Side Dominance Research Articles

Primary hemifacial spasm: anatomical insights.

Primary Hemifacial Spasm (pHFS) is a disorder caused by compression of vessels on the root of the facial nerve. There has been conflicting evidence regarding the side of the face that is more frequently affected. Moreover, it has been found in several studies that women are afflicted by approximately twice as many as men. We reviewed the literature to explain HFS tendencies from an anatomical aspect. We wanted to see whether there are anatomical variations that can increase the risk of developing HFS or underlie its tendency to a specific gender and side of the face. A PubMed search was done for the articles on "Hemifacial Spasm" published in English literature, and we selected the articles regarding the significant anatomical differences in HFS patients. AICA proximal branching pattern, highly originated PICA, VA dominancy, and VA deviation are among the predisposing anatomical variances. Overall, both sides of the face are equally affected in HFS. However, there are side preferences based on the causative vessels, which may be due to differences in the anatomical features of the left and right side vessels. Various anatomical variations regarding posterior circulation can increase the risk of HFS. Recent evidence suggests whether there is no side dominance or a tendency exists toward the left side. There is no comprehensive explanation for precise reasons underlying the tendency of HFS to affect women. Evidence regarding anatomical variations of the posterior circulation comparing men and women with HFS is scarce, and further studies are required.

Asymmetry in linear measurements and cross-sectional geometry in the humerus during ontogeny.

Adult upper limb asymmetry is used to reconstruct behavior. However, the developmental trajectory of asymmetry in bone length, cross-sectional geometry (CSG), and joint dimensions is poorly understood. This study examines the development trajectory of humeral asymmetry and if asymmetry in bone length, joint size, and CSG develop in concert. Linear measurements of bone length and metaphyseal/epiphyseal breadth, bending rigidity (Imax and Imin), and cross-sectional shape (Imax/Imin) at 30%, 50%, and 70% of bone length were acquired from 3D models of humeri from four skeletal samples of prehistoric hunter-gatherer populations (n = 82). Dental age cohorts were used to assess ontogenetic trends. Percent absolute (%AA) and directional (%DA) asymmetry were calculated for paired measures. Percentage of matching direction of asymmetry across variables and correlation analysis tested relationships between variables. Within the total pooled sample, Imax shows the highest %AA and %DA, followed by shape and linear dimensions. Asymmetry is lowest in neonates and increases with age, particularly %DA of Imax in mid-proximal sections. Correlations among variables are low to moderate and strongest between Imax measures. Matching direction of asymmetry between variables is low and generally increases with age. Higher correlations with age in CSG likely indicate greater responsiveness to mechanical loading. Low correlations in magnitude of asymmetry and side dominance suggest independence in the development of asymmetry between maximum rigidity, shape, and linear measures. Differences in how asymmetric loading affects the ontogeny of linear and CSG variables may account for the heterogeneous development of asymmetry.

Exploring the Association Between Trunk Asymmetry and Dominance Preference

Background: Trunk asymmetry, an indicator of potential scoliosis, manifests as an uneven distribution in body alignment such as shoulder, head, and hip positions. An individual's inherent preference to use one side of the body over the other, known as laterality, may contribute to such imbalances. This study aimed to explore the correlation between trunk asymmetry and side preference in adults, particularly in relation to hand, foot, ear, and eye dominance. Methodology: In this cross-sectional study, 164 young adults aged 18-25 were screened using the Adam’s forward bend test. Data collection encompassed three phases: demographic and anthropometric data collection (Phase 1), a visual inspection for head tilt, shoulder and pelvic asymmetry, and spinal curvature deviation (Phase 2), and an assessment of side dominance using a 16-item lateral preference inventory questionnaire (Phase 3). Results: Hand dominance correlated significantly with head tilt (p < 0.01), shoulder asymmetry (p < 0.05), and ear asymmetry (83.5% concordance), while foot dominance was associated with pelvic tilt (57.3% concordance). Eye dominance showed a 65.9% concordance with ear asymmetry, and ear dominance was linked to head tilt and shoulder asymmetry (81.7% and 94.5% concordance, respectively). Spinal curve deviation displayed a chi-square value of 3.158 (p < 0.05) with hand dominance and 4.321 (p < 0.05) with foot dominance. Conclusion: The study establishes a significant association between trunk asymmetry and dominance preference. These findings advocate for the integration of laterality assessments in the clinical evaluation of trunk asymmetry to potentially enhance diagnostic accuracy and inform therapeutic approaches.

