South Tibet expressways are built in the Yalu Tsangpo valley along the route to high-altitude and cold-temperature valleys, which are the main environmental characteristics of the region. Given that the blown sand environment and its potential harm are unclear, targeted prevention and control are not conducive, but its absence would result in severe wind-sand hazards on these expressways. In this research, the blown sand environment of the South Tibet Valley and the mechanism of sand damage to expressway bridges were studied via field observations, wind tunnel experiments and numerical simulations. The sand-moving wind is mainly west wind. The sand-moving wind frequency, sand drift potential, and maximum possible sand transport quantity are high in winter and spring (November-April) and low in summer and autumn (May-October). The sand drift direction is in the east direction. Expressway bridges have a considerable impact on the near-surface blown sand environment, forming a zone for increasing the wind speed between the top of the slope shoulder of the windward side of the bridge to the center of the bridge abutment, forming a zone for weakening the wind speed between the - 3H distances of the upwind direction to the bottom of the slope middle of the windward side of the bridge, further forming a zone for weakening the wind speed centered in the slope shoulder of the leeward side of the bridge. The wind speed within a distance of 40H downwind direction of the bridge generally did not recover. The wind-sand flow is partially blocked when it passes through the bridge and accumulates near the bridge, which cause harm. The impact of the bridge on the blown sand environment in the downwind is greater than that in the upwind. The results of this study can provide a reference for preventing and controlling wind-sand hazards on South Tibet expressways.