Shear Stress Conditions Research Articles

In-plane dynamic analysis of supershear rupture transition due to poroelastic pressurization

Summary Although pore fluid has received increased attention in the problems of earthquake rupture, its effects on coseismic rupture are not fully understood. In this paper, we numerically simulate dynamic rupture in saturated poroelastic media to study the interplay between poroelastic pressurization and rupture evolution. Particular attention is paid to the physical process of the supershear transition. The spontaneous rupture is assumed to be governed by slip weakening law and the fault is treated as a leaky interface where pore pressure equilibrium is delayed. Results show that the pore pressure induced by coseismic mechanical deformation can strengthen the fault on the extensional side but weaken the fault on the compressional side. As a result, the poroelastic pressurization on the compressional side can promote the occurrence of the transition to supershear rupture while its strengthening effect on the extensional side can suppress this transition even in the state of high initial shear stress. Meanwhile, it is found that the permeability distribution along the fault plane also affects rupture evolution. Faults with nucleation zones located in low permeability regions are more likely to undergo a supershear rupture.

Permanent deformation and particle crushability of calcareous sands under cyclic traffic-induced loadings through simple shear apparatus

This study focuses on investigating permanent deformations, encompassing normal and shear strains, of calcareous sandy soils subjected to drained cyclic traffic-induced loadings. The investigation utilizes a Simple Shear (SS) apparatus allowing for variations in both normal and shear stress components over each cycle and incorporates Principal Stress Rotation (PSR), a feature not replicable in conventional cyclic uniaxial triaxial tests which is the key aspect of this research. The study also accounts for the harmonically changing the effective horizontal stress resulting from cyclic variations of effective vertical stress, conducted under a horizontally constrained boundary condition with zero lateral strain. A series of drained cyclic simple shear experiments is carried out, implementing a heart-shaped stress path, encompassing up to 1000 cycles. The objective of the study is to analyze permanent normal and shear deformations, along with associated total particle crushing, using both sieving analyses and 2D image processing of particles. The study also evaluates the impact of an initial static shear stress originating from the longitudinal slope of roads. The findings highlight the influences of induced cyclic amplitudes of stress components, principal stress and strain rate rotation, and initial static shear stress on the development of permanent strains. Furthermore, the research characterizes particle crushability in terms of total crushability over such loading, examining its dependency on relative density and variations in both shear and normal stress components.

Endothelial-Derived Nitric Oxide Impacts Vascular Smooth Muscle Cell Phenotypes Under High Wall Shear Stress Condition

Endothelial-Derived Nitric Oxide Impacts Vascular Smooth Muscle Cell Phenotypes Under High Wall Shear Stress Condition

Selection of the optimal formulation of the biopolymer system for the stimulation of productive formations

The object of study in this paper is the biopolymer system «X» – a complex composition that includes a biopolymer, salts and a thermal stabiliser intended for use in drilling fluids at high temperatures. The components of the formulation include complex reagent «X» for regulating structural, mechanical, rheological and filtration properties, as well as inhibitors (sodium and potassium chloride) and filler. Components of the biopolymer system (sodium chloride, organo-mineral colmatant thermal stabiliser) increase its thermal stability. One of the most problematic areas is the mechanism of sodium chloride's thermal stabilising effect. It is associated with an increase in the overall mineralisation of the drilling mud, which leads to a certain conformation of biopolymer molecules, accelerates gelation processes and counteracts the temperature dilution of the system. The results obtained can be explained as follows: – an increase in the concentration of sodium chloride leads to an increase in the ionic strength of the solution, which contributes to a change in the conformation of biopolymer molecules, enhancing intermolecular interactions and, as a result, increasing the viscosity and stability of the system; – the organo-mineral colmatant heat stabiliser promotes the formation of a filtration crust on the well walls, which prevents fluid loss and reduces rock permeability; – all components of the system interact with each other, affecting the properties of the solution. The optimum ratio of components allows achieving the required rheological characteristics and ensuring the stability of the system at high temperatures. As a result of processing the information on technologies for tapping productive horizons, the disadvantages and advantages of each of them were noted. The existing drilling fluid systems used to tap productive horizons at high temperatures were considered. However, more attention was paid to the selection of a new optimal formulation of the biopolymer system, in accordance with the specified rheological and structural and mechanical properties for further implementation in practice. This ensures the possibility of obtaining predictive parameters of the drilling mud. The proposed system has a number of advantages over similar ones, namely: – the system retains its properties at high temperatures; – the system provides the required values of viscosity, filtration and static shear stress; – due to the use of an optimal formulation, high efficiency is achieved at a relatively low cost.