The sphenoidal emissary foramina prevalence: a meta-analysis of 6,369 subjects

PurposeTo estimate the prevalence of the sphenoidal emissary foramina (SEF), and the effect of possible moderators on it.MethodsA systematic online literature search was conducted. The pooled prevalence with 95% confidence intervals was estimated. Outlier and influential analyses were performed. The presence of small-study effect and publication bias were evaluated. Moderator analyses were executed to investigate the effect of the specimens’ continent of origin, type of study (dried skull or imaging), probing for the evaluation of SEF patency (conduction and instruments used), side dominance (bilateral or unilateral), morphometric data [SEF diameter, distances SEF–Foramen ovale (FO) and SEF–Foramen spinosum (FS)], and the methodology used for the morphometric measurements (caliper, DICOM Viewer, and image analysis software) on the estimated prevalence.ResultsIn total, 6,460 subjects from 26 studies were included in the meta-analysis. The overall SEF prevalence was estimated as 38.1%. The heterogeneity was high and statistically significant. No indications of publication bias and small-study effect were identified. The conducted subgroup analyses did not yield statistically significant differences in the SEF prevalence between groups, except of the type of side dominance. Both results of the univariable and multivariable regression analyses showed the association of the unilateral dominance with a decrease in the reported SEF prevalence.ConclusionThe identification of more unilateral than bilateral foramina in a given cohort is associated with a decrease in the reported crude SEF prevalence. Laterality-specific estimates should be established for a precisive estimation of the emissary foramina prevalence.

Anatomic Factors Associated With the Development of an Anterior Cruciate Ligament Rerupture in Men: A Case-Control Study

Background: Although several factors are associated with anterior cruciate ligament (ACL) rerupture, the effect of anatomic factors associated with ACL rupture on ACL rerupture development has not been evaluated. Purpose: To determine individual anatomic parameters independently associated with ACL rerupture and the diagnostic values of these parameters. Study Design: Case-control study; Level of evidence, 3. Methods: A total of 91 male patients with ACL rerupture and 182 age-, sex-, body mass index–, and side dominance–matched patients without rerupture who underwent ACL reconstruction with a 5-year follow-up were included. In all, 35 parameters that were previously defined as risk factors for primary ACL rupture were compared between the 2 groups. Uni- and multivariate logistic regression models were created to evaluate independently associated factors. Receiver operating characteristic curve analysis was performed for independently associated parameters to predict sensitivity, specificity, and cutoff values. Results: The mean ± standard deviation age of patients at the time of index surgery was 26.5 ± 6.7 years. Notch shape index (P = .014), tibial proximal anteroposterior (AP) distance (TPAPD) (P < .001), lateral femoral condylar AP distance (LCAPD)/TPAPD ratio (P < .001), medial meniscal cartilage bone height (P < .001), and lateral meniscal bone angle (P = .004) were found to be significantly different between the 2 groups. Only the LCAPD/TPAPD ratio (odds ratio, 2.713; 95% CI, 1.998-5.480; P < .001) was found to be independently associated with ACL rerupture development. The LCAPD/TPAPD ratio revealed 78.9% sensitivity and 75.5% specificity (area under the curve, 0.815; 95% CI, 0.760-0.870) for values above 1.52. Conclusion: The LCAPD/TPAPD ratio can be used to distinguish patients who are at risk of developing ACL rerupture from patients who are not. In the clinical practice, findings of this study may help to develop surgical and nonsurgical preventive strategies in ACL rerupture development.

A screening instrument for side dominance in competitive adolescent alpine skiers.

