Short-duration Exercise Research Articles

High-intensity interval training attenuates renal injury induced by myocardial ischemia-reperfusion in rats

Background: High-Intensity Interval Training (HIIT) has been recognized as an effective form of short-duration exercise. The purpose of this study was to assess whether HIIT could reduce renal injury induced by myocardial ischemia-reperfusion in rats. Methods: Male Sprague-Dawley rats were randomly assigned to the Sham Group (SHAM), Coronary Artery Occlusion (CAO) group, HIIT group, and Ischemic Precondition (IPC) group. Rats underwent 40 minutes of left anterior descending coronary artery occlusion under anesthesia, followed by 3 hours of reperfusion, to induce myocardial ischemia-reperfusion (MIR). Post-surgery, rats were sacrificed, and their blood, heart, and kidney tissues were examined. The HIIT group underwent 4 weeks of HIIT training before surgery. Results: HIIT intervention significantly reduced renal injury after MIR and the concentrations of Blood Urea Nitrogen (BUN) and Creatinine (CRE) in the serum. Moreover, pro-inflammatory cytokines, including Tumor Necrosis Factor-α (TNF-α), Interleukin-1β (IL-1β), and IL-6, were significantly decreased, while the anti-inflammatory cytokine IL-10 was significantly increased in the serum. Additionally, HIIT intervention suppressed the expression of FoxO1, BAX/Bcl-2 ratio, TNF-α, and Cleaved-caspase-3/caspase-3 ratio in kidney tissues, ultimately reducing renal cell apoptosis. Conclusion: This study is the first to demonstrate that HIIT has effects similar to IPC, significantly reducing renal injury after MIR. HIIT regulates the production of pro-inflammatory and anti-inflammatory cytokines, inhibits renal cell apoptosis, thereby reducing the occurrence of cardio-renal syndrome.

Acute Effect of Three Aerobic Exercise Intensities on Glomerular Filtration Rate in Healthy Older Adults.

To assess the immediate effects of three aerobic exercise intensities on the estimated glomerular filtration rate (eGFR) in healthy, sedentary older adults. Eighteen healthy, sedentary older adults (ten men and eight women) voluntarily participated in this study. The participants underwent three standardized aerobic exercise tests (100%, 80%, and 60% of the maximal heart rate) on a bicycle ergometer. Blood samples were collected to determine cholesterol, triacylglycerols, glucose, serum creatinine (Cr), Cystatin C (CysC) concentrations, and eGFR. eGFR and serum concentrations of Cr and CysC were not modified at any exercise intensity. There was a negative correlation between blood total cholesterol vs. eGFR (R = -0.512, R = -0.582, R = -0.531; p < 0.05) at rest, 60%, and 100% of the maximal heart rate, respectively. In addition, a negative correlation existed for age vs. eGFR at 60% of the maximal heart rate (R = -0.516; p < 0.05). Short-duration aerobic exercise of low, moderate, and vigorous intensity did not significantly affect eGFR and is considered safe for kidney function in healthy, sedentary older adults. However, regular monitoring of kidney function in older people engaged in moderate- and high-intensity exercise is advised.

Inclined treadmill short-duration exercise for walk regularity of recreation horses

Knowledge on horse symmetry and regularity is essential for every training/rehabilitation programs. Present studies compare biomechanical parameters for different treadmill positions, but not the effect of such exercise. The aim of the presented work was to study recreation horse movement parameters before and immediately after inclined short-duration exercise in walk. The hypothesis was that inclined short-duration exercise gave greater stride regularity and symmetry. Walk biomechanical parameters of 12 Warmblood recreation horses were monitored as temporal data using video analysis [50 frames/sec] before and after 5-minute inclined work on a treadmill at 3% incline. Control group (6 horses) consisted from earlier evaluated horses that performed on the other day the same walk exercise without incline. Analysis of variance was conducted for temporal and spatial parameters of walk (237 measurements for incline and 109 for control) using the Mixed SAS procedure. For both data sets the statistical model with the random effect of horse, fixed effects of exercise and successive stride was applied. Control group showed not differences before/after short walk exercise. The influence of inclined exercise was statistically significant for the lateral limbs sequence, regularity and standard deviation of strides regularity (p<0.05). The lateral limbs sequence and regularity increased after inclined exercise (3-5%). The standard deviation of regularity was almost 2-fold lower. Inclined treadmill exercise has a positive effect on walk regularity.

