Short Intervals Research Articles

Hepatic focal nodular hyperplasia during follow-up of patients after cyclophosphamide- or oxaliplatin-based chemotherapy: differentiation from liver metastasis

ObjectivesNewly detected hepatic nodules during follow-up of cancer survivors receiving chemotherapy may pose a diagnostic dilemma. We investigated a series of hepatic focal nodular hyperplasia (FNH) diagnosed by either typical MRI features and follow-up or pathology in cancer survivors.MethodsThis retrospective study evaluated 38 patients with tumours who developed new hepatic FNH after cyclophosphamide-based (n = 19) and oxaliplatin-based (n = 19) chemotherapies. The main tumour types were breast cancer (n = 18) and colorectal cancer (n = 17). MRI findings, clinical features, and temporal evolution of all target hepatic lesions (n = 63) were reported. In addition, the two chemotherapy drug groups were compared.ResultsThe median interval between chemotherapy completion and FNH detection was 30.4 months (12.9, 49.4). Six patients underwent biopsy or surgery, while the remaining patients were diagnosed based on typical MRI features and long-term follow-up. Among the patients, 60.5% (23/38) presented with multiple nodules and 63 target lesions were detected. The median size of target lesions was 11.5 mm (8.4, 15.1). The median follow-up time was 32.5 months (21.2, 48.6), and 15 patients experienced changes in their lesions during the follow-up period (11 increased and 4 decreased). The cyclophosphamide-based treatment group had a younger population, a greater proportion of females, and a shorter time to discovery than the oxaliplatin-based chemotherapy group (all p ≤ 0.016).ConclusionsFNH may occur in cancer survivors after cyclophosphamide- or oxaliplatin-based chemotherapy. Considering a patient’s treatment history and typical MRI findings can help avoid misdiagnosis and unnecessary invasive treatment.Clinical relevance statementWhen cancer survivors develop new hepatic nodules during follow-up, clinicians should think of the possibility of focal nodular hyperplasia in addition to liver metastasis, especially if the cancer survivors were previously treated with cyclophosphamide or oxaliplatin.Key PointsCancer survivors, after chemotherapy, can develop hepatic focal nodular hyperplasia.Cyclophosphamide and oxaliplatin are two chemotherapeutic agents that predispose to focal nodular hyperplasia development.Focal nodular hyperplasia occurs at shorter intervals in patients treated with cyclophosphamide.Graphical

Accelerometers-based position and time interval comparisons for predicting the behaviors of young bulls housed in a feedlot system

Animal behavior monitoring is an important tool for animal production. This behavior monitoring strategy can indicate the well-being and health of animals, which can lead to better productive performance. This study aimed to assess the most effective accelerometer attachment position (on either the halter or a neck collar) and data transmission time intervals (ranging from 6 to 600 s) for predicting behavioral patterns, including water and food intake frequencies, as well as other activities in young beef cattle bulls within a feedlot system. A range of machine learning algorithms were applied to satisfy the aims of the study, including the random forest, support vector machine, multilayer perceptron, and naive Bayes classifier algorithms. All studied models produced high performance metrics (above 0.90) when using both attachment positions, except for the models built using the naive Bayes classifier. Therefore, coupling accelerometers with collars is a more viable alternative for use on animals, as doing so is easier than applying accelerometers to halters. Utilizing a dataset with more observations (i.e., shorter time intervals) did not result in considerable improvements in the performance metrics of the trained models. Therefore, using datasets with fewer observations is more advantageous, as it can lead to decreased computational and temporal demands for model training, in addition to saving the battery of the device considered in this study.

A crucial step towards a safer healthcare system: Embracing the WHO surgery checklist in Pakistan.

