Shift Of Axis Research Articles

The role of Rh spacer layer thickness on the noncollinear interlayer exchange coupling

Abstract The relationship between noncollinear interlayer exchange coupling (IEC) and magnetic anisotropic behavior in Fe/Rh/Fe trilayers is studied in detail by using magneto-optical Kerr effect (MOKE) and anisotropic magnetoresistance (AMR) techniques. It is found that the Rh spacer layer thickness strongly affects IEC and magnetic anisotropy in these trilayers. The role of Rh spacer layer thickness is shown in the oscillatory behavior in the magnitude of the magnetic anisotropy, the transition from uniaxial to four-fold anisotropy, the shift of easy axis for magnetic anisotropy, and the unusual increase in the sheet resistance. As an outcome of this study, we discuss the underlying mechanism based on the noncollinear IEC across the Fe/Rh/Fe interlayer. As a result, it has been shown that the noncollinear IEC can be controlled by the various Rh spacer thicknesses among nonmagnetic transition layers.

Comparison of Standard and Prone-Position Electrocardiograms in COVID-19 Patients With Pulmonary Complications: Correlations and Implications.

Previous research highlighted variability in electrocardiogram (ECG) readings across patient positions, particularly in the context of COVID-19 patients with pulmonary complications requiring prone positioning as part of the treatment. This study aimed to elucidate the effects of prone positioning on ECG parameters and explore its association with the severity of COVID-19. A prospective cohort study involved 60 patients diagnosed with COVID-19 and presenting pulmonary complications. ECGs were recorded in both supine and prone positions, and analyzed for various parameters including heart rate, QRS axis, and QTc interval. Clinical severity was assessed using APACHE II scores and SpO2/FiO2 ratios. Prone positioning led to an increase in heart rate (mean difference: 2.100, 95% CI: 0.471-3.729, p = 0.012), with minor shifts in the QRS axis. Heart rate and QRS axis demonstrated strong positive correlations between positions, with Pearson's correlation coefficients of 0.927 and 0.894, respectively. The study also found a significant association between prolonged QTc intervals in the prone position and elevated APACHE II scores, with a relative risk of 10.75 (95% CI: 1.82-63.64, p = 0.008). The prone positioning caused minor yet significant changes in heart rate and QRS axis. The correlation of prolonged QTc intervals in the prone position with higher APACHE II scores suggests the prognostic relevance of prone ECG in COVID-19 patients. However, further research is needed to fully understand the clinical implications and mechanisms of these findings.

PoLambRimetry: a multispectral polarimetric atlas of lamb brain.

Mueller matrix imaging (MMI) is a comprehensive form of polarization imaging useful for assessing structural changes. However, there is limited literature on the polarimetric properties of brain specimens, especially with multispectral analysis. We aim to employ multispectral MMI for an exhaustive polarimetric analysis of brain structures, providing a reference dataset for future studies and enhancing the understanding of brain anatomy for clinicians and researchers. A multispectral wide-field MMI system was used to measure six fresh lamb brain specimens. Multiple decomposition methods (forward polar, symmetric, and differential) and polarization invariants (indices of polarimetric purity and anisotropy coefficients) have been calculated to obtain a complete polarimetric description of the samples. A total of 16 labels based on major brain structures, including grey matter (GM) and white matter (WM), were identified. -nearest neighbors classification was used to distinguish between GM and WM and validate the feasibility of MMI for WM identification. As the wavelength increases, both depolarization and retardance increase, suggesting enhanced tissue penetration into deeper layers. Moreover, utilizing multiple wavelengths allowed us to track dynamic shifts in the optical axis of retardance within the brain tissue, providing insights into morphological changes in WM beneath the cortical surface. The use of multispectral data for classification outperformed all results obtained with single-wavelength data and provided over 95% accuracy for the test dataset. The consistency of these observations highlights the potential of multispectral wide-field MMI as a non-invasive and effective technique for investigating the brain's architecture.

