Short-term Prevention Research Articles

Modern management of acute atrial fibrillation and atrial flutter.

This clinical review is intended to assist emergency physicians manage patients who present to the emergency department (ED) with acute/recent-onset atrial fibrillation (AF) or flutter (AFL). This article is based primarily on the 2021 Canadian Association of Emergency Physicians (CAEP) Acute Atrial Fibrillation/Flutter Best Practices Checklist. We encourage readers to download the open access CAEP Checklist article (https://link.springer.com/article/10.1007/s43678-021-00167-y) and the free smartphone app (CAEP Atrial Fibrillation Guide). We focus on four key elements of ED care: assessment and risk stratification, rate and rhythm control, short-term and long-term stroke prevention, and disposition and follow-up. It is important to determine if AF/AFL with rapid ventricular response is a primary arrhythmia or secondary to medical causes. While it is unusual for patients with primary AF to be unstable, urgent cardioversion is occasionally required. The criteria for when cardioversion is safe have recently changed and it is essential that physicians are well versed in them. When rhythm control is not safe, provide effective and safe IV rate control. When rhythm control is safe, either pharmacological or electrical cardioversion acceptable, per patient and physician preference. Rapid ventricular pre-excitation (Wolff-Parkinson-White Syndrome) usually, but not always, requires urgent electrical cardioversion. ED physicians should prescribe oral anticoagulants at discharge if indicated. No specific direct oral anticoagulant is preferred, and references should be freely consulted for optimal dosing. Hospital admission is rarely required for acute AF/AFL patients, who should be given good discharge instructions.

FBS-TGCN: a temporal graph-convolutional-network model for spatiotemporal prediction of spam messages from fake base stations

Spam messages affect the normal communication of mobile phone users and public security. Fake base station (FBS) is the main channel for sending spam messages. Accurate spatiotemporal prediction of spam messages from FBS is important for implementing short-term spam prevention measures by the police. However, existing models used for spam messages modeling often focus on capturing spatial dependencies based on distance, thus failing to fully exploit spatial dependencies hidden in the data. Meanwhile, they encounter difficulties in mitigating the impact of excessive zero data. Therefore, based on the crowdsourced spam message data, a temporal graph-convolutional-network model (FBS-TGCN) is developed for the spatiotemporal prediction of spam messages from FBS. This model includes graph convolutional network (GCN) and gated temporal convolutional network (TCN) to capture the spatial and temporal dependencies alternatively. We further combine a weighted adjacency matrix and a self-adaptive adjacency matrix to capture both distance-based spatial dependencies and hidden spatial dependencies. A weighted loss function is used to mitigate the influence of excessive zero data. Experimental results using the spam dataset in Beijing demonstrate the effectiveness of the proposed model when compared to the baseline models, especially in the prediction of spam messages quantity and high spamming areas.

Spatiotemporal multi-graph convolutional network-based provincial-day-level terrorism risk prediction.

Predicting terrorism risk is crucial for formulating detailed counter-strategies. However, this task is challenging mainly because the risk of the concerned potential victim is not isolated. Terrorism risk has a spatiotemporal interprovincial contagious characteristic. The risk diffusion mechanism comes from three possibilities: cross-provincial terrorist attacks, internal and external echoes, and internal self-excitation. This study proposed a novel spatiotemporal graph convolutional network (STGCN)-based extension method to capture the complex and multidimensional non-Euclidean relationships between different provinces and forecast the daily risks. Specifically, three graph structures were constructed to represent the contagious process between provinces: the distance graph, the province-level root cause similarity graph, and the self-excited graph. The long short-term memory and self-attention layers were extended to STGCN for capturing context-dependent temporal characters. At the same time, the one-dimensional convolutional neural network kernel with the gated linear unit inside the classical STGCN can model single-node-dependent temporal features, and the spectral graph convolution modules can capture spatial features. The experimental results on Afghanistan terrorist attack data from 2005 to 2020 demonstrate the effectiveness of the proposed extended STGCN method compared to other machine learning prediction models. Furthermore, the results illustrate the crucial of capturing comprehensive spatiotemporal correlation characters among provinces. Based on this, this article provides counter-terrorism management insights on addressing the long-term root causes of terrorism risk and performing short-term situational prevention.