Mistakes happen. We all make mistakes that makes us human. But when a surgeon makes mistake, it costs lives. Being surgeon, a little negligence might make catastrophic incidents happen. An unintentionally retained needle in the abdominal cavity or surgery of a normal limb instead of faulty gall bladder can have serious consequences not only for the patient and the patient-physician relation but also for the healthcare system. Such negligence events have become common in Pakistan. In Faisalabad, it was reported that a patient with gall stones was mixed up with a patient of limb surgery having the same name that led to inappropriate surgical procedures performed on both.[1] In Abbottabad, an incident was reported where the patient had to undergo an arm surgery but an eye surgery was performed in a private hospital. [2] Everyone blamed the surgeon and the health care system but no one dared to dig into the cause. Why are such childish mistakes happening? And if happened once how is this being repeated? How could a surgeon, a practically learned man make such non-sense? The answer to all these questions lies in the WHO Surgical Safety Checklist. “Safe Surgery Save Lives” was initiated by the World Health Organization (WHO) in 2007 in order to alleviate the number of such unwanted events encountered in the surgical procedures. For the purpose of improving patient safety with least of the resource utilization, WHO came on board with safety checklist in 2008.[3] The WHO 19-item checklist is based on advocating safety checks and a good communication among surgery team members during perioperative periods. It also contains a time-out procedure. In Pakistan, in spite of the great effectiveness, the time-out is either not practiced or is done by some junior, and not by the operating surgeon at the preoperative time. A time-out is a short interval before incision during which it is confirmed that the patient on the surgery bed is the correct one, the procedure to be performed on it is exact and at the required part of body either marked or unmarked.[4] The surgeon should be present at the time-out and all members should guarantee the correct patient, procedure and site. Patient participation in the time-out process is also advised. Majority of the patients show great compliance and satisfaction for participating in the time-out procedure. ---Continue

“Optimizing mine management: integrating lean theories and short interval control in surface mining”

ABSTRACT Frontline supervisors are pivotal in mining productivity, but face challenges due to the long working hours and rapid decision-making skills required. This paper proposes the application of Short Interval Control (SIC) to streamline information flow and support decision systems in mining, by developing a framework that aims to improve shovel performance during critical hours. Initial results demonstrated improvements in shift change and reduced operational disruption due to lunchtime breaks. Conclusively, although the methodology didn’t translate directly to significant improvements due to data availability, it became evident that SIC can help identify deviations and facilitate quick shifts within operational mining processes.

Seismic source analysis and directivity of the November 2021 Fin doublet earthquake in southern Iran: challenges and findings

Studying the source characteristics of doublet or multiple earthquake sequences presents significant challenges in seismology, especially with short time intervals between events. On November 14, 2021, a doublet earthquake (Mw 6.0 and Mw 6.1) occurred near Fin city, southern Iran, within a span of less than two minutes and 10 km apart. We employed the Kinematic Waveform Inversion (KIWI) procedure to determine the point and extended source parameters of these events, using a multistep inversion approach for stable solutions. Our analysis highlighted the directivity of the earthquakes: the first event exhibited bilateral directivity, causing a rupture area that reached the surface, while the second event showed unilateral westward directivity, supported by waveform amplitude differences observed at various stations. This directivity analysis plays an essential role in seismic hazard studies. Our findings regarding the source parameters of these recent doublet earthquakes in the Fin region align well with regional geological trends and fault patterns. However, retrieving the main fault plane for the second earthquake was challenging due to the complexities of the waveform. Moment tensor decomposition revealed significant non-double-couple components for the second event, indicating the complexity inherent in analyzing doublet events. This study underscores the critical role of precise waveform analysis and robust inversion techniques in understanding complex seismic events.

