Side Of Body Research Articles

Research on the impact of traction rods on coupler separation in the middle locomotive of 20,000-tonne heavy-haul trains

Aiming at the coupler separation problem in the middle locomotive of 20,000-tonne heavy-haul trains in China, this study investigates the influence of the locomotive traction rod. A theoretical kinematic model was developed to compare the motion of locomotives equipped with single and double traction rods, and the mechanism of coupler separation was analysed. A dynamic model, considering the three-dimensional interaction of couplers, was also established to simulate the dynamic process of coupler separation during braking and release stages. The simulation results indicate that locomotives equipped with double rods (positioned at both sides of the car body) are more prone to coupler separation than those with single rods (placed at the middle of the car body). The pitch angle of the double-rod model reaches a maximum of 0.20° when the electric braking force is 200 kN, approximately 10 times that of the single-rod model. For double-rod locomotives prone to coupler separation, maintaining a coupler knuckle friction coefficient greater than 0.1 and an initial height difference of less than 50 mm can significantly reduce the risk of coupler separation.

Study on the effect of the distribution of bone cement of residual back pain after percutaneous vertebra plasty

To investigate the effect of bone cement distribution on efficacy of residual back pain after percutaneous vertebra plasty(PVP). From January 2017 to December 2020, a total of 65 cases with single segment osteoporotic thoracolumbar vertebral fractures underwent parallel vertebroplasty surgery. On the basis of the postoperative X-ray films of bone cement distribution were divided into two groups. The bone cement was biased to the lateral side of the vertebral body (partial group, 20 cases), there were 9 males and 11 famales with an average age of (70.3±7.4) years old ranging from 60 to 84 years old. The bone cement was over the vertebral midline, and completely filled with contralateral vertebral body (bilateral group, 45 cases), there were 10 males and 35 famales with an average age of (70.7±8.0) years old ranging from 60 to 86 years old. All of them underwent PVP surgery, bone cement was injected into the vertebral body through paitail transpedicular approach. The amount of bone cement injection, the visual analogue scale(VAS) of preoperation and 1 day, 1 month, 3 months after surgery between two groups were observed and compared. The amount of cement injection was (4.25±0.99) ml in the partial group, and (4.07±1.18) ml in the bilateral group, there was no significant difference between two groups (P>0.05). Postoperative pain was relieved than preoperative pain (P<0.05), the VAS of 1 day, 1 and 3 months after operation (3.90±1.37), (2.35±0.67) and (1.55±0.51) in the partial group were higher than (2.67±0.60), (1.62±0.58) and (1.31±0.47) in the bilateral group (P<0.05). There were 9 cases in partial group, the pain was not relieved due to unfilled cement until the contralateral bone was injected into the bone cement. The distribution of bone cement is one of the main factors affecting residual back pain after PVP, and in the clinical, we should make sure the distribution of bone cement over the midline of vertebral body.

Life-threatening postoperative hemorrhage caused by lumbar artery injury in asymmetrical pedicle subtraction osteotomy for severe spinal deformity: two case reports.

To present two cases of life-threatening hemorrhage related to lumbar artery injury in adult spinal deformity (ASD) patients following S2‑alar‑iliac (S2AI) fixation and asymmetrical pedicle subtraction osteotomy (PSO), and discuss the possible reasons for postoperative hemorrhage in these patients. Patient A was a 52-year-old female with degenerative lumbar scoliosis who underwent posterior spinal fusion from T8-S2 and one-level PSO at L2. Patient B was a 24-year-old male with severe kyphoscoliosis due to non-ambulatory cerebral palsy, who underwent posterior spinal fusion from T3-S2 and one-level PSO at L1. Both patients underwent asymmetric PSO, where a larger wedge was resected from the convex side of the vertebral body rather than the concave side. Both patients occurred a sudden increase in drainage within 3h postoperatively, who were under anesthesia in AICU. Digital subtraction angiography (DSA) was emergently performed and revealed that the bleeding sites were from the lumbar artery, which was adherent to the convex side of the osteotomized vertebra in both cases. Then successful bleeding control was achieved through vascular embolization. Postoperative CT revealed spike formation at the anterior edges of the open wedge at the PSO level due to sagittal translation (ST), with noticeable derotation of the osteotomized vertebra. For patients with severe kyphoscoliosis, asymmetrical PSO increases the risk of lumbar artery injury on the convex side, and postoperative ST may further contribute to this risk. In cases where a sudden increase in drainage is observed postoperatively, it is crucial to consider the possibility of lumbar artery injury, particularly on the convex side of the osteotomized vertebra.