Fight against cholera outbreak, efforts and challenges in Malawi.

Cholera is endemic in many African countries with recurrent seasonal outbreaks in parts of the region. Malawi has been experiencing seasonal outbreaks of Cholera since 1998, and it is one of the major public health problems. The current cholera outbreak is one of Malawi's worst cholera outbreaks in the past 10 years. Since the beginning of the outbreak about 56,090 cumulative cases of cholera have been reported with 1712 deaths representing a case fatality rate of 3.1%. This is happening when the country is recovering from the COVID-19 epidemic, the devastating effects of tropical storms, and is also tackling the polio outbreak. Clearly, the Malawian health system is overstretched. Nevertheless, the country has taken a positive step in responding to the current cholera outbreak. Setting up treatment facilities, stepping up Water, Sanitation, and Hygiene (WASH) initiatives in impacted areas, and improving the surveillance system for early case detection and treatment are some of the actions taken. As the fight against cholera continues there is a need to significantly increase monitoring in all districts, particularly at the community level for early detection and control of the cholera. Considering there are some cross-border cases from neighboring countries such as Mozambique, good collaboration between the two countries in strengthening surveillance and hygiene practices in the borders will help in controlling the spread of the disease. While it is commendable that dozens of oral cholera vaccines have been given, it should be noted that this provides short-term prevention. In addressing the nation's ongoing and recurrent cholera outbreaks, we advise prioritizing WASH efforts in addition to oral cholera vaccine administration.

Integrins in GtoPdb v.2023.1

Integrins are unusual signalling proteins that function to signal both from the extracellular environment into the cell, but also from the cytoplasm to the external of the cell. The intracellular signalling cascades associated with integrin activation focus on protein kinase activities, such as focal adhesion kinase and Src. Based on this association between extracellular signals and intracellular protein kinase activity, we have chosen to include integrins in the 'Catalytic receptors' section of the database until more stringent criteria from NC-IUPHAR allows precise definition of their classification.Integrins are heterodimeric entities, composed of α and β subunits, each 1TM proteins, which bind components of the extracellular matrix or counter-receptors expressed on other cells. One class of integrin contains an inserted domain (I) in its α subunit, and if present (in α1, α2, α10, α11, αD, αE, αL, αM and αX), this I domain contains the ligand binding site. All β subunits possess a similar I-like domain, which has the capacity to bind ligand, often recognising the RGD motif. The presence of an α subunit I domain precludes ligand binding through the β subunit. Integrins provide a link between ligand and the actin cytoskeleton (through typically short intracellular domains). Integrins bind several divalent cations, including a Mg2+ ion in the I or I-like domain that is essential for ligand binding. Other cation binding sites may regulate integrin activity or stabilise the 3D structure. Integrins regulate the activity of particular protein kinases, including focal adhesion kinase and integrin-linked kinase. Cellular activation regulates integrin ligand affinity via inside-out signalling and ligand binding to integrins can regulate cellular activity via outside-in signalling.Several drugs that target integrins are in clinical use including: (1) abciximab (αIIbβ3) for short term prevention of coronary thrombosis, (2) vedolizumab (α4β7) to reduce gastrointestinal inflammation, and (3) natalizumab (α4β1) in some cases of severe multiple sclerosis.

An Update in Anticoagulant Therapy for Patients with Cancer-Associated Venous Thromboembolism.

This review aims to assess the treatment options for cancer-associated venous thromboembolism (VTE) based on the most robust level of evidence recommendations and suggestions based on expert opinion. Several classes of anticoagulants have been studied in the treatment of cancer-associated thrombosis (CAT). Since the CLOT trial, guidelines recommend the use of low-molecular-weight heparin (LMWH) for the treatment of this condition. However, since 2018, some direct oral anticoagulants became an alternative first-line treatment for CAT. Three Xa antagonists (rivaroxaban, apixaban, and edoxaban) proved to be at least as effective as the LMWH strategy for the short-term prevention of VTE recurrence. The right choice of treatment in the context of anticoagulation strategy, thrombo-hemorrhagic risk management, and a patient's comorbidities represents a challenge. The correct management of CAT and a more individualized approach are needed to identify risk factors and offer the best treatment for each patient.