Experimental Verification of the Gouy Phase for Higher-Order Hermite-Gaussian Beams

The Gouy phase is related to the axial phase shift experienced by any focused light beam with respect to a reference plane wave when passing through its focus. Generally, the Gouy phase ΦG for a higher-order Hermite-Gaussian (HG) beam is this for the fundamental Gaussian beam multiplied by a factor, which is the sum of the mode indices of the HG beam plus unity. Although this result is a paradigm in optics, we are not aware of its experimental verification. In this paper, we present experimental results obtained with a single-lens interferometer for higher-order HG modes generated using spatial light modulator. The retrieved Gouy phase ΦG is found in a very good quantitative agreement with the mentioned theoretical result.

Directionality Reversal and Shift of Rotational Axis in a Hemithioindigo Macrocyclic Molecular Motor.

Molecular motors are central driving units for nanomachinery, and control of their directional motions is of fundamental importance for their functions. Light-driven variants use easy to provide, easy to dose, and waste-free fuel with high energy content, making them particularly interesting for applications. Typically, light-driven molecular motors work via rotations around dedicated chemical bonds where the directionality of the rotation is dictated by the steric effects of asymmetry in close vicinity to the rotation axis. In this work, we show how unidirectional rotation around a virtual axis can be realized by reprogramming a molecular motor. To this end, a classical light-driven motor is restricted by macrocyclization, and its intrinsic directional rotation is transformed into a directional rotation of the macrocyclic chain in the opposite direction. Further, solvent polarity changes allow to toggle the function of this molecular machine between a directional motor and a nondirectional photoswitch. In this way, a new concept for the design of molecular motors is delivered together with elaborate control over their motions and functions by simple solvent changes. The possibility of sensing the environmental polarity and correspondingly adjusting the directionality of motions opens up a next level of control and responsiveness to light-driven nanoscopic motors.

Interference of high-order perfect optical vortex beams

We investigate the interference of high-order perfect optical vortex (POV) beams with different topological charges. Through numerical simulations, we reveal a remarkable phenomenon: keeping the beam width, and beam radius fixed while changing the topological charge, the splitting of the composite POV beam into two distinct individual perfect vortices occurs exactly at the same inter-axial separation. The observed interference pattern exhibits pronounced sensitivity to factors such as axial separation, phase shift, beam radius, and topological charges of the constituent beams. Notably, our findings are contrasted with the interference of high-order Laguerre-Gauss (LG) beams, highlighting that the splitting of composite vortices into their individual components is more rapid in the case of LG beams. We also investigate the evolution of the interference pattern for both POV, and LG beams along the propagation direction in free-space. Our research provides significant insights into the distinct interference properties of high-order POV beams, presenting potential applications in the fields of optical manipulation and communication systems.

Differentiating Left Ventricular Remodeling in Aortic Stenosis From Systemic Hypertension.

Left ventricular (LV) hypertrophy occurs in both aortic stenosis (AS) and systemic hypertension (HTN) in response to wall stress. However, differentiation of hypertrophy due to these 2 etiologies is lacking. The aim was to study the 3-dimensional geometric remodeling pattern in severe AS pre- and postsurgical aortic valve replacement and to compare with HTN and healthy controls. Ninety-one subjects (36 severe AS, 19 HTN, and 36 healthy controls) underwent cine cardiac magnetic resonance. Cardiac magnetic resonance was repeated 8 months post-aortic valve replacement (n=18). Principal component analysis was performed on the 3-dimensional meshes reconstructed from 109 cardiac magnetic resonance scans of 91 subjects at end-diastole. Principal component analysis modes were compared across experimental groups together with conventional metrics of shape, strain, and scar. A unique AS signature was identified by wall thickness linked to a LV left-right axis shift and a decrease in short-axis eccentricity. HTN was uniquely linked to increased septal thickness. Combining these 3 features had good discriminative ability between AS and HTN (area under the curve, 0.792). The LV left-right axis shift was not reversible post-aortic valve replacement, did not associate with strain, age, or sex, and was predictive of postoperative LV mass regression (R2=0.339, P=0.014). Unique remodeling signatures might differentiate the etiology of LV hypertrophy. Preliminary findings suggest that LV axis shift is characteristic in AS, is not reversible post-aortic valve replacement, predicts mass regression, and may be interpreted to be an adaptive mechanism.

