Short-term Consolidation Research Articles

Repetitive magnetic stimuli over the motor cortex impair long-term consolidation of a balance task by suppressing up-regulation of intracortical inhibition

Introduction
 Recent findings have demonstrated that low-frequency repetitive magnetic stimulations (rTMS) over the primary motor cortex (M1) impaired short-term consolidation of a balance task, underscoring the causal connection between M1 and the consolidation of balancing skills (Egger et al., 2023). However, the underlying neural mechanisms induced by rTMS and whether these adaptations endure over an extended period, encompassing multiple acquisition sessions, remain insufficiently elucidated (Censor & Cohen, 2011). So far, its is widely acknowledged that GABAergic processes play an important role for consolidation (Sanes & Donoghue, 2000), at the same time, are affected by learning balance skills (Mouthon & Taube, 2019; Taube et al., 2020). Therefore, the present study aimed to investigate the impact of rTMS on GABA-mediated short-interval intracortical inhibition (SICI) and to explore the role of M1 in the long-term consolidation of a balance task (i.e., across multiple acquisition sessions).
 Methods
 Thirty-one volunteers underwent six balance acquisition sessions on a rocker-board, each followed by either rTMS or sham rTMS based on group affiliation. During the first and last training session, SICI was measured twice; before the balance acquisition and after the application of rTMS or sham-rTMS to investigate potential short- and long-term adaptations in intracortical inhibition. Adaptations were assessed during the execution of the learned balance task and in a non-learning postural control task (i.e., stable upright stance).
 Results
 Regardless of group affiliation, all participants achieved comparable improvements within the balance acquisition sessions. However, consolidation varied between groups. In particular, between the third and the fourth acquisition session, as Tukey corrected post-hoc tests showed a significant decline in performance for the rTMS group (p = 0.006). Both short- (p = 0.014) and long-term (p = 0.038) adaptations in SICI were affected by rTMS: while the sham rTMS group upregulated SICI, rTMS led to reduced levels of inhibition. No neurophysiological effects were observed in the non-learning control task (upright stance).
 Discussion/Conclusion
 The interfering effect of rTMS on balance consolidation and on upregulation of SICI indicates that increased intracortical inhibition is an important mechanism to protect and engrave newly acquired motor memory. Importantly, adaptations in SICI were only apparent during the execution of the learned task.
 References
 Censor, N., & Cohen, L. G. (2011). Using repetitive transcranial magnetic stimulation to study the underlying neural mechanisms of human motor learning and memory. The Journal of Physiology, 589(1), 21-28. https://doi.org/10.1113/jphysiol.2010.198077
 Egger, S., Wälchli, M., Rüeger, E., & Taube, W. (2023). Short-term balance consolidation relies on the primary motor cortex: A rTMS study. Scientific Reports, 13, Article 5169. https://doi.org/10.1038/s41598-023-32065-x
 Mouthon, A., & Taube, W. (2019). Intracortical inhibition increases during postural task execution in response to balance training. Neuroscience, 401, 35-42. https://doi.org/10.1016/j.neuroscience.2019.01.007
 Sanes, J. N., & Donoghue, J. P. (2000). Plasticity and primary motor cortex. Annual Review of Neuroscience, 23, 393-415. https://doi.org/10.1146/annurev.neuro.23.1.393
 Taube, W., Gollhofer, A., & Lauber, B. (2020). Training-, muscle- and task-specific up- and downregulation of cortical inhibitory processes. The European Journal of Neuroscience, 51(6), 1428-1440. https://doi.org/10.1111/ejn.14538

Conditioning procedures to enhance the reproducibility of mud settling and consolidation experiments

The means by which mud is conditioned for use in laboratory experiments affects the behaviour of the mud during the experiments, and hence the results and reproducibility. This study discusses the impact of different mud conditioning techniques and procedures using multiple series of short-term consolidation tests. The mud used originates from the Zeebrugge docks of the Port of Antwerp-Bruges, Belgium. For all experiments the initial density of the mud was around 1.08 g⋅ cm−3, which is below its gel density. This has the advantage that the comparison can be limited to the behaviour during the typical initial settling phases, allowing experiments to be restricted in time to seven days. Each series of experiments is repeated multiple times using two separate batches of mud. The objective is to quantify the repeatability across these different series of experiments, and to identify the ideal conditioning procedure for optimal reproducibility for future laboratory experiments using mud. Distinct differences in settling curves are observed which confirm the intended influence of each mixing technique. A conditioning procedure based on a combination of axial and radial mixing yields the most control over settling behaviour during the initial stages of the sedimentation process and therefore results in the best repeatability of settling behaviour. It is recommended that such a mud conditioning procedure is further used for experiments with mud to allow for a better uniformity in research where the behaviour of mud is critical.