Expert consensus established around flexible, individualized migraine treatment utilizing a modified Delphi panel.

To characterize treatment decision-making processes and formalize consensus regarding key factors headache specialists consider in treatment decisions for patients with migraine, considering novel therapies. Migraine therapies have long been subject to binary classification, acute versus preventive, due to limitations of available drugs. The emergence of novel therapies that can be used more flexibly creates an opportunity to rethink this binary classification. To determine the role of these novel therapies in treatment, it is critical to understand whether existing guidelines reflect clinical practice and to establish consensus around factors driving management. A three-round modified Delphi process was conducted with migraine clinical experts. Round 1 consisted of an online questionnaire; Round 2 involved an online discussion of aggregated Round 1 results; and Round 3 allowed participants to revise Round 1 responses, incorporating Round 2 insights. Questions elicited likelihood ratings (0= highly unlikely to 100=highly likely), rankings, and estimates on treatment decision-making. Nineteen experts completed three Delphi rounds. Experts strongly agreed on definitions for "acute" (median= 100, inter-quartile range [IQR]=5) and "preventive" treatment (median=90, IQR=15), but noted a need for treatment customization for patients (median=100, IQR=6). Experts noted certain aspects of guidelines may no longer apply based on established tolerability and efficacy of newer acute and preventive agents (median=91, IQR=17). Further, experts agreed on a treatment category referred to as "situational prevention" (or "short-term prevention") for patients with reliable and predictable migraine triggers (median=100, IQR=10) or time-limited periods when headache avoidance is important (median=100, IQR=12). Using the modified Delphi method, a panel of migraine experts identified the importance of customizing treatment for people with migraine and the utility of "situational prevention," given the ability of new treatment options to meet this need and the potential to clinically identify patients and time periods when this approach would add value.

Associations between Solitary Confinement and Psychosis Symptoms in the Postrelease Community Setting

AbstractSome evidence suggests that the practice of solitary confinement in incarceration settings is linked to poor mental health outcomes; however, prior research has not yet examined associations between experiences of solitary confinement and psychosis symptoms. To address this gap, authors conducted a cross-sectional survey of 201 formerly incarcerated men and women in the United States to examine the relationship between solitary confinement and psychosis symptoms in the postrelease community setting. Results indicated that solitary confinement was significantly associated with higher levels of current psychosis symptoms after controlling for demographic factors and clinical characteristics. These findings highlight the need for short-term and long-term community-based mental health interventions and prevention efforts in the postrelease community setting. Social workers and practitioners in community mental health settings should be cognizant of patients’ histories with solitary confinement and consider how these experiences may present risks to current mental health symptoms (i.e., early onset psychosis). Future studies are needed on protective mechanisms that may buffer the effects of prior solitary confinement on psychosis.

Краткосрочная профилактика интернет-зависимости у старших подростков

The work is devoted to the analysis of the implementation of the program of short-term prevention of Internet addiction in older adolescents in the ever-increasing informatization of society, in the conditions of metropolitan gymnasiums. Domestic scientists focus on various aspects of Internet addiction, which are manifested in adolescents. Foreign research is carried out at the intersection of psychology with pharmacotherapy, psychiatry, philosophy, sociology, and addictology. The novelty of the study lies in highlighting the stages of forming ideas about the phenomenon of Internet addiction based on methodological and theoretical analysis, as well as clarifying the concepts of “informatization”, “digitalization”, “Internet addiction”. Based on the generally accepted paradigm of Internet addiction as a standard non-chemical addiction, acting as desocializing or interfering with normal socialization, based on the development of the modern information society, there is a need to prevent Internet addiction. The purpose of the article was to describe the empirical results of a study of short-term prevention of Internet addiction in older adolescents in urban gymnasiums. It was assumed that purposefully organized prevention of Internet addiction would contribute to its reduction, regardless of the timing of the implementation of preventive measures. The study involved 50 students of the 9th grade aged 14 to 16 years. An analysis of the results of the primary diagnosis of grade 9 of two different educational organizations before the start of the program showed that 94 % of students are at risk for the formation of Internet addiction and allowed us to say that older adolescence is a key factor in the emergence of a tendency to Internet addictive behavior. Experimental work was aimed at the implementation of a short-term group program for the prevention of Internet addiction in students of older adolescence. According to the results of the final diagnosis, the only significant quantitative change in the experimental group was the change in the Scale of intrapersonal problems, which may indicate the effectiveness of the training part of the preventive work, as well as the effectiveness of individual consulting work provided to students. The factors of inefficiency of a short-term prevention program and targets in building a comprehensive work on the prevention of Internet addiction among students of educational institutions are identified.

