A numerical technique for solving geometrically nonlinear problems for an orthotropic cylindrical shell of elliptical cross-section weakened by a circular hole is developed. The system of governing equations is derived using the Kirchhoff–Love theory of deep shells and Hooke’s law for orthotropic materials. The technique employs the procedure of incremental loading, as well as the modified Newton–Kantorovich and finite-element methods. The effect of finite deflections and mechanical and geometrical parameters on the stress–strain state of the shell near the circular hole acted upon by axial tensile forces is analyzed.