Attentional Refreshing in the Absence of Long-Term Memory Content: Role of Short-Term and Long-Term Consolidation.

Contradictory results in the literature suggest that attentional refreshing can seemingly not operate efficiently in the absence of semantic representations, while at the same time it does not rely directly on retrieval from semantic memory. The objective of the present study was a better understanding of the bidirectional links between working memory (WM) and long-term memory (LTM), by assessing on the one hand the role of WM mechanisms in long-term recall and on the other hand how their functioning is modulated by the prior LTM content. Through two experiments, we investigated a new hypothesis: attentional refreshing requires stable WM representations independently of the presence or the absence of associated LTM traces. We manipulated this stability through short-term consolidation (Experiment 1) and multiple presentations of memoranda (Experiment 2) to evaluate how it would affect maintenance of words and pseudowords. While we found that lexicality, short-term consolidation and multiple presentations affected short-term and long-term recall, both experiments converged on the conclusion that none of these factors modulated the effect of the cognitive load of the concurrent processing task, suggesting that refreshing does not depend on LTM content nor WM representations' stability. Additionally, we found that delayed recall performance was not affected by the cognitive load, in contradiction with previous literature. These results provide new insight into the functioning of refreshing and the links between WM and LTM.

When does working memory get better with longer time?

Longer free time between presentation of verbal list items often leads to better immediate serial recall. The present series of three experiments demonstrates that this beneficial effect of time is more general than has been known: It is found for verbal items presented visually and auditorily (Experiments 1 and 2), and also when people engage in concurrent articulation during presentation, thereby preventing rehearsal (Experiment 3). The effect of time is to improve memory most strongly for the later part of the list, contrary to what is predicted from the assumption that time between items is used to bolster memory traces of already encoded items through rehearsal, refreshing, or elaboration. The data are compatible with a ballistic form of short-term consolidation, and with the assumption that encoding an item into working memory partially depletes a limited resource, which is replenished over time. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Finite versus Indefinite Nucleos(t)ide Analogue Therapy of Patients with Chronic Hepatitis B Exhibiting Negative HBsAg Levels after Treatment.

Aim To determine whether a decrease in HBsAg to <0.05 IU/mL could be a criterion for cessation of finite nucleos(t)ide analogue (NUC) therapy in patients with chronic hepatitis B (CHB). Methods This was a retrospective analysis of 6715 patients with CHB between January 1998 and May 2016. Patients were followed up every 12–24 weeks. Among 104 patients achieving HBsAg levels < 0.05 IU/mL, 71 were eligible for inclusion in the analysis: 31 received finite NUC therapy, and 40 received indefinite NUC therapy. In the finite therapy group, 9 patients received no NUC consolidation therapy, 6 received short-term (<1 year) consolidation, and 16 received long-term (>1 year) consolidation. The outcome measures were alanine aminotransferase (ALT), total bilirubin, albumin, hepatitis B virus DNA, and HBsAg levels. Results Baseline parameters and characteristics at the time when HBsAg levels had fallen to <0.05 IU/mL were similar between the finite and indefinite therapy groups. No patients experienced viral breakthrough/relapse during a median follow-up of 120 weeks. There were little or no differences in long-term outcomes between the finite and indefinite therapy groups and between the short-term and long-term consolidation groups. Conclusions Discontinuation of NUCs may be acceptable in patients whose HBsAg levels fall to <0.05 IU/mL. Consolidation therapy lasting <1 year appears adequate to prevent poor long-term prognosis.