Practical research on coal pillar retention in deep mining roadways

To address the limitations of traditional coal pillar design methods in engineering practice for deep retreat mining roadways, this research focuses on the retreat mining face at the Pinggang Coal Mine in Heilongjiang Province. Combining mechanical experiments, theoretical calculations, numerical simulations, and field tests, this study calculates the ultimate equilibrium size of coal pillars. It also analyses the stress transfer and surrounding rock plastic evolution characteristics under different coal pillar sizes in deep retreat mining faces and carries out a field engineering application. After the factors mentioned above are analysed, the appropriate size for coal pillars that align with the current state of the surrounding rock in deep mines is established. The research findings indicate a correlation between the theoretically calculated ultimate stability range of coal pillars and the numerical simulation results on coal pillar size, suggesting a close consistency. The determined ultimate equilibrium coal pillar size falls within the range of 7.12–8.22 m. When the coal pillar size changes, the stress around the deep retreat mining roadway is transferred, and the plastic state of the surrounding rock also gradually changes. When the coal pillar width is 3–6 m, a stress concentration appears in the coal body, and the coal pillar has a lower bearing capacity and is prone to plastic failure. When the width is 7–8 m, the stress concentration gradually shifts to the sides of the coal pillar, enhancing its control over the roof, and a loosening zone forms in the surrounding rock. When the coal pillar width reaches 9–10 m, the stress concentration shifts completely from the coal body side to the coal pillar side, and the bearing performance of the coal pillar no longer improves. Plastic failure of the coal pillar disappears, but a greater degree of stress concentration occurs on the side of the coal pillar. The optimal size of the coal pillar is determined to be 7–8 m. Verified by the coal pillar retention engineering application at the Pinggang Coal Mine, when an 8 m coal pillar is retained, a peak stress of 27.54 MPa appears 12 m from the roadway, and the maximum deformations of both sides, the roof, and the coal pillar side are within the ideal range, indicating a relatively good overall state of the roadway. These research results provide new theoretical and practical guidance for minimizing coal loss and eliminating the safety hazards posed by unreasonable coal pillar retention at the Pinggang Coal Mine and offer a reference for the reasonable retention of coal pillars under similar conditions in the Northeast China mining area, thereby promoting the sustainable development of the coal industry.

An initial investigation of transcutaneous delivery of plasmid DNA encoding interleukin-10 for the treatment of psoriatic skin conditions