Previous research has shown that high school ski students injure their left anterior cruciate ligament (ACL) more often than their right ACL, and that a prevention program focusing on equal load to the right and left ski turns prevents ACL injuries. Whether the injuries were in the dominant or non-dominant side of ski students was not determined but may be important knowledge to ski coaches for future design of ski-specific training programs. There is no gold standard on how to investigate the dominant side of alpine skiers. Therefore, the aim of this study was to develop a screening instrument consisting of five questions for identifying side dominance and to evaluate side dominance in competitive adolescent alpine skiers. First, 121 competitive adolescent alpine skiers answered the questions on side dominance using a test-retest design. The questions were: which hand/arm (left/right) or foot/leg (left/right) one uses as the first choice when writing, throwing, kicking a ball, jumping over a fence and stair-climbing. A question about safer/better ski turn to the left or to the right was also added. Second, 274 skiers answered the questions at one occasion. A very good agreement was shown in writing and throwing and kicking a ball, and a fair agreement was shown in jumping over a fence and stair climbing. A total of 243 skiers reported right-sided dominance, and seven skiers reported left-sided dominance. One hundred and nineteen of the 121 skiers who took part in the test-retest design answered the question safer/better ski turn, and of those 70 (59%) reported that they had a safer/better ski turn to one side than to the other side. However, the side was not consistent between the two test occasions, and the question did not correlate with side dominance. A combination of the three questions “What hand/arm do you use as first choice when writing?” “What hand/arm do you use as first choice when throwing?” and “What foot/leg do you use as first choice when kicking a ball?”, may be used to decide side dominance in adolescent alpine skiers. Most adolescent alpine skiers reported right-sided dominance.

An Investigation of Bilateral Symmetry in Softball Pitchers According to Body Composition

IntroductionHigh body fat percentage (bf%) is considered a potential injury risk factor for softball pitchers amidst the already high rates of pitching-related injury. Similarly, research points out that large bilateral asymmetries are another risk factor for softball pitchers. As softball pitching is a highly asymmetric sport and the repetitive nature of the windmill pitch places high stress on the body while pitchers are in unbalanced and asymmetric positions, research examining body composition and asymmetry is necessary.PurposeThe purpose of this study was to compare functional characteristics of softball pitchers with a healthy and a high bf%. Bilateral symmetry was assessed for pitchers' hip and shoulder isometric strength (ISO) and range of motion (ROM) between the following two groups of softball pitchers: (1) those with a high bf% (≥32%) and (2) those with a healthy bf% (<32%).MethodsA total of 41 high school female softball pitchers from the southern United States agreed to participate (1.69 ± 0.07 m, 76.14 ± 17.08 kg, 15.1 ± 1.1 years). Pitchers completed a dual-energy X-ray absorptiometry (DEXA) scan and were grouped into one of the following two categories based on their bf%: healthy (<32 bf%) and high (≥32 bf%). Bilateral symmetry was assessed for pitchers' hip and shoulder ISO and ROM using a handheld dynamometer and inclinometer, respectively. Bilateral arm bone and lean mass was also measured via the DEXA.ResultsMixed analyses of variance revealed a significant interaction between bf% groups and side dominance for internal rotation shoulder ROM, F(1, 39) = 14.383, p < 0.001, η2p = 0.269. Main effects for side dominance were also observed for shoulder external rotation ISO, F(1, 39) = 8.133, p = 0.007, η2p = 0.173, hip internal rotation ISO, F(1, 39) = 4.635, p = 0.038, η2p = 0.106, arm bone mass, F(1, 39) = 38.620, p < 0.001, η2p = 0.498, and arm lean mass, F(1, 39) = 101.869, p < 0.001, η2p = 0.723.ConclusionAsymmetries and slight differences in functional characteristics exist between bf% groups. Altered functional characteristics may influence pitchers' windmill pitch movement and should be acknowledged by support staff to improve softball pitchers' health and longevity.ImplicationsInsight into asymmetries can help researchers and clinicians understand the implication of excess body fat and further theorize mechanisms of injury among this athlete population.

Correlation of Rehabilitation and Throwing Program Milestones With Outcomes After Ulnar Collateral Ligament Reconstruction: An Analysis of 717 Professional Baseball Pitchers