Postpartum contraception provision across Europe: preliminary findings from a multi country survey

Introduction Looking after a baby and recovering from birth pose barriers to accessing and initiating effective contraception in the postpartum period. Another pregnancy at this time can end in abortion or a short interbirth interval. These are preventable if contraception is provided immediately from maternity settings. Our aim was to survey contraceptive experts across Europe about provision of postpartum contraception (PPC) in their country to develop a greater understanding of availability of and delivery of PPC services within the region. Materials and Methods Contraceptive experts across Europe were invited to participate in an anonymous mixed-methods online survey consisting of free text and fixed-response questions focusing on: (1) national guidelines/policy (2) antenatal contraceptive discussion and (3) immediate postpartum provision of methods. Respondents were asked to rate PPC provision in their region and detail perceived facilitators or barriers. Results Experts from 28 countries completed the survey. Fifteen (40%) reported their country had national guidelines for PPC provision, 40% reported that some antenatal contraceptive counselling was offered and 51% reported that contraceptive methods were provided in some (43%) or all (8%) maternity settings. Country-level PPC provision was reported as ‘poor’ or ‘very poor’ by 54% of respondents. Reported barriers to PPC provision included: cost, lack of policy/government support, awareness and training of maternity staff. Conclusions There is significant variation in PPC provision across Europe. Few countries offer antenatal contraceptive counselling or provide contraception from maternity settings. Introduction of supportive PPC policies, funding and training for staff could improve outcomes for mothers and babies.

T cell activation markers CD38 and HLA-DR indicative of non-seroconversion in anti-CD20-treated patients with multiple sclerosis following SARS-CoV-2 mRNA vaccination

BackgroundMessenger RNA (mRNA) vaccines provide robust protection against SARS-CoV-2 in healthy individuals. However, immunity after vaccination of patients with multiple sclerosis (MS) treated with ocrelizumab (OCR), a B cell-depleting anti-CD20...

Facile synthesis of poly(tannic acid-1,4-butanediamine) microsphere based on the “self-assembly to polymerization” mechanism and its fast removal feature toward Cr(VI) ions

To remediate toxic Cr(VI) ions in wastewater is a daunting environmental challenge nowadays, thus advanced adsorbents are developed and used to overcome the low removal rate of existing technologies. Herein, poly(tannic acid-1,4-butanediamine) (PTBA) microspheres were synthesized for the purpose of fast removal of Cr(VI) from the aqueous phase. The synthesis was based on the “self-assembly to polymerization” mechanism. The microstructures and chemical characteristics of the fresh and used adsorbents PTBA were characterized systematically by means of TEM, SEM, FT-IR, XPS, TGA and XRD. Effects of pH, contact time, Cr(VI) initial concentration, PTBA dosage, temperature, and the presence of foreign ions on the removal of Cr(VI) had been investigated sequentially. The results indicated that almost 100% of removal efficiency could be achieved in short time intervals, based on the initial concentration of Cr(VI). The spontaneous and endothermic adsorption behavior could be well described by the pseudo-2nd-order (P2O) and Langmuir isotherm models. Finally, the process of partial reduction of Cr(VI) to non-toxic Cr(III) during the adsorption process was explained. Overall, the refined PTBA adsorbent presents a satisfactory behavior to ameliorate the Cr(VI)-pollution elimination means.

What an anesthesiologist should know about pediatric arrhythmias.