Psoriasis is a chronic immune-mediated skin disorder characterized by intense local inflammation, epidermal hyperplasia, and leukocyte infiltration. Current treatment approaches for psoriasis aim to alleviate symptoms and prevent disease progression, including systemically administered drugs with whole body side effects. Despite some advances in psoriasis treatment, success has been quite limited. To begin to address this challenge, we undertook an initial investigation of whether transcutaneous delivery of an endogenous anti-inflammatory cytokine could provide an effective, local treatment of psoriatic-like skin conditions. To do this, we utilized a previously documented rodent model of psoriasis, induced via a single topical application of Imiquimod (IMQ) to the shaved back of rats. The therapeutic approach used for this initial investigation was delivery of plasmid DNA encoding rat interleukin-10 (pDNA-rIL10), a non-viral gene therapy approach previously shown to be effective in suppressing neuroinflammatory disorders after localized delivery either intracerebrally or intrathecally. Translation of this CNS therapeutic for use in psoriatic-like skin disorders required reformulation to enable transcutaneous delivery. Toward that end, pDNA-rIL10 was topically applied in Lipoderm HMW, a base explicitly designed to deliver higher molecular weight compounds into skin. Here we show that a single topical application of pDNA-rIL10 in Lipoderm HMW was effective in decreasing mRNA levels of pro-inflammatory cytokines as well as reducing the recruitment of T-cells to IMQ-treated skin. Furthermore, this transcutaneous IL-10 gene therapy decreased signs of skin inflammation, reflected by reduced erythema. Moreover, the results provide an initial indication that IL10 may stimulate hair regrowth in psoriatic-like skin.

Effects Of Bilateral Upper Extremity Exercises Training On Trunk Performance, Posture And Gait In Patients With Subacute Stroke-A Quasi Experimental Study

Background and objective: Stroke is one of the neurological disorders which is caused by disturbance in blood supply to the brain resulting in weakness in contralateral limbs and axial musculature. Stroke is the leading cause of physical impairment where the most prominent motor deficit is paresis of one side of body, which is contralateral to the event. This study was conducted with an aim to assess the effectiveness of bilateral upper extremity training on trunk performance, posture and gait in patients with subacute stroke. Method: 30 subjects with subacute stroke were selected for the study. Subjects were treated for 3 days/week for 12 sessions with 45 minutes of task oriented, strengthening training and PNF technique for bilateral upper extremity along with conventional training. The rehabilitation protocol consists of bilateral functional exercises, activity of daily living goal, exercises in multiple movement games, strengthening exercises for lower limb, controlled sitting training, sit to stand training, weight bearing and balance training Conclusion: Significant improvement in all items of TIS, PASS and DGI were observed after intervention (P&lt; 0.001). The study concluded that bilateral upper extremity training is more effective in improving trunk control, posture and gait in subacute stroke patients.

Mismeasurement of the virtual human body: analysing error of landmark acquisition

Modern physical anthropology increasingly employs non-invasive methods that use 3D models representing the human body. Frequently, these are 3D models of a person’s physical appearance, i.e., face or body. A traditional approach to analyse these records is to process discrete points (landmarks, feature points) collected manually on the model surface. The digitization of landmarks and associated errors have been sufficiently studied in the context of the human face, due to its functional and aesthetic importance. However, other parts of the human body have not received the same level of attention. The aim of the present study was to quantify the error of body landmarks when collected in 3D fullbody models and to explore how it relates to other model properties, such as a demographic and somatic indicators. The study tested two datasets of 10 body landmarks acquired in 60 models (32 males and 28 females). The data acquisition was carried out during the time span of 14 days. The magnitude of the digitization error for each point was acquired and tested between groups defined according to their anatomical location (shoulders, arms, legs; torso and limbs or body side), sex, age, height and body type. The results of this study showed that the error of digitising landmarks in a 3D model was greater compared to the error reported in the literature when acquiring landmarks on the human body. The digitization error was independent of participants’ age, sex, height, and body type but was correlated with the anatomical location, where the upper chest, neck, and back on the knee yielded the highest digitization errors. In addition, this study showed that landmarks located on the shoulders and arms exhibited an error which was correlated negatively with the volume of the lower and upper half of the body and positively with the body depth.