Investigation of Scaling and Materials' Performance in Simulated Geothermal Brine.

Geothermal energy generation faces challenges in efficiency, partly due to restrictions on reinjection temperatures caused by scaling issues. Therefore, developing strategies to prevent scaling is critical. This study aims to simulate the scaling tendencies and corrosion effects of geothermal fluids on various construction materials used in scaling reactor/retention tank systems. A range of materials, including carbon steel, austenitic stainless steel, duplex stainless steel, two proprietary two-part epoxy coatings, and thermally sprayed aluminium (TSA), were tested in a simulated geothermal brine. Experiments were conducted in a laboratory vessel designed to replicate the wall shear stress conditions expected in a scaling reactor. The tests revealed varying scaling tendencies among the materials, with minimal corrosion observed. The dominant scale formed was calcium carbonate, consistent with geochemical modelling. The findings suggest that despite the high operating temperatures, the risk of corrosion remains low due to the brine's low chloride content, while the wettability of materials after immersion may serve as a useful indicator for selecting those that promote scaling.

Development of a microfluidic system with a bearing micropump for applying fluid shear force in an intervertebral disc degeneration model involving mechanical stimulation

Background: The intervertebral disc (IVD) functions as a shock absorber with viscoelastic tissues, including the gelatinous nucleus pulposus and the collagenous annulus fibrosus (AF). External mechanical loading influences IVD homeostasis but can cause damage and inflammatory reactions, contributing to disc degeneration. There is a lack of in vitro platforms for modeling IVD disease with mechanical stimulation.Methods: This study aimed to create a mechanical stimulation-based model by subjecting AF cells to shear stress using a micropump system. A micropump platform was used to measure pulsation, flow rate, and shear stress. AF cells were exposed to fluid shear stress of 0.5 and 1 dyne/cm², and morphological changes, cytotoxicity, and cell viability were analyzed through a live/dead assay. Perimeter, area, diameter, and elongation were assessed using live cell imaging and imaging analysis software.Results: The micropump platform exhibited optimal rotor characteristics for uniform pulsation and shear stress. Fluid shear stress at 0.5 dyne/cm² showed no significant difference from the control group, while 1 dyne/cm² reduced cell adhesion and survival. Comparing the 0.5 dyne/cm² shear stress group and interleukin-1β group to the control, significant decreases in perimeter, area, and diameter were observed.Conclusion: The study successfully developed a micro-peristaltic pump platform for applying fluid shear stress to cells, identifying an optimal rotor for uniform stress application. The platform effectively modeled IVD disease, revealing reduced cell adhesion and survival under specific shear stress conditions. This platform has potential promise for discovering biomarkers and exploring cellular responsiveness to external stimuli.

Application of the Extension Strain Criterion for Sandstone Failure Evaluation under Tension and Shear Stress Conditions

Application of the Extension Strain Criterion for Sandstone Failure Evaluation under Tension and Shear Stress Conditions

An investigation of the rheological parameters of slurry composed of ordinary Portland cement, Portland pozzolana cement and Portland slag cement

ABSTRACT This paper compares the rheological parameters of ordinary Portland cement of grade 43 (OPC 43), ordinary Portland cement of grade 53 (OPC 53), Portland pozzolana cement (PPC) and Portland Slag Cement (PSC) to study the thixotropic built. Five slurries with increasing water/cement (w/c) ratios from 0.52 to 0.6 were prepared and examined at resting times of 1 minute, 5 minutes and 10 minutes. Static shear stress (τs), dynamic shear stress (τd) and thixotropic index (β) were studied to analyze the thixotropic built of the slurries. The rheological parameters increase for all the mixes with decreasing w/c ratios and increasing resting times. However, for a w/c ratio greater than 0.60, all the mixes lose their plastic viscosity and the rheological parameters approach non-significant values. The τs and τd values for PPC and PSC pastes are higher than those of the OPC pastes because of the increase in cement fineness and increased rate of structuration and hydration. OPC 53 paste shows high β because of the large extent of reversible thixotropic built. The τs values obtained from the viscometrical tests were then compared the mini slump test values. Results show that the rheological parameters are more consistent than the flow values of the mini slump cone test.

