Significance Of Serum C-reactive Protein Research Articles

The Significance of Serum C-Reactive Protein and Neutrophil-Lymphocyte Ratio in Predicting the Diagnostic Outcomes of Renal Mass Biopsy Procedure.

This study aimed to investigate the predictive role of serum C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR) on renal mass biopsy outcomes. A total of 71 patients with suspected kidney masses who underwent renal mass biopsy procedure between January 2017 and January 2021 were retrospectively evaluated. Pathological results after the procedure were obtained and pre-procedural serum CRP and NLR levels were extracted from the patients' data. The patients were grouped into benign and malignant pathology groups according to the histopathology results. The parameters were compared between the groups. Diagnostic role of the parameters in terms of sensitivity, specificity, and positive and negative predictive values was also determined. Additionally, Pearson correlation analysis, and univariate and multivariate cox proportional hazard regression analyses were also performed to investigate the above association with tumor diameter and pathology results, respectively. At the end of the analyses, a total of 60 patients had malignant pathology on histopathological investigations of the mass biopsy specimens, whereas the remaining 11 patients had a benign pathological diagnosis. Significantly higher CRP and NLR levels were detected in the malignant pathology group. The parameters positively correlated with the malignant mass diameter, as well. Serum CRP and NLR determined the malignant masses before the biopsy with sensitivity and specificity of 76.6 and 81.8%, and 88.3 and 45.4%, respectively. Moreover, univariate and multivariate analyses showed that serum CRP level had a significant predictive value for malignant pathology (HR: 0.998, 95% CI: 0.940-0.967, P < 0.001 and HR: 0.951, 95% CI: 0.936-0.966, P < 0.001, respectively). In conclusion, serum CRP and NLR levels were significantly different in patients with malignant pathology after renal mass biopsy compared to the patients with benign pathology. Serum CRP level, in particular, diagnosed malignant pathologies with acceptable sensitivity and specificity values. Additionally, it had a substantial predictive role in determining the malign masses prior the biopsy. Therefore, pre-biopsy serum CRP and NLR levels may be used to predict the diagnostic outcomes of renal mass biopsy in clinical practice. Further studies with larger cohorts can prove our findings in the future.

Changes in Serum CRP and PCT Levels in Patients with Acute Simple Lower Urinary Tract Infection and Evaluation of the Efficacy of Treatment with Shuangdong Capsules.

Objective The aim of this study is to investigate the changes and significance of serum C-reactive protein (CRP) and procalcitonin (PCT) levels in patients with acute simple lower urinary tract infection (ALUTI) and to analyze the efficacy of treatment with Shuangdong capsules, so as to provide a basis for the rational clinical application of drugs. Methods 92 patients with ALUTI (observation group) were randomly divided into 46 cases each in group A and group B. Group A was treated with basic anti-infective drugs, while group B was treated with Shuangdong capsules, and the duration of treatment in both groups was 14 days. The curative effect of the two groups was analyzed, and the changes in serum PCT and CRP levels were compared before and after treatment and compared with 40 healthy people in the control group. Results The serum PCT and CRP levels, the number of urinary leukocyte count (LEU), and the number of urinary bacterial count (BACT) were significantly higher in Group A and Group B than in the healthy control group before treatment (P < 0.05). After treatment, the total clinical efficiency of patients in group B (97.83%) was significantly higher than that in group A (78.26%) (P < 0.05). The serum PCT and CRP levels, the number of urinary LEU, and the number of urinary BACT decreased in both groups after treatment compared with those before treatment, and all of them were significantly lower in group B than in group A (P < 0.05). The area under the curve (AUC) values of serum PCT and CRP levels for the diagnosis of acute simple lower urinary tract infection were 0.747 (95% CI 0.633–0.860) and 0.926 (95% CI 0.870∼0.982), both with high sensitivity and specificity. Conclusion The Shuangdong capsule combined with conventional antibacterial drugs has better clinical efficacy in the treatment of acute simple lower urinary tract infection; serum CRP and PCT levels in patients with acute simple lower urinary tract infection can be used as indicators for diagnosis and efficacy determination of the infection.