A LASSO-Based Prediction Model for Child Influenza Epidemics: A Case Study of Shanghai, China

Child influenza is an acute infectious disease that places substantial burden on children and their families. Real-time accurate prediction of child influenza epidemics can aid scientific and timely decision-making that may reduce the harm done to children infected with influenza. Several models have been proposed to predict influenza epidemics. However, most existing studies focus on adult influenza prediction. This study demonstrates the feasibility of using the LASSO (least absolute shrinkage and selection operator) model to predict influenza-like illness (ILI) levels in children between 2017 and 2020 in Shanghai, China. The performance of the LASSO model was compared with that of other statistical influenza-prediction techniques, including autoregressive integrated moving average (ARIMA), random forest (RF), ordinary least squares (OLS), and long short-term memory (LSTM). The LASSO model was observed to exhibit superior performance compared to the other candidate models. Owing to the variable shrinkage and low-variance properties of LASSO, it eliminated unimportant features and avoided overfitting. The experimental results suggest that the LASSO model can provide useful guidance for short-term child influenza prevention and control for schools, hospitals, and governments.

Bisphosphonate Use for Glucocorticoid-Induced Osteoporosis in Elderly Patients with Immune Thrombocytopenia Receiving Prolonged Steroid Therapy: A Single Institute Retrospective Study.

Prednisolone, used as a standard initial treatment for immune thrombocytopenia (ITP), is an important risk factor for osteoporosis. To investigate the prevention of glucocorticoid-induced osteoporosis (GIO) in elderly ITP patients receiving prolonged steroid therapy, associations between GIO prevention and the real-world data of score changes of a dual-energy X-ray absorptiometry (DXA) scan, FRAX® and the Garvan tool during the initial loading of prednisolone were examined. In our institute, 22 ITP patients aged ≥ 70 years received 0.5–1.0 mg/kg prednisolone for 2–3 weeks as the initial ITP treatment between 2014 and 2021. The femoral neck bone mineral density (BMD) measured by DXA scan was entered into FRAX® to define the risk-adapted approach to bisphosphonate during the initial loading of prednisolone. Bisphosphonate was administered according to <−1.0 femoral neck BMD T-score measured by DXA scan. Worse scores of FRAX® and the Garvan tool were associated with bisphosphonate use for short-term fracture prevention in primary GIO; however, there were no incidents of fracture or significant differences in probabilities determined by FRAX® and the Garvan tool. During the initial loading of prednisolone, prescribing bisphosphonate might prevent the reduction in BMD in elderly patients with ITP receiving prolonged steroid therapy.

Opioid relapse and MOUD outcomes following civil commitment for opioid use

IntroductionOpioid use disorder (OUD) continues to present a major public health problem in the United States. Civil commitment for substance use is one mandatory form of treatment for severe opioid use that has become increasingly available in recent years, but empirical data on this approach are lacking. This study examines clinical outcomes of civil commitment in a sample of adults with severe opioid use. MethodsParticipants were 121 persons with opioid use who were interviewed at the point of entry into civil commitment, then followed for 12 weeks after their release. ResultsPrior to civil commitment, this sample exhibited serious substance use characteristics (including high rates of illicit opioid use, other substance use, and injection drug use), as well as mental health problems (diagnoses of depression and anxiety disorders). During follow-up, approximately 41 % of the sample reported at least one illicit opioid use day. More than 64 % of the sample reported at least one day of medication for opioid use disorder (MOUD) receipt, and participants were significantly less likely to use illicit opioids on days that they received MOUDs. No participants died during the follow-up period. ConclusionsIn this sample of persons with severe opioid use, clinical outcomes of civil commitment included illicit opioid relapse as well as varying levels of MOUD uptake. Civil commitment may be a viable method for short-term prevention of overdose for a subset of this vulnerable patient population.