Prediction of automotive body-in-white distortion in paint baking process

Thermal-induced distortion prediction of thin shell structures is a challenging task. It often involves highly nonlinear buckling behaviour, where the critical buckling temperature and post-buckling deformations are very sensitive not only to structural stiffness and boundary conditions but also minute geometric imperfections (a.k.a., “surface quality”) of the incoming parts. In the present work, novel Computer Aided Engineering (CAE) methods were developed to predict the thermal-induced distortion of automotive Body-in-White (BIW) panels during paint shop oven-baking processes. The CAE methodology consist of a set of three Finite Element Analysis (FEA) procedures, i.e., thermal-buckling mode analysis, thermo-structural analysis, and imperfection analysis. Two vehicle level case studies showed that simulations successfully predicted the thermal-induced distortion for panels such as the Body Side Outer (BSO) header. It was concluded that the distortion depends primarily on the temperature difference between the BSO and the rest of the BIW during the oven-baking process, rather than the temperatures themselves. Body panel forming quality (e.g., residual stresses and thickness thinning) and assembly dimensional quality were also found to impact the distortions.

Two new species of Leptolaimus (Nematoda: Plectida) from Chinese sea area.

Two new Leptolaimus species from the Chinese sea area are described and illustrated. Leptolaimus gracilis sp. nov. is characterized by rounded labial region offset from body contour; cephalic setae 5-6 µm long; males with eight tubular and without alveolar supplements, tubular supplements sickle-shaped with pointed tips; spicules arcuated and about 18 µm long; gubernaculum with straight dorso-caudal apophysis; female without supplements, vulva midventral; tail elongate conical. The new species can be easily identified from other known species by males with eight sickle-shaped supplements with pointed tips and the spacing of adjacent supplements almost equal except that of the most anterior two supplements. Leptolaimus hamatus sp. nov. is characterized by small body size; cephalic setae 2-3 µm long; amphidial fovea located 2.6-3.3 times of head diameter from anterior end; male with six tubular and without alveolar supplements, tubular supplements hooked distally; spicules slightly curved, knife-like, 22-24 µm long; gubernaculum with straight dorso-caudal apophysis; females without supplements, vulva situated at right subventral side of body, tail conico-cylindrical.

Kin Cognition and Communication: What Talking, Gesturing, and Drawing About Family Can Tell us About the Way We Think About This Core Social Structure.

When people talk about kinship systems, they often use co-speech gestures and other representations to elaborate. This paper investigates such polysemiotic (spoken, gestured, and drawn) descriptions of kinship relations, to see if they display recurring patterns of conventionalization that capture specific social structures. We present an exploratory hypothesis-generating study of descriptions produced by a lesser-known ethnolinguistic community to the cognitive sciences: the Paamese people of Vanuatu. Forty Paamese speakers were asked to talk about their family in semi-guided kinship interviews. Analyses of the speech, gesture, and drawings produced during these interviews revealed that lineality (i.e., mother's side vs. father's side) is lateralized in the speaker's gesture space. In other words, kinship members of the speaker's matriline are placed on the left side of the speaker's body and those of the patriline are placed on their right side, when they are mentioned in speech. Moreover, we find that the gesture produced by Paamese participants during verbal descriptions of marital relations are performed significantly more often on two diagonal directions of the sagittal axis. We show that these diagonals are also found in the few diagrams that participants drew on the ground to augment their verbo-gestural descriptions of marriage practices with drawing. We interpret this behavior as evidence of a spatial template, which Paamese speakers activate to think and communicate about family relations. We therefore argue that extending investigations of kinship structures beyond kinship terminologies alone can unveil additional key factors that shape kinship cognition and communication and hereby provide further insights into the diversity of social structures.

Anatomic Research of the Safe Space Between the Cervical Uncinate Process and the V2 Vertebral Artery