Report of the Scientific Committee of the Spanish Agency for Food Safety and Nutrition (AESAN) on the risk associated with the consumption of food supplements that contain creatine as an ingredient

Abstract Creatine is an endogenous substance synthesised in the pancreas, kidneys and liver, which can also be provided through the diet, mainly through the intake of meat and fish, or in the form of a food supplement ingredient, with creatine monohydrate and creatine hydrochloride being the most common marketed forms of creatine. Creatine is effective in improving the training and performance of short duration and high intensity physical exercise. In fact, Regulation (EU) No. 432/2012 includes the health claims attributable to foods that provide a daily intake of 3 g of creatine and related to the effect of creatine on physical exercise. Based on the information currently available on creatine and considering that creatine monohydrate and hydrochloride are the forms of creatine commonly used in the manufacture of food supplements with creatine, the Scientific Committee considers that the maximum daily amounts of 3.41 g of creatine monohydrate and 3.84 g of creatine hydrochloride provide a maximum daily amount of 3 g/day of creatine and are acceptable from the standpoint of their safety in use as food supplements for a healthy adult population.

Effects of Ramadan Fasting on Sleep and Physical Fitness among Young Female Handball Players.

This study examines the potential impact of Ramadan fasting on sleep patterns and physical fitness in under 14 (U14) and under 17 (U17) female handball players. For this study, sixty-five female handball players' (U14, n = 33 and U17, n = 32) sleep habits were assessed before (BR) and during the first (R1) and last weeks (R4) of Ramadan using: the Pittsburgh Sleep Quality Index (PSQI), the Insomnia Severity Index (ISI), and the Epworth Sleepiness Scale (ESS). Physical ability tests including balance and jumps were conducted throughout these periods.; Results: During Ramadan, both groups noted significant increases in PSQI and ISI scores during R1 (p < 0.01 and p < 0.05, respectively) and R4 (p < 0.05 and p < 0.05, respectively) compared to before Ramadan (BR). For the U14 group, a significant increase occurred in ESS scores during R1 (p < 0.01) and R4 (p < 0.05), whereas for the U17 group, this increase was limited over the R1 period (p < 0.05). In contrast, for all physical ability parameters, both groups showed no significant difference during R1 and R4; Conclusions: During adolescence, Ramadan fasting may alter sleep patterns in young female athletes but appears to have no effect on their performance in short-duration exercises.

The kinetics of cardiac troponin T release during and after 1- and 6-h maximal cycling trials

ObjectivesIn this study, the effects of short-duration high-intensity exercise and long-duration exercise on high-sensitivity cardiac troponin T (hs-cTnT) levels were compared. MethodsTwelve male amateur cyclists performed 1- and 6-h cycling trials. In both exercise trials, hs-cTnT was assessed at rest, immediately postexercise and at 1, 3, 6, 12, and 24 h postexercise. Additionally, hs-cTnT levels were assessed every hour during the 6-h trial. ResultsExercise resulted in an increase in hs-cTnT levels in all subjects. Circulating hs-cTnT levels increased in both exercise trials (p < 0.001), with higher peak values occurring after the 1-h trial compared with those of the 6-h trial (p = 0.023). The upper reference limit (URL) exceeded 83 % of the participants in the 1-h trial and 42 % of the participants in the 6-h trial. There was substantial individual variability in peak hs-cTnT in both trials. Values of hs-cTnT were greater after exercise than during exercise for the 6-h trial. For both exercise trials, the maximum postexercise hs-cTnT values correlated with the %HRMAX (r = 0.906 for the 1-h trial, r = 0.735 for the 6-h trial). For the 1-h trial, the maximum postexercise hs-cTnT values were observed at 3 h in all subjects. No significant difference in the hs-cTnT values was observed for the 6-h trial during the first 12 h postexercise. ConclusionsOur results demonstrated greater hs-cTnT levels in young male participants after a 1-h cycling trial than after a 6-h cycling trial, despite a substantially greater energy expenditure and total external work completed in the 6-h trial. Postexercise hs-cTnT values are associated with relative exercise intensity.