Identifying and treating pediatric arrhythmias is essential for pediatric anesthesiologists. Pediatric patients can present with narrow or wide complex tachycardias, though the former is more common. Patients with inherited channelopathies or cardiomyopathies are at increased risk. Since most pediatric patients present for anesthesia without a baseline electrocardiogram, the first identification of an arrhythmia may occur under general anesthesia. Supraventricular tachycardia, the most common pediatric tachyarrhythmia, represents a broad category of predominately narrow complex tachycardias. Stimulating events including intubation, vascular guidewire manipulation, and surgical stimulation can trigger episodes. Valsalva maneuvers are unreliable as treatment, making adenosine or other intravenous antiarrhythmics the preferred acute therapy. Reentrant tachycardias are the most common supraventricular tachycardia in pediatric patients, including atrioventricular reciprocating tachycardia (due to a distinct accessory pathway) and atrioventricular nodal reentrant tachycardia (due to an accessory pathway within the atrioventricular node). Patients with ventricular preexcitation, often referred to as Wolff-Parkinson-White syndrome, have a wide QRS with short PR interval, indicating antegrade conduction through the accessory pathway. These patients are at risk for sudden death if atrial fibrillation degenerates into ventricular fibrillation over a high-risk accessory pathway. Automatic tachycardias, such as atrial tachycardia and junctional ectopic tachycardia, are causes of supraventricular tachycardia in pediatric patients, the latter most typically noted after cardiac surgery. Patients with inherited arrhythmia syndromes, such as congenital long QT syndrome, are at risk of developing ventricular arrhythmias such as polymorphic ventricular tachycardia (Torsades de Pointes) which can be exacerbated by QT prolonging medications. Patients with catecholaminergic polymorphic ventricular tachycardia are at particular risk for developing bidirectional ventricular tachycardia or ventricular fibrillation during exogenous or endogenous catecholamine surges. Non-selective beta blockers are first line for most forms of long QT syndrome as well as catecholaminergic polymorphic ventricular tachycardia. Anesthesiologists should review the impact of medications on the QT interval and transmural dispersion of repolarization, to limit increasing the risk of Torsades de Pointes in patients with long QT syndrome. This review explores the key anesthetic considerations for these arrhythmias.

Clinicopathological and genetic characterization of radiotherapy-induced undifferentiated pleomorphic sarcoma following breast cancer: a case series of three tumors and comprehensive literature review

AimsCompared to primary breast sarcoma (BSs), radiotherapy-induced sarcoma (RIS) is a less frequent type of secondary breast sarcoma. Undifferentiated pleomorphic sarcoma (UPS) is an even rarer occurrence within the RIS category. This study aimed to present the clinicopathologic and molecular features of breast radiotherapy-induced UPS.MethodsA retrospective study was conducted at the Third Affiliated Hospital of Soochow University to analyze three patients with radiation-induced undifferentiated pleomorphic sarcoma (UPS) following breast cancer, spanning from 2006 to 2023. The clinical and pathological variables were extracted from the medical records, while immunohistochemistry was employed to analyze the immunophenotypes of these tumors. Genomic characteristics were assessed through DNA and RNA sequencing techniques. Another 15 cases from the literature were also reviewed to better characterize the tumor.ResultsThe affected areas encompass the chest wall and breasts, with an incubation period ranging from 6 to 17 years. The tumor cells exhibit pleomorphism and demonstrate a high degree of pathological mitosis. Notably, two cases displayed an accelerated disease progression, characterized by recurrent tumors and metastases occurring within short intervals of 48 and 7 months respectively subsequent to the initial diagnosis. The two prevailing identified genes were TP53 (2/3, 66.7%) and RB1 (1/3, 33.3%). Through analysis of somatic copy number variation (CNV), it was discovered that two oncogenes, MCL1 (1/3, 33.3%) and MYC (1/3, 33.3%), had experienced gains in CNV. The Tumor Mutational Burden (TMB) values for case 1, case 2, and case 3 were 5.9 mut/Mb, 1.0 mut/Mb, and 3.0 mut/Mb, respectively. Moreover, the analysis of RNA-NGS (next-generation sequencing) revealed the presence of a novel gene fusion, named COL3A1-GULP1, in case 2.ConclusionsBased on our thorough analysis of research findings and previous reports, it is evident that radiotherapy-induced UPS exhibits a highly diverse and frequently severe clinical and biological behavior. Identifying tumor formation using genome sequencing can help understand its biological behavior and determine personalized treatments.

How do plateau pikas use burrows during population reestablishment?