StudyDesign Retrospective study Objective To observe and measure the safe distance between the uncinate process (UP) and the V2 vertebral artery (VA). MethodsTwo hundred and sixteen patients who underwent head and neck CTA date were selected and measured. The Upper Tip (UT) of the UP, the Posterior Tip (PT) of the UP and the Center of the VA (CA) were identified. Then, the width between the UT and the CA (WUA), the depth between the UT and the CA (DUA), the distance between the UT and the CA (LUA) were measured. Meanwhile, the width between the PT and the CA (WPA), the depth between the PT and the CA (DPA) and the length between the PT and the CA (LPA) were measured. The values above were compared between the left and right sides of the same vertebral body, also the results of the same side from C3 to C6 were compared. ResultsThat WUA fluctuates between 6.1- 4.4 mm on the left side with the narrowest at C5 and C6 (4.4 mm), 6.5- 4.6 mm on the right side with the narrowest at C5 (4.6 mm). It could be concluded that the safe space for operation outside UP is about 4mm and more care should be taken when operating on the caudal spine. WPA fluctuates between 10.6- 10.0 mm on the left side with the narrowest at C3 (10mm), 11.0- 9.9 mm on the right side with the narrowest at C4 (9.9 mm). The safe space for operation outside the PT is about 10mm and more care should be taken when operating on the cephalad spine. DPA fluctuates between 6.5- 4.6 mm on the left and is narrowest at C3 (4.6 mm), 6.5- 4.7 mm on the right and narrowest at C3 (4.7 mm). The safe space for operation from the PT to the ventral side is about 4.5 mm, and more care should be taken when operating on the cephalad side of the cervical spine. ConclusionUP and PT could be seen as the landmarks in the operations of ACDF. The safe space outside UP is about 4mm and more care should be taken when operating on the caudal spine. The safe space outside PT is about 10mm and more care should be taken when operating on the cephalad spine. The safe space for operation from the PT to the ventral side is about 4.5 mm, and more care should be taken when operating on the cephalad side of the cervical spine.

Computational biomechanics for a standing human body: Modal analysis and simulation.

We develop computational mechanical modeling and methods for the analysis and simulation of the motions of a human body. This type of work is crucial in many aspects of human life, ranging from comfort in riding, the motion of aged persons, sports performance and injuries, and many ergonomic issues. A prevailing approach for human motion studies is through lumped parameter models containing discrete masses for the parts of the human body with empirically determined spring, mass, damping coefficients. Such models have been effective to some extent; however, a much more faithful modeling method is to model the human body as it is, namely, as a continuum. We present this approach, and for comparison, we choose two digital CAD models of mannequins for a standing human body, one from the versatile software package LS-DYNA and another from open resources with some of our own adaptations. Our basic view in this paper is to regard human motion as a perturbation and vibration from an equilibrium position which is upright standing. A linear elastodynamic model is chosen for modal analysis, but a full nonlinear viscoelastoplastic extension is possible for full-body simulation. The motion and vibration of these two mannequin models is analyzed by modal analysis, where the normal vibration modes are determined. LS-DYNA is used as the supercomputing and simulation platform. Four sets of low-frequency modes are tabulated, discussed, visualized, and compared. Higher frequency modes are also selectively displayed. We have found that these modes of motion and vibration form intrinsic basic modes of biomechanical motion of the human body. This view is supported by our finding of the upright walking motion as a low-frequency mode in modal analysis. Such a "walking mode" shows the in-phase and out-of-phase movements between the legs and arms on the left and right sides of a human body, implying that this walking motion is spontaneous, likely not requiring any directives from the brain. Dynamic motions of CAD mannequins are also simulated by drop tests for comparisons and the validity of the models is discussed through Fourier frequency analysis. All computed modes of motion are collected in several sets of video animations for ease of visualization. Samples of LS-DYNA computer codes are also included for possible use by other researchers.