Livelihood Capital Effects on Famers' Strategy Choices in Flood-Prone Areas-A Study in Rural China.

The global climate change has resulted in huge flood damages, which seriously hinders the sustainable development of rural economy and society and causes famers’ livelihood problems. In flood-prone areas, it is imperative to actively study short and long-term strategies and solve farmers’ livelihood problems accordingly. Following the sustainable development analysis framework proposed by the Department for International Development (DFID), this study collects empirical data of 360 rural households in six sample villages in the Jialing River Basin of Sichuan Province, China through a village-to-household field questionnaire and applies the Multinominal Logit Model (MNL) to explore the influence of farmer households’ capital on livelihood strategy choice. Research results show that: (1) In human capital category, the education level of the household head has a significant positive impact on the livelihood strategies of farmers’ families; (2) In physical capital category, farmer households with larger space have more funds to choose among flood adaptation strategies; (3) In natural capital category, house location and the sale of family property for cash have the greatest negative impact on farmers’ livelihood strategies; (4) Rural households with more credit opportunities in financial capital are more willing to obtain emergency relief funds; (5) Farmers’ families helped by the village for a long time will probably not choose to move to avoid floods, but are more likely to choose buying flood insurance. This study provides an empirical reference for effective short and long term prevention and mitigation strategies design and application in rural in flood-prone areas.

Relapse-Free Course in Nearly Half of Crohn's Disease Patients With Infliximab and Plant-Based Diet as First-Line Therapy: A Single-Group Trial.

Introduction Incorporation of a plant-based diet was effective in both induction and short-term relapse prevention in Crohn's disease. Ten-year long-term relapse-free rates in Crohn's disease are around 10% to 23%. Objective We investigated whether infliximab and plant-based diet as first-line therapy enhance the long-term relapse-free rate in patients with Crohn's disease. Methods This single-group, prospective study was performed in tertiary hospitals in Japan. Remission was induced in 24 consecutive newly diagnosed adult patients with Crohn's disease during hospitalization via 3 standard infliximab infusions together with a plant-based diet. Patients were instructed to continue the diet after discharge. Scheduled maintenance infliximab infusion was not used. The primary endpoint was relapse, which was defined as the appearance of symptoms resulting in the alteration of therapeutic modality. The secondary endpoints were C-reactive protein level, plant-based diet score, and surgery. Results The median follow-up period was 8.6 years. Thirteen cases were relapse-free. The relapse-free rate evaluated by Kaplan-Meier survival analysis at 1, 2, 3, and 4 years was 79%, 66%, 57%, and 52%, respectively. There was no further reduction afterward up to 10 years. The relapse-free rate with normal C-reactive protein levels at 1 to 2 and 3 to 10 years was 57% and 52%, respectively. The plant-based diet score at 20 months and 5 years was significantly higher relative to baseline (p < 0.0001). Surgical rates at 5 and 10 years were 12% and 19%, respectively. Conclusions Infliximab and plant-based diet as first-line therapy created an unprecedented relapse-free course in nearly half of patients with Crohn's disease.

Nonbacterial Thrombotic Endocarditis: Presentation, Pathophysiology, Diagnosis and Management.

Initially described in 1936, non-bacterial thrombotic endocarditis (NBTE) is a rare entity involving sterile vegetations on cardiac valves. These vegetations are usually small and friable, typically associated with hypercoagulable states of malignancy and inflammatory diseases such as systemic lupus erythematosus. Diagnosis remains challenging and is commonly made post-mortem although standard clinical methods such as echocardiography (transthoracic and transesophageal) and magnetic resonance imaging may yield the clinical diagnosis. Prognosis of NBTE is poor with very high morbidity and mortality usually related to the serious underlying conditions and high rates of systemic embolization. Therapeutic anticoagulation with unfractionated heparin has been described as useful for short term prevention of recurrent embolic events in patients with NBTE but there are no guidelines for management of this disease.

