The knowledge of salinity in a specific sea area with high accuracy is required to solve several acoustic and hydrophysical problems on the ocean shelf. Unlike temperature, which can be measured continuously for a long time, with, for example, thermistor strings (thermostrings), salinity values of required accuracy can be obtained only using CTD profiling. This is why methods of estimating salinity from temperature could be helpful. In this paper, the authors propose using the regression method for solving this type of problem and demonstrate the efficiency of this method using examples of temperature measurements from anchored thermostrings. For the correct construction of regressions, the authors analyzed the errors of CTD measurements and suggested a method for the dynamic correction of raw CTD data. From CTD profiling datasets of 12 years (2011–2022), after their dynamic correction, the authors obtained regression polynomial formulas for calculating salinity from temperature and studied data stability in space and time at the hydrophysical test site, located in the shelf zone of the Sea of Japan. The authors consider this method efficient and applicable in solving a variety of acoustic and hydrophysical problems.