Walking symmetry is speed and index dependent

Gait symmetry is one of the most informative aspects describing the quality of gait. Many indices have been proposed to quantify gait symmetry. Among them, indices focusing on the comparison of the two body sides (e.g., Symmetry Angle, SA) and indices based on the analysis of the locomotor act as a whole, dealing with the body center of mass (e.g., Symmetry Index, SIBCoM) or lower trunk accelerometry (e.g., improved Harmonic Ratio, iHR) have been proposed. Remarkably, the relationship between these indices has received little attention so far, as well as the influence of gait speed on their values. The aim of this study is to investigate this relationship by comparing the SA, SIBCoM, and iHR, and to explore the effect of walking speed on these indices. Ten healthy adults walked for 60 s on a treadmill at seven different speeds (from 0.28 to 1.95 m s−1) and simulate an asymmetric gait (ASYM) at 0.83 m s−1. Marker-based trajectories were recorded, and the body center of mass 3D trajectory was obtained. Simultaneously, lower trunk 3D linear accelerations were collected using a triaxial accelerometer. SIBCoM, iHR, and SA were calculated for each stride, each anatomical direction, and each condition. Perfect symmetry was never displayed in any axes and any indices. Significant differences existed between SIBCoM, and iHR in all anatomical directions (p < 0.0001). The walking speed significantly affected SIBCoM and iHR values in anteroposterior and craniocaudal directions, but not in mediolateral. Conversely, no walking speed effect was found for SA (p = 0.28). All three indices significantly discriminated between ASYM and the corresponding walking condition (p < 0.05). Gait symmetry may differ significantly according to the data source, mathematical approach, and walking speed. Healthy individuals display an asymmetrical gait and acknowledging this aspect is crucial when establishing rehabilitation objectives and assessing the quality of gait in the clinical setting.

Ultraviolet radiation protection factors of livestock shade cloths for free-range pigs.

Protection from solar ultraviolet radiation (UVR) is paramount in light-skinned pig breeds such as Yorkshire or Landrace to avoid sunburn. Determination of the UVR exposure of a pig and the sun protection abilities of shade cloths with different shade rates. Life-sized plastic model of a Landrace pig. The model was equipped with 20 UVR meters at various anatomical positions that recorded the erythemal effective solar irradiance. A turntable enabled irradiation from different directions. Solar irradiance was measured in direct sunlight as well as under three shade cloths with different shade rates (50%, 75% and 90%) and a camouflage net. The sun protection factors (SPF) were determined as the ratio of unshaded-to-shaded measurements at the same solar elevation. The exposure ratio to ambient (ERTA) was calculated for each body site with respect to ambient irradiance. It allows determination of when pigs are at risk of sunburn and protection is needed. The calculated ERTA values show that some body parts may receive higher values than ambient UVR. Measurements showed that the SPF of shade cloths depends on textile denseness. Selected shade cloths reached values of 3.5 (shade rate 50%), 4.2 (75%) and 5.8 (90%). Protection by the camouflage net was poor. The highest SPF was gained on body sides where ERTA was highest. Shade cloths can protect all body sites effectively and vulnerable sites in particular. The results of our study enable an estimation of when pigs are at risk of sunburn and provide quantitative metrics for sun protection. This allows effective prevention of UVR-caused skin damage and secondary disorders.

Assessment of Reliability, Agreement, and Accuracy of Masseter Muscle Ultrasound Thickness Measurement Using a New Standardized Protocol.

There is no validated method of assessing masseter muscle thickness (MMT) by ultrasound imaging (US). However, this is important to ensure study and measurement quality of MMT by US in future studies, as MMT differs depending on the examined area. Thus, this study's aim was to present a new standardized method for assessing the MMT by US and to evaluate the reliability, consistency, and accuracy of its measurements. We also compared the results of MMT measurements obtained by US and computer tomography (CT). The study included nine healthy adults. The US and CT scans were collected in a supine rest position with the mandible in relaxed position. US measurements were determined according to a new standardized protocol (with precise probe location). The MMT measured by CT and US over a seven-day interval showed excellent intra-rater reliability. The mean MMT measured by CT was 12.1 mm (1.74) on the right side and 11.9 mm (1.61) on the left side. The mean MMT measured by US was 12.7 mm (2.00) on the right side and 11.5 mm (1.37) on the left side. The mean percent error in MMT measurement between CT and US was below 6%. A strong linear relationship was found between the CT and US measurements of the MMT on both body sides (p < 0.001, r ≥ 0.93). The proposed method of MMT measurement using US demonstrated excellent reliability, yielding results similar to those obtained from CT images. We recommend the use of this standardization protocol in further studies where precise assessment of MMT by US is expected.

