Revealing hidden reservoirs that are severely shielded by strong background interference (SBI) is critical to subsequent refined interpretation. To enhance the characterization of these reservoirs, current interpretation workflows merge multiple attribute information, necessitating intensive human expertise. As an alternative, we regard SBI suppression as a signal separation problem and develop a workflow to suppress SBI by cascading a sparse representation method and deep learning. SBI has coherent morphological characteristics in seismic sections; reservoir seismic responses, such as channels and karst caves, have a narrow spatial distribution, exhibiting abrupt morphological characteristics. As their morphologies differ, we select two 2D sparse representation dictionaries to identify their individual components. Through the morphological component analysis (MCA) technique, we can obtain adequate SBI separation results. However, the MCA separation is inevitably limited because 2D dictionaries cannot adequately represent 3D structures, but 3D dictionaries are not viable due to computing constraints. As an extension, we use 3D deep learning to improve the separation results based on the 2D MCA results. Specifically, the network is fed with training samples from a region with better SBI suppression results obtained by the MCA method. After learning a direct mapping from noisy data to SBI, the network can improve the separation results and remove more SBI than the previous conventional method. Field data experiments demonstrate that our separation workflow successfully enhances reservoir structures after removing SBI.