Background: There remains room for improvement in surgical outcomes after medial ulnar collateral ligament reconstruction (MUCLR) in professional pitchers. The role and influence of postoperative rehabilitation on the outcomes of MUCLR are unknown. There is a paucity of clinical data in the current literature comparing the success of various postsurgical rehabilitation protocols after MUCLR. Purpose: To summarize the current rehabilitation process for professional pitchers recovering from MUCLR, evaluates what player and surgical factors correlate with outcomes, and determines whether rehabilitation timing and milestones correlate with successful outcomes. Study Design: Case series; Level of evidence, 4. Methods: 717 professional baseball pitchers who underwent MUCLR between 2010 and 2016 were identified and included in the analysis. Player characteristics evaluated included age at the time of surgery, throwing side dominance, primary pitching role (starter vs reliever), and level of play (MLB, AAA, AA, A). Surgical factors studied included date of surgery, graft type (palmaris longus autograft vs gracilis autograft), and surgical technique (figure of 8 vs docking vs other). The rehabilitation and throwing progression details were as follows: initiation date; first throw date; dates to start throwing from various distances; longest distance thrown; first flat ground throw date; first mound throw date; and first live batting practice (BP) date. The primary outcomes of interest were the ability to return to play at any level (RTP), the ability to return to the same level (RSL), and the time to RTP/RSL. Results: On average, pitchers threw a baseball for the first time 4.9 months after surgery, with a broad range (2.8-14.9 months). For the 675 (94%) pitchers who were able to progress to mound throwing, the first throws off a mound occurred at a mean of 9.4 months after surgery. Before progressing to the mound, the mean longest long-toss distance reached was 137.5 feet, with a broad range (105-300 feet). A high variation in the time to RTP (7.6-53.9 months) and RSL (8.6-60.7 months) was noted. A total of 599 (84%) pitchers were able to RTP at a mean time of 14.9 ± 4.9 months after surgery (range, 7.6-53.9 months). Also, 528 (74%) pitchers were able to RSL after MUCLR at a mean of 17.4 ± 7 months (range, 8.6-60.7 months) postoperatively. Age was the most significant predictor of RTP (hazard ratio [HR], 1.03 [95% CI, 1.01-1.05]; P = .01) and RSL (HR, 0.96 [95% CI, 0.93-0.99]; P < .01). For every 1-year increase in age, there was a 3% increase in the chance of RTP. Conversely, for every 1-year decrease in age, there was a 4% increase in the chance of RSL. MLB players were more likely to RTP (HR, 1.39 [95% CI, 1.18-1.63]; P < .01) but not necessarily to RSL (HR, 0.90 [95% CI, 0.75-1.08]; P = .24). The time from surgery to any of the rehabilitation milestones of interest (first throw, first flat ground pitching, first mound throwing, and first live BP) did not correlate with RTP or RSL (all, P >.05). The same was true for the greatest long-toss distance thrown before transitioning to the mound. Conclusion: Significant variability in the postoperative rehabilitation protocols after MUCLR was observed in 717 professional baseball pitchers. The timing of achievement of throwing progression and rehabilitation milestones postoperatively varied widely but did not correlate with outcomes. Player characteristics—except for player age and professional pitching level—did not correlate with RTP and RSL outcomes. Older pitchers and MLB pitchers were more likely to RTP, but younger players were more likely to RSL. Surgical factors did not correlate with rehabilitation outcomes.

Lateralization Direction, Strength, and Consistency in Juvenile and Adolescent Idiopathic Scoliosis: A Case Control Pilot Study

The aim of this study was to assess the hypothesis that functional laterality features are associated with scoliosis incidence. The study included 59 patients with radiologically confirmed idiopathic scoliosis (mean age 13 years, 41 girls and 18 boys) and 55 controls (mean age 10.5 years, 38 girls and 17 boys). Side dominance was determined by the Lateral Preference Inventory. Direction, strength, and consistency of lateral dominance was obtained. Continuous data were compared by Student’s t-test or U Mann-Whitney test where appropriate. Categorical data were compared by chi-squared test and Fisher’s exact test. Groups were significantly different in terms of age (p &lt; 0.001) and dependent variables: height (p &lt; 0.001) and weight (p &lt; 0.001). Lateralization analysis showed some trends, but the results obtained were not statistically significant. Statistical significance of lateralization direction are respectively: for hand (p = 0.364); leg (p = 0.277); eye (p = 0.804); ear (p = 0.938); number of right/left sided participants p = 0.492; p = 0.274; p = 0.387; p = 0.839, and right/mixed/left sided participants p = 0.930; p = 0.233; p = 0.691; p = 0.804. For laterality consistency depending on definition used, p = 0.105; p = 0.108; p = 0.380. The relationship between scoliosis and laterality is not a simple causal relationship and needs further investigation.

Lateralization of bladder function in normal female canines.

