As the value and importance of urban air mobility (UAM) are being recognized, there is growing attention towards UAM. To ensure that urban air traffic can serve passengers to the greatest extent while ensuring safety and generating revenue, there is an urgent need for a transportation scheduling plan based on safety considerations. The region of Beijing–Tianjin–Hebei was selected as the case study in this research. A real-time demand transportation scheduling model for a single day was constructed, with the total service population and total cost as objective functions, and safety intervals, eVTOL performance, and passenger maximum waiting time as constraints. A Joint Optimization of Cost and Scheduling Particle Swarm Optimization (JOCS-PSO) algorithm was utilized to obtain the optimal solution. The optimal solution obtained in this study can serve 138,610,575 passengers during eVTOLs’ entire lifecycle (15 years) with a total cost of CNY 368.57 hundred million, with the cost of CNY 265.9 per passenger. Although it is higher than the driving cost, it saves 1–1.5 h and thus has high cost effectiveness during rush hours.