Mortality events associated with microsporidian, Spraguea sp., in White Trevally culture in Japan.

In 2021, White Trevally or Striped Jack cultured in the western part of Japan exhibited mild, but chronic mortalities from late September through early October. The cumulative mortality rate was approximately 0.02% per a net pen containing approximately 50,000 fish. Although the cumulative mortality rate was not high, most of the fish in net pens showed characteristic gross signs and an abnormal swimming behaviour. The body of diseased fish became pale and the yellow lines on the lateral sides of fish body became darken. In addition, silver lines along the dorsal fin became apparent. Loss of schooling behaviour was noted during the mortality event. In addition, affected fish became lethargic and failed to swim against current, or frequently stopped swimming and sank to the bottom of net pens after feeding. The goal of this study was to identify the cause of the mortality event. To achieve the goal, we used histopathology and metatranscriptome analysis. Histopathological examination revealed that xenoma of microsporidian were frequently observed in the nerve axon in the brain and spinal cord. Spores observed in the sections were stained with a fluorescent dye, Uvitex 2B, indicating those spores are microsporidian. The data from metatranscriptome analysis indicated that the microsporidian is Spraguea sp. The microsporidian was frequently detected from diseased fish with similar symptoms collected in the same region, suggesting that the microsporidian was highly associated with abnormal swimming behaviour of fish.

Numerical Analysis on The Aerodynamic Performance of A High-speed Train Operating on Various Embankment Heights Under The Influence of Crosswinds

Given the unavoidable geographical surface, railings must be raised above ground level in some cases, which is known as an embankment. It was discovered that the height of the embankment had a significant influence on the slipstream on the train's leeward side especially during crosswind conditions. The primary objectives of this study were to investigate the impact of varying embankment heights on the aerodynamic characteristics of a high-speed train under different crosswind conditions using computational fluid dynamics (CFD) analysis. The German Aerospace Center DLR's Next-Generation High-speed Train (NG-HST) model has been used for this study. The yaw angles (ψ) are ranging from 10° to 50° in 10° increments. The Reynolds number based on the model's height and freestream velocity at the computational domain is 1.3 x 106. In the results, it shows that embankment height and crosswind ψ has a significant impact on the aerodynamic characteristics. Essential aerodynamic parameters that have a significant impact on train stability, such as the drag, lift, and side force coefficients, as well as the roll, yaw, and pitch moment coefficients, revealed that the higher the ψ, which included 40° and 50°, produced poor results compared to the lower ψ, which included 10°, 20°, and 30°. In terms of visual appearance, rising of crosswind angles have a greater impact on the formation of vortices on the leeward side of the train body and embankment. Thus, it can be concluded that the embankment heights and crosswind angles are crucial in determining train safety operations.

Lowered ratio of corticospinal excitation to inhibition predicts greater disability, poorer motor and cognitive function in multiple sclerosis