Mechanical and failure behaviors of adhesively bonded dissimilar materials joints incorporating bio-inspired morphological irregularities

Adhesive dissimilar material joints between stainless steel grade 316L and polyethylene terephthalate glycol (PETG) plastic were examined, in which irregular interface morphologies inspired by natural sutures were incorporated. The joint interfaces exhibited various teeth-like, non-repetitive zigzag patterns based on a pseudo-randomization method and sutural interdigitation index. Effects of their irregularities on mechanical and failure characteristics of adhesive butt joints were studied by means of experiments and FE simulations. The cohesive zone model, Drucker-Prager plasticity model and ductile failure criterion were applied for the interface and PETG, respectively. Predicted load-displacement curves of joints with different teeth profiles were well validated. The degree of irregularity became higher to 20%, 40%, and 60%, the joint strengths decreased by 1.47%, 5.39%, and 11.95%, while the total energies to failure increased by 110.74%, 129.33%, and 161.23%, accordingly. More inhomogeneous morphologies led to earlier local damage initiation, but enhanced damage evolution range by impeding abrupt joint separation. Smaller teeth angles provided higher joint strength, whereas significant declines of bonding strength were observed by too acute teeth angle due to excessive stress localization and resulting teeth breakage. The teeth angle of 45º enabled the superior joint performance owing to a proper combination of interlocking and large adhesive force under shear stress state. Finally, a key insight for designing an optimal dissimilar joint with morphological irregularities was provided.

The Effect of Initial Static Shear Stress on Liquefaction Triggering of Coarse-Grained Materials

The Effect of Initial Static Shear Stress on Liquefaction Triggering of Coarse-Grained Materials

NADPH Oxidase 4: Crucial for Endothelial Function under Hypoxia-Complementing Prostacyclin.

Aim: The primary endothelial NADPH oxidase isoform 4 (NOX4) is notably induced during hypoxia, with emerging evidence suggesting its vasoprotective role through H2O2 production. Therefore, we aimed to elucidate NOX4's significance in endothelial function under hypoxia. Methods: Human vessels, in addition to murine vessels from Nox4-/- mice, were explored. On a functional level, Mulvany myograph experiments were performed. To obtain mechanistical insights, human endothelial cells were cultured under hypoxia with inhibitors of hypoxia-inducible factors. Additionally, endothelial cells were cultured under combined hypoxia and laminar shear stress conditions. Results: In human occluded vessels, NOX4 expression strongly correlated with prostaglandin I2 synthase (PTGIS). Hypoxia significantly elevated NOX4 and PTGIS expression and activity in human endothelial cells. Inhibition of prolyl hydroxylase domain (PHD) enzymes, which stabilize hypoxia-inducible factors (HIFs), increased NOX4 and PTGIS expression even under normoxic conditions. NOX4 mRNA expression was reduced by HIF1a inhibition, while PTGIS mRNA expression was only affected by the inhibition of HIF2a under hypoxia. Endothelial function assessments revealed hypoxia-induced endothelial dysfunction in mesenteric arteries from wild-type mice. Mesenteric arteries from Nox4-/- mice exhibited an altered endothelial function under hypoxia, most prominent in the presence of cyclooxygenase inhibitor diclofenac to exclude the impact of prostacyclin. Restored protective laminar shear stress, as it might occur after thrombolysis, angioplasty, or stenting, attenuated the hypoxic response in endothelial cells, reducing HIF1a expression and its target NOX4 while enhancing eNOS expression. Conclusions: Hypoxia strongly induces NOX4 and PTGIS, with a close correlation between both factors in occluded, hypoxic human vessels. This relationship ensured endothelium-dependent vasodilation under hypoxic conditions. Protective laminar blood flow restores eNOS expression and mitigates the hypoxic response on NOX4 and PTGIS.