Appraisal of the hypoplastic model for the numerical prediction of high-rise building settlement in Neogene clay based on real-scale monitoring data

This article presents the finite element modeling (FEM) based settlement analysis of two high-rise buildings founded on the stiff raft foundations 12.0 m below the ground level in Neogene clay using a modified hypoplastic model with the concept of intergranular strains. The numerical prognoses of the settlement for different phases i.e., deconsolidation, short term and long-term consolidation deformations pertaining to excavation, construction, and operation, respectively, were compared with the real-scale geotechnical monitoring (GTM) data acquired through deformeter installed in a borehole below the foundation. The results showed that the prediction of the settlement of high-rise buildings in stiff Neogene clay using the hypoplastic model can be equitable to the actual values given that calibration of model based on precisely performed laboratory tests, i.e., triaxial oedometer, simple shear and small strain element tests, high coefficient of earth pressure (K0 > 1.0) and appropriate design loads are considered for the analysis. The optimization of intergranular strain parameters showed that mR value in conjunction with r parameter affected the predicted deformation in the excavation, construction and operational phases of high-rise buildings, whereas, βr only affected the deformations during excavation and construction phases. Overall, the predictions of deformation of excavation and short-term consolidation phases using the hypoplastic model were close to the GTM as compared to that of the long-term consolidation phase, which was found to be sensitive to the contact load, σol. Moreover, in comparison to Mohr Coulomb's and cam clay models, the hypoplastic model yielded more reliable subsoil deformation for high-rise buildings based on directly calibrated parameters, proving to be a more value-added model for meticulous numerical analysis. The difference between the predictions of total settlement using the hypoplastic model for all optimization schemes was observed to be in a reasonably good range of 16–29% in comparison to the real-scale settlement.

Short-Term Consolidation of Information for Episodic Memory: The Role of Attention

Pieces of evidence from rapid serial visual presentation, attentional blink, and dual-task interference phenomena propose that human beings have a significant limitation on the short-term consolidation process. Short-term consolidation is transferring perceptual representations to a more durable form of memory. Although previous research has shown that masks presented after targets interrupt the consolidation process of information, there is not enough evidence for the role of attention in consolidation for episodic memory. Three experiments were conducted to investigate the effects of attention and stimulus onset asynchrony (SOA) between targets and masks on episodic memory. Masks were presented after targets with varying SOAs. The participants in the divided attention condition performed the attention-demanding secondary task after the presentation of the masks, whereas participants in the full attention condition were not requested to perform the secondary task after the presentation of masks. The results showed that reducing SOA between targets and masks caused an impairment in memory performance for divided attention but not for full attention, providing evidence for the necessity of attention for the short-term consolidation process.

Association between sleep disorders and cognitive dysfunctions in non-demented patients with advanced Parkinson\u2019s disease

BackgroundParkinson’s disease (PD) is increasingly recognized as a multidimensional disorder, characterized by several non-motor symptoms, including disturbances of sleep and cognition. Current studies on the relationship between sleep problems and neuropsychological functions, mainly conducted in early to moderate PD patients, outline mixed results. In this study, we analysed the relationship between subjectively reported sleep alterations and cognitive functions in a large cohort of 181 advanced PD patients.MethodsAll consecutive, non-demented, advanced PD patients candidates for device-aided therapy completed two self-administered sleep questionnaires—the Parkinson’s Disease Sleep Scale (PDSS-2) and the Epworth Sleepiness Scale (ESS)—and underwent a comprehensive battery of neuropsychological tests encompassing five cognitive domains (reasoning, memory, attention, frontal executive functions, and language).ResultsPatients showed mild to moderate sleep problems (PDSS-2 score: 23.4 ± 1.2) and mild daytime sleepiness (ESS 8.6 ± 5.1). A significant correlation was found between PDSS-2 total score and non-verbal reasoning, as well as attentive skills, executive functions, and language abilities. No correlations were found between sleep measures and memory tests scores. Patients with clinically relevant sleep disturbances performed worse on attention, executive functions, and language. No significant correlations were found between daytime sleepiness and any neuropsychological test.ConclusionsIn advanced PD patients, sleep disturbances selectively correlate with specific neuropsychological functions and not with short-term memory and consolidation. Even if confirmations by means of longitudinal studies are needed, our observations suggest the importance of considering treatment of sleep disturbances to minimize their potential impact on cognition.

What Is Time Good for in Working Memory?

Giving people more time to process information in working memory improves their performance on working memory tasks. It is often assumed that free time given after presentation of an item enables maintenance processes to counteract forgetting of this item, suggesting that time has a retroactive benefit. Two other hypotheses—short-term consolidation and temporal distinctiveness—entail a local effect of time on immediately preceding and following items. Here, we show instead a novel global and proactive benefit of time in working memory. In three serial-recall experiments (Ns = 21, 25, and 26 young adults, respectively), we varied the position and duration of the free time within a seven-item list of consonants. Experiment 1 showed that the effect is global and not local. Experiments 2a and 2b showed that increased interitem time benefited performance only for the subsequent items, implying a proactive benefit. This finding rules out maintenance processes, short-term consolidation, and temporal distinctiveness as explanations of the free-time benefit but is consistent with the proposal of a gradually recovering encoding resource.