The construction of burrow systems is one of the most important challenges for burrowing animals, especially during population reestablishment. Efficient use of the existing resources could help improve the survival chances. To explore the strategies burrowing animals take in using the burrow resources, we conducted monthly field monitoring of the four features (Active burrows (AcB), abandoned burrows (AbB), latrine pits (LP), and shallow duck holes (SDH)) of plateau pika (Ochotona curzoniae) burrow systems after population extermination. The results indicated that the existing burrows were largely utilized in rebuilding their new burrow systems. The use rates of the four features were in the order of AcBs > AbBs > LPs > SDHs. More energy-saving measures were taken in using the existing burrows during population reestablishment than in the undisturbed natural ecosystems, including higher maintenance rates, higher transformation rates to AcBs, lower disappearing rates and new adding rates, especially in short time intervals; and burrows at the early breeding season are used more stable than at other times. Our study has implications for the population reestablishment of endangered burrowing animals.

Remarks on the Connection of the Riemann Hypothesis to Self-Approximation

By the Bagchi theorem, the Riemann hypothesis (all non-trivial zeros lie on the critical line) is equivalent to the self-approximation of the function ζ(s) by shifts ζ(s+iτ). In this paper, it is determined that the Riemann hypothesis is equivalent to the positivity of density of the set of the above shifts approximating ζ(s) with all but at most countably many accuracies ε>0. Also, the analogue of an equivalent in terms of positive density in short intervals is discussed.

Pain perception, aqueous humour cytokines, and miosis response following first and second eye femtosecond laser-assisted cataract surgery: A randomised, prospective, intraindividual study.

To compare pain perception, pupil behaviours, and cytokine levels during first-eye and second-eye femtosecond laser-assisted cataract surgery (FLACS) and determine which is better regarding a short or long interval for bilateral FLACS. Notably, 96 eyes of 48 patients with bilateral cataracts underwent the first surgeries in the left or right eye, according to a random sequence. They were further randomised into 2- and 6-week subgroups based on surgery intervals. Pupil size was measured from captured images, and pain perception was assessed using a visual analog scale (VAS). Aqueous humour prostaglandin E2 (PGE2), monocyte chemoattractant protein-1 (MCP-1), interleukin (IL)-6, and IL-8 levels were also quantitatively analysed. All patients were followed for 1 week to evaluate changes in endothelial cell density (ECD), central corneal thickness (CCT), and macular central subfield thickness (CST). Ocular pain was significantly higher in patients who underwent second-eye FLACS. First tear break-up time was negatively correlated with VAS score. MCP-1 levels were significantly higher in patients who underwent second-eye FLACS, and VAS scores were positively correlated with MCP-1 levels across all patients. There were no differences between sequential FLACS in miosis, PGE2, IL-6, IL-8 levels and changes in postoperative ECD, CCT, and CST. Patients who underwent second-eye FLACS after 6 weeks showed more CCT, CST, and MCP-1 changes than baseline. Second-eye FLACS causes more pain and upregulated MCP-1. There was no difference between sequential FLACS in PGE2 levels, miosis, and postoperative inflammation. Furthermore, first-eye FLACS triggered a sympathetic irritation, particularly after a 6-week interval.

Racial and ethnic associations with interstitial lung disease and healthcare utilization in patients with systemic sclerosis.

Racial and ethnic differences in presentation and outcomes have been reported in systemic sclerosis (SSc) and SSc-interstitial lung disease (ILD). However, prior studies have limited diversity. We aim to evaluate if there are racial/ethnic differences associated with ILD, time intervals between SSc and ILD and with emergency department (ED) visit or hospitalization rates. Clinical and sociodemographic variables were extracted for 756 patients with SSc from longitudinal health records in an integrated health-system. Logistic regression models analyzed the association of covariates with ILD and age at SSc-ILD. Healthcare outcomes were analyzed with complementary log-log regression models. Overall, 33.7% of patients in the cohort had an ILD code, with increased odds for Asian (odds ratio [OR], 2.60; 95% confidence interval [CI], 1.29-5.28; p=0.008) compared with White patients. The predicted age in years of SSc-ILD was younger for Hispanic (estimate, -6.5; 95% CI, -13--0.21; p = 0.04) and Black/African American patients (-10; 95% CI -16--4.9; p < 0.001) compared with White patients. Black/African American patients were more likely to have an ILD code before an SSc code (59% compared with 20.6% of White patients), and the shortest interval from SSc to ILD (3 months). Black/African American (HR, 2.59; 95% CI 1.47-4.49; p = 0.001) and Hispanic patients (HR 2.29; 95% CI 1.37- 3.82; p = 0.002) had higher rates of an ED visit. We found that odds of SSc-ILD differed by racial/ethnic group, minoritized patients had earlier age of presentation, and greater rates of an ED visit.

