The present analytical, numerical, and experimental investigations are performed to study the flow field in acoustically simulated solid rocket motor (SRM) chamber geometry. The computational solution is carried out for a high Reynolds number and low Mach number internal flows driven by sidewall mass addition in a long chamber with end-wall disturbances. This kind of flow (transient, weakly viscous, and contains vorticity) have several features in common with a turbulent flow field. The numerical study is performed by solving the unsteady Reynolds-averaged Navier–Stokes equations along with the energy equation using the control volume approach based on a staggered grid system. The v2-f turbulence model has been implemented in the current study. A comparison of the SIMPLE and PISO algorithms showed that both algorithms provide identical results, and the computational time using the PISO algorithm is higher by about 6% than the corresponding value of the SIMPLE algorithm. A fair agreement has been obtained between the numerical, analytical, and experimental results. Moreover, the results showed that the complex turbulent internal flow patterns are induced inside the chamber due to the strong interaction of the sidewall injection with the traveling acoustic waves. Such a complex internal structure is shown to be dependent on the piston frequency and sidewall mass flux. The current study, for the first time, emphasizes the acoustic-fluid dynamics interaction mechanism and the accompanying unsteady rotational fields along with the effect of the generated turbulence on the unsteady vorticity and its impact on the real burning rate.