Statistical and sequence learning lead to persistent memory in children after a one-year offline period

Extraction of environmental patterns underlies human learning throughout the lifespan and plays a crucial role not only in cognitive but also perceptual, motor, and social skills. At least two types of regularities contribute to acquiring skills: (1) statistical, probability-based regularities, and (2) serial order-based regularities. Memory performance of probability-based and/or serial order-based regularities over short periods (from minutes to weeks) has been widely investigated across the lifespan. However, long-term (months or year-long) memory performance of such knowledge has received relatively less attention and has not been assessed in children yet. Here, we aimed to test the long-term memory performance of probability-based and serial order-based regularities over a 1-year offline period in neurotypical children between the age of 9 and 15. Participants performed a visuomotor four-choice reaction time task designed to measure the acquisition of probability-based and serial order-based regularities simultaneously. Short-term consolidation effects were controlled by retesting their performance after a 5-h delay. They were then retested on the same task 1 year later without any practice between the sessions. Participants successfully acquired both probability-based and serial order-based regularities and retained both types of knowledge over the 1-year period. The successful retention was independent of age. Our study demonstrates that the representation of probability-based and serial order-based regularities remains stable over a long period of time. These findings offer indirect evidence for the developmental invariance model of skill consolidation.

THE FORMATION OF NON-FORMAL GROUPS OF NOMENCLATURE IN THE USSR DURING THE 1930-ies (ON THE EXAMPLE OF THE SOVIET PARTY LEADERSHIP IN DNIPROPETROVSK REGION)

The main purpose of the research is to cover principles of the existence and functioning of the Soviet party leadership in Dnipropetrovsk during the 1930-ies – at the beginning of the 1940-ies. T he Methodological Basis. The research is based on the principle of systematicity, anthropologist and interdisciplinary. The scientific novelty lies in the fact that it was the first time in the Ukrainian historiography that on the background of the memoirs and archival documents analysis the attempts to clarify the reasons of the Dnipropetrovsk nomenclature formation during the end of the 1930-ies – the beginning 1940-ies as well as to demonstrate the consequences of the “ nomenclature revolutions” in Dnipropetrovsk region were made. The Conclusions. It was clarified that during the 1930-ies in the environment of Dnipropetrovsk party nomenclature occurred a short-term consolidation around the top figure in the region – Mendel Khataievych. The local version of a “ leader cult” formed in the region. That process was interrupted by political repressions in 1937 – 1938. During the “ Great Terror” almost all Soviet party nomenclature of the region was killed. The so-called «staff revolution» launched “ political mobility” that opened wide opportunities to promote alive lower levels leaders. After that “ cleaning” , the highest management of Dnipropetrovsk region was reached by Leonid Brezhnev, Kostiantyn Hrushevii and etc. There were names who would the so-called “ Dnipropetrovsk clan” be associated with since the 1950-ies up to the collapse of the Soviet Union, the representatives of the clan held the highest party and government posts used to give tone to the political system of the USSR. Renovation of the party system in Dnipropetrovsk region connected with Mykyta Khrushchov and his appointees Demian Korotchenko and Semen Zadionchenko.

Nanolime for the consolidation of lime mortars: A comparison of three available products

Nanolime products are one of the most promising consolidation methods for historic calcareous substrates. Whilst the popularity of nanolime has been growing, its consolidation mechanism still needs to be fully understood when applied to highly porous substrates. The aim of this paper is to compare the three available nanolime products in terms of consolidation efficacy on lime mortar specimens. It is shown that repeated applications of a low concentrated nanolime can increase the superficial cohesion and the mechanical strength of the mortar within 1 cm from the surface, while also reducing porosity, number of micro-pores and capillary water absorption coefficient. Nanorestore Plus® yielded the highest short-term consolidation effect. However, L’Aquila nanolime showed a higher durability which was attributed to a better developed crystalline structure.

Cortical sources of the auditory attentional blink.