A data-driven control method for ground locomotion on sloped terrain of a hybrid aerial-ground robot

In this work, we present a data-driven solution for the attitude control of DoubleBee on slopes. DoubleBee is a novel hybrid aerial-ground robot with two rotors and two active wheels. Inspired by the physcics modeling of the system, we add a channel-separated attention head to a deep ReLU neural network to predict disturbances from ground effects, motor torques and rotation axis shift. The proposed neural network is Lipschitz continuous, has fewer parameters and performs better for disturbance estimation than the baseline deep ReLU neural network. Then, we design a sliding mode controller using these predictions and establish its input-to-state stability and error bounds. Experiments show improvements of the proposed neural network in training speed and robustness over a baseline ReLU network, and a 40% reduction in tracking error compared to a baseline PID controller.

Posterior Circulation Ischemic Stroke Is Associated with More Severe Forward Head Posture in Patients with Cervicalgia

Chronic risk factors of posterior circulation ischemic strokes remain unknown. There is, however, evidence that anatomical variations within the vertebrobasilar system could potentially lead to the development of posterior circulation strokes. We investigated the association of forward head posturing (FHP), a chronic anatomical change seen in patients with cervicalgia, with posterior circulation strokes. In this case-control study, we identified adult patients diagnosed with cervicalgia and ischemic posterior circulation infarcts from 2007 to 2023. Cases were paired with controls with cervicalgia without posterior circulation stroke and matched for known risk factors. C0-C2 angle, C2-C7 angle, and sagittal vertical axis shift were measured as metrics for FHP severity on lateral cervical spine x-rays. Paired t tests were applied to compare stroke risk factors and FHP between groups. Participants included 206 patients (103 cases and 103 controls) with a mean age of 64.4 years; 51.5% were female. There were no statistically significant differences between risk factors for stroke, including hypertension, hyperlipidemia, diabetes, smoking, hypercoagulable state, and atrial fibrillation. There were statistically significant differences in C0-C2 angle (30.7° vs. 23.2°, P=0.002) and sagittal vertical axis shift (35.4 mm vs. 25.3 mm, P < 0.001). This case-control matched-pair study found that in adults with cervicalgia, posterior circulation ischemic stroke was associated with more severe FHP as noted in C0-C2 angle and sagittal vertical axis shift measurements. Further, this association may be due to chronic changes in circulation flow dynamics within the vertebrobasilar system with the postural change.

Application of intra-articular graft length measurement in total anterior cruciate ligament reconstruction

To investigate the clinical efficacy of arthroscopic measurement of intra-articular graft length in the application of total internal reconstruction of the anterior cruciate ligament(ACL). The 60 patients with ACL injury treated between January 2020 and January 2022 were retrospectively analyzed. There were 37 males and 23 females, aged from 22 to 44 years. According to the different surgical methods, they were divided into two groups:conventional surgery group (conventional group) and pull-line measurement group (measurement group), with 30 cases in each group. In the conventional group, there were 20 males and 10 females, with an average age of (30.00±3.95) years old;the body mass index (BMI) was (22.58±1.41) kg·m-2;there were 9 cases on the left side and 21 cases on the right side;the time from injury to operation was (3. 00±1.35) days. In the measurement group, there were 17 males and 13 females, with an average of(32.00±4.29) years;BMI was (23.29±1.39) kg·m-2;there were 12 cases on the left side and 18 cases on the right side;the time from injury to operation was (3.00±1.27) days. The clinical data of the patients before surgery, 6 months after surgery and 12 months after surgery were collected and recorded. The clinical efficacy of the two methods was compared in terms of postoperative VAS, KOOS, Lysholm score, IKDC score, knee stability (Lachman test, anterior drawer test and axial shift test), the degree of widening of bone tunnel diameter measured by CT at different stages of the postoperative period and MRI scoring system. At 12 months after surgery, the VAS of the measurement group was lower than that of the conventional group(P<0.001). At 12 months after surgery, KOOS scores in the measurement group were higher than those in the conventional group, and there were statistically significant differences in all scores except symptom scores (P<0.05). Six months after operation, Lysholm total score and IKDC total score in the measurement group were higher than those in the conventional group, and the difference was statistically significant (P<0.05). At 12 months after surgery, knee stability tests were performed, and the differences between the Lachman test, anterior drawer test and axial shift test measurement group and the conventional group were not statistically significant (P>0.05). However, overall knee instability analysis showed that the knee stability of the measurement group was better than that of the control group, and the difference between the groups was statistically significant (P=0.038). The imaging assessment of patients in both groups at 6 months after surgery showed that the widening of tendon tunnel diameter in both femur and tibia was reduced in the measurement group compared with the conventional group after surgery, and the difference was statistically significant(P<0.05);MRI scores were higher in all patients in the measurement group those in the conventional group, at 6 months and 12 months agter surgery(P<0.05). Arthroscopic measurement of intra-articular cavity graft length in total internal technique for ACL reconstruction, high tendon utilization, good stability, the knee joint function has recovered satisfactorily within one year, and the therapeutic effect is affirmed.