The effect of ischemic preconditioning on repeated sprint cycling performance: a randomized crossover study.

Ischemic preconditioning (IPC) has been suggested to improve exercise performance by 1-8%. Prior research concerning its impact on short-duration exercises, such as sprints, has been limited and yielded conflicting results. The aim of this study, which included a non-occlusion-based placebo control, was to determine whether IPC improves repeated sprint performance in a manner that accounted for psychophysiological effects. Twenty-two healthy males participated in this study, which employed a randomized crossover design. Following the 10-min baseline period, participants received intervention under four different conditions: 1) no-intervention control (CON); 2) non-occlusion-based placebo control (SHAM); 3) remote IPC (RIPC); and 4) local IPC (LIPC). Participants then performed a standardized repeated sprint cycling (5×10s maximal cycling sprint, separated by a 40-s rest in each set). Repeated sprint performance, as indexed by average power output, peak power output, and total work, the improvement was observed in the RIPC and LIPC during the initial phase (set 1-3) when compared with CON (P<0.05). SHAM condition also showed an increase in peak power output in the set 1 (CON 9.97±1.05 vs. SHAM 10.30±1.13 w/kg, P<0.05), which may represent a psychophysiological component in the IPC-induced improvement. Higher lactate concertation was found in the SHAM and LIPC groups, than in the CON group, 5 minutes after the exercise (CON 15.72±0.68 vs. SHAM 16.82±0.41 vs. LIPC 17.19±0.39 mmol/L, P<0.0001 for both, respectively). In conclusion, LIPC enhanced repeated sprint cycling performance during the initial phase, beyond what could be accounted for entirely by a psychophysiological effect. The improvement associated with RIPC, however, did not surpass the effect of a placebo intervention.

Hemodynamics of short-duration light-intensity physical exercise in the prefrontal cortex of children: a functional near-infrared spectroscopy study

Identifying the types of exercise that enhance cerebral blood flow is crucial for developing exercise programs that enhance cognitive function. Nevertheless, few studies have explored the amount of light-intensity, short-duration exercises that individuals can easily perform on cerebral blood flow, particularly in children. We examined the effects of these exercises on the hemodynamics of the prefrontal cortex (PFC) using functional near-infrared spectroscopy. Participants comprised 41 children (aged 12.1 ± 1.5 years, 37% female) who engaged in seven light-intensity exercises, with each movement performed in two patterns lasting 10 or 20 s. Changes in oxygenated hemoglobin (oxy-Hb) levels at rest and during exercise were compared using analysis of covariance, with sex and age as covariates. Significant increases in oxy-Hb were observed in multiple regions of the PFC during all forms of exercise (including dynamic and twist stretching [66.6%, 8/12 regions, η2 = 0.07–0.27], hand and finger movements [75.0%, 9/12 regions, η2 = 0.07–0.16], and balance exercises (100.0%, 6/6 regions, η2 = 0.13–0.25]), except for static stretching with monotonic movements. This study implies that short-duration, light-intensity exercises, provided that they entail a certain degree of cognitive and/or physical demands, can activate the PFC and increase blood flow.

Tai Chi Exercise of Short Duration Alters Circulating Oxylipins in Post-menopausal Women With Knee Osteoarthritis

Tai Chi Exercise of Short Duration Alters Circulating Oxylipins in Post-menopausal Women With Knee Osteoarthritis

Osteosarcopenia in women with rheumatoid arthritis: association with nutritional status and physical condition