Serum procalcitonin and C-reactive protein concentrations in dogs with degenerative mitral valve disease and infective endocarditis

This study aimed to investigate the clinical significance of serum C-reactive protein (CRP) and procalcitonin (PCT) concentrations in dogs with degenerative mitral valve disease (DMVD) and infective endocarditis. It also aimed to evaluate whether there is a relationship between the degree of disease and serum PCT and CRP concentrations. A total of 100 dogs with MVD were prospectively recruited into the study. According to clinical/laboratory signs and echocardiography, the dogs were divided into infective and degenerative groups. The degenerative group was also classified into four stages based on the American College of Veterinary Internal Medicine (ACVIM) guidelines (Stages A-D). Serum PCT and CRP concentrations were determined with dog-specific commercial test kits. The serum CRP (P&lt;0.05) and PCT (P&lt;0.001) concentrations in the infective group were significantly higher than the degenerative group. In the degenerative group, the serum CRP concentration of stage D dogs was significantly higher than the other stages (P&lt;0.001), and the degree of disease correlated significantly positively with serum CRP concentration (r=0.531 P=0.000). In conclusion, serum CRP and PCT concentrations may aid traditional diagnostic techniques to differentiate infective and degenerative mitral valve disease. This study also demonstrated that serum CRP concentrations were elevated in Stage D dogs, and that there is a positive correlation between the degree of disease and serum CRP concentration. This can be useful in determining the severity of the inflammatory state in dogs with DMVD.

Significance of Serum C-Reactive Protein in Assessing the Severity of Covid Illness Among Vaccinated and Non-Vaccinated Individuals

C-reactive protein (CRP) is a protein produced by the liver. CRP levels in the blood, rises when there is an inflammatory condition in the body. A CRP test determines the amount of CRP in the blood to detect inflammation caused by acute conditions or to monitor disease severity in chronic conditions. Covid – 19 is an inflammatory condition, and an increase in CRP level helps in assessing the severity of covid illness. Our aim is to compare the severity of covid illness between the vaccinated and non-vaccinated individuals by estimating the CRP level. This is a cross-sectional study that included 100 Covid positive patients who were clinically diagnosed with fever at Sree Balaji Medical College and Hospital and were randomly selected (both vaccinated and unvaccinated) for the study. The level of serum C-Reactive Protein was estimated in all covid positive patients using the latex agglutination method. Of the 100 covid positive patients, 30 were vaccinated and 70 were not, with 8 vaccinated and 63 non-vaccinated individuals hospitalized due to increased severity. Only 27% of vaccinated people had elevated CRP levels, whereas up to 90% of non-vaccinated people had elevated CRP levels, emphasizing the importance of vaccination in reducing the severity of covid-19 infection. From this study, it was concluded that it is mandatory to estimate CRP level in covid- 19 patients as it is an inflammatory marker to assess the severity of the infection in them. Consequently, it is found that vaccines play an important role in reducing the severity of covid infection (as inflammation is reduced)

Increased serum C-reactive protein levels are associated with shorter survival and development of second cancers in chronic lymphocytic leukemia

Background: Chronic lymphocytic leukemia (CLL) is characterized by a heterogeneous clinical course, ranging from stable to more aggressive disease. Herein, we determined the prognostic significance of serum C-reactive protein (CRP) levels in patients with CLLMethods: A retrospective cohort study reviewing the records of 107 consecutive treatment naïve patients with CLL and a control group comprised of apparently healthy individuals attending for periodic health examinations.Results: The median CRP level of patients with CLL was 0.19 mg/dL (0–2.9). In univariate analysis, high-CRP levels (≥0.4 mg/dL) were significantly associated with an increased risk of mortality (HR = 3.97, 95%CI 1.64–9.62, p = .002) and development of second solid cancers (HR = 4.54, 95%CI 1.57–13.11, p = .005), compared to low-CRP values (<0.4 mg/dL). In multivariate analysis, high-CRP retained statistical significance for all-cause mortality (HR = 2.81, 95%CI 1.04–7.57, p = .04) and the development of second solid malignancies (HR = 4.54, 95%CI 1.57–13.11, p = .005). Moreover, when compared to an apparently healthy population, CLL patients with high CRP levels had more than an eightfold risk of cancer.Conclusions: Elevated baseline CRP levels are associated with shorter survival and development of second cancers in patients with CLL. We suggest that increased CRP in patients with CLL may justify a more rigorous search for second cancers.KEY MESSAGESElevated CRP levels are associated with a shorter overall survival in CLL.Elevated CRP levels are associated with an increased risk of second cancers in CLL.Increased CRP in patients with CLL may justify a more rigorous search for second cancers.