Impact of zirconia-based oxide on endothelial cell dynamics and extracellular matrix remodeling

IntroductionZirconia (ZrO2) is highly regarded in dental restoration due to its aesthetic compatibility and mechanical properties that align with biological tissues. This study explores the effects of stabilized ZrO2 on endothelial cell function and extracellular matrix (ECM) remodeling, processes critical to successful osseointegration in dental implants. MethodologyHuman Umbilical Vein Endothelial Cells (HUVECs) were cultured in ZrO2 -enriched medium under both static and shear stress conditions. Newly implemented techniques, including detailed zirconia surface characterization using scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), and X-ray diffraction (XRD), were used to verify material properties. Gene and protein expression related to cell adhesion, proliferation, and ECM remodeling were assessed through RT-qPCR and Western blotting. Zymography was used to evaluate the activity of matrix metalloproteinases (MMP2 and MMP9) involved in ECM remodeling. ResultsCharacterization data confirmed the stability and structural properties of ZrO2, revealing a tetragonal crystalline structure and rough surface morphology conducive to cell adhesion. ZrO2 exposure led to the downregulation of Src, a key regulator of cell adhesion, while upregulating cell cycle regulators p15, CDK2, and CDK4, indicating enhanced cell proliferation. Under shear stress, ZrO2 modulated TGF-β and MAPK signaling, affecting cell proliferation and angiogenesis. MMP2 and MMP9 activity increased in static conditions but decreased under shear stress, suggesting ZrO2 dynamic role in ECM remodeling. ConclusionThis study shows that stabilized zirconia (ZrO2) modulates endothelial cell dynamics and ECM remodeling, key for osseointegration. ZrO2 downregulated Src expression and upregulated cell cycle regulators, enhancing endothelial proliferation. It also affected TGF-β and MAPK pathways, influencing angiogenesis, and differentially modulated MMP2 and MMP9 activity depending on mechanical conditions. These findings highlight ZrO2 has potential ability to enhance vascular and tissue integration in dental applications.

AMP dependent protein kinase regulates endothelial heparan sulfate expression in response to an inflammatory stimulus under arterial shear stress

Heparan sulfate (HS) is the most abundant glycosaminoglycan on the vascular endothelium and can regulate endothelial cell morphology and function in response to mechanical stimuli. This study investigated endothelial HS response to an inflammatory stimulus under static and arterial shear stress conditions. Human aortic endothelial cells (HAECs) under static conditions expressed significantly higher HS when treated with an inflammatory stimulus compared to untreated controls. HAECs exposed to an inflammatory stimulus after being conditioned with 10 dyn/cm2 of shear stress for 24 h did not express significantly higher HS compared to untreated controls under flow. To investigate the mechanism underlying this differential endothelial HS expression in response to an inflammatory stimulus under static and shear stress conditions, we hypothesized a shear dependent increase in AMP dependent protein kinase (AMPK) was regulating HS response to the inflammatory stimulus. AMPK inhibition using compound C decreased HAEC HS expression in response to inflammatory stimulus under arterial shear stress, revealing AMPK as a regulator of HS expression. Further investigation is needed to elucidate the mechanistic pathways underlying the interactions between HS and AMPK expression in endothelial cells and how they regulate HAEC inflammatory response.

Behaviour of sand under the constant shear drained stress path: the role of fines

This paper presents a specifically designed experimental study aimed at exploring the role of fines in altering the behaviour of sand under the constant shear drained (CSD) stress path. The novelty of this study includes that the interplay of several key factors (fines shape, fines content, void ratio) was investigated systematically and the true constant shear stress condition was fulfilled by means of an advanced servo system which allowed the entire loading response to be captured. One of the marked findings is that the presence of fines not only alters the onset of instability of loose sand but also affects the deformation development thereafter. Drained instability can be triggered more easily in loose sand mixed with silica fines compared with the sand on its own. At the same quantity of fines, instability can be triggered more easily for sand mixed with rounded fines. However, the effect of fines appears to be marginal for sand at dense state. For all tested specimens, values of the axial strain rate at instability fall in a narrow range (0.008%/min–0.016%/min), meaning that the axial strain rate can be potentially a useful guide for quantitatively determining the inception of instability under the CSD conditions. The stress ratio q/p′ at onset of instability under the CSD conditions is also state dependent as under the undrained conditions.