Enhanced photocatalytic degradation of brilliant green using g-C3N5/WO3 nanocomposite: A Z-scheme charge transfer approach under visible light irradiation

The industrial use of dyes is harming natural ecosystems. Photocatalysis is a potentially useful method for addressing these kinds of environmental contaminants. The present study addresses the synthesis of a novel g-C3N5/WO3 Z-scheme heterojunction via the ultra-sonication method and the calcination method with the use of a triazole. The toxic dye, brilliant green (BG) was degraded by utilizing the prepared photocatalyst. The elemental composition, surface morphology and structureof the prepared g-C3N5/WO3nanocomposite were analysed using various techniques including XPS, PL, SEM-EDAX, HRTEM, and XRD. The average diameter of the g-C3N5/WO3 nanocomposite was found to be 44 nm using TEM. The optical properties were analysed using UV-DRS. The as-synthesized g-C3N5/WO3nanocomposite had a direct band gap of 2.27 eV, as determined fromTauc’s plot and demonstrated exceptional photocatalytic degradation efficacy for the elimination of the BG dye via the Advanced Oxidation Process (AOP). A degradation efficacy of 99.4 % within a short interval of time of 60 min was achieved by the prepared photocatalyst under various optimum situations. The rate constant of the photocatalytic reaction was calculated to be 0.05994 min−1 following a pseudo first order kinetics. Additionally, with an efficiency of90.17 %the photocatalyst can be recycled upto the fourth cycle. The current work accomplishes the goal of creating an innovative and effective photocatalyst that is responsive towards visible light.

Linking Inter-professional Newborn and Contraception Care (LINCC) trial: Protocol for a stepped wedge cluster randomized trial to link postpartum contraception care with routine Well-Baby Visits

BackgroundPregnancies conceived within 18 months of a prior delivery (termed short inter-pregnancy interval [IPI]) place mothers and infants at high risk for poor health outcomes. Despite this, nearly one third of U.S. women experience a short IPI. ObjectiveTo address the gap in the current model of postpartum (PP) contraception care by developing and implementing a novel approach to link (co-schedule) PP contraception care with newborn well-baby care to improve access to timely PP contraception. MethodsThe LINCC Trial will take place in seven clinical locations across five community health centers within the U.S. PP patients (planned n = 3150) who are attending a Well-Baby Visit between 0 and 6 months will be enrolled. The LINCC Trial aims to leverage the Electronic Health Record to prompt providers to ask PP patients attending a Well-Baby Visit about their PP contraception needs and facilitate co-scheduling of PP contraception care with routine newborn care visits. The study includes a cluster randomized, cross-sectional stepped wedge design to roll out the intervention across the seven sites. The outcomes of the study include receipt of most or moderately effective methods of contraception by two and six months PP; and rate of short IPI pregnancies. Implementation outcomes will be assessed at baseline and 6 months after site enters intervention period. ConclusionsThe LINCC Trial seeks to evaluate the effectiveness and feasibility of a linked care model in comparison to usual care.