Attentional blink (AB) refers to the situation where correctly identifying a target impairs the processing of a subsequent probe in a sequence of stimuli. Although the AB often coincides with a modulation of scalp-recorded cognitive event-related potentials (ERPs), the neural sources of this effect remain unclear. In two separate experiments, we used classical LORETA analysis recursively applied (CLARA) to estimate the neural sources of ERPs elicited by an auditory probe when it immediately followed an auditory target (i.e., AB condition), when no auditory target was present (i.e., no-AB condition), and when the probe followed an auditory target but occurred outside of the AB time window (i.e., no-AB condition). We observed a processing deficit when the probe immediately followed the target, and this auditory AB was accompanied by reduced P3b amplitude. Contrasting brain electrical source activity from the AB and no-AB conditions revealed reduced source activity in the medial temporal region as well as in the temporoparietal junction (extending into inferior parietal lobe), ventromedial prefrontal cortex, left anterior thalamic nuclei, mammillary body, and left cerebellum. The results indicate that successful probe identification following a target relies on a widely distributed brain network and further support the suggestion that the auditory AB reflects the failure of the probe to reach short-term consolidation. NEW & NOTEWORTHY Within a rapid succession of auditory stimuli, the perception of a predefined target sound often impedes listeners' ability to detect another target sound that is presented close in succession. This attentional blink may be related to activity in brain areas supporting attention and memory. We show that the auditory attentional blink is associated with brain activity changes in a network including the medial temporal lobe, parietal cortex, and prefrontal cortex. This study suggests that a problem in the interaction between attention and memory underlies the auditory attentional blink.

The relationship between masking and short-term consolidation during recall from visual working memory.

The presentation of a similar but irrelevant stimulus immediately following presentation of a memory item is called masking. Masking is known to reduce performance on working memory tests. This is the type of memory used to hold information in mind for brief periods of time for use in ongoing cognition. Two approaches to understanding masking effects have been proposed in different literatures. Working memory researchers often assume that the reduction in working memory performance after masking is because masking interferes with a transient sensory representation that is needed to complete consolidation into a working memory state. Researchers focused on the attentional blink, a finding that attention cannot be directed to new stimuli during working memory consolidation, have an alternative theory. Attentional blink researchers assume that masking slows the short-term consolidation process, thereby extending the length of the attentional blink. In two experiments, we contrast these two approaches to explaining masking effects and investigate the validity of both hypotheses. Some aspects of both approaches are validated, but neither theoretical perspective alone sufficiently explains the entire pattern of results.

The nature of short-term consolidation in visual working memory.

Short-term consolidation is the process by which stable working memory representations are created. This process is fundamental to cognition yet poorly understood. The present work examines short-term consolidation using a Bayesian hierarchical model of visual working memory recall to determine the underlying processes at work. Our results show that consolidation functions largely through changing the proportion of memory items successfully maintained until test. Although there was some evidence that consolidation affects representational precision, this change was modest and could not account for the bulk of the consolidation effect on memory performance. The time course of the consolidation function and selective influence of consolidation on specific serial positions strongly indicates that short-term consolidation induces an attentional blink. The blink leads to deficits in memory for the immediately following item when time pressure is introduced. Temporal distinctiveness accounts of the consolidation process are tested and ruled out. (PsycINFO Database Record

Suppression of irrelevant sounds during auditory working memory

Auditory working memory (WM) processing in everyday acoustic environments depends on our ability to maintain relevant information online in our minds, and to suppress interference caused by competing incoming stimuli. A challenge in communication settings is that the relevant content and irrelevant inputs may emanate from a common source, such as a talkative conversationalist. An open question is how the WM system deals with such interference. Will the distracters become inadvertently filtered before processing for meaning because the primary WM operations deplete all available processing resources? Or are they suppressed post perceptually, through an active control process? We tested these alternative hypotheses by measuring magnetoencephalography (MEG), EEG, and functional MRI (fMRI) during a phonetic auditory continuous performance task. Contextual WM maintenance load was manipulated by adjusting the number of “filler” letter sounds in-between cue and target letter sounds. Trial-to-trial variability of pre- and post-stimulus activations in fMRI-informed cortical MEG/EEG estimates was analyzed within and across 14 subjects using generalized linear mixed effect (GLME) models. High contextual WM maintenance load suppressed left auditory cortex (AC) activations around 250–300 ms after the onset of irrelevant phonetic sounds. This effect coincided with increased 10–14 Hz alpha-range oscillatory functional connectivity between the left dorsolateral prefrontal cortex (DLPFC) and left AC. Suppression of AC responses to irrelevant sounds during active maintenance of the task context also correlated with increased pre-stimulus 7–15 Hz alpha power. Our results suggest that under high auditory WM load, irrelevant sounds are suppressed through a “late” active suppression mechanism, which prevents short-term consolidation of irrelevant information without affecting the initial screening of potentially meaningful stimuli. The results also suggest that AC alpha oscillations play an inhibitory role during auditory WM processing.