ObjectiveInvestigate excitatory-inhibitory (E/I) (im)balance using transcranial magnetic stimulation (TMS) in individuals with Multiple Sclerosis (MS) and determine its validity as a neurophysiological biomarker of disability. MethodsParticipants with MS (n = 83) underwent TMS, cognitive, and motor function assessments. TMS-induced motor evoked potential amplitudes (excitability) and cortical silent periods (inhibition) were assessed bilaterally through recruitment curves. The E/I ratio was calculated as the ratio of excitation to inhibition. ResultsParticipants with greater disability (Expanded Disability Status Scale, EDSS≥3) exhibited lower excitability and increased inhibition compared to those with lower disability (EDSS<3). This resulted in lower E/I ratios in the higher disability group. Individuals with higher disability presented with asymmetrical E/I ratios between brain hemispheres, a pattern not present in the group with lower disability. In regression analyses controlling for demographics, lowered TMS-probed E/I ratio predicted variance in disability (R2 = 0.37, p < 0.001), upper extremity function (R2 = 0.35, p < 0.001), walking speed (R2 = 0.22, p = 0.005), and cognitive performance (R2 = 0.25, p = 0.007). Receiver Operating Characteristic curve analysis confirmed ‘excellent’ discriminative ability of the E/I ratio in distinguishing high and low disability. Finally, excitation superiorly correlated with the E/I ratio than overall inhibition in both hemispheres (p ≤ 0.01). ConclusionThe E/I ratio is a potential neurophysiological biomarker of disability level in MS, especially when assessed in the hemisphere corresponding to the weaker body side. Interventions aimed at increasing cortical excitation or reducing inhibition may restore E/I balance potentially stalling progression or improving function in MS.

The effect of the Montessori program using physical activity games in enhancing the sensory-motor perception abilities of kindergarten children aged 5 to 6 years

The research aims to propose an educational approach inspired by Montessori's method using motor games to develop sensory motor skills in children aged (5-6) years, and to identify the impact of using Montessori's method with motor games in developing some cognitive sensory motor skills for children. The experimental method was used with the matched group design. The sample represented children from the Braum Al-Amal Nursery in Basra, who were selected to take the Haywood test to measure cognitive sensory motor abilities. It was concluded that Montessori's method using motor games contributed to the development of sensory motor skills and helped in enhancing overall and partial visual perception for children. The child learned about parts of the body, distinguished between body sides, and helped in enhancing balance and spatial awareness. The method also aided in teaching the child how to determine location. It was recommended to benefit from the Montessori method in developing motor and cognitive abilities, and to introduce specific courses for preschool teachers in teaching the Montessori method. Key words: Montessori method, motor games, sensory motor perception, preschool education, teaching methods

Application Of Onboard PIV To Front Wheelhouse Wake Behavior Under Stationary Crosswind Conditions

When driving a car, the driver and passengers may feel larger drag from a headwind, the steering wheel would be taken away by a crosswind or pushed by a tailwind. Anytime, anywhere, we will encounter various scenes with natural wind under real world conditions such as urban, suburb and highway. We will develop the appropriate vehicle by simulating these conditions to satisfy with various customer requirements. For vehicle aerodynamic research and development, we are simply running simulations in physical- and cyber-space, that is, wind tunnel facility and computational fluid dynamics to reproduce these real worlds. However, it is not easy to simulate these wind inlet conditions, such as the temporal change in crosswind, especially, in wind tunnel facility. The stationary yaw angle by rotating turntable would reproduce a crosswind, if there is no turbulent generator system like in Pininfarina and Swing in FKFS. Therefore, we focus on the unsteady and asymmetrical flow from the front wheelhouse of the vehicle with tire rotation. There is three-dimensional complicated flow that are interacted by the flow from various directions, such as the flow along the front bumper, the flow along the rotating tire and wheel, the blowing flow from the rotating wheel opening area and the flow from the tire house. These complicated flow produces the front wheelhouse wake along the body side that affects the vehicle aerodynamic performance. Furthermore, there are asymmetrical flows around the vehicle by different front wheelhouse wake in windward and leeward sides. The larger side wake increases the aerodynamic drag, and the fluctuating side wake may induce the instability of the vehicle handling stability. Here, the proposed onboard 2D-3C PIV measurement system in the previous study enables us to measure same measurement area along the vehicle body side without change in optical configuration effectively, that indicates to reduce the time by resetting the optical configuration. We will investigate what kind of flow field should be focused on and controlled to prevent the vehicle instability by investigating these asymmetrical flow field around the vehicle under crosswinds.