Non-linear bending analysis and control of graphene-platelets-reinforced porous sandwich plates with piezoelectric layer subjected to electromechanical loading

Piezoelectric materials as the controlling element have been widely utilized to produce intelligent engineering structures, while these smart structures may fail to realize effective control of composite structures with large deformations. However, investigations on such issues are less reported in published literature, as an accurate and efficient model is required to well forecast the geometrically nonlinear behaviors of smart sandwich structures. As a result, a novel sinusoidal Legendre global-local higher-order shear deformation plate theory (SLHSDT) has been developed to accurately capture geometrically nonlinear behaviors of piezoelectric sandwich plates. The proposed model can fulfill the compatible conditions of transverse shear stresses and contain transverse normal strain, which can ensure precision in predicting electromechanical behaviors. The multi-patch isogeometric analysis (IGA) method for sandwich plates partially bonded with piezoelectric layers is proposed to overcome C1-continuity between patches for the first time. Moreover, the Newmark-β method and Newton-Raphson technique are attempted to solve the nonlinear equations. The present model has been utilized to investigate electromechanical behaviors of laminated structures with piezoelectric layers, which has been compared with the published results. In addition, experiments on macro fiber composite (MFC) integrated sandwich plates have been also carried out in the present work, which can effectively verify the performance of proposed model. Subsequently, the proposed model is employed to study electromechanical behaviors of the five-layer piezoelectric sandwich plates containing internal pores and graphene platelets. Then, influences of the porosity coefficient and GPLs weight fraction on the nonlinear electromechanical behaviors of sandwich plates are investigated. Eventually, the active control on nonlinear behaviors of piezoelectric porous sandwich plates with GPLs reinforcement is studied by using a closed-loop control system, and an effective approach slowing down large deformation has been proposed by selecting an appropriate distribution of GPLs along the thickness direction.

Simultaneous Measurement of Fiber-Matrix Interface Debonding and Tunneling Using a Dual-Vision Experimental Setup

BackgroundFiber-matrix debonding is a precursor for transverse cracking and several other types of damage in fiber composites. However, to date, there are limited experiment-based reports that study the fundamental mechanisms of fiber-matrix debonding.ObjectiveThis work aims to uncover the governing mechanisms of fiber-matrix interface debonding by full-field measurements supplemented by numerical simulations. In particular, the application of a dual-vision image-based characterization approach on single glass macro fiber samples is discussed and proven useful in understanding the in-plane and out-of-plane debonding characteristics at the fiber-matrix interface.MethodsFull-field strain and displacement measurements based on digital image correlation are performed on model single-fiber composites. The use of a dual-vision system allows strain measurements in the vicinity of the fiber-matrix interface, also allowing for the identification of critical strain and stress values corresponding to the initiation and propagation of debonding damage. The experimental data are used to calibrate an inverse identification approach that outputs the shape of the debonded interface along the fiber length.ResultsFull-field measurements allow for establishing correlations between local and global strain fields. Observation of debonding propagation along the fiber axis seems to be representative of the crack tunneling during the early stages of the failure process, i.e., when the crack tip is subjected to opening mode only.ConclusionsSide view measurements are useful as a first-order approximation of the debonding propagation velocity along the fiber axis but fail to provide accurate measurements for the debonding shape, esp. in areas where the crack is under a dominantly shear stress state. This issue can be resolved by full-field measurements coupled with computational simulations.