Prognostic significance of serum C-reactive protein in diffuse large B-cell lymphoma

Objective To investigate the prognostic significance of serum C-reactive protein (CRP) in diffuse large B-cell lymphoma (DLBCL). Methods 106 cases of newly diagnosed DLBCL patients with average age of 55.23 years old were analyzed retrospectively. Determine the level of serum CRP and other factors, including tumour stage, revised Internation Prognostic Index (R-IPI) before the treatment. After median follow-up of 62 months, the relationships between serum CRP and overall survival (OS) and event-free survival (EFS) were observed. Results 106 DLBCL patients were divided into 4 Ann Arbor stages. Median serum CRP levels significantly increased in higher Ann Arbor stages [stage Ⅰ (9.49±2.73) mg/L, stage Ⅱ (14.96±2.60) mg/L, stage Ⅲ (22.03±3.39) mg/L, stage Ⅳ (28.96±4.56) mg/L] (all P 0.05), sex (r= 0.085, P > 0.05). The patients with serum CRP levels >19.0 mg/L had shorter 5-year ESF and OS than patients with serum CRP levels ≤19.0 mg/L(P < 0.05). Univariate and multivariate Cox regression models showed that old age, high R-IPI score and high CRP level were independent adverse prognostic factors. Conclusion In DLBCL patients,high CRP level not only reflects tumor burded, but also delivers prognostic information. Key words: Lymphoma, large B-cell, diffuse; Serum C-reactive protein; Prognosis

GW26-e2337 Clinical significance of serum C-reactive protein and blood homocysteine detection in patients with coronary heart disease

GW26-e2337 Clinical significance of serum C-reactive protein and blood homocysteine detection in patients with coronary heart disease

Ten Commandments of Interpreting and Applying Results of Biomarker Research

Prognostic and diagnostic capabilities of a biomarker are ‘two sides of the same coin’ in medicine. For instance, serum troponin is very useful in diagnosing acute myocardial infarction and, at the same time, the peak concentrations of serum troponin are also useful in assessing the prognosis of both ST-elevation myocardial infarction (STEMI) and non-STEMI1. In this issue of the Journal, we have two interesting studies on prognostic significance of serum C-reactive protein (CRP) or lactate concentrations in critically ill patients2,3, and they conclude that these non-specific biomarkers may be useful to predict mortality of critically ill patients.

Change in serum proteome during allogeneic hematopoietic stem cell transplantation and clinical significance of serum C-reactive protein and haptoglobin

Successful hematopoietic stem cell transplantation (HSCT) involves the restoration of hematopoietic function after engraftment, arising from the differentiation and proliferation of hematopoietic stem cells. Several factors could influence the course of allogeneic-HSCT (allo-HSCT). Therefore, knowledge of serum proteome changes during the allo-HSCT period might increase the efficacy of diagnosis and disease prevention efforts. This study conducted proteomic analyses to find proteins that were significantly altered in response to allo-HSCT. Sera from five representative patients who underwent allo-HSCT were analyzed by 2-dimensional gel electrophoresis and liquid chromatography tandem mass spectrometry, and were measured on a weekly basis before and after allo-HSCT in additional 78 patients. Fourteen protein spots showing changes in expression were further examined, and most proteins were identified as acute phase proteins (APPs). Studies of 78 additional patients confirmed that C-reactive protein (CRP) and haptoglobin undergo expression changes during allo-HSCT and thus may have the potential to serve as representative markers of clinical events after allo-HSCT. Maximal CRP level affected the development of major transplant-related complications (MTCs) and other problems such as fever of unknown origin. Particularly, an increase in CRP level 21 days after allo-HSCT was found to be an independent risk factor for MTC. Maximal haptoglobin and haptoglobin level 14 days after allo-HSCT were predictive of relapses in underlying hematologic disease. Our results indicated that CRP and haptoglobin were significantly expressed during allo-HSCT, and suggest that their level can be monitored after allo-HSCT to assess the risks of early transplant-related complications and relapse.

Changes in Serum Protein Profiles During Allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT): Clinical Significance of Serum C-Reactive Protein and Haptoglobin Levels.

Abstract 4658 BackgroundSuccessful hematopoietic stem cell transplantation involves the restoration of hematopoietic function after engraftment, arising from the differentiation and proliferation of hematopoietic stem cells. Several factors influence the course of allo-HSCT. In particular, knowledge of serum proteome changes during the allo-HSCT period might increase the efficacy of diagnosis and disease prevention efforts. MethodThe sera from five representative patients who underwent allo-HSCT were analyzed by 2-DE and LC-MS/MS. To verify the clinical significance of identified serum proteome, we assessed the representative APPs, C-reactive protein (CRP) and haptoglobin in 78 patients who underwent allo-HSCT at Chonnam National University Hospital (CNUH) who were included between June 2002 and April 2008. Serum level of CRP and haptoglobin were measured weekly from D-7 or D-0 to D+21 of allo-HSCT. ResultFourteen proteins showing significant changes in expression were further examined, and most were identified as APPs. Studies of 78 additional patients confirmed that CRP and haptoglobin undergo expression changes during allo-HSCT and thus have the potential to serve as representative markers of various hematologic diseases. Maximal CRP level affected the development of MTCs and other problems, FUO. In particular, an increase in CRP level 21 days after allo-HSCT was found to be an independent risk factor for MTC. Maximal haptoglobin and haptoglobin level 14 days after allo-HSCT were predictive of relapses in underlying hematologic disease. ConclusionOur results reveal the usefulness of a proteomic approach in the clinical follow-up of patients after allo-HSCT, and suggest that CRP and haptoglobin can be monitored after allo-HSCT to assess risks of early transplant-related complications and relapse. Disclosures:No relevant conflicts of interest to declare.