MMAIndoor: Patched MLP and multi-dimensional cross attention based self-supervised indoor depth estimation

Depth estimation can provide auxiliary information for scene perception. Generally, extensive textureless surfaces, such as walls and ceilings, exist in indoor environments, and they share similar scene and semantic content. Overly consistent features of local textureless areas fail to reflect changes in depth information, thus degrading the performance of existing depth estimation methods. In response to this challenge, we propose a special indoor depth estimation method, named as MMAIndoor, which can provide global semantic guidance and shape priors for local textureless depth estimation. The depth estimation network is designed efficiently, encompassing the initial convolutional stage and the latent patched multi-layer perceptron (Pat-MLP) stage. The novel Pat-MLP block utilizes MLP partitioning to globally model depth-local information from the convolutional stage and it incorporate axial shift operations to extract local information from various spatial locations, suppressing the smoothing effect of MLP and improving precise estimation of sharp depth changes or small structures indoors. Further, we build a multi-dimensional cross attention (MCA) module to address the weak correlation of the current residual connections for the global context. This MCA captures global dependencies across multi-dimensions by sequentially executing cross attention on both channels and spatial, and effectively mitigate semantic gaps in residual connections. Sufficient experimental results demonstrate the state-of-the-art performance of MMAIndoor on benchmark datasets including NYUv2, ScanNet, and InteriorNet.

Electrocardiographic changes in pneumothorax: an updated review

ECG changes in pneumothorax have gained recognition as important indicators of cardiopulmonary interactions. This narrative review examines the existing literature to provide insights into the various ECG abnormalities observed in patients with pneumothorax, their underlying mechanisms, and clinical implications. The review highlights the commonly reported changes, including alterations in the electrical axis, ST segment deviations, T-wave abnormalities, and arrhythmias. The rightward shift of the electrical axis is attributed to cardiac displacement caused by increased intrathoracic pressure. ST segment deviations may reflect the influence of altered intrathoracic pressure on myocardial oxygen supply and demand. T-wave abnormalities may result from altered myocardial repolarization and hypoxemia. Arrhythmias, although varying in incidence and type, have been associated with pneumothorax. The clinical implications of these ECG changes are discussed, emphasizing their role in diagnosis, risk stratification, treatment optimization, and prognostication. Additionally, future research directions are outlined, including prospective studies, mechanistic investigations, and the integration of artificial intelligence. Enhancing our understanding of ECG changes in pneumothorax can lead to improved patient care, better management strategies, and the development of evidence-based guidelines. The objective of this review is to demonstrate the presence of various ECG abnormalities in patients with pneumothorax.