Cyclic response of unsaturated weathered red mudstone: Experimental investigation and a cyclic model

The mechanical properties and constitutive model of unsaturated soils under cyclic loading are crucial for understanding the behavior of foundations and slopes subjected to dynamic motions such as earthquakes and traffic loading. In this study, multilevel strain-controlled cyclic simple shear tests of unsaturated weathered red mudstone (WRM) were conducted. The detailed investigation focused on cyclic responses, including shear stress-strain behavior and volume change, strain-dependent secant shear modulus and damping ratio, and stress–dilatancy behavior. This study revealed the significant influences of the degree of saturation and vertical stress on these responses, with the initial static shear stress mainly affecting the shear stress-strain behavior and volume changes at the initial loading stage. Based on the experimental observations, a cyclic constitutive model was proposed for unsaturated WRM. The model incorporates a slightly revised Davidenkov model and Masing criterion to generate shear stress-strain hysteresis loops with or without initial static shear stress. Additionally, a stress-dilatancy equation was included to capture the volume changes during cyclic loading. The proposed model was verified by comparing representative test data and calculation results, demonstrating the excellent performance of the proposed model in modeling the main features of unsaturated WRM under cyclic loading.

Investigating Flow-Induced Corrosion of Magnesium in Ophthalmological Milieu.

Although the impact of local fluid dynamics in the biodegradation of magnesium is well known, currently no studies in the literature address the degradation effects of ocular vitreous on bioresorbable devices made of magnesium, which could be developed as drug delivery carriers. The aim of this study was to investigate the flow-induced corrosion mechanism of magnesium in an ophthalmological environment for future applications in ophthalmic drug delivery. To achieve this, experimental and computational methods were combined. Specifically, a CFD model was employed to design experimental conditions that replicate the ocular flow-induced shear stress (FISS) on manufactured magnesium samples. Pure Mg samples were tested in a bioreactor system capable of imposing the ocular CFD calculated values of FISS on the Mg samples' surface by varying the pump flow rate. Optimal flow rates for a range of different FISS values specific to the ophthalmological fluid dynamics affecting the device were indeed determined before running the experiments. After conducting customized corrosion tests, morphological observations and profilometric maps of the eroded surfaces of Mg samples were obtained using scanning electron microscopy (SEM) and confocal laser scanning microscopy (CLSM). These maps were then post-processed for the parametric evaluation of corrosion rates. Pre-existing localized superficial defects did affect the final corrosion pattern. SEM images and CLSM data confirmed a uniform corrosion mechanism, with corrosion rates of 1.9, 2.7, and 3.4 μm/day under different shear stress conditions (0, 0.01, and 0.032 Pa, respectively). More generally, uniform corrosion on pure Mg samples increased with higher FISS values, and at higher shear stress values (FISS = 0.032 Pa), a notable washing-out effect of the corrosion products was observed. The removal of corrosion products at higher shear stresses suggests that the dynamic ocular environment, influenced by saccadic movements, plays a significant role in the corrosion mechanism of pure magnesium. The corrosion rates determined in this study, in conjunction with clinical drug release requirements, are crucial for designing potential drug-release devices for ocular applications.

An improved dual shear unified strength model (IDSUSM) considering strain softening effect

This study proposes an improved dual shear unified strength model by introducing the plastic internal variable which reflects the collective effects of strain softening, intermediate principal stress and unequal strength under tension and compression. The improved model is then simplified into simple forms for typical stress states, including uniaxial tension and compression, plane stress pure shear and tri-axial stress states. The smooth method and conjugate gradient method are utilized to facilitate its numerical implementation, avoiding numerical singularity and non-convergence in the solution process. The physical meanings of the parameters are further clarified and their values for self-compacting concrete are determined from the results of triaxial compression tests through a combination of direct determination, equation solution and back propagation (BP) neural network optimization. Validated against the test results, the improved model gives a more accurate prediction than the traditional dual shear unified strength model and Mohr-Coulomb model, in terms of both the overall trend and representative values. Validation results show that the improved model is applicable to materials for which the compressive strength is greater than the tensile strength and the tensile strength is greater than the shear strength.

Sensitivity to entrance conditions of wall shear stress in a curved vessel

Sensitivity to entrance conditions of wall shear stress in a curved vessel