Objective: to evaluate nutritional status, muscle strength, functional status of skeletal muscles and physical activity (PHA) and their relationship with the osteopenic body composition phenotype in women in post menopause with rheumatoid arthritis (RA). Material and methods. The case-control study included 134 women in post menopause with RA, 52 of them had osteosarcopenia (OSP) according to densitometry and 82 had no decrease in bone mineral density (BMD) and muscle mass (mean age 62.0 ± 7.2 and 59.6 ± 7.5 years, respectively; p &gt; 0.05). A clinical and laboratory examination as well as tests to assess muscle strength and functional status were performed. The MNA-SF and IPAQ questionnaires were used to determine nutritional status and physical activity. Results and discussion. Malnutrition was found in 51.9 % of patients, and low and average levels of PHA were found in 5.8 and 50.0 % of patients with OSP, respectively. Factors associated with OSP were identified: nutritional status according to MNA-SF &lt; 12 points (odds ratio, OR 2.52; 95 % confidence interval, CI 1.10–5.77; p = 0.029), dietary calcium intake &lt; 500 mg/day (OR 3.23; 95 % CI 1.49–7.01; p = 0.003), 25(OH)D level &lt; 30 ng/ml (OR 4.55; 95 % CI 1.86–11.16; p = 0.001), moderate PHA &lt; 1 hour per day (OR 2.67; 95 % CI 1.06–6.75; p = 0.037), walking &lt; 1 hour per day and &lt; 4 hours per week (OR 3.25; 95 % CI 1.26–8.38; p = 0.015 and OR 3.17; 95 % CI 1.19–8.46; p = 0.021, respectively). Conclusion. Reduced nutritional status was found in 51.9 % and average or low levels of PHA in 55.8 % of patients with OSP. The risk of OSP development was increased by low nutritional status, inadequate dietary calcium intake, low vitamin D levels, short duration of daily moderate exercise, and inadequate daily and weekly walking time.

Does mild chronic obstructive pulmonary disease need a standard pulmonary rehabilitation program? A case report

Background: Patients with mild chronic obstructive pulmonary disease (COPD) are usually not recommended for a standard pulmonary rehabilitation (PR)program based on the GOLD guideline in mild COPD GOLD A classification. Especially, the scientific evidence on exercise capacity that can be identified for recruitment in PR programs has been less reported. Thus, a preliminary case study to identify the exercise capacity under cardiopulmonary responses by aerobic exercise testing among patients in mild COPD GOLD A classification was the aim of this study. Objective: To evaluate the cardiopulmonary responses from exercise capacity testing in individual COPD patients with mild COPD GOLD A Classification. Materials and methods: Four participants with mild COPD GOLD A performed an exercise endurance capacity test at home using Spot Marching Exercise Test (SMT), marching on the spot with high hip and arm raising. The load of SMT was indicated by a controlled stepping rate at 70, 80, 90, 100, and 110 steps/min. Every participant performed Incremental SMT (ISMT) with every 3 min incremental load, and the Constant SMT (CSMT) at the peak load. Both exercise tests were terminated at symptom limit. Resting time between ISMT and CSMT was at least 30 minutes. Cardiopulmonary exercise responses, Borg perceived breathlessness (RPB) and exertion (RPE) were monitored every minute during the exercise test. The duration of exercises was recorded. Results: Peak exercise capacity using ISMT was low with the end exercise load at 70, 80, 80, and 90 steps/min which is equivalent to moderate to high intensity at 81%, 62%, 65% and 93% of age-predicted maximum heart rate (HRmax). The exercise test was stopped by breathlessness at RPB 7, 8, 6, and 5. Respiratory rates (RR) were 36, 26, 38, and 38 breaths/min. With CSMT, the results showed very short exercise duration 1.78, 4.60, 2.15, and 2.47 mins with RPB 7, 8, 5, and 5 and RR of 33, 27, 34, and 41 breaths/min respectively. Conclusion: This preliminary report reveals that all four mild COPD GOLD A show low exercise capacity and very poor exercise endurance that should identify the appropriated standard PR program in the future.

Effects of 3days of citrulline malate supplementation on short-duration repeated sprint running performance in male team sport athletes.