High-accuracy attitude angle measurement system using laser collimation

We propose a high-precision attitude angle measurement system utilizing laser collimation to rectify environmental errors that significantly impact the precision of high-accuracy star sensors. Environmental factors, primarily temperature variations, can induce shifts in the optical axis of star sensors deployed in orbit, leading to errors in attitude angle measurements. Leveraging the conventional star sensor architecture, we have augmented the system with an additional laser path and a four-quadrant detector (4QD) positioned in the image plane. This setup converts angular deviations of the optical axis into positional shifts of the laser spot, facilitating the measurement of environmental errors. Both simulations and experimental findings demonstrate that the laser collimation system effectively mitigates environmental errors, thereby enhancing the attitude accuracy of the star sensors.

Clinical outcome of combined over-the-top reconstruction with modified Lemaire procedure in one-stage revision anterior cruciate ligament reconstruction

Objective: To investigate the clinical effect of over-the-top (OTT) reconstruction of the anterior cruciate ligament (ACL) combined with the modified Lemaire technique in one-stage ACL revision. Methods: It's a retrospective study. The clinical data of 37 patients who underwent one-stage revision of ACL using OTT combined with modified Lemaire technique from April 2020 to May 2023 in the Department of Sports Medicine of Xinhua Hospital Affiliated to Dalian University were retrospectively analyzed. There were 28 males and 9 females with a mean age of (32.7±5.7) years. The postoperative knee function and surgical revision effect were evaluated by subjective and objective evaluation indexes of the knee joint before and 3 months and 24 months after surgery. The subjective evaluation indexes included the International Knee Documentation Committee (IKDC) score, Lysholm score, and Tegner score; and the objective evaluation indexes included the anterior-posterior static displacement distance of the tibia, tibia-femur relative rotation angle, the Lachman test, the axial shift test, and the ratio of the loss of muscle strength of the lower limb. Results: At the final follow-up, all patients returned to pre-injury motor level, with significant improvements in IKDC scores (45.3±6.8 preoperatively, 67.5±4.7 and 93.2±2.3 at 3 months and 2 years after the operation, respectively), Lysholm scores (57.2±2.6 preoperatively, 72.6±2.9 and 89.7±3.7 at 3 months and 2 years after the operation, respectively), and Tegner scores (3.1±0.7 preoperatively, 4.9±0.6 and 5.8±1.3 at 3 months and 2 years after the operation, respectively) (all P<0.001). The anterior-posterior static displacement distance of the tibia reduced significantly [from (5.2±0.5) mm before the operation to (1.4±0.5) mm at 2 years postoperatively) (P<0.001)]; and the relative rotation angle of the tibia-femur restored to the normal physiological range, it was reduced from 6.2°±1.2° before the operation to 1.7°±0.3° 2 years after (P<0.001). The Lachman test and axial shift test at 2 years postoperatively were all negative. The muscle strength loss ratio of the affected lower limb was significantly better than that before the operation (P<0.001). Conclusion: The use of OTT reconstruction combined with modified Lemaire technique for revision of ACL in patients with ACL reconstruction failure can circumvent the tunnel problem for one-stage revision and better restore the stability and function of the knee joint, with ideal clinical results.

Structural design and lifecycle analysis of an orthotropic steel deck bascule bridge

This study presents the structural design and lifecycle analysis of an orthotropic steel deck (OSD) bascule bridge in Viareggio (Italy), considering various operational states and constraints. The analysis varied the bridge’s opening angle in 15-degree increments from 0 to 90 degrees, using two steel grades, S355 and S450, by comparing hydraulic or electro-mechanically driven activation mechanisms. The findings reveal that as the static model transitions from pinned-pinned to cantilevered when the bridge is opened, the structural demand for bending moment and shear force increases, with a maximum of nearly 15°–30°. At the same time, axial forces shift from tensile to compressive. Structural design has been carried out using higher grade steel (S450), which has led to a 17.17% mass reduction, cost savings of 3.4%, and a notable decrease in CO2 emissions by 16%. This proves that despite using higher-grade steel characterized by more significant CO2 emissions, the mass reduction associated with the refined design leads to an overall lower environmental footprint. This fact underscores the importance of selecting proper steel grades for steel to achieve an optimal trade-off between CO2 emissions and mass reduction.