Clinical significance of serum C-reactive protein in patients with cerebral infarction

目的 探讨急性脑梗死患者血清C反应蛋白(CPR)浓度变化及对其预后的影响.方法对85例脑梗死患者、26例腔隙性脑梗死患者和30名健康体检者(对照组)进行血清CPR含量检测,计算异常率,并按照脑梗死患者临床神经功能缺损程度评分(CNFDS)标准进行评分.结果脑梗死组CRP含量高于腔隙性脑梗死组,腔隙性脑梗死组高于对照组(P均＜0.05).脑梗死组CRP异常率高于腔隙性脑梗死组.CRP异常的患者CNFDS评分的改善低于CRP正常组,且CRP异常者预后中无变化和死亡率明显高于正常对照组.结论 CRP水平是反映脑梗死预后的一个重要标志物。

Serum C-reactive protein elevation predicts poor clinical outcome in patients with distal type acute aortic dissection: association with the occurrence of oxygenation impairment

Background Acute aortic dissection (AAD) is sometimes complicated by respiratory failure due to severe lung oxygenation impairment. Systemic activation of inflammatory system after aortic injury may play some roles in the development of this complication. The aim of this study was to determine the significance of serum C-reactive protein (CRP) elevation in the development of oxygenation impairment and clinical outcome with distal type AAD. Methods and results A total of 61 patients, who were admitted with distal type AAD within 24 h from the onset, were examined. Serum CRP levels, white blood cell (WBC) counts and body temperature were measured serially for at least 4 days. Oxygenation impairment, defined as the lowest PaO 2/FIO 2 ratio ≤200 mmHg, was noted in 31 patients (51%). In patients with oxygenation impairment, peak CRP levels (20.7±7.9 vs. 12.7±3.8 mg/dl, P<0.001), peak WBC counts (14,600±3600 vs. 11,800±4300/mm 3, P=0.008) and body temperature (38.4±0.5 vs. 38.0±0.6 °C, P=0.004) were significantly higher than those without. Peak CRP level was inversely correlated with the lowest PaO 2/FIO 2 ( P<0.001). Patients who underwent urgent surgical treatment and/or died in the hospital had higher peak CRP levels (25.1±12.3 vs. 16.1±7.4 mg/dl, P=0.010) than those who did not. Multivariate analysis revealed that a peak CRP level ≥15 mg/dl (relative risk=12.6, P<0.001) was an independent determinant of the development of oxygenation impairment. Conclusion The greater serum CRP elevation after distal type AAD was associated with a higher incidence of oxygenation impairment and poor clinical outcome. Systemic activation of the inflammatory system after aortic injury may play an important role in the development of oxygenation impairment.

C-reactive protein as a predictor of infarct expansion and cardiac rupture after a first Q-wave acute myocardial infarction.

Pump failure after acute myocardial infarction (AMI) can be predicted by several indices that estimate infarct size. However, there are few indices that predict infarct expansion and cardiac rupture. We focused on the prognostic significance of serum C-reactive protein (CRP) after AMI. Serum CRP levels were measured every 24 hours in 220 patients with a first Q-wave AMI. In-hospital complications, predischarge left ventriculographic findings, and long-term prognosis were assessed in relation to peak CRP levels. Peak levels of both CRP and creatine kinase (CK) were higher in patients with pump failure than in those without pump failure. In patients with cardiac rupture, peak CRP levels were higher than in those without rupture (P=.001); peak CK levels were not predictive. Higher CRP levels were found in patients with left ventricular aneurysm (P=.001 versus those without), aggravated heart failure (P=.03 versus those without), and cardiac death (P<.0001 versus survivors) during the first year after AMI. Multivariate analysis confirmed that an elevation of the peak CRP level > or = 20 mg/dL was an independent predictor of cardiac rupture (relative risk, 4.72; P=.004), left ventricular aneurysmal formation (relative risk, 2.11; P=.03), and 1-year cardiac death (relative risk, 3.44; P<.0001). Cardiac rupture, left ventricular aneurysmal formation, and 1-year cardiac death were associated with an elevation of serum CRP early after AMI, suggesting that elevation of CRP levels after AMI may predict infarct expansion.