Citrulline malate (CM) is purported to be an ergogenic aid during various types of exercise performance. However, the effects of CM on repeated sprint performance (RSP) are under-explored. In a placebo-controlled, double-blind, counterbalanced cross-over design, male university-level team sport athletes (n=13) performed two familiarization trials, after which CM or placebo (PLA) (8×1g tablets each day) were taken on the 2days prior to, and with breakfast on the morning of, each main experimental trial. The main experimental trials employed a RSP protocol consisting of 10 repetitions of 40m maximal shuttle run test (MST) with a 30s interval between the start of each sprint. Sprint times and heart rate were recorded throughout the MST, and blood lactate concentrations were measured before, immediately after, and 5min after completing the MST. CM resulted in better RSP compared to PLA, as indicated by a lower sprint performance decrement (Sdec: CM, 4.68%±1.82% vs. PLA, 6.10%±1.83%; p=0.03; ES=0.77), which was possibly influenced by the fastest sprint time being faster in CM (CM, 8.16±0.34s vs. PLA, 8.29±0.39s; p=0.011; ES=0.34). There were no differences between CM and PLA in average sprint time (p=0.54), slowest sprint time (p=0.48), blood lactate concentrations (p=0.73) or heart rate (p=0.18), nor was there a condition×time interaction effect across the 10 sprints (p=0.166). Three days of CM supplementation (8g daily) attenuated the sprint performance decrement during short-duration high-intensity exercise in the form of running RSP in male university-level team sport athletes.

Acute alcohol ingestion decreases the work done above the end-test power during a 3-min all-out cycling exercise.

Alcohol ingestion influences metabolism during a subsequent exercise session, as evidenced by increased blood lactate concentration during fixed-intensity exercise. Therefore, augmented blood concentrations of alcohol may interfere with the anaerobic metabolism during high-intensity, short-duration exercise bout, thereby leading to impaired athletic performance. This study investigated whether the acute ingestion of alcohol as ethanol modulates performance parameters derived from the power-duration relationship in a 3-min all-out cycling test that allows for identifying the power output related to heavy and severe exercise intensities. Twenty-four recreationally active cyclists (16 men and 8 women) ingested a beverage containing either 0.4g ethanol.kg-1 body mass (EtOH) or a placebo (PLA) solution. Thirty minutes following ingestion, they completed a 3-min all-out test to measure power output and determine the end-test power (EP) and the work done above EP (WEP). Alcohol ingestion decreased WEP by 16% (EtOH: 5.6 ± 2.5kJ vs. PLA: 6.7 ± 2.4kJ; P = .003) but did not change EP (EtOH: 211 ± 44W vs. PLA: 212 ± 44W; P = .671). The alcohol-mediated effect in WEP was not influenced when controlling for participants' sex or accuracy in identifying the beverage ingested. Our data indicate that alcohol ingestion impaired the anaerobic work capacity, as evidenced by the reduction in WEP during the 3-min all-out test. Moreover, the ability to exercise at an intensity above the heavy domain may be decreased after ingestion of a moderate alcohol dose.

A comparative analysis of energy expenditure and substrate metabolism in male university students with overweight/obesity: Tabata vs HIIT and MICT.

Exploring the energy expenditure and substrate metabolism data during exercise, 10-minute recovery, and 20-minute recovery phases in Tabata, HIIT(High-Intensity Interval Training), and MICT(Moderate-Intensity Continuous Training). This study explores the scientific aspects of weight reduction strategies, examining energy expenditure and substrate metabolism from various training perspectives. The aim is to establish a theoretical foundation for tailoring targeted exercise plans for individuals within the population with overweight/obesity. This study used an experimental design with fifteen male university students with overweight/obesity. Participants underwent random testing with Tabata, HIIT, and MICT. Tabata involved eight sets of 20 seconds exercise and 10 seconds rest, totaling 4 minutes. HIIT included four sets of power cycling: 3 minutes at 80% VO2max intensity followed by 2 minutes at 20% VO2max. MICT comprised 30 minutes of exercise at 50% VO2max intensity. Gas metabolism indices were continuously measured. Subsequently, fat and glucose oxidation rates, along with energy expenditure, were calculated for each exercise type. During both the exercise and recovery phases, the Tabata group exhibited a significantly higher fat oxidation rate of (0.27 ± 0.03 g/min) compared to the HIIT group (0.20 ± 0.04 g/min, p<0.05) and the MICT group (0.20 ± 0.03g/min, p<0.001). No significant difference was observed between the HIIT and MICT groups (p=0.854). In terms of energy expenditure rate, the Tabata group maintained a substantially elevated level at 5.76 ± 0.74kcal/min compared to the HIIT group (4.81 ± 0.25kcal/min, p<0.01) and the MICT group (3.45 ± 0.25kcal/min, p<0.001). Additionally, the energy expenditure rate of the HIIT group surpassed that of the MICT group significantly (p<0.001). The study finds that male college students with overweight/obesity in both exercise and recovery, Tabata group has lower fat and glucose oxidation rates, and energy expenditure compared to HIIT and MICT groups. However, over the entire process, Tabata still exhibits significantly higher rates in theseaspects than HIIT and MICT. Despite a shorter exercise duration, Tabata shows a noticeable "time-efficiency" advantage. Tabata can be used as an efficient short-term weight loss exercise program for male college students with overweight/obesity.