An in-depth comparative FEA on through-thickness residual stresses in press-braked cold-formed steel section

The finite element (FE) is one of the techniques implemented to predict residual stresses. The selection of the proper FE technique is essential to achieve accurate results. This study investigated the prediction of residual stress distribution in pressed-braked thin-walled cold-formed steel sections using the 3D-Shell finite element (FE) technique. Cold-forming processes produce residual stresses and affect the structural capacity of thin-walled cold-formed steel sections. Previous studies have used and recommended the 3D-Solid FE technique to predict residual stresses; however, limited studies have applied this 3D-Shell FE technique. Therefore, the results showed this study had compared the longitudinal/transverse residual stresses and the neutral axis shift obtained by the 3D-Shell FE technique with the results from the literature using the 3D-Solid FE technique. It is also revealed that there are limitations in the 3D-Shell FE technique for predicting residual stresses.

Numerical analysis of turbulent nitrogen-diluted hydrogen flames stabilised by star-shaped bluff bodies

In this paper, we investigate the flow and flame dynamics within a combustion chamber supplied with nitrogen-diluted hydrogen fuel and air as oxidiser. The chamber is equipped with a bluff body that serves as a flame stabiliser. We focus primarily on the influence of the bluff body shape on the formation of large and small-scale vortical structures generated at the bluff body edge. We analyse how the geometry of the bluff body alters these structures and examine the impact of resulting modifications on flame characteristics, including key features such as flame length and radial extent, temperature and species field, and completeness of the combustion process. We consider four bluff body geometries, namely a typical cylindrical shape, a star-shaped wall, and a small triangular sharp and smooth wavy structure. The research employs the Large Eddy Simulation (LES) method, providing deep insight into the complex physics of unsteady flow. In the cylindrical bluff body configuration, the key mechanism driving the fuel-oxidiser mixing process is the periodic occurrence of large toroidal vortices shed at an exit of the oxidiser duct and on the bluff body edge. They exert the flow towards and away from a recirculation zone formed above the bluff body. When its geometry is irregular, the appearance of the large vortices is suppressed, however, the wall irregularities induce small-scale flow phenomena that enhance mixing in the shear layer formed between the recirculation zone and the oxidiser stream. The mixing efficiency is largely dependent on the shape of the bluff body wall, and it turns out that seemingly small changes (sharp vs. smooth small triangular parts), which in non-reactive regimes have only a minor effect on the flow dynamics, significantly change the flame length and fuel consumption rate. Compared to the cylindrical bluff body configuration, the small triangular parts cause an axial shift of the maximum temperature downstream and slow down fuel consumption. Contrary, large triangular elements in the star-shape bluff body clearly influence the flow both in non-reactive and reactive regimes. They cause the formation of local oxidiser streams directed towards the fuel-rich mixture. Consequently, the injected fuel burns at a rate similar to that observed in the case of the cylindrical bluff body, but the combustion process occurs at an average temperature approximately 200 K lower and its fluctuations are reduced. These factors may influence the thermal reduction of NOx. On the other hand, a negative aspect is the highest level of hydrogen in the closest vicinity of the bluff body, which in practical applications may accelerate the embrittlement of its surface.

Abstract 264: Differentiation therapy: Esculetin as a potent agent to alter cellular plasticity of leukemic &amp; solid tumor stem cells