This study aimed to identify potential lateralization of bladder function. Electrical stimulation of spinal roots or the pelvic nerve’s anterior vesical branch was performed bilaterally in female dogs. The percent difference between the left and right stimulation-induced increased detrusor pressure was determined. Bladders were considered left or right-sided if differences were greater or less than 25% or 10%. Based on differences of 25%, upon stimulation of spinal roots, bladders were left-sided in 17/44 (38.6%), right-sided in 12/44 (27.2%) and bilateral in 15/44 (34.2%). Using ± 10%, 48% had left side dominance (n = 21/44), 39% had right side dominance (n = 17/44), and 14% were bilateral (n = 6/44). With stimulation of the pelvic nerve’s anterior vesical branch in 19 dogs, bladders were left-sided in 8 (42.1%), right-sided in 6 (31.6%) and bilateral in 5 (26.3%) using 25% differences and left side dominance in 8 (43%), right sided in 7 (37%) and bilateral in 4 (21%) using 10% differences. These data suggest lateralization of innervation of the female dog bladder with left- and right-sided lateralization occurring at similar rates. Lateralization often varied at different spinal cord levels within the same animal.

Individual and Combined Anatomic Risk Factors for the Development of an Anterior Cruciate Ligament Rupture in Men: A Multiple Factor Analysis Case-Control Study

Background: No comparative studies have evaluated anatomic risk factors in a large cohort including both patients with anterior cruciate ligament (ACL) ruptures and healthy participants. Purpose: To determine which anatomic parameters are independently associated with an ACL rupture and the diagnostic values of the individual and combined anatomic parameters. Study Design: Case-control study; Level of evidence, 3. Methods: A total of 352 male patients who underwent arthroscopic ACL reconstruction because of a primary ACL rupture and 350 age-, sex-, body mass index–, and side dominance–matched healthy participants were included. Measurements of 32 previously determined parameters and 7 calculations were performed. Between-group differences were calculated. Univariate and multivariate logistic regression models and receiver operating characteristic curve analysis were conducted for the individual and combined independently associated factors. Results: The mean age and body mass index of all participants were 29.9 ± 7.7 years and 27.2 ± 3.1, respectively. There were significant differences between the groups regarding the notch width (NW), notch shape index, anterior tibial slope, notch width index, NW–eminence width (NW:EW) ratio, notch height, axial lateral wall angle, medial intercondylar ridge thickness, alpha angle, medial tibial depth (MTD), lateral tibial slope (LTS), coronal tibial plateau width, eminence width index, tibial proximal anteroposterior distance (TPAP), lateral condylar anteroposterior distance (LCAP)/TPAP, ACL cross-sectional area, ACL volume, medial and lateral meniscal cartilage height, medial and lateral meniscal cartilage angle (MCA), and medial and lateral meniscal cartilage bone height. The NW:EW ratio (odds ratio [OR], 4.419; P = .017), MTD (OR, 8.617; P = .001), LTS (OR, 2.254; P = .011), LCAP/TPAP (OR, 2.782; P = .037), and medial MCA (OR, 1.318; P = .010) were independently associated with the development of an ACL rupture. Combining the independently associated factors revealed a sensitivity of 93% and a specificity of 94% (area under the curve, 0.968). Conclusion: Patients with ACL ruptures could be distinguished from uninjured controls with high sensitivity and specificity via the combined use of the NW:EW ratio, MTD, LTS, LCAP/TPAP, and medial MCA. In clinical practice, these findings may contribute to the development of preventive strategies for ACL ruptures.

Foot and Ankle Injuries in Elite Taekwondo Athletes: A 4-Year Descriptive Analysis.

