry were used to profile serum metabolites in mice. The findings demonstrated that EP-H (100 mg/Kg) reduced serum ALT and AST activity by 2.31-fold and 2.32-fold, respectively, when compared to the alcohol-induced liver injury group. H&E staining revealed a significant attenuation of microvesicular steatosis and ballooning pathology in the EP-H group compared to the model group. EP administration was found to enhance alcohol metabolism by regulating metabolite-related enzymes (ADH and ALDH) and decreasing CYP2E1 expression. EP also modulated the Nrf2/HO-1 signaling pathway to bolster hepatic antioxidant capacity. Furthermore, EP restored the levels of lipid metabolites (Glycine, Butanoyl-CoA, and Acetyl-CoA) to normalcy. In summary, EP confers protection to the liver through the regulation of antioxidant activity and lipid metabolites in the murine liver.

Experimental study on the flow-induced vibrations of a circular cylinder with a rear flexibly hinged splitter plate

The flow around a circular cylinder is a canonical configuration that may be encountered in many engineering applications, as for instance, civil engineering, architecture, or marine structures. In particular, when bluff bodies are slender and feature low mass-damping characteristics, they may undergo flow-induced vibrations (FIVs), which may result in severe structural fatigue and damage. Here, we present an experimental study on the effect of flexibly hinged splitter plates in the FIV of a flexibly mounted circular cylinder (of diameter D) subject to an uniform cross-flow of velocity u∞. The dynamic response and forcing of the low mass-damping system is characterized for plates of different lengths Lp and different values of the torsional stiffness of the hinge kp. Reductions of the dynamic response of more than 90% can be generally reached at the upper branch, especially when a plate of length l*=Lp/D=2 with intermediate degree of torsional stiffness is attached, which is shown to represent the best solution as it mitigates the oscillations of the system (cylinder and plate) for the whole range investigated of reduced velocity U*=u∞/fnD=[3.9,9.8], where fn is the natural frequency of oscillation. In general, the hinged plates are able to attenuate the vortex-induced vibration system response by increasing shedding frequency, until the ratio f*=f/fn>1 is reached. At high values of U*, a general transition to galloping-like dynamics, characterized by f*<1, occurs. The tested hinged plates modify the transition between regimes, which is associated with shifts in the phase difference between the forcing and response, combining features of the dynamics of both flexible and static rigid plates already reported in the literature. The use of hinged plates has been proven to provide with a significant attenuation of the system response and its associated drag, a feature that can be considered of practical relevance in many engineering applications. In addition, the key aspects for designing these elements as the torsional stiffness and plate length have been analyzed here.

Oleuropein, a phenolic component of Olea europaea L. ameliorates CCl4-induced liver injury in rats through the regulation of oxidative stress and inflammation.

This study aimed to assess the hepatoprotective role of oleuropein (Olp), a phenolic compound found in olive, against carbon tetrachloride (CCl4)-induced liver damage in rats. The research involved male albino rats, which received intraperitoneal injections of 100 mg/kg b.w. of oleuropein for 8 consecutive weeks before being subjected to carbon tetrachloride (CCl4) at a dosage of 1.0 ml/kg b.w. Changes induced by CCl4 in antioxidant and inflammatory marker levels were assessed using ELISA assay kits. Moreover, CCl4-induced liver tissue architecture alteration, fibrosis, and expression pattern of protein were evaluated by performing H&E, Sirius red, Masson trichrome, and immunohistochemistry staining. Increased serum transaminases and massive hepatic damage were observed by this liver toxicant. The hepatic injury was further evidenced by a significant decrease in antioxidant enzyme activity [superoxide dismutase (SOD), glutathione peroxidase (GPx), Glutathione (GSH) and Total Antioxidant Capacity (T-AOC)]. The administration of CCl4 resulted in an increased inflammatory response, which was measured by C-reactive protein, interleukin-6, as well as tumor necrosis factor-alpha. Olp as a curative regimen led to significant attenuation in the inflammatory response and oxidative/nitrosative stress. This polyphenol treatment improved the hepatic tissue architecture and decreased fibrosis. In the CCl4 treatment group, the expression pattern of IL-6 protein was high, whereas expression was decreased after Olp, as evidenced by immunohistochemistry staining. The study suggests that oleuropein treatment has the potential to reduce liver damage caused by CCl4 induction by inhibiting oxidative stress and inflammation and maintaining liver tissue architecture. This could make it a promising treatment option for liver pathogenesis.

Inhibition of PDE-4 isoenzyme attenuates frequency and overall contractility of agonist-evoked ureteral phasic contractions.