The ADRA2B gene in the production of false memories for affective information in healthy female volunteers

False memories are common memory distortions in everyday life and seem to increase with affectively connoted complex information. In line with recent studies showing a significant interaction between the noradrenergic system and emotional memory, we investigated whether healthy volunteer carriers of the deletion variant of the ADRA2B gene that codes for the α2b-adrenergic receptor are more prone to false memories than non-carriers. In this study, we collected genotype data from 212 healthy female volunteers; 91 ADRA2B carriers and 121 non-carriers. To assess gene effects on false memories for affective information, factorial mixed model analysis of variances (ANOVAs) were conducted with genotype as the between-subjects factor and type of memory error as the within-subjects factor. We found that although carriers and non-carriers made comparable numbers of false memory errors, they showed differences in the direction of valence biases, especially for inferential causal errors. Specifically, carriers produced fewer causal false memory errors for scripts with a negative outcome, whereas non-carriers showed a more general emotional effect and made fewer causal errors with both positive and negative outcomes. These findings suggest that putatively higher levels of noradrenaline in deletion carriers may enhance short-term consolidation of negative information and lead to fewer memory distortions when facing negative events.

Стресс, кортикостероидные повреждения гиппокампа и нервно-психическая патология

The review presents a literature data review concerning the role of stress-induced elevation of corticosteroid secretion in the damage of hippocampus in rodents and primates. Hippocampal atrophy induced by corticosteroids may play an important role in the pathogenesis of a wide range of neuropsychiatric disorders. Hippocampus is necessary for short-term memory consolidation and HPA axis regulation. Signs of hippocampal damage (HPA dysregulation in combination with memory impairment) are found in affective disorders, Alzheimer’s disease, and in posttraumatic stress disorder. MRI volumetry reveals reduced hippocampal volume in these diseases. The evidence supporting the “glucocorticoid hypothesis” of psychiatric disorders is considered. The unresolved questions concerning temporary aspects of neurodegeneration, causality, reversibility, damage types, factors increasing hippocampal vulnerability, and both pharmacological (CRH antagonists, antiglucocorticoid drugs, GABA-ergic, serotoninergic, glutamatergic agents) and nonpharmacological (psychotherapy) treatment approaches are also under discussion.

Temporal cuing modulates alpha oscillations during auditory attentional blink.

Attentional blink (AB) refers to the phenomenon whereby the correct identification of a visual or auditory target impairs processing of a subsequent probe. Although it has been shown that knowing in advance, when the probe would be presented, reduces the attentional blink and increases the amplitude of event-related potential (ERP) elicited by the probe, the neural mechanism by which attention mitigates the AB remains unclear. Here, we used time-frequency analysis to further explore the mechanism of the auditory attentional blink. Participants were presented a series of rapid auditory stimuli and asked to indicate whether a target and a probe were present in the sequence. In half of the trials, participants were cued to the probe position relative to the target ('Early' or 'Late'). Probe detection and ERP amplitude elicited by the probe decreased when the probe was presented shortly after the target compared to when it was presented later after the target. Importantly, the behavioral and ERP correlates of probe discrimination significantly improved when the 'Early' cue was presented. The improvement in processing the probe in the cued condition was accompanied by the decrease in alpha activity (8-13Hz) after the time when the probe was expected; suggesting that successfully directing attention to time window where the probe would likely occur reduces the processing resources needed to suppress distractors. This in turn freed up available processing resources for the target and probe at the short-term consolidation stage, which ultimately reduced the auditory attentional blink.

Motor Memory Deficits Contribute to Motor Impairments in Autism Spectrum Disorder.

Sensorimotor abnormalities are common in individuals with autism spectrum disorder (ASD); however, the processes underlying these deficits remain unclear. This study examined force production with and without visual feedback to determine if individuals with ASD can utilize internal representations to guide sustained force. Individuals with ASD showed a faster rate of force decay in the absence of visual feedback. Comparison of force output and tests of social and verbal abilities demonstrated a link between motor memory impairment and social and verbal deficits in individuals with ASD. This finding suggests that deficits in storage or retrieval of motor memories contribute to sensorimotor deficits and implicates frontoparietal networks involved in short-term consolidation of action dynamics used to optimize ongoing motor output.