Dynamic Metabolic Bottlenecks of a Geobacter sulfurreducens Bioelectrochemical System Studied Using Microfluidics and the Arrhenius Equation

To target development of bioelectrochemical systems, we developed an advanced microfluidic method to identify reaction bottlenecks in the metabolic activity of a pure‐culture Geobacter sulfurreducens electroactive biofilm (EAB). The microfluidic system was devised to include perpendicular flow orientation for improved boundary layer uniformity and was combined with an embedded 3‐electrode system to accurately apply a constant potential during the entire experimental duration. A 3‐sensor temperature control system provided the basis of accurate temperature pulsing, which modified the EAB metabolic activity over short time intervals relative to the bacterial doubling rate. The system, together with the unique ability to control hydrodynamic, electrochemical, and thermal conditions, was used as the basis for an Arrhenius approach to obtain activation energy barrier values at different growth times, acetate concentrations, and flow rates. The results indicated that bottlenecks in the overall metabolic activity after 1 month of growth time were related to electron transfer through extracellular cytochrome c. After the EAB further matured to 4 months old, the bottleneck appeared to switch to enzyme‐driven acetate oxidation. Based on this hypothesis, we observed after 4‐months, that strong increases in effective enzyme concentration were primarily obtained by increasing flow rate, and secondarily by increasing acetate concentration.

On certain unbounded multiplicative functions in short intervals

On certain unbounded multiplicative functions in short intervals

Anatomical and electrophysiological analysis of the fasciola cinerea of the mouse hippocampus.

The hippocampus is considered essential for several forms of declarative memory, including spatial and social memory. Despite the extensive research of the classic subfields of the hippocampus, the fasciola cinerea (FC)-a medially located structure within the hippocampal formation-has remained largely unexplored. In the present study, we performed a morpho-functional characterization of principal neurons in the mouse FC. Using in vivo juxtacellular recording of single neurons, we found that FC neurons are distinct from neighboring CA1 pyramidal cells, both morphologically and electrophysiologically. Specifically, FC neurons displayed non-pyramidal morphology and granule cell-like apical dendrites. Compared to neighboring CA1 pyramidal neurons, FC neurons exhibited more regular in vivo firing patterns and a lower tendency to fire spikes at short interspike intervals. Furthermore, tracing experiments revealed that the FC receives inputs from the lateral but not the medial entorhinal cortex and CA3, and it provides a major intra-hippocampal projection to the septal CA2 and sparser inputs to the distal CA1. Overall, our results indicate that the FC is a morphologically and electrophysiologically distinct subfield of the hippocampal formation; given the established role of CA2 in social memory and seizure initiation, the unique efferent intra-hippocampal connectivity of the FC points to possible roles in social cognition and temporal lobe epilepsy.

Marketing Strategy for Online Condition Monitoring (Case Study: Nanoprecise Machine Doctor)

Today’s industry is facing ever-increasing competition. To stay competitive, a company needs to maintain the high reliability and productivity of its assets. Companies must invest in maintenance programs to prevent unplanned downtime and reach their optimal reliability. Predictive maintenance or condition-based maintenance is an important aspect of a maintenance program to maintain asset reliability. One emerging predictive maintenance tool, fueled by digital disruption, is online condition monitoring. Online condition monitoring provides diagnostics with shorter intervals than walking survey analysis with portable analyzers, allowing it to diagnose faults not detectable by other condition monitoring methods. Adikari Wisesa Indonesia, a firm specializing in maintenance services, has partnered with Nanoprecise Sci Corp and is the sole distributor of Machine Doctor sensors in Indonesia to enhance its maintenance service. However, the sales of Machine Doctor were suboptimal. This study aims to identify the business issue, provide analysis, and propose a solution to the business issue. The market is analyzed using the STP framework. Then, the general environment (PESTEL), industry environment (Five Forces), and competitor analysis are performed to better understand the external environment Adikari Wisesa is currently in. After analyzing the external environment, the internal environment of Adikari Wisesa is studied by using a Resource-Based View, VRIO, and Value Chain Analysis. Then, a SWOT analysis is performed summarizing the business situation of the company. A business solution is then proposed based on a TOWS matrix.