Clinical value and mechanistic analysis of HIIT on modulating risk and symptoms of depression: A systematic review

BackgroundThe exact causal mechanisms of depression remain unclear due to the complexity of the triggers, which has led to limitations in treating depression using modern drugs. High-intensity interval training (HIIT) is as effective as medication in treating depression without toxic side effects. Typically, HIIT requires less time commitment (i.e., shorter exercise duration) and exhibits pronounced benefits on depressive symptoms than other forms of physical exercise. This review summarizes the risk reduction and clinical effects of HIIT for depression and discusses the underlying mechanisms, providing a theoretical basis for utilizing HIIT in treating depression. MethodsA database search was conducted in PubMed, Embase, Web of Science, and Scopus from inception up to October 2022. The methodological quality of the included literature was evaluated by the physiotherapy evidence database (PEDro) scale criteria. The review focused on evaluating the changes in depression risk or symptoms of HIIT interventions in healthy individuals, patients with depression, and patients with other disorders co-morbid with depression. Consequently, the mechanisms associated with depression related HIIT were summarized. ResultsA total of 586 participants (52 % female; mean age: 43.58±8.93 years) from 22 studies were included. Implementing HIIT using different exercise types alleviates depressive symptoms in individuals with depression and in individuals with depression who have exhibited comorbidities and reduced depression scale scores in subjects immediately after acute exercise. In addition, the long-interval HIIT and short-interval HIIT in the treatment of patients with cardiovascular or psychiatric disorders may reduce depressive symptoms via complex exercise-related changes on several levels, including by effecting the following measures: releasing monoamines, reducing neuronal death, inducing neurogenesis, modulating the functional homeostasis of the HPA axis, and enhancing the level of inflammation in the body. ConclusionHIIT is a relatively safe and effective antidepressant, which may involve multiple neurobiological mechanisms (release of monoamines, reducing neuronal death, inducing neurogenesis, modulating the functional homeostasis of the HPA axis, and enhancing the level of inflammation in the body), thereby reducing the risk or symptoms of depression in participants.

Mouse skeletal muscle adaptations to different durations of treadmill exercise after the cessation of FOLFOX chemotherapy.