Pollution Characteristics and Influencing Factors of PM2.5 in Shanxi Province Based on Wavelet Transform

Based on the daily average concentration of PM2.5, social influencing factor data, and meteorological data of 11 cities in Shanxi Province from 2015 to 2019, the concentration period of PM2.5 was determined using wavelet transform. The correlation between PM2.5 and social influencing factors and meteorological factors was explored respectively through Spearman correlation and the wavelet coherence spectrum, and the main influencing factors of long-term and short-term management and control of PM2.5 were determined. The results showed that the concentration of PM2.5 in Shanxi Province showed an upward trend from 2015 to 2017, with an average annual increase rate of 4.3% and a downward trend from 2018 to 2019, with an average annual decrease rate of 4.2%. The average concentration of PM2.5 showed a "U" distribution, with the highest value in January (95 μg·m-3) and the lowest in August (34 μg·m-3); the average value in winter was approximately twice that in summer. The ρ(PM2.5) in southern cities such as Linfen was 62 μg·m-3, and the average value in Datong and other northern cities was 45 μg·m-3, which was high in the south and low in the north. There were significant periodic changes in PM2.5 concentration in the 11 cities, including a long period of approximately 293 d and a short period of approximately 27 d. Among them, the energy consumption level and industrial structure were the strong driving factors affecting the PM2.5 concentration in the long period of Shanxi Province. In the short period, it was greatly affected by the change in atmospheric circulation, and different cities were affected by typical meteorological factors. Linfen, Yuncheng, Datong, Shuozhou, and Xinzhou were vulnerable to wind speed; Jinzhong and Luliang were vulnerable to temperature; and Taiyuan, Jincheng, Yangquan, and Changzhi were uniquely and significantly affected by relative humidity. Therefore, industrial structure adjustment and energy structure adjustment are key to the long-term control of atmospheric PM2.5 and the long-term improvement of air quality in Shanxi Province. The differential impact of different urban meteorological factors on PM2.5 should be considered when carrying out short-term regional joint prevention and control.

In-hospital complications and long-term outcomes associated with timing of carotid endarterectomy

ObjectiveCarotid revascularization performed within 2 weeks of symptoms has proven to reduce risk of recurrent stroke in patients with symptomatic carotid artery stenosis. However, the optimal timing of revascularization within the 2-week window has yet to be determined. The objective of this study was to perform a comprehensive analysis of in-hospital and long-term outcomes of carotid endarterectomy (CEA) performed within different time intervals after most recent symptoms. MethodsWe analyzed 2003 to 2016 data from the Vascular Quality Initiative Vascular Implant Surveillance and Interventional Outcomes Network. Only revascularizations performed for symptomatic carotid artery stenosis were included. Procedures were categorized as urgent (0-2 days from latest symptom), early (3-14 days), or late (15-180 days). The primary in-hospital outcome was stroke/death. The primary long-term outcomes of interest were 5-year recurrent ipsilateral stroke/death. Multivariable logistic regression, Kaplan-Meier analysis, and Cox regression were utilized to compare outcomes. ResultsA total of 18,970 revascularizations were included: 1130 (6.0%) urgent, 4643 (24.5%) early, and 13,197 (69.6%) late. Earlier CEA had increased odds of in-hospital stroke/death compared with late CEA (urgent: adjusted odds ratio, 1.9; 95% confidence interval [CI], 1.3-2.8; P = .001; early: adjusted odds ratio, 1.7; 95% CI, 1.3-2.2; P < .001). No differences were seen in 5-year risk of stroke/death (urgent: adjusted hazard ratio, 0.95; 95% CI, 0.79-1.15; P = .592; early: adjusted hazard ratio, 0.97; 95% CI, 0.87-1.07; P = .928). ConclusionsUrgent and early CEA were associated with increased perioperative risk without difference in 5-year outcomes compared with late CEA. Short-term recurrent stroke prevention could not be assessed. Updated population-based studies comparing recurrent stroke prevention with urgent or early revascularization vs best medical management are warranted.