Abstract Background The “Differentiation therapy” has been emerging as a promising and more effective strategy against acute leukemia relapses. Objective In extension to the revolutionising therapeutic outcomes of All Trans Retinoic Acid (ATRA) to induce terminal differentiation of Acute Promyelocytic Leukemic (APL) blast cells, we decipher the potential effect of a natural compound “Esculetin” to serve as a differentiating agent in Acute Myeloid Leukemia (AML) as well as solid tumour cells. Underlaying role of Wnt signaling pathways in esculetin mediated blast cell differentiation was also evaluated. Methods Human acute myeloid leukemic cells (Kasumi-1) with t(8;21/AML-ETO) translocation were used as a model system. Growth inhibitory and cytotoxic activity of esculetin were analysed using growth kinetics and MTT assay. Morphological alterations, cell scatter characteristics, NBT reduction assay and cell surface marker expression pat- terns were analysed to detect terminally differentiated phenotypes. We employed RT2profiler PCR array system for the analysis of transcriptome profile of Wnt signaling components. Calcium inhibitors (TMB8 and Amlodipine) and Transforming growth factor beta (TGF-β) were used to modulate the Wnt signaling axes. To investigate whether esculetin exerts the similar effects on the invasive solid tumour cancer stem cells subset, we used a cellular model system of colon carcinoma HCT116 cells reflecting EMT phenotype. Results We illustrate cytotoxic as well as blast cell differentiation potential of esculetin on Kasumi-1 cells. Morphological alterations akin to neutrophilic differentiation as well as the corresponding acquisition of myeloid lineage markers indicate terminal differentiation potential of esculetin in leukemic blast cells. Exposure to esculetin also resulted in downregulation of canonical Wnt axis while upto ~ 21 fold upregulation of non-canonical axis associated genes. Esculetin also showed potential to revert the CSC marker expressions and concurrent EMT consistent with reduced functional aggressiveness in colon cancer cells. Conclusions Our study highlights the importance of selective use of calcium pools as well as “axis shift” of the canonical to non-canonical Wnt signaling upon esculetin treatment which might abrogate the inherent proliferation to release maturation arrest and induce the differentiation in leukemic blast cells as well as CSC stem cells. The current findings provide further therapeutic interventions to consider esculetin as a potent differentiating agent to counteract relapses. Citation Format: Ankit Mathur, Daman Saluja. Differentiation therapy: Esculetin as a potent agent to alter cellular plasticity of leukemic &amp; solid tumor stem cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 264.

Flexural behavior of novel marine concrete filled CFRP-aluminum alloy tube member

This study proposes a novel marine concrete filled CFRP-aluminum alloy tube (CFRP-CFAT) member for marine engineering. Six specimens including one marine concrete filled aluminum alloy tube (CFAT) and five CFRP-CFAT specimens were tested under uniaxial bending to investigate the flexural behavior of CFRP-CFAT. The effects of CFRP pasting positions, CFRP layers and shear span ratio were investigated. The failure patterns, mid span deflection curves, distribution of the deflection curves, strain, ultimate moment, ductility, flexural stiffness were analyzed. The experiment results illustrate that the failure pattern of CFAT specimen can be improved by CFRP. With the increase in mid-span deflection, the neutral axis shifts towards the compression zone. CFRP enhances the flexural capacity of CFAT specimens, the enhancement of inner CFRP was slightly better. The shear-span ratio does not have a significant impact on the flexural capacity. Compared to CFAT specimens, the use of CFRP leads to a decrease in ductility due to its brittle fracture. Calculation methods for CFRP-CFAT stiffness and bending moment capacity considering the influence of CFRP were proposed.

Demonstration of Two Multi‐Component Target Ablation Approaches and Their Application in Combinatorial Pulsed Laser Deposition

AbstractCombinatorial pulsed laser deposition (C‐PLD) based on segmented targets has led to new possibilities in the pace of discovery of novel advanced materials with significantly reduced deposition time and material consumption. However, fabrication of established segmented targets may be complex or not even possible for certain material combinations. In this article, two alternative C‐PLD techniques based on easy‐to‐fabricate segmented targets are presented. One approach uses two semi‐circular segments A and B with a systematic adjustable lateral shift of the target rotation axis from the target center. The other approach is based on a new target design defined by an ABA‐segmentation where B is a horizontal bar between two semi‐circular segments of A. Both approaches enable growth of discrete composition libraries. The concepts and important parameters are introduced and computer simulations as function of the geometric parameters are made to yield the expected thin film compositions. As proof‐of‐concept, the techniques are employed on the transparent, semiconducting ternary alloy zinc‐tin‐oxide. The simulations are in very good agreement with the experimental data. Physical properties of films grown by the demonstrated approaches are compared with those obtained by established PLD processes.