Fiber reinforced polymer (FRP)-interlayer-steel confined concrete (FISC) columns are proposed by bonding a filament-wound FRP tube with a concrete-filled steel tube (CFST) using grouting material to increase the corrosion resistance of CFST columns. FISC columns have high bearing capacity, benefiting from the dual confinement provided by both FRP and steel tubes on the core concrete. Despite this, the current research on the behaviors of FISC columns is limited, particularly regarding the confinement mechanism in FISC columns under eccentric compression. In this paper, a total of twenty short specimens were tested under eccentric compression, including seventeen FISC specimens, two FRP confined concrete-filled steel tubular (CCFT) columns, and one CFST specimen. Failure modes, load versus deflection curves and strain development for FISC specimens were presented and discussed, considering variations in eccentricity, FRP types, FRP thicknesses, and the ratio of FRP and steel confining indexes. Additionally, confining stresses of the FRP and steel tubes were obtained, revealing a non-uniform distribution of confinement on concrete along the sectional circumference, which decreased with increasing eccentricity. Furthermore, by regarding the concrete and grouting material as a whole unity and accounting for the influence of eccentricity, a sectional numerical analysis model for FISC columns was established and validated against test results, and the influences of steel thickness, FRP thickness, and concrete-grouting strength on the N-M correlation curves of FISC columns were investigated.