Workplace Interventions Aimed to Reduce the Risk of Cardiovascular Disease: A Systematic Review

Introduction: Primary prevention of cardiovascular diseases in the workplace can have a considerable effect on reducing human and labor losses. Objective: To summarize and to systematize the results of academic studies on workplace interventions to reduce the risk of cardiovascular diseases. Materials and methods: We conducted a systematic review of academic studies published in English and Russian and uploaded to PubMed и Web of Science. We selected 41 studies containing empirical assessments of the effectiveness of both short-term and long-term prevention programmes in the workplace and grouped them by intervention types. Results: Education programmes have controversial signs of a cardiovascular risk preventive effect associated with blood and weight parameters. Comprehensive programmes aimed to form a healthy lifestyle show similar results, whereas the programmes aimed to increase physical activity of employees proved their effectiveness in reducing the risk of cardiovascular diseases through normalizing the body weight, blood pressure, high density lipoprotein and total cholesterol levels; yet, these results had only a short-term effect. Ergonomics-related interventions and shift rotation failed to demonstrate strong evidence of the potential to lower the risk of heart diseases. Conclusion: Understanding the effectiveness of prevention programs will help employers and governments to identify necessary interventions to reduce losses related to cardiovascular diseases and to make the right health and social protection decisions.

The effects of short-term mindfulness-based group intervention utilising a school setting for Japanese adolescents with trauma

The use of mindfulness as a tool to improve mental health has received increased attention. Schools provide ideal environments for short-term prevention and skill development for mental health. Further, teachers can promote and reinforce students’ daily use of mindfulness. This study explored the effects of a short-term group mindfulness-based intervention on the mental health of adolescents who have experienced trauma. A total of 49 high school students received a mindfulness-based intervention session followed by homework and teacher reinforcement. The results suggest that a short-term group intervention for mindfulness can potentially improve mindfulness attention awareness and reduce depression and anxiety symptoms in adolescents. As there was no control group, additional research examining the effectiveness of the intervention is essential.

Management of initial carious lesions of hypomineralized molars (MIH) with silver diamine fluoride or silver-modified atraumatic restorative treatment (SMART): 1-year results of a prospective, randomized clinical trial.

ObjectivesThis study evaluated and compared the effect of silver diamine fluoride (SDF) and silver-modified atraumatic restorative treatment (SMART) sealants for the treatment of initial carious lesions of permanent molars affected by molar incisor hypomineralization (MIH).MethodsOne hundred and twelve hypomineralized permanent molars with ICDAS 1 or 2 lesions were selected in 48 children. The teeth were randomized into SDF and SMART sealant groups (n = 56 teeth/group) in a split-mouth fashion. Hypersensitivity, formation of caries, and enamel breakdown were evaluated in both groups. Hypersensitivity was assessed by Schiff Cold Air Sensitivity Scale (SCASS), and clinical assessments of SMART sealants were performed according to modified USPHS criteria at 1, 6, and 12 months. The data were analyzed statistically using Fisher’s exact test, Kaplan–Meier analysis, Mann–Whitney U test, and Friedman test.ResultsTwenty-six hypomineralized molars with marked baseline hypersensitivity showed significantly lower SCASS scores at all evaluation periods (p < 0.001). There was no significant difference in hypersensitivity scores between the groups at the repeated applications of SDF at 1, 6, and 12 months. The cumulative survival rates of SMART sealants on occlusal and palatal surfaces were 88.7% and 58.8%, respectively.ConclusionsIn hypomineralized molars, both SDF and SMART sealants showed favorable short-term prevention against dental caries while providing effective desensitization. Marginal discoloration was the most common side effect of the SMART sealants as a result of SDF application.Clinical SignificanceBoth SDF and SMART sealants showed similar short-term effectiveness as non-aerosol procedures in arresting enamel caries and reducing hypersensitivity in hypomineralized molars.Trial registrationClinical Trials Registration Number: NCT03862014.