FOLFOX (5-fluorouracil, leucovorin, oxaliplatin) chemotherapy is a treatment for colorectal cancer that can induce persistent fatigue and metabolic dysfunction. Regular exercise after chemotherapy cessation is widely recommended for cancer patients and has been shown to improve fatigue resistance in mice. However, gaps remain in understanding whether the early systemic and skeletal muscle adaptations to regular exercise are altered by prior FOLFOX chemotherapy treatment. Furthermore, the effects of exercise duration on early metabolic and skeletal muscle transcriptional adaptations are not fully established. Purpose: Investigate the effects of prior FOLFOX chemotherapy treatment on the early adaptations to repeated short- or long-duration treadmill exercise, including the fasting regulation of circulating metabolic regulators, skeletal muscle COXIV activity and myokine/exerkine gene expression in male mice. Methods: Male C57BL6/J mice completed 4 cycles of FOLFOX or PBS and were allowed to recover for 4-weeks. Subsets of mice performed 14 sessions (6d/wk, 18m/min, 5% grade) of short- (10min/d) or long-duration (55min/d) treadmill exercise. Blood plasma and muscle tissues were collected 48-72h after the last exercise bout for biochemical analyses. Results: Long-duration exercise increased fasting plasma osteocalcin, LIF, and IL-6 in healthy PBS mice, and these changes were ablated by prior FOLFOX treatment. Slow-oxidative soleus muscle COXIV activity increased in response to long-duration exercise in PBS mice, which was blocked by prior FOLFOX treatment. Fast-glycolytic plantaris muscle COXIV activity increased with short-duration exercise independent of FOLFOX administration. There was a main effect for long-duration exercise to increase fasting muscle IL-6 and COXIV mRNA expression independent of FOLFOX. FOLFOX administration reduced muscle IL-6, LIF, and BDNF mRNA expression irrespective of long-duration exercise. Interestingly, short-duration exercise suppressed the FOLXOX induction of muscle myostatin mRNA expression. Conclusion: FOLFOX attenuated early exercise adaptations related to fasting circulating osteocalcin, LIF, and IL-6. However, prior FOLFOX treatment did not alter the exercise adaptations of plantaris muscle COXIV activity and plasma adiponectin. An improved understanding of mechanisms underlying exercise adaptations after chemotherapy will provide the basis for successfully treating fatigue and metabolic dysfunction in cancer survivors.

Effects of 12 Weeks of Continuous Exercise and Accumulation of Short-Duration Exercise on Body Composition, Physical Fitness, and Lifestyle Disease indices in Overweight Men in their 30s

PURPOSE This study aimed to investigate the effects of continuous exercise and the accumulation of short-duration exercise for 12 weeks on body composition, physical fitness, and lifestyle disease indices in overweight men in their 30s.METHODS Participants in the continuous exercise group (CE; &lt;i&gt;n&lt;/i&gt;=13) performed a circuit exercise program of 30 min/session, 3 sessions/week for 12 weeks. Participants in the accumulation of short duration exercise group (ASE; &lt;i&gt;n&lt;/i&gt;=12) performed the same exercise time of 30 min per day, divided into three sessions of 10 min. Body composition, physical fitness, and lifestyle disease indices were measured pre- and post-test and were compared by utilizing a repeated two-way ANOVA.RESULTS 1) Regarding body composition, body weight, body mass index, skeletal muscle mass, waist circumference, and fat mass decreased significantly, while hip circumference increased significantly in the CE group. Waist circumference and skeletal muscle mass decreased significantly, while hip circumference increased significantly in the ASE group. 2) Regarding physical fitness, right grip strength, sit and reach, sit up, and maximal oxygen uptake increased significantly in both groups. 3) Regarding hypertension indices, there were no significant differences in both groups, but they showed a tendency to improve. 4) Regarding hyperlipidemia indices, triglycerides (TG) decreased significantly in both groups, and total cholesterol (TC) decreased significantly in the CE group. 5) Regarding diabetes indices, there were no significant differences in both groups, but a tendency to improve was noticed. 6) Regarding arteriosclerosis indices: TG/high density lipoprotein-cholesterol ratio decreased significantly in both groups, and the TC/high density lipoprotein-cholesterol ratio decreased significantly in the CE group.CONCLUSIONS We concluded that both the accumulation of short duration exercise and continuous exercise can be effective in improving body composition, physical fitness, and lifestyle disease in overweight men.

Head movement kinematics are differentially altered for extended versus short duration gait exercises in individuals with vestibular loss

Head kinematics are altered in individuals with vestibular schwannoma (VS) during short duration gait tasks [i.e., Functional Gait Assessment (FGA)], both before and after surgery, yet whether these differences extend to longer duration gait exercises is currently unknown. Here we examined the effects of vestibular loss and subsequent compensation on head kinematics in individuals with VS during gait exercises of relatively extended versus short duration (< 10 versus 30 s), compared to age-matched controls. Six-dimensional head movements were recorded during extended and short duration gait exercises before and then 6 weeks after sectioning of the involved vestibular nerve (vestibular neurectomy). Standard functional, physiological, and subjective clinical assessments were also performed at each time point. Kinematics were differentially altered in individuals with vestibular loss at both time points during extended versus short duration exercises. Range of motion was significantly reduced in extended tasks. In contrast, movement variability predominately differed for the short duration exercises. Overall, our results indicate that quantifying head kinematics during longer duration gait tasks can provide novel information about how VS individuals compensate for vestibular loss, and suggest that measurements of range of motion versus variability can provide information regarding the different strategies deployed to maintain functional locomotion.