Background:Foot and ankle injuries are a common but underestimated problem in taekwondo. Detailed data on injury incidence rates (IIRs), patterns, and injury mechanism are missing.Purpose:The primary aims were to evaluate the prevalence of foot and ankle injuries and the exposure-adjusted IIR of elite taekwondo athletes during matches while training (ie, sparring) and in competitions. The secondary aims were to evaluate injury site, type, sport-specific mechanism, and time loss.Study Design:Descriptive epidemiology study.Methods:Athletes from a single national Olympic taekwondo training center were assessed prospectively for foot and ankle injuries over 4 years (between January 1, 2016, and December 31, 2019). Data were collected regarding number and type of injuries, anatomic location, and total exposure time during training and competition for each athlete. Injury mechanism and dominant foot were assessed via personal interview. Time loss from sport was analyzed retrospectively. The injury prevalence and IIR were calculated. Correlation between mechanism and injury type, location, and dominant foot was evaluated. Time loss according to location and injury type was assessed. The chi-square test and Fisher exact test were used to test for differences in sex, age, and taekwondo experience and for comparison of injury location and type, injury mechanism, and side dominance, respectively. Training and competition IIRs and prevalence were calculated with 95% CIs (for Poisson rates).Results:From an initial 107 athletes, 79 (73.8%) were included in the final data set. Of these athletes, 38 were injured (n = 112 injuries) for a prevalence of 48.1% (95% CI, 43%-52%). The overall IIR of the ankle joint was 13.14 injuries per 1000 athletes (95% CI, 1.5-25.9) and was significantly higher during competition versus training (P < .001). Ankle joint injuries were most common (n = 71; 63%). Significantly more noncontact versus contact ankle ligament injuries (n = 46; 83%) occurred (P < .001). The forefoot (n = 18; 66%) was mainly affected by contact injuries (P < .001). Time loss was the highest for midfoot fractures (mean ± SD, 23.0 ± 0.6 days; range, 23-24 days).Conclusion:Noncontact ligamentous ankle injuries were most common, with a higher incidence during competition. Improvement of strength, endurance, and postural stability under strain is recommended for prevention.

Use of Dual-Energy X-Ray Absorptiometry to Assess Soft Tissue Composition in Breast Cancer Survivors With and Without Lymphedema.

Background: In patients with lymphedema (LE), in addition to hand dominance, between-group comparisons of interlimb soft tissue differences need to account for differences in whole-body adiposity, measured directly by dual energy X-ray absorptiometry (DXA) or indirectly by body mass index. No study has evaluated the effects of hand dominance and whole-body adiposity on limb composition in patients with LE. This study's purpose was to compare soft tissue composition of affected and unaffected limbs of women with breast cancer, who did and did not have LE, controlling for dominance and percent body fat. Methods and Results: Whole-body DXA scans were acquired and included measures of percent body fat, upper limb total mass, upper limb fat mass, and upper limb fat-free mass. Participants were classified into one of three groups: women without LE; women with only subjective LE; and women with objective signs of LE at the time of assessment. Differences among the LE groups were evaluated using analysis of variance (ANOVA) and Chi-square analyses. Analysis of covariance (ANCOVA) was used to control for percent body fat and for the affected limb dominance. Compared to women without LE, women with objective signs of LE have greater total limb mass, fat mass, and fat-free mass in their affected limbs, independent of affected side dominance and percent body fat. In addition, the interlimb differences in total mass, fat mass, and fat-free mass were greater for the women with objective signs of LE, compared to the other two groups. Conclusions: DXA is useful in identifying soft tissue changes in patients with LE. Given that limb circumferences measure only changes in limb volume and that bioimpedance provides estimates of extracellular fluid, DXA has the advantage of being able to estimate the volumes of specific tissues in the limb.

Cerebral Microbleeds, Cerebrospinal Fluid, and Neuroimaging Markers in Clinical Subtypes of Alzheimer's Disease

Lobar cerebral microbleeds (CMBs) in Alzheimer's disease (AD) are associated with cerebral amyloid angiopathy (CAA) due to vascular amyloid beta (Aβ) deposits. However, the relationship between lobar CMBs and clinical subtypes of AD remains unknown. Here, we enrolled patients with early- and late-onset amnestic dominant AD, logopenic variant of primary progressive aphasia (lvPPA) and posterior cortical atrophy (PCA) who were compatible with the AD criteria. We then examined the levels of cerebrospinal fluid (CSF) biomarkers [Aβ1-42, Aβ1-40, Aβ1-38, phosphorylated tau 181 (P-Tau), total tau (T-Tau), neurofilament light chain (NFL), and chitinase 3-like 1 protein (YKL-40)], analyzed the number and localization of CMBs, and measured the cerebral blood flow (CBF) volume by 99mTc-ethyl cysteinate dimer single photon emission computerized tomography (99mTc ECD-SPECT), as well as the mean cortical standard uptake value ratio by 11C-labeled Pittsburgh Compound B-positron emission tomography (11C PiB-PET). Lobar CMBs in lvPPA were distributed in the temporal, frontal, and parietal lobes with the left side predominance, while the CBF volume in lvPPA significantly decreased in the left temporal area, where the number of lobar CMBs and the CBF volumes showed a significant inversely correlation. The CSF levels of NFL in lvPPA were significantly higher compared to the other AD subtypes and non-demented subjects. The numbers of lobar CMBs significantly increased the CSF levels of NFL in the total AD patients, additionally, among AD subtypes, the CSF levels of NFL in lvPPA predominantly were higher by increasing number of lobar CMBs. On the other hand, the CSF levels of Aβ1-38, Aβ1-40, Aβ1-42, P-Tau, and T-Tau were lower by increasing number of lobar CMBs in the total AD patients. These findings may suggest that aberrant brain hypoperfusion in lvPPA was derived from the brain atrophy due to neurodegeneration, and possibly may involve the aberrant microcirculation causing by lobar CMBs and cerebrovascular injuries, with the left side dominance, consequently leading to a clinical phenotype of logopenic variant.