The aim of this study was to investigate the functional role of phosphodiesterase enzymes (PDE) in the isolated porcine ureter. Distal ureteral strips were mounted in organ baths and pre-contracted with 5-HT (100 μM). Upon generation of stable phasic contractions, PDE-4 and PDE-5 inhibitors were added cumulatively to separate tissues. PDE-4 inhibitors, such as rolipram (10 nM and greater) and roflumilast (100 nM and greater), resulted in significant attenuation of ureteral contractile responses, while a higher concentration of piclamilast (1 μM and greater) was required to induce a significant depressant effect. The attenuation effect by rolipram was abolished by SQ22536 (100 μM). PDE-5 inhibitors, such as sildenafil and tadalafil, were not nearly as effective and were only able to suppress the 5-HT-induced contractions at higher concentrations of 1 μM. Rolipram significantly enhanced the depressant effect of forskolin, while sodium nitroprusside-induced attenuation of contractile responses remained unchanged in the presence of tadalafil. In summary, our study demonstrates that PDE-4 inhibitors are effective in attenuating 5-HT-induced contractility in porcine distal ureteral tissues, while PDE-5 inhibitors are less effective. These findings suggest that PDE-4 inhibitors, such as rolipram, may hold promise as potential therapeutic agents for the treatment of ureteral disorders attributable to increased intra-ureteral pressure.

Fabrication of MoSe2/Bi3O4Br Z-scheme heterojunction with enhanced photocatalytic performance

Exploring a Z-scheme heterojunction photocatalyst with efficient charge separation and outstanding redox ability is necessary but very challenging. MoSe2 has received much attention as a co-catalyst due to its excellent optical properties. Herein, First-principles density functional theory (DFT) was employed for theoretical calculations of the energy band structure of Bi3O4Br, revealing crossed energy band structures with MoSe2, indicating favorable conditions for heterojunction formation. A solvothermal method was then used to synthesize MoSe2/Bi3O4Br heterostructure photocatalysts with a 2D/2D layered configuration. Characterization via SEM, TEM, DRS, XPS, BET, EIS, and PL confirmed that the MoSe2/Bi3O4Br heterostructure exhibited a larger specific surface area, more active sites, lower impedance, and reduced carrier recombination rate compared to pure Bi3O4Br and MoSe2. These features are advantageous for photocatalytic reactions. The optimized 2.5% MoSe2/Bi3O4Br photocatalyst demonstrated superior performance, achieving nearly 100% photodegradation of RhB under 90 min of simulated sunlight, with an apparent rate constant k value 7.57 times higher than that of Bi3O4Br. The composite photocatalyst exhibited excellent cycling stability over five experiments without significant reactivity attenuation. Finally, a plausible Z-scheme photocatalytic mechanism for MoSe2/Bi3O4Br heterojunctions is proposed based on experimental findings. This study provides new insights for exploring the construction of wide-band semiconductor heterojunctions.

Streptococcal arginine deiminase system defences macrophage bactericidal effect mediated by XRE family protein XtrSs

ABSTRACT The arginine deiminase system (ADS) has been identified in various bacteria and functions to supplement energy production and enhance biological adaptability. The current understanding of the regulatory mechanism of ADS and its effect on bacterial pathogenesis is still limited. Here, we found that the XRE family transcriptional regulator XtrSs negatively affected Streptococcus suis virulence and significantly repressed ADS transcription when the bacteria were incubated in blood. Electrophoretic mobility shift (EMSA) and lacZ fusion assays further showed that XtrSs directly bind to the promoter of ArgR, an acknowledged positive regulator of bacterial ADS, to repress ArgR transcription. Moreover, we provided compelling evidence that S. suis could utilize arginine via ADS to adapt to acid stress, while ΔxtrSs enhanced this acid resistance by upregulating the ADS operon. Moreover, whole ADS-knockout S. suis increased arginine and antimicrobial NO in the infected macrophage cells, decreased intracellular survival, and even caused significant attenuation of bacterial virulence in a mouse infection model, while ΔxtrSs consistently presented the opposite results. Our experiments identified a novel ADS regulatory mechanism in S. suis, whereby XtrSs regulated ADS to modulate NO content in macrophages, promoting S. suis intracellular survival. Meanwhile, our findings provide a new perspective on how Streptococci evade the host’s innate immune system.

Interleukin 17A Contributes to Blood-Brain Barrier Disruption of Hypothalamic Paraventricular Nucleus in Rats With Myocardial Infarction.