Sobre a pedagogia de projetos: a experiência conduzindo o indivíduo à teoria

Este artigo-ensaio versa sobre a pedagogia de projetos: a experiência conduzindo o indivíduo à teoria. A proposta é esclarecer que a aprendizagem acontece por intermédio de contato empírico com a realidade e com os fenômenos que acontecem na natureza. A sua relevância científica encontra-se no fato de apresentar uma discussão técnica sobre uma metodologia de estudos que permite a relação direta, recíproca e simultânea entre a prática e a teoria. A sua relevância social está em colocar à disposição da sociedade um mecanismo que eleva, de forma exponencial, os ganhos de aprendizagem dos estudantes, permitindo-lhe suma visão pragmática dos conteúdos programáticos com os quais trava contato acadêmico. A metodologia utilizada para esta investigação foi a bibliográfica, agregada à prática pedagógica e didática dos autores no ensino. Procurou-se apresentar uma discussão profunda, ampla, em que se preconiza a supremacia da experiência sobre a teoria, em que a primeira conduz a segunda, esta expressando e comunicando o conhecimento adquirido. A Pedagogia de Projetos surgiu da necessidade de desenvolver uma metodologia de trabalho pedagógico, que tivesse como meta a valorização da participação do educando e do educador no processo de aprendizagem-ensino, considerando que a aprendizagem apresenta primazia sobre o ensino. Ao propor a Pedagogia de Projetos como metodologia de ensino, isto significa acabar com o monopólio do professor tradicional que decide e define ele mesmo o conteúdo e as tarefas a serem desenvolvidas e que verdades devam ser consideradas e/ou negadas, valorizando, dentro de rigorosos princípios acadêmico-científicos, o que os estudantes já sabem e respeitando o que desejam aprender naquele momento, cientes de que a situação-problema suscitada é o leitmotiv da experiência a ser posta em evidência, culminando na aprendizagem. Quando se aborda a questão da aprendizagem intermediada por projetos está-se, necessariamente, referindo à formulação de questões pelo autor do projeto, pelo indivíduo que vai construir conhecimentos a partir de uma situação-problema.

Applying a muscle fatigue model when optimizing load-sharing between muscles for short-duration high-intensity exercise: A preliminary study.

Introduction: Multiple different mathematical models have been developed to represent muscle force, to represent multiple muscles in the musculoskeletal system, and to represent muscle fatigue. However, incorporating these different models together to describe the behavior of a high-intensity exercise has not been well described. Methods: In this work, we adapted the three-compartment controller (3CCr) muscle fatigue model to be implemented with an inverse-dynamics based optimization algorithm for the muscle recruitment problem for 7 elbow muscles to model a benchmark case: elbow flexion/extension moments. We highlight the difficulties in achieving an accurate subject-specific approach for this multi-level modeling problem, considering different muscular models, compared with experimental measurements. Both an isometric effort and a dynamic bicep curl were considered, where muscle activity and resting periods were simulated to obtain the fatigue behavior. Muscle parameter correction, scaling and calibration are addressed in this study. Moreover, fiber-type recruitment hierarchy in force generation was added to the optimization problem, thus offering an additional novel muscle modeling criterion. Results: It was observed that: i) the results were most accurate for the static case; ii) insufficient torque was predicted by the model at some time points for the dynamic case, which benefitted from a more precise calibration of muscle parameters; iii) modeling the effects of muscular potentiation may be important; and iv) for this multilevel model approach, the 3CCr model had to be modified to avoid reaching situations of unrealistic constant fatigue in high intensity exercise-resting cycles. Discussion: All the methods yield reasonable estimations, but the complexity of obtaining accurate subject-specific human models is highlighted in this study. The proposed novel muscle modeling and force recruitment criterion, which consider the muscular fiber-type distinction, show interesting preliminary results.