A quantitative analysis of gilthead seabream (Sparus aurata) juvenile dentition as a tool to assess the effect of diet

Gilthead seabream (Sparus aurata Linnaeus, 1758 (Perciformes, Sparidae)) is an important aquaculture species in the Mediterranean Sea basin. Yet, quantitative data on its dentition under standard farming conditions are currently lacking. Furthermore, it is unknown if the dentition can adapt to food of different sizes. Here, we describe the lower jaw dentition of juvenile S. aurata fed a standard pellet size (4 mm) and present a detailed analysis of 11 representative teeth. Overall, the number of teeth showed large individual variation, but it was not significantly related to fish length. Considerable left–right differences were observed, without clear side dominance. We also assessed the influence of feeding S. aurata a smaller (2 mm) or larger (6 mm) pellet size. Four months of feeding with different pellet sizes did not cause detectable differences in total tooth number on the dentaries at the time of harvest, nor in size of the teeth assumed to be most relevant in food processing. If and how different pellet sizes may nevertheless affect digestion, and eventually fish health, is subject for further studies.

The Neanderthal mandible BD 1 from La Chaise-de-Vouthon Abri Bourgeois-Delaunay (Charente, Southwestern France, OIS 5e). Dental tissue proportions, cortical bone distribution and endostructural asymmetry

The 23 fossil human remains found at La Chaise-de-Vouthon Abri Bourgeois-Delaunay (Charente, Southwestern France) are all attributed to Neanderthals. The BD 1 mandible represents one of the best preserved specimens recovered in this assemblage, still bearing the entire set of 16 teeth, and attributed to an adult - likely 20-35 years old –individual. The geochronological and paleontological data indicate that the Neanderthals from Abri Bourgeois-Delaunay lived in a temperate environment between 127 and 116 ka (i.e., during the OIS 5e). In this study, we integrate and expand the morphometric record of BD 1 by quantifying the tissue proportions of its entire permanent dentition, including radicular thickness repartition of four front teeth, and comparing its degree of endostructural asymmetry in tooth tissue organization and postcanine cortical bone topography with the patterns shown by Regourdou 1. Our results show that crown and radicular dental internal signature is typically Neanderthal, comparable with the available data for Regourdou 1, and is unambiguously distinct from the fossil and extant modern human patterns. Asymmetry in tooth tissue proportions in BD 1 and Regourdou 1 is clearly non-directional, as side dominance is nearly equally distributed between the left and the right antimeres. Similarly, both Neanderthal mandibles show no marked cortical bone asymmetry at the molar level, even if a slight right dominance is found in BD 1. Even if these results are globally consistent for the two Neanderthal mandible, extensive methodological research on the patterns of age- and sex-related endostructural variation displayed by human population samples from diverse chrono-geographic, socio-economic and biocultural contexts is still needed to more confidently evaluate the evolutionary and adaptive significance of the signals from the fossil record.

Evaluation of skeletal asymmetry of nasomaxillary complex in normal symmetrical face

This study was intended to evaluate the symmetry of nasomaxillary complex. It was carried on the sample of 100 Iraqi adults (50 males and 50 females) aged 18-25 years with Angle class I normal occlusion was selected according to certain criteriafrom the students in Mosul University. Statistical analysis of the data indicated that in both sexes the left and right sides of nasomaxillary complex had no significant differences with slight left side dominance over right side, except the canine area was slightly larger in the right side.