Elevated inflammatory cytokines in the periphery have been identified as active contributors to neuroinflammation and sympathetic overactivity in heart failure (HF). Yet, the exact mechanisms by which these cytokines breach the blood-brain barrier (BBB) to exert their effects on the brain remain elusive. Interleukin 17A has been linked to BBB disruption in various neurologic disorders, and its levels were significantly augmented in circulation and the brain in HF. The present study aimed to determine whether the BBB integrity was compromised within the hypothalamic paraventricular nucleus (PVN), and if so, whether interleukin 17A contributes to BBB disruption in myocardial infarction-induced HF. Male Sprague-Dawley rats underwent coronary artery ligation to induce HF or sham surgery. Some HF rats received bilateral PVN microinjections of an interleukin 17 receptor A small interfering RNA or a scrambled small interfering RNA adeno-associated virus. Four weeks after coronary artery ligation, the permeability of the BBB was evaluated by intracarotid injection of fluorescent dyes (fluorescein isothiocyanate-dextran 10 kDa+rhodamine-dextran 70 kDa). Compared with sham-operated rats, HF rats exhibited an elevated extravasation of fluorescein isothiocyanate-dextran 10 kDa within the PVN but not in the brain cortex. The plasma interleukin 17A levels were positively correlated with fluorescein isothiocyanate 10 kDa extravasation in the PVN. The expression of caveolin-1, a transcytosis marker, was augmented, whereas the expression of tight junction proteins was diminished in HF rats. Interleukin 17 receptor A was identified within the endothelium of PVN microvessels. Treatment with interleukin 17 receptor A small interfering RNA led to a significant attenuation of fluorescein isothiocyanate 10 kDa extravasation in the PVN and reversed expression of caveolin-1 and tight junction-associated proteins in the PVN. Collectively, these data indicate that BBB permeability within the PVN is enhanced in HF and is likely attributable to increased interleukin 17A/interleukin 17 receptor A signaling in the BBB endothelium, by promoting caveolar transcytosis and degradation of tight junction complexes.

Individual investor trading and stock returns after the Covid-19 pandemic: Evidence from Korea

This paper reveals a significant attenuation in the previously observed positive association between individual investors’ purchases and stock returns following the Covid-19 pandemic. To investigate these changes, I utilize a comprehensive dataset of daily stock transactions, categorized by investor groups, from the Korean main board market. By employing a difference-in-difference regression model, I find that stocks influenced by the influx of amateur investors or attention-based trading post-pandemic are the key drivers behind this transformation. These findings suggest that policymakers might need to consider implementing systematic liquidity provision programs, such as market-making activities, to fill the liquidity gap created by individual investors.

Effect of physical activity on the relationship between adiposity and cardiac autonomic modulation in female breast cancer survivors: a longitudinal study

ABSTRACT This longitudinal study aimed to analyze the influence of physical activity (PA) on the relationship between body adiposity and cardiac autonomic modulation (CAM) in women survivors of breast cancer. We collected body adiposity through electrical bioimpedance considering body fat percentage (BFP), CAM through heart rate variability (considering RMSSD, SDNN, PNN50, LF (m2), HF (m2), SD1 indexes and SD1/SD2 ratio) and PA through a questionnaire in 64 participants (58.0 ± 9.6 years), recruited through the local association of support for breast cancer and by direct indications from city mastologists. After insertion of PA into the multivariate statistical model, significant attenuation was observed in the relationship between body adiposity and CAM for the indices: SDNN (β = −0.94; 95 percent CI: −1.93; 0.04; p = .060) and SD1/SD2 (β = −0.01;95 percent CI = −0.02; 0.001; p = .065). In conclusion, it was observed that PA was able to mitigate the relationships between BFP and CAM (considering SDNN index and SD1/SD2 ratio) in breast cancer survivors.

Modulating microwave attributes of Ba1−xSrxTiO3 nanoparticles: Insights into strontium concentration, structural intricacies and electromagnetic dynamics

In this pioneering investigation, we meticulously synthesized Ba1−xSrxTiO3 nanoparticles, with Sr concentrations varying between 0.0 and 0.4 at intervals of 0.1, via a refined chemical approach. The crux of our study lies in establishing the intricate correlations between the chemical constitution (primarily Sr concentration), salient structural attributes (encompassing lattice and microstructural parameters), electrical dynamics and consequential microwave characteristics. X-ray diffraction (XRD) analyses reinforced the unity between the average ionic radii of the Ba/Sr ions and the lattice constants. Scanning electron spectroscopy (SEM) furnished insights into the microstructural intricacies, while the nominal chemical composition was ascertained via energy-dispersive X-ray (EDX) spectroscopy. A deep dive into the electrical realm revealed the temperature and field-dependent behaviors of permittivity, tangent losses and polarization. The electromagnetic traits of Ba1−xSrxTiO3 (where 0.0 < x < 0.4) were meticulously delineated by analyzing the experimentally determined S-parameters across a frequency spectrum of 6 to 18 GHz. Our findings elucidate that the predominant losses of electromagnetic wave energy are attributable to aggregated electrical losses, predominantly steered by polarization processes. Our findings demonstrate a significant attenuation in the reflected wave energy, with values spanning from − 14.3 to − 17.1 dB, highlighting the potential of these nanoparticles for cutting-edge applications in electromagnetic interference mitigation.

Guest‐Facilitated Heteroleptic Assembly of Helical Anionocages Enables Reversible Chirality Modulation

AbstractWe report a novel strategy for reversible modulation of the supramolecular chirality based on guest‐facilitated heteroleptic assembly of helical anionocages. Two triple‐stranded helical anionocages including a chiral cage 1 (A2L13) and a crown ether functionalized achiral cage 2 (A2L23) were synthesized by anion coordination of bis‐monourea‐based ligands and PhPO32−. Both cages exhibited favorable binding with tetraethylammonium TEA+ and cobaltocenium Cob+ (endo‐guest, bound in the cavity). Additionally, cage 2 could reversibly release and recapture the guests through binding the exo‐guest potassium ions (K+) in the crown ethers and subsequent removal of the K+ by [2,2,2]‐cryptand. The circular dichroism (CD) spectrum of cage 1 was not significantly affected by guest encapsulation or mixing with the “empty” cage 2. However, in the presence of both cage 2 and an endo‐guest/exo‐guest, the Cotton effects were reversed at 391 nm and significantly enhanced at 310 nm. This observation was attributed to the guest‐facilitated formation of heteroleptic cages that enabled effective chirality transfer from the chiral to the achiral ligands. The CD changes induced by K+ could be fully reversed by removing it with [2,2,2]‐cryptand. Sequential addition and removal of K+ allowed reversible modulation of the chirality for at least 10 cycles without significant attenuation.

Guest-Facilitated Heteroleptic Assembly of Helical Anionocages Enables Reversible Chirality Modulation.

We report a novel strategy for reversible modulation of the supramolecular chirality based on guest-facilitated heteroleptic assembly of helical anionocages. Two triple-stranded helical anionocages including a chiral cage 1 (A2 L1 3 ) and a crown ether functionalized achiral cage 2 (A2 L2 3 ) were synthesized by anion coordination of bis-monourea-based ligands and PhPO3 2- . Both cages exhibited favorable binding with tetraethylammonium TEA+ and cobaltocenium Cob+ (endo-guest, bound in the cavity). Additionally, cage 2 could reversibly release and recapture the guests through binding the exo-guest potassium ions (K+ ) in the crown ethers and subsequent removal of the K+ by [2,2,2]-cryptand. The circular dichroism (CD) spectrum of cage 1 was not significantly affected by guest encapsulation or mixing with the "empty" cage 2. However, in the presence of both cage 2 and an endo-guest/exo-guest, the Cotton effects were reversed at 391 nm and significantly enhanced at 310 nm. This observation was attributed to the guest-facilitated formation of heteroleptic cages that enabled effective chirality transfer from the chiral to the achiral ligands. The CD changes induced by K+ could be fully reversed by removing it with [2,2,2]-cryptand. Sequential addition and removal of K+ allowed reversible modulation of the chirality for at least 10 cycles without significant attenuation.

A novel programmed hybrid modulation for electromagnetic interference mitigation and current ripple control in miniaturised synchronous machine drives

AbstractA novel programmed hybrid spreading spectrum modulation method to mitigate electromagnetic interference (EMI) emission and bearing current in the context of miniaturised and lightweight synchronous machine drives is proposed. The proposed method adopts the combination of conventional pulsewidth modulation (PWM) and low common mode voltage PWM. The offline look‐up table for switching frequency is acquired by analysing the root mean square voltage values at different modulation indices and angles. By adjusting the switching frequency according to this table, the spectrum can be spread into the sidebands of the switching frequency, and the harmonic spike can be suppressed. To address the challenge of increased current ripple and harmonic distortion in high torque density motors under overload conditions, a motor model that considers the cross‐saturation and slotting effect is presented. This motor model is used to derive the switching frequency correction factors, aiming to mitigate the influence of saturation and slotting effect on harmonic amplification. The proposed method is well‐suited for controlling synchronous motors using three‐phase two‐level voltage source inverters. The simulation and experimental results validate the effectiveness of the proposed method, showcasing its advantages in terms of computational complexity reduction and significant attenuation of peak EMI currents.