Changes In Peak Accelerations And Shock Attenuation Over The Course Of A Marathon

Peak tibial and peak sacral accelerations have been shown to increase during a fatiguing run. Peak accelerations are often used as a surrogate for impacts on the body during running. High tibial impacts have been linked to development of tibial stress fractures. To understand how impacts are related to injury development, we need more insight in how shocks propagate through the body, especially under the influence of fatigue. PURPOSE: To investigate bilateral peak accelerations and shock attenuation over the course of a Marathon. METHODS: 5 trained athletes (2M 3F, 33.8±11.8 years, 182.3±5.8 cm, 73.9±9.1 kg years) ran a Marathon during competition. Inertial measurement units (240Hz) were placed on the sternum, pelvis, and bilaterally on the tibia and foot. Mean peak accelerations around initial contact and shock attenuation (% decrease of peak acceleration) were calculated over 25 strides during the 2nd and 42nd km of the Marathon. Paired sample t-tests were used to test for statistical differences between the 2nd and 42nd km and between the dominant and non-dominant side. RESULTS: See Table 1. Mean finish time was 4:07:40±0:19:07. CONCLUSION: Impacts and shock attenuation changed asymmetrically during a Marathon. Both side dominance and fatigue significantly influenced shock attenuation. However, on sternum level, only fatigue influenced impacts and shock attenuation, implying some sort of protective mechanism to keep proximal impacts low. The non-dominant side showed larger impacts during the whole Marathon, possibly because this side is less strong and therefore less able to actively (i.e. muscle contractions) absorb shocks. Overall, impacts increased and shock attenuation decreased towards the end of the Marathon, possibly increasing the risk of overuse injuries.

Evaluation of carrying angle in 1st yr. Medical students of SVS medical college, Mahabubnagar

Background:The carrying angle is defined as the acute angle made by the median axis of the upper arm with that of the fully extended and supinated forearm, and thus it measures the lateral obliquity of the forearm. Aim of this study is to evaluate the elbow carrying angle by clinical measurement to check if there is a statistically significant difference among carrying angles of males and females of same age group and to study variation in age, sex, and also special reference to side dominance and to know variation of carrying angle in females considering weight & hip circumference. Materials and methods: 147 students of 1st yr. mbbs students of svs medical college were selected for the study. Out of which 94 were females and 53 were males. Carrying angle was calculated in both males and females for both upper limbs in standing position with forearm supinated and elbow extended by using goniometer Materials: goniometer, measuring tape, weighing machine. Results: Data was analyzed by Graph Pad Prism 6.01 version. All p-values less than 0.05 were considered as statistically significant. Carrying angle is more in females than in males. i.e median carrying angle in females is 16 on right side, 9 on left side. In males mean carrying angle is 10 on right side, 6 on left side. Conclusion: From the study we conducted there is significant difference in carrying angle among males and females of same age group. Dominant side carrying angle more than non-dominant side. There is no significant relationship between carrying angle and hip circumference in our study in females. There is no significant relationship between carrying angle and weight in our study in females.

Normative reference values for handgrip strength, shoulder and ankle range of motion and upper-limb and lower limb stability for 137 youth judokas of both sexes

ObjectivesTo provide reference values for handgrip strength, shoulder and ankle range of motion (ROM) and upper-limb and lower limb stability for youth judokas of both sexes and investigate the effects of sex and side dominance. DesignCross-sectional. MethodsA total of 137 youth judokas from under-18 (n=60) and under-21 (n=77) categories of both sexes were assessed. Handgrip strength was assessed using a Jamar dynamometer, ankle ROM was measured by lunge test, shoulder ROM was assessed by an inclinometer and upper-limb and lower limb stability were assessed by the Closed Kinetic Chain Upper Extremity Stability Test and by the Modified Star Excursion Balance Test (mSEBT). ResultsIn both categories, males had greater handgrip strength. In the under-18 category, the dominant side had greater handgrip strength, the non-dominant side of females had smaller shoulder external rotation ROM than the dominant side and also than both sides of males, and females had greater shoulder IR ROM. In the under-21 category, the dominant side of females had greater ankle dorsiflexion ROM than the dominant side of males, the dominant sides and females had greater shoulder ER ROM, and males had better performance in the mSEBT. ConclusionsThis study provided reference values for handgrip strength, shoulder and ankle ROM, upper and lower limb stability for youth judokas, which can be used to guide assessment during preseason. Sex influenced on shoulder ER and IR ROM, handgrip strength and lower limb stability. In addition, side dominance influenced on shoulder